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Edward P Debold PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Amherst
DepartmentSchool of Public Health and Health Sciences
AddressTotman Phys Ed Building
Amherst, MA 01003
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu S, Marang C, Woodward M, Joumaa V, Leonard T, Scott B, Debold E, Herzog W, Walcott S. Modeling Thick Filament Activation Suggests a Molecular Basis for Force Depression. bioRxiv. 2023 Sep 29. PMID: 37808737.
    2. Marang C, Scott B, Chambers J, Gunther LK, Yengo CM, Debold EP. A mutation in switch I alters the load-dependent kinetics of myosin Va. Nat Commun. 2023 05 30; 14(1):3137. PMID: 37253724.
      Citations:    Fields:    
    3. Debold EP. Recent insights into the relative timing of myosin's powerstroke and release of phosphate. Cytoskeleton (Hoboken). 2021 09; 78(9):448-458. PMID: 35278035.
      Citations: 5     Fields:    
    4. Scott B, Marang C, Woodward M, Debold EP. Myosin's powerstroke occurs prior to the release of phosphate from the active site. Cytoskeleton (Hoboken). 2021 05; 78(5):185-198. PMID: 34331410.
      Citations: 4     Fields:    Translation:Cells
    5. Gunther LK, Rohde JA, Tang W, Cirilo JA, Marang CP, Scott BD, Thomas DD, Debold EP, Yengo CM. FRET and optical trapping reveal mechanisms of actin activation of the power stroke and phosphate release in myosin V. J Biol Chem. 2020 12 18; 295(51):17383-17397. PMID: 33453985.
      Citations: 10     Fields:    Translation:AnimalsCells
    6. Woodward M, Ostrander E, Jeong SP, Liu X, Scott B, Unger M, Chen J, Venkataraman D, Debold EP. Positional Isomers of a Non-Nucleoside Substrate Differentially Affect Myosin Function. Biophys J. 2020 08 04; 119(3):567-580. PMID: 32652059.
      Citations:    Fields:    Translation:Cells
    7. Unger M, Debold EP. Acidosis decreases the Ca2+ sensitivity of thin filaments by preventing the first actomyosin interaction. Am J Physiol Cell Physiol. 2019 10 01; 317(4):C714-C718. PMID: 31339771.
      Citations: 2     Fields:    Translation:AnimalsCells
    8. Jarvis K, Woodward M, Debold EP, Walcott S. Acidosis affects muscle contraction by slowing the rates myosin attaches to and detaches from actin. J Muscle Res Cell Motil. 2018 08; 39(3-4):135-147. PMID: 30382520.
      Citations: 6     Fields:    Translation:Animals
    9. Woodward M, Debold EP. Acidosis and Phosphate Directly Reduce Myosin's Force-Generating Capacity Through Distinct Molecular Mechanisms. Front Physiol. 2018; 9:862. PMID: 30042692.
    10. Longyear T, Walcott S, Debold EP. The molecular basis of thin filament activation: from single molecule to muscle. Sci Rep. 2017 05 12; 7(1):1822. PMID: 28500282.
      Citations: 12     Fields:    Translation:Cells
    11. Debold EP, Fitts RH, Sundberg CW, Nosek TM. Muscle Fatigue from the Perspective of a Single Crossbridge. Med Sci Sports Exerc. 2016 11; 48(11):2270-2280. PMID: 27434086.
      Citations: 33     Fields:    Translation:HumansCells
    12. Debold EP. Decreased Myofilament Calcium Sensitivity Plays a Significant Role in Muscle Fatigue. Exerc Sport Sci Rev. 2016 10; 44(4):144-9. PMID: 27526194.
      Citations: 6     Fields:    Translation:HumansCells
    13. Debold EP. Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species. Front Physiol. 2015; 6:239. PMID: 26388779.
    14. Debold EP. Biological machines: Molecular motor teamwork. Nat Nanotechnol. 2015 Aug; 10(8):656-7. PMID: 26243000.
      Citations:    Fields:    Translation:Humans
    15. Woodward M, Previs MJ, Mader TJ, Debold EP. Modifications of myofilament protein phosphorylation and function in response to cardiac arrest induced in a swine model. Front Physiol. 2015; 6:199. PMID: 26236240.
    16. Nelson CR, Debold EP, Fitts RH. Phosphate and acidosis act synergistically to depress peak power in rat muscle fibers. Am J Physiol Cell Physiol. 2014 Nov 15; 307(10):C939-50. PMID: 25186012.
      Citations: 21     Fields:    Translation:AnimalsCells
    17. Swenson AM, Trivedi DV, Rauscher AA, Wang Y, Takagi Y, Palmer BM, M?ln?si-Csizmadia A, Debold EP, Yengo CM. Magnesium modulates actin binding and ADP release in myosin motors. J Biol Chem. 2014 Aug 22; 289(34):23977-91. PMID: 25006251.
      Citations: 15     Fields:    Translation:AnimalsCells
    18. Longyear TJ, Turner MA, Davis JP, Lopez J, Biesiadecki B, Debold EP. Ca++-sensitizing mutations in troponin, P(i), and 2-deoxyATP alter the depressive effect of acidosis on regulated thin-filament velocity. J Appl Physiol (1985). 2014 May 01; 116(9):1165-74. PMID: 24651988.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    19. Debold EP, Walcott S, Woodward M, Turner MA. Direct observation of phosphate inhibiting the force-generating capacity of a miniensemble of Myosin molecules. Biophys J. 2013 Nov 19; 105(10):2374-84. PMID: 24268149.
      Citations: 30     Fields:    Translation:AnimalsCells
    20. Kobayashi M, Debold EP, Turner MA, Kobayashi T. Cardiac muscle activation blunted by a mutation to the regulatory component, troponin T. J Biol Chem. 2013 Sep 06; 288(36):26335-26349. PMID: 23897817.
      Citations: 7     Fields:    Translation:AnimalsCells
    21. Debold EP, Longyear TJ, Turner MA. The effects of phosphate and acidosis on regulated thin-filament velocity in an in vitro motility assay. J Appl Physiol (1985). 2012 Nov; 113(9):1413-22. PMID: 23019317.
      Citations: 18     Fields:    Translation:AnimalsCells
    22. Walcott S, Warshaw DM, Debold EP. Mechanical coupling between myosin molecules causes differences between ensemble and single-molecule measurements. Biophys J. 2012 Aug 08; 103(3):501-510. PMID: 22947866.
      Citations: 50     Fields:    Translation:Cells
    23. Debold EP. Recent insights into the molecular basis of muscular fatigue. Med Sci Sports Exerc. 2012 Aug; 44(8):1440-52. PMID: 22330018.
      Citations: 16     Fields:    Translation:Humans
    24. Debold EP. Recent insights into muscle fatigue at the cross-bridge level. Front Physiol. 2012; 3:151. PMID: 22675303.
    25. Debold EP, Turner MA, Stout JC, Walcott S. Phosphate enhances myosin-powered actin filament velocity under acidic conditions in a motility assay. Am J Physiol Regul Integr Comp Physiol. 2011 Jun; 300(6):R1401-8. PMID: 21346239.
      Citations: 24     Fields:    Translation:AnimalsCells
    26. Debold EP, Saber W, Cheema Y, Bookwalter CS, Trybus KM, Warshaw DM, Vanburen P. Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro. J Mol Cell Cardiol. 2010 Feb; 48(2):286-92. PMID: 19799913.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    27. Debold EP, Schmitt JP, Patlak JB, Beck SE, Moore JR, Seidman JG, Seidman C, Warshaw DM. Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H284-91. PMID: 17351073.
      Citations: 86     Fields:    Translation:Animals
    28. Schmitt JP, Debold EP, Ahmad F, Armstrong A, Frederico A, Conner DA, Mende U, Lohse MJ, Warshaw D, Seidman CE, Seidman JG. Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14525-30. PMID: 16983074.
      Citations: 49     Fields:    Translation:AnimalsCells
    29. Debold EP, Patlak JB, Warshaw DM. Slip sliding away: load-dependence of velocity generated by skeletal muscle myosin molecules in the laser trap. Biophys J. 2005 Nov; 89(5):L34-6. PMID: 16169988.
      Citations: 38     Fields:    Translation:AnimalsCells
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