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Sam R Nugen BS, MS, PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Amherst
DepartmentCollege of Natural Sciences
Address246 Chenoweth Laboratory
Amherst, MA 01003
Phone413.545.1025
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Anderson RK, Nugen SR. Genetic engineering of bacteriophage S16 for Salmonella separation, concentration, and detection. Anal Bioanal Chem. 2025 May 27. PMID: 40425868.
      Citations:    
    2. Parker DR, Nugen SR. Bacteriophage-Based Bioanalysis. Annu Rev Anal Chem (Palo Alto Calif). 2024 Jul; 17(1):393-410. PMID: 39018352.
      Citations:    
    3. Carmody CM, Nugen SR. Monomeric streptavidin phage display allows efficient immobilization of bacteriophages on magnetic particles for the capture, separation, and detection of bacteria. Sci Rep. 2023 09 27; 13(1):16207. PMID: 37758721.
      Citations:    Fields:    Translation:Cells
    4. Hufziger KA, Farquharson EL, Werner BG, Chen Q, Goddard JM, Nugen SR. In Vivo Capsid Engineering of Bacteriophages for Oriented Surface Conjugation. ACS Appl Bio Mater. 2022 11 21; 5(11):5104-5112. PMID: 36264000.
      Citations:    Fields:    Translation:Cells
    5. Farquharson EL, Nugen SR. Enterobacteria Phage Ac3's Genome Annotation and Host Range Analysis Against the ECOR Reference Library. Phage (New Rochelle). 2022 Sep 01; 3(3):165-170. PMID: 36199530.
      Citations:    
    6. Huang C, Zhao J, Lu R, Wang J, Nugen SR, Chen Y, Wang X. A phage-based magnetic relaxation switching biosensor using bioorthogonal reaction signal amplification for Salmonella detection in foods. Food Chem. 2023 Jan 30; 400:134035. PMID: 36063677.
      Citations: 2     Fields:    Translation:Cells
    7. Alonzo LF, Hinkley TC, Miller A, Calderon R, Garing S, Williford J, Clute-Reinig N, Spencer E, Friend M, Madan D, Dinh VTT, Bell D, Weigl BH, Nugen SR, Nichols KP, Le Ny AM. A microfluidic device and instrument prototypes for the detection of Escherichia coli in water samples using a phage-based bioluminescence assay. Lab Chip. 2022 05 31; 22(11):2155-2164. PMID: 35521688.
      Citations: 3     Fields:    Translation:Cells
    8. Alonzo LF, Jain P, Hinkley T, Clute-Reinig N, Garing S, Spencer E, Dinh VTT, Bell D, Nugen S, Nichols KP, Le Ny AM. Rapid, sensitive, and low-cost detection of Escherichia coli bacteria in contaminated water samples using a phage-based assay. Sci Rep. 2022 05 11; 12(1):7741. PMID: 35562180.
      Citations: 3     Fields:    Translation:Cells
    9. Carmody CM, Farquharson EL, Nugen SR. Enterobacteria Phage SV76 Host Range and Genomic Characterization. Phage (New Rochelle). 2022 Mar; 3(1):59-63. PMID: 35495085.
      Citations:    
    10. Farquharson EL, Lightbown A, Pulkkinen E, Russell T, Werner B, Nugen SR. Evaluating Phage Tail Fiber Receptor-Binding Proteins Using a Luminescent Flow-Through 96-Well Plate Assay. Front Microbiol. 2021; 12:741304. PMID: 34975779.
      Citations:    
    11. Carmody CM, Goddard JM, Nugen SR. Bacteriophage Capsid Modification by Genetic and Chemical Methods. Bioconjug Chem. 2021 03 17; 32(3):466-481. PMID: 33661607.
      Citations: 8     Fields:    Translation:Cells
    12. Chen A, Wang D, Nugen SR, Chen J. An Engineered Reporter Phage for the Fluorometric Detection of Escherichia coli in Ground Beef. Microorganisms. 2021 Feb 19; 9(2). PMID: 33669833.
      Citations:    
    13. McLamore ES, Alocilja E, Gomes C, Gunasekaran S, Jenkins D, Datta SPA, Li Y, Mao YJ, Nugen SR, Reyes-De-Corcuera JI, Takhistov P, Tsyusko O, Cochran JP, Tzeng TJ, Yoon JY, Yu C, Zhou A. FEAST of biosensors: Food, environmental and agricultural sensing technologies (FEAST) in North America. Biosens Bioelectron. 2021 Apr 15; 178:113011. PMID: 33517232.
      Citations: 6     Fields:    
    14. Duong MM, Carmody CM, Ma Q, Peters JE, Nugen SR. Optimization of T4 phage engineering via CRISPR/Cas9. Sci Rep. 2020 10 26; 10(1):18229. PMID: 33106580.
      Citations: 18     Fields:    Translation:Cells
    15. Duong MM, Carmody CM, Nugen SR. Phage-based biosensors: in vivo analysis of native T4 phage promoters to enhance reporter enzyme expression. Analyst. 2020 Sep 28; 145(19):6291-6297. PMID: 32945826.
      Citations: 4     Fields:    Translation:Cells
    16. Zurier HS, Duong MM, Goddard JM, Nugen SR. Engineering Biorthogonal Phage-Based Nanobots for Ultrasensitive, In Situ Bacteria Detection. ACS Appl Bio Mater. 2020 Sep 21; 3(9):5824-5831. PMID: 34179727.
      Citations: 6     Fields:    
    17. Hinkley TC, Garing S, Jain P, Williford J, Le Ny AM, Nichols KP, Peters JE, Talbert JN, Nugen SR. A Syringe-Based Biosensor to Rapidly Detect Low Levels of Escherichia Coli (ECOR13) in Drinking Water Using Engineered Bacteriophages. Sensors (Basel). 2020 Mar 31; 20(7). PMID: 32244369.
      Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
    18. Singh S, Hinkley T, Nugen SR, Talbert JN. Colorimetric detection of Escherichia coli using engineered bacteriophage and an affinity reporter system. Anal Bioanal Chem. 2019 Nov; 411(27):7273-7279. PMID: 31511947.
      Citations: 5     Fields:    Translation:Cells
    19. Chen J, Nugen SR. Detection of protease and engineered phage-infected bacteria using peptide-graphene oxide nanosensors. Anal Bioanal Chem. 2019 May; 411(12):2487-2492. PMID: 30903224.
      Citations: 5     Fields:    Translation:Cells
    20. Pulkkinen EM, Hinkley TC, Nugen SR. Utilizing in vitro DNA assembly to engineer a synthetic T7 Nanoluc reporter phage for Escherichia coli detection. Integr Biol (Camb). 2019 Mar 01; 11(3):63-68. PMID: 30927414.
      Citations: 15     Fields:    
    21. Wang D, Hinkley T, Chen J, Talbert JN, Nugen SR. Phage based electrochemical detection of Escherichia coli in drinking water using affinity reporter probes. Analyst. 2019 Feb 11; 144(4):1345-1352. PMID: 30564809.
      Citations: 11     Fields:    Translation:Cells
    22. Hinkley TC, Singh S, Garing S, Le Ny AM, Nichols KP, Peters JE, Talbert JN, Nugen SR. A phage-based assay for the rapid, quantitative, and single CFU visualization of E. coli (ECOR #13) in drinking water. Sci Rep. 2018 10 02; 8(1):14630. PMID: 30279488.
      Citations: 20     Fields:    Translation:CellsPHPublic Health
    23. Chen J, Picard RA, Wang D, Nugen SR. Lyophilized Engineered Phages for Escherichia coli Detection in Food Matrices. ACS Sens. 2017 11 22; 2(11):1573-1577. PMID: 29043791.
      Citations: 8     Fields:    Translation:CellsPHPublic Health
    24. Chen J, Alcaine SD, Jackson AA, Rotello VM, Nugen SR. Development of Engineered Bacteriophages for Escherichia coli Detection and High-Throughput Antibiotic Resistance Determination. ACS Sens. 2017 Apr 28; 2(4):484-489. PMID: 28723178.
      Citations: 13     Fields:    
    25. Chen J, Andler SM, Goddard JM, Nugen SR, Rotello VM. Integrating recognition elements with nanomaterials for bacteria sensing. Chem Soc Rev. 2017 Mar 06; 46(5):1272-1283. PMID: 27942636.
      Citations: 66     Fields:    Translation:HumansCells
    26. Wang D, Chen J, Nugen SR. Electrochemical Detection of Escherichia coli from Aqueous Samples Using Engineered Phages. Anal Chem. 2017 02 07; 89(3):1650-1657. PMID: 28208254.
      Citations: 17     Fields:    Translation:CellsPHPublic Health
    27. Dai M, Chen J, Goddard JM, Nugen SR. Facile hierarchical assembly of gold particle decorated conductive polymer nanofibers for electrochemical sensing. Nanotechnology. 2017 Feb 10; 28(6):06LT01. PMID: 28044995.
      Citations:    Fields:    
    28. Koo CK, Senecal K, Senecal A, Nugen SR. Dehydration of bacteriophages in electrospun nanofibers: effect of excipients in polymeric solutions. Nanotechnology. 2016 Dec 02; 27(48):485102. PMID: 27819799.
      Citations: 5     Fields:    
    29. Wang D, Wang Z, He F, Kinchla AJ, Nugen SR. Enzymatic Digestion for Improved Bacteria Separation from Leafy Green Vegetables. J Food Prot. 2016 Aug; 79(8):1378-86. PMID: 27497125.
      Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    30. Jackson AA, Hinkley TC, Talbert JN, Nugen SR, Sela DA. Genetic optimization of a bacteriophage-delivered alkaline phosphatase reporter to detect Escherichia coli. Analyst. 2016 Oct 07; 141(19):5543-8. PMID: 27412402.
      Citations: 11     Fields:    Translation:CellsPHPublic Health
    31. Huang K, Chen J, Nugen SR, Goddard JM. Hybrid Antifouling and Antimicrobial Coatings Prepared by Electroless Co-Deposition of Fluoropolymer and Cationic Silica Nanoparticles on Stainless Steel: Efficacy against Listeria monocytogenes. ACS Appl Mater Interfaces. 2016 Jun 29; 8(25):15926-36. PMID: 27268033.
      Citations: 3     Fields:    Translation:Cells
    32. Talbert JN, Alcaine SD, Nugen SR. Engineering bacteriophage for a pragmatic low-resource setting bacterial diagnostic platform. Bioengineered. 2016 Apr; 7(3):132-6. PMID: 27246532.
      Citations: 1     Fields:    Translation:Cells
    33. Chen J, Pang S, He L, Nugen SR. Highly sensitive and selective detection of nitrite ions using Fe3O4@SiO2/Au magnetic nanoparticles by surface-enhanced Raman spectroscopy. Biosens Bioelectron. 2016 Nov 15; 85:726-733. PMID: 27262558.
      Citations: 22     Fields:    
    34. Wang Z, Wang D, Kinchla AJ, Sela DA, Nugen SR. Rapid screening of waterborne pathogens using phage-mediated separation coupled with real-time PCR detection. Anal Bioanal Chem. 2016 Jun; 408(15):4169-78. PMID: 27071764.
      Citations: 9     Fields:    Translation:Cells
    35. Chen J, Jackson AA, Rotello VM, Nugen SR. Colorimetric Detection of Escherichia coli Based on the Enzyme-Induced Metallization of Gold Nanorods. Small. 2016 05; 12(18):2469-75. PMID: 26997252.
      Citations: 22     Fields:    Translation:Cells
    36. Wang P, Pang S, Chen J, McLandsborough L, Nugen SR, Fan M, He L. Label-free mapping of single bacterial cells using surface-enhanced Raman spectroscopy. Analyst. 2016 Feb 21; 141(4):1356-62. PMID: 26750611.
      Citations: 10     Fields:    Translation:Cells
    37. Wang Z, Wang D, Chen J, Sela DA, Nugen SR. Development of a novel bacteriophage based biomagnetic separation method as an aid for sensitive detection of viable Escherichia coli. Analyst. 2016 Feb 07; 141(3):1009-16. PMID: 26689710.
      Citations: 8     Fields:    Translation:Cells
    38. Chen J, Duncan B, Wang Z, Wang LS, Rotello VM, Nugen SR. Bacteriophage-based nanoprobes for rapid bacteria separation. Nanoscale. 2015 Oct 21; 7(39):16230-6. PMID: 26315848.
      Citations: 11     Fields:    Translation:Cells
    39. Chen J, Li Y, Huang K, Wang P, He L, Carter KR, Nugen SR. Nanoimprinted Patterned Pillar Substrates for Surface-Enhanced Raman Scattering Applications. ACS Appl Mater Interfaces. 2015 Oct 07; 7(39):22106-13. PMID: 26402032.
      Citations: 13     Fields:    Translation:Cells
    40. Chen J, Alcaine SD, Jiang Z, Rotello VM, Nugen SR. Detection of Escherichia coli in drinking water using T7 bacteriophage-conjugated magnetic probe. Anal Chem. 2015 Sep 01; 87(17):8977-84. PMID: 26172120.
      Citations: 37     Fields:    Translation:Cells
    41. Chen J, Jiang Z, Ackerman JD, Yazdani M, Hou S, Nugen SR, Rotello VM. Electrochemical nanoparticle-enzyme sensors for screening bacterial contamination in drinking water. Analyst. 2015 Aug 07; 140(15):4991-6. PMID: 26042607.
      Citations: 18     Fields:    Translation:Cells
    42. Chen J, Zhou Y, Wang D, He F, Rotello VM, Carter KR, Watkins JJ, Nugen SR. UV-nanoimprint lithography as a tool to develop flexible microfluidic devices for electrochemical detection. Lab Chip. 2015 Jul 21; 15(14):3086-94. PMID: 26095586.
      Citations: 21     Fields:    Translation:Cells
    43. He F, Grimes J, Alcaine SD, Nugen SR. A hybrid paper and microfluidic chip with electrowetting valves and colorimetric detection. Analyst. 2014 Jun 21; 139(12):3002-8. PMID: 24719901.
      Citations: 3     Fields:    
    44. Dai M, Senecal A, Nugen SR. Electrospun water-soluble polymer nanofibers for the dehydration and storage of sensitive reagents. Nanotechnology. 2014 Jun 06; 25(22):225101. PMID: 24815520.
      Citations: 8     Fields:    Translation:Cells
    45. Talbert JN, He F, Seto K, Nugen SR, Goddard JM. Modification of glucose oxidase for the development of biocatalytic solvent inks. Enzyme Microb Technol. 2014 Feb 05; 55:21-5. PMID: 24411441.
      Citations: 1     Fields:    Translation:AnimalsCells
    46. Wang Y, Nugen SR. Development of fluorescent nanoparticle-labeled lateral flow assay for the detection of nucleic acids. Biomed Microdevices. 2013 Oct; 15(5):751-8. PMID: 23525961.
      Citations: 5     Fields:    Translation:AnimalsCells
    47. Koo CK, He F, Nugen SR. An inkjet-printed electrowetting valve for paper-fluidic sensors. Analyst. 2013 Sep 07; 138(17):4998-5004. PMID: 23828822.
      Citations: 14     Fields:    Translation:Animals
    48. Dai M, Jin S, Nugen SR. Water-soluble electrospun nanofibers as a method for on-chip reagent storage. Biosensors (Basel). 2012 Oct 08; 2(4):388-95. PMID: 25586029.
      Citations: 9     Fields:    
    49. Wang Y, Fill C, Nugen SR. Development of chemiluminescent lateral flow assay for the detection of nucleic acids. Biosensors (Basel). 2012 Jan 18; 2(1):32-42. PMID: 25585630.
      Citations: 5     Fields:    
    50. Goddard JM, Mandal S, Nugen SR, Baeumner AJ, Erickson D. Biopatterning for label-free detection. Colloids Surf B Biointerfaces. 2010 Mar 01; 76(1):375-80. PMID: 19939644.
      Citations: 3     Fields:    
    51. Kumanan V, Nugen SR, Baeumner AJ, Chang YF. A biosensor assay for the detection of Mycobacterium avium subsp. paratuberculosis in fecal samples. J Vet Sci. 2009 Mar; 10(1):35-42. PMID: 19255522.
      Citations: 4     Fields:    Translation:AnimalsCells
    52. Nugen SR, Asiello PJ, Connelly JT, Baeumner AJ. PMMA biosensor for nucleic acids with integrated mixer and electrochemical detection. Biosens Bioelectron. 2009 Apr 15; 24(8):2428-33. PMID: 19168346.
      Citations: 15     Fields:    
    53. Connelly JT, Nugen SR, Borejsza-Wysocki W, Durst RA, Montagna RA, Baeumner AJ. Human pathogenic Cryptosporidium species bioanalytical detection method with single oocyst detection capability. Anal Bioanal Chem. 2008 May; 391(2):487-95. PMID: 18311563.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    54. Nugen SR, Leonard B, Baeumner AJ. Application of a unique server-based oligonucleotide probe selection tool toward a novel biosensor for the detection of Streptococcus pyogenes. Biosens Bioelectron. 2007 May 15; 22(11):2442-8. PMID: 17011180.
      Citations: 4     Fields:    Translation:Cells
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