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William F Flynn Jr. MD

TitleAdjunct Assistant Professor
InstitutionUMass Chan Medical School
DepartmentSurgery
Address22 Mill Street, Suite 301
Arlington VA 02476
Phone781-643-6313
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentSurgery


    Collapse Biography 
    Collapse education and training
    Boston College, Chestnut Hill, MA, United StatesBALiberal Arts
    Yale University School of Medicine, New Haven, CT, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tan Y, Flynn WF, Sivajothi S, Luo D, Bozal SB, Davé M, Luciano AA, Robson P, Luciano DE, Courtois ET. Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues. Nat Cell Biol. 2022 08; 24(8):1306-1318. PMID: 35864314.
      Citations:    Fields:    
    2. Abdelfattah N, Kumar P, Wang C, Leu JS, Flynn WF, Gao R, Baskin DS, Pichumani K, Ijare OB, Wood SL, Powell SZ, Haviland DL, Parker Kerrigan BC, Lang FF, Prabhu SS, Huntoon KM, Jiang W, Kim BYS, George J, Yun K. Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target. Nat Commun. 2022 02 09; 13(1):767. PMID: 35140215.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    3. Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Langhi Prata LGP, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell Metab. 2022 Jan 04; 34(1):186. PMID: 34986334.
      Citations: 2     Fields:    
    4. Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Prata LGPL, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell Metab. 2022 01 04; 34(1):75-89.e8. PMID: 34813734.
      Citations: 6     Fields:    Translation:Animals
    5. Fujita A, Zhong L, Antony MS, Chamiec-Case E, Mickelsen LE, Kanoski SE, Flynn WF, Jackson AC. Neurokinin B-Expressing Neurons of the Central Extended Amygdala Mediate Inhibitory Synaptic Input onto Melanin-Concentrating Hormone Neuron Subpopulations. J Neurosci. 2021 11 17; 41(46):9539-9560. PMID: 34642212.
      Citations:    Fields:    Translation:AnimalsCells
    6. Cleary CM, Milla BM, Kuo FS, James S, Flynn WF, Robson P, Mulkey DK. Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing. Elife. 2021 05 20; 10. PMID: 34013884.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Mickelsen LE, Flynn WF, Springer K, Wilson L, Beltrami EJ, Bolisetty M, Robson P, Jackson AC. Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus. Elife. 2020 10 29; 9. PMID: 33119507.
      Citations: 4     Fields:    Translation:Animals
    8. Zhao Y, Pan Z, Namburi S, Pattison A, Posner A, Balachander S, Paisie CA, Reddi HV, Rueter J, Gill AJ, Fox S, Raghav KPS, Flynn WF, Tothill RW, Li S, Karuturi RKM, George J. CUP-AI-Dx: A tool for inferring cancer tissue of origin and molecular subtype using RNA gene-expression data and artificial intelligence. EBioMedicine. 2020 Nov; 61:103030. PMID: 33039710.
      Citations: 10     Fields:    Translation:Humans
    9. Nehar-Belaid D, Hong S, Marches R, Chen G, Bolisetty M, Baisch J, Walters L, Punaro M, Rossi RJ, Chung CH, Huynh RP, Singh P, Flynn WF, Tabanor-Gayle JA, Kuchipudi N, Mejias A, Collet MA, Lucido AL, Palucka K, Robson P, Lakshminarayanan S, Ramilo O, Wright T, Pascual V, Banchereau JF. Mapping systemic lupus erythematosus heterogeneity at the single-cell level. Nat Immunol. 2020 09; 21(9):1094-1106. PMID: 32747814.
      Citations: 59     Fields:    Translation:HumansCells
    10. Gowthaman U, Chen JS, Zhang B, Flynn WF, Lu Y, Song W, Joseph J, Gertie JA, Xu L, Collet MA, Grassmann JDS, Simoneau T, Chiang D, Berin MC, Craft JE, Weinstein JS, Williams A, Eisenbarth SC. Identification of a T follicular helper cell subset that drives anaphylactic IgE. Science. 2019 08 30; 365(6456). PMID: 31371561.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    11. Elyada E, Bolisetty M, Laise P, Flynn WF, Courtois ET, Burkhart RA, Teinor JA, Belleau P, Biffi G, Lucito MS, Sivajothi S, Armstrong TD, Engle DD, Yu KH, Hao Y, Wolfgang CL, Park Y, Preall J, Jaffee EM, Califano A, Robson P, Tuveson DA. Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts. Cancer Discov. 2019 08; 9(8):1102-1123. PMID: 31197017.
      Citations: 365     Fields:    Translation:HumansAnimalsCells
    12. Sharma M, Srivastava A, Fairfield HE, Bergstrom D, Flynn WF, Braun RE. Identification of EOMES-expressing spermatogonial stem cells and their regulation by PLZF. Elife. 2019 05 31; 8. PMID: 31149899.
      Citations: 14     Fields:    Translation:AnimalsCells
    13. Xia J, Flynn W, Gallicchio E, Uplinger K, Armstrong JD, Forli S, Olson AJ, Levy RM. Massive-Scale Binding Free Energy Simulations of HIV Integrase Complexes Using Asynchronous Replica Exchange Framework Implemented on the IBM WCG Distributed Network. J Chem Inf Model. 2019 04 22; 59(4):1382-1397. PMID: 30758197.
      Citations: 2     Fields:    Translation:Cells
    14. Xia J, Flynn W, Levy RM. Improving Prediction Accuracy of Binding Free Energies and Poses of HIV Integrase Complexes Using the Binding Energy Distribution Analysis Method with Flattening Potentials. J Chem Inf Model. 2018 07 23; 58(7):1356-1371. PMID: 29927237.
      Citations: 3     Fields:    Translation:Cells
    15. Haldane A, Flynn WF, He P, Levy RM. Coevolutionary Landscape of Kinase Family Proteins: Sequence Probabilities and Functional Motifs. Biophys J. 2018 01 09; 114(1):21-31. PMID: 29320688.
      Citations: 10     Fields:    Translation:Cells
    16. Flynn WF, Haldane A, Torbett BE, Levy RM. Inference of Epistatic Effects Leading to Entrenchment and Drug Resistance in HIV-1 Protease. Mol Biol Evol. 2017 06 01; 34(6):1291-1306. PMID: 28369521.
      Citations: 23     Fields:    Translation:HumansCells
    17. Pal RK, Haider K, Kaur D, Flynn W, Xia J, Levy RM, Taran T, Wickstrom L, Kurtzman T, Gallicchio E. Erratum to: A combined treatment of hydration and dynamical effects for the modeling of host-guest binding thermodynamics: the SAMPL5 blinded challenge. J Comput Aided Mol Des. 2017 01; 31(1):45. PMID: 27815770.
      Citations:    Fields:    
    18. Levy RM, Haldane A, Flynn WF. Potts Hamiltonian models of protein co-variation, free energy landscapes, and evolutionary fitness. Curr Opin Struct Biol. 2017 04; 43:55-62. PMID: 27870991.
      Citations: 23     Fields:    
    19. Pal RK, Haider K, Kaur D, Flynn W, Xia J, Levy RM, Taran T, Wickstrom L, Kurtzman T, Gallicchio E. A combined treatment of hydration and dynamical effects for the modeling of host-guest binding thermodynamics: the SAMPL5 blinded challenge. J Comput Aided Mol Des. 2017 01; 31(1):29-44. PMID: 27696239.
      Citations: 8     Fields:    Translation:HumansCells
    20. Deng N, Flynn WF, Xia J, Vijayan RS, Zhang B, He P, Mentes A, Gallicchio E, Levy RM. Large scale free energy calculations for blind predictions of protein-ligand binding: the D3R Grand Challenge 2015. J Comput Aided Mol Des. 2016 09; 30(9):743-751. PMID: 27562018.
      Citations: 9     Fields:    Translation:HumansCells
    21. Haldane A, Flynn WF, He P, Vijayan RS, Levy RM. Structural propensities of kinase family proteins from a Potts model of residue co-variation. Protein Sci. 2016 08; 25(8):1378-84. PMID: 27241634.
      Citations: 29     Fields:    Translation:HumansCells
    22. Gallicchio E, Xia J, Flynn WF, Zhang B, Samlalsingh S, Mentes A, Levy RM. Asynchronous Replica Exchange Software for Grid and Heterogeneous Computing. Comput Phys Commun. 2015 Nov; 196:236-246. PMID: 27103749.
      Citations:    
    23. Xia J, Flynn WF, Gallicchio E, Zhang BW, He P, Tan Z, Levy RM. Large-scale asynchronous and distributed multidimensional replica exchange molecular simulations and efficiency analysis. J Comput Chem. 2015 Sep 05; 36(23):1772-85. PMID: 26149645.
      Citations: 11     Fields:    Translation:Cells
    24. Flynn WF, Chang MW, Tan Z, Oliveira G, Yuan J, Okulicz JF, Torbett BE, Levy RM. Deep sequencing of protease inhibitor resistant HIV patient isolates reveals patterns of correlated mutations in Gag and protease. PLoS Comput Biol. 2015 Apr; 11(4):e1004249. PMID: 25894830.
      Citations: 21     Fields:    Translation:HumansCells
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