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Edward P Debold PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Amherst
DepartmentSchool of Public Health and Health Sciences
AddressTotman Phys Ed Building
Amherst, MA 01003
Phone413-545-4944
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Unger M, Debold EP. Acidosis decreases the Ca++-sensitivity of thin filaments by preventing the first actomyosin interaction. Am J Physiol Cell Physiol. 2019 Jul 24. PMID: 31339771.
      View in: PubMed
    2. Jarvis K, Woodward M, Debold EP, Walcott S. Acidosis affects muscle contraction by slowing the rates myosin attaches to and detaches from actin. J Muscle Res Cell Motil. 2018 Oct 31. PMID: 30382520.
      View in: PubMed
    3. Woodward M, Debold EP. Acidosis and Phosphate Directly Reduce Myosin's Force-Generating Capacity Through Distinct Molecular Mechanisms. Front Physiol. 2018; 9:862. PMID: 30042692.
      View in: PubMed
    4. Longyear T, Walcott S, Debold EP. The molecular basis of thin filament activation: from single molecule to muscle. Sci Rep. 2017 May 12; 7(1):1822. PMID: 28500282.
      View in: PubMed
    5. Debold EP, Fitts RH, Sundberg CW, Nosek TM. Muscle Fatigue from the Perspective of a Single Crossbridge. Med Sci Sports Exerc. 2016 Nov; 48(11):2270-2280. PMID: 27434086.
      View in: PubMed
    6. Debold EP. Decreased Myofilament Calcium Sensitivity Plays a Significant Role in Muscle Fatigue. Exerc Sport Sci Rev. 2016 Oct; 44(4):144-9. PMID: 27526194.
      View in: PubMed
    7. Debold EP. Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species. Front Physiol. 2015; 6:239. PMID: 26388779.
      View in: PubMed
    8. Debold EP. Biological machines: Molecular motor teamwork. Nat Nanotechnol. 2015 Aug; 10(8):656-7. PMID: 26243000.
      View in: PubMed
    9. Woodward M, Previs MJ, Mader TJ, Debold EP. Modifications of myofilament protein phosphorylation and function in response to cardiac arrest induced in a swine model. Front Physiol. 2015; 6:199. PMID: 26236240.
      View in: PubMed
    10. Nelson CR, Debold EP, Fitts RH. Phosphate and acidosis act synergistically to depress peak power in rat muscle fibers. Am J Physiol Cell Physiol. 2014 Nov 15; 307(10):C939-50. PMID: 25186012.
      View in: PubMed
    11. Swenson AM, Trivedi DV, Rauscher AA, Wang Y, Takagi Y, Palmer BM, Málnási-Csizmadia A, Debold EP, Yengo CM. Magnesium modulates actin binding and ADP release in myosin motors. J Biol Chem. 2014 Aug 22; 289(34):23977-91. PMID: 25006251.
      View in: PubMed
    12. Longyear TJ, Turner MA, Davis JP, Lopez J, Biesiadecki B, Debold EP. Ca++-sensitizing mutations in troponin, P(i), and 2-deoxyATP alter the depressive effect of acidosis on regulated thin-filament velocity. J Appl Physiol (1985). 2014 May 1; 116(9):1165-74. PMID: 24651988.
      View in: PubMed
    13. Debold EP, Walcott S, Woodward M, Turner MA. Direct observation of phosphate inhibiting the force-generating capacity of a miniensemble of Myosin molecules. Biophys J. 2013 Nov 19; 105(10):2374-84. PMID: 24268149.
      View in: PubMed
    14. Kobayashi M, Debold EP, Turner MA, Kobayashi T. Cardiac muscle activation blunted by a mutation to the regulatory component, troponin T. J Biol Chem. 2013 Sep 06; 288(36):26335-49. PMID: 23897817.
      View in: PubMed
    15. Debold EP, Longyear TJ, Turner MA. The effects of phosphate and acidosis on regulated thin-filament velocity in an in vitro motility assay. J Appl Physiol (1985). 2012 Nov; 113(9):1413-22. PMID: 23019317.
      View in: PubMed
    16. Walcott S, Warshaw DM, Debold EP. Mechanical coupling between myosin molecules causes differences between ensemble and single-molecule measurements. Biophys J. 2012 Aug 8; 103(3):501-10. PMID: 22947866.
      View in: PubMed
    17. Debold EP. Recent insights into the molecular basis of muscular fatigue. Med Sci Sports Exerc. 2012 Aug; 44(8):1440-52. PMID: 22330018.
      View in: PubMed
    18. Debold EP. Recent insights into muscle fatigue at the cross-bridge level. Front Physiol. 2012; 3:151. PMID: 22675303.
      View in: PubMed
    19. Debold EP, Turner MA, Stout JC, Walcott S. Phosphate enhances myosin-powered actin filament velocity under acidic conditions in a motility assay. Am J Physiol Regul Integr Comp Physiol. 2011 Jun; 300(6):R1401-8. PMID: 21346239.
      View in: PubMed
    20. Debold EP, Saber W, Cheema Y, Bookwalter CS, Trybus KM, Warshaw DM, Vanburen P. Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro. J Mol Cell Cardiol. 2010 Feb; 48(2):286-92. PMID: 19799913.
      View in: PubMed
    21. Debold EP, Schmitt JP, Patlak JB, Beck SE, Moore JR, Seidman JG, Seidman C, Warshaw DM. Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H284-91. PMID: 17351073.
      View in: PubMed
    22. Schmitt JP, Debold EP, Ahmad F, Armstrong A, Frederico A, Conner DA, Mende U, Lohse MJ, Warshaw D, Seidman CE, Seidman JG. Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14525-30. PMID: 16983074.
      View in: PubMed
    23. Debold EP, Patlak JB, Warshaw DM. Slip sliding away: load-dependence of velocity generated by skeletal muscle myosin molecules in the laser trap. Biophys J. 2005 Nov; 89(5):L34-6. PMID: 16169988.
      View in: PubMed
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