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Laura L Gibson MD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentPediatrics
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone774-441-8230
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases

    InstitutionT.H. Chan School of Medicine
    DepartmentPediatrics

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMasters in Clinical Investigation

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPopulation Health Sciences


    Collapse Biography 
    Collapse education and training
    Yale University, New Haven, CT, United StatesBAArts
    University of Massachusetts Medical School, Worcester, MA, United StatesMD

    Collapse Overview 
    Collapse overview

    Research/Clinical Interests:

    • Human T cell responses to cytomegalovirus (CMV) in children and transplant recipients
    • General and transplant-related infections
    • Travel Medicine


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Broach J, Achenbach C, Behar S, O'Connor L, Tarrant S, Ferranto J, Wright C, Hartin P, Orwig T, Nanavati J, Kalibala B, Woods K, Shaw B, Flahive J, Barton B, Hafer N, Herbert C, Fahey N, Gibson L, Simin K, Kowalik T, Ward DV, Mirza AW, Murphy RL, Caputo M, Buchholz B, Fantasia H, Koren A, Marchand L, Oludare S, Sogade F, Ritland D, Davis C, Grenier A, Baron C, Brent E, McKenney JB, Elder N, Michaels L, Ferrara L, Theron G, Palmer Z, Levy B, Daly J, Parang K, Schmidt M, Buxton D, Heetderks W, Manabe YC, Soni A, McManus D. Design, creation, and use of the Test Us Bank (TUB) COVID-19 sample biorepository. BMC Infect Dis. 2024 Nov 12; 24(1):1282. PMID: 39528968.
      Citations:    
    2. Herbert C, Wang B, Lin H, Yan Y, Hafer N, Pretz C, Stamegna P, Wright C, Suvarna T, Harman E, Schrader S, Nowak C, Kheterpal V, Orvek E, Wong S, Zai A, Barton B, Gerber BS, Lemon SC, Filippaios A, Gibson L, Greene S, Colubri A, Achenbach C, Murphy R, Heetderks W, Manabe YC, O'Connor L, Fahey N, Luzuriaga K, Broach J, Roth K, McManus DD, Soni A. Performance of and Severe Acute Respiratory Syndrome Coronavirus 2 Diagnostics Based on Symptom Onset and Close Contact Exposure: An Analysis From the Test Us at Home Prospective Cohort Study. Open Forum Infect Dis. 2024 Jun; 11(6):ofae304. PMID: 38911947.
      Citations:    
    3. Farjo M, Koelle K, Martin MA, Gibson LL, Walden KKO, Rendon G, Fields CJ, Alnaji FG, Gallagher N, Luo CH, Mostafa HH, Manabe YC, Pekosz A, Smith RL, McManus DD, Brooke CB. Within-host evolutionary dynamics and tissue compartmentalization during acute SARS-CoV-2 infection. J Virol. 2024 Jan 23; 98(1):e0161823. PMID: 38174928.
      Citations:    Fields:    Translation:HumansCells
    4. Soni A, Herbert C, Lin H, Yan Y, Pretz C, Stamegna P, Wang B, Orwig T, Wright C, Tarrant S, Behar S, Suvarna T, Schrader S, Harman E, Nowak C, Kheterpal V, Rao LV, Cashman L, Orvek E, Ayturk D, Gibson L, Zai A, Wong S, Lazar P, Wang Z, Filippaios A, Barton B, Achenbach CJ, Murphy RL, Robinson ML, Manabe YC, Pandey S, Colubri A, O'Connor L, Lemon SC, Fahey N, Luzuriaga KL, Hafer N, Roth K, Lowe T, Stenzel T, Heetderks W, Broach J, McManus DD. Performance of Rapid Antigen Tests to Detect Symptomatic and Asymptomatic SARS-CoV-2 Infection : A Prospective Cohort Study. Ann Intern Med. 2023 07; 176(7):975-982. PMID: 37399548.
      Citations: 7     Fields:    Translation:HumansCells
    5. Soni A, Herbert C, Pretz C, Stamegna P, Filippaios A, Shi Q, Suvarna T, Harman E, Schrader S, Nowak C, Schramm E, Kheterpal V, Behar S, Tarrant S, Ferranto J, Hafer N, Robinson M, Achenbach C, Murphy RL, Manabe YC, Gibson L, Barton B, O'Connor L, Fahey N, Orvek E, Lazar P, Ayturk D, Wong S, Zai A, Cashman L, Rao LV, Luzuriaga K, Lemon S, Blodgett A, Trippe E, Barcus M, Goldberg B, Roth K, Stenzel T, Heetderks W, Broach J, McManus D. Design and implementation of a digital site-less clinical study of serial rapid antigen testing to identify asymptomatic SARS-CoV-2 infection. J Clin Transl Sci. 2023; 7(1):e120. PMID: 37313378.
      Citations:    
    6. Herbert C, Broach J, Heetderks W, Qashu F, Gibson L, Pretz C, Woods K, Kheterpal V, Suvarna T, Nowak C, Lazar P, Ayturk D, Barton B, Achenbach C, Murphy R, McManus D, Soni A. Feasibility of At-Home Serial Testing Using Over-the-Counter SARS-CoV-2 Tests With a Digital Smartphone App for Assistance: Longitudinal Cohort Study. JMIR Form Res. 2022 Oct 18; 6(10):e35426. PMID: 36041004.
      Citations:    
    7. Soni A, Herbert C, Filippaios A, Broach J, Colubri A, Fahey N, Woods K, Nanavati J, Wright C, Orwig T, Gilliam K, Kheterpal V, Suvarna T, Nowak C, Schrader S, Lin H, O'Connor L, Pretz C, Ayturk D, Orvek E, Flahive J, Lazar P, Shi Q, Achenbach C, Murphy R, Robinson M, Gibson L, Stamegna P, Hafer N, Luzuriaga K, Barton B, Heetderks W, Manabe YC, McManus D. Comparison of Rapid Antigen Tests' Performance Between Delta and Omicron Variants of SARS-CoV-2 : A Secondary Analysis From a Serial Home Self-testing Study. Ann Intern Med. 2022 12; 175(12):1685-1692. PMID: 36215709.
      Citations: 20     Fields:    Translation:HumansCells
    8. Herbert C, Shi Q, Kheterpal V, Nowak C, Suvarna T, Durnan B, Schrader S, Behar S, Naeem S, Tarrant S, Kalibala B, Singh A, Gerber B, Barton B, Lin H, Cohen-Wolkowiez M, Corbie-Smith G, Kibbe W, Marquez J, Baek J, Hafer N, Gibson L, O'Connor L, Broach J, Heetderks W, McManus D, Soni A. Use of a Digital Assistant to Report COVID-19 Rapid Antigen Self-test Results to Health Departments in 6 US Communities. JAMA Netw Open. 2022 08 01; 5(8):e2228885. PMID: 36018589.
      Citations: 6     Fields:    Translation:Humans
    9. Robinson ML, Mirza A, Gallagher N, Boudreau A, Garcia Jacinto L, Yu T, Norton J, Luo CH, Conte A, Zhou R, Kafka K, Hardick J, McManus DD, Gibson LL, Pekosz A, Mostafa HH, Manabe YC. Limitations of Molecular and Antigen Test Performance for SARS-CoV-2 in Symptomatic and Asymptomatic COVID-19 Contacts. J Clin Microbiol. 2022 07 20; 60(7):e0018722. PMID: 35730949.
      Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
    10. Herbert C, Kheterpal V, Suvarna T, Broach J, Marquez JL, Gerber B, Schrader S, Nowak C, Harman E, Heetderks W, Fahey N, Orvek E, Lazar P, Ferranto J, Noorishirazi K, Valpady S, Shi Q, Lin H, Marvel K, Gibson L, Barton B, Lemon S, Hafer N, McManus D, Soni A. Design and Preliminary Findings of Adherence to the Self-Testing for Our Protection From COVID-19 (STOP COVID-19) Risk-Based Testing Protocol: Prospective Digital Study. JMIR Form Res. 2022 Jun 16; 6(6):e38113. PMID: 35649180.
      Citations:    
    11. Ke R, Martinez PP, Smith RL, Gibson LL, Mirza A, Conte M, Gallagher N, Luo CH, Jarrett J, Zhou R, Conte A, Liu T, Farjo M, Walden KKO, Rendon G, Fields CJ, Wang L, Fredrickson R, Edmonson DC, Baughman ME, Chiu KK, Choi H, Scardina KR, Bradley S, Gloss SL, Reinhart C, Yedetore J, Quicksall J, Owens AN, Broach J, Barton B, Lazar P, Heetderks WJ, Robinson ML, Mostafa HH, Manabe YC, Pekosz A, McManus DD, Brooke CB. Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness. Nat Microbiol. 2022 05; 7(5):640-652. PMID: 35484231.
      Citations: 56     Fields:    Translation:HumansCells
    12. Ke R, Martinez PP, Smith RL, Gibson LL, Achenbach CJ, McFall S, Qi C, Jacob J, Dembele E, Bundy C, Simons LM, Ozer EA, Hultquist JF, Lorenzo-Redondo R, Opdycke AK, Hawkins C, Murphy RL, Mirza A, Conte M, Gallagher N, Luo CH, Jarrett J, Conte A, Zhou R, Farjo M, Rendon G, Fields CJ, Wang L, Fredrickson R, Baughman ME, Chiu KK, Choi H, Scardina KR, Owens AN, Broach J, Barton B, Lazar P, Robinson ML, Mostafa HH, Manabe YC, Pekosz A, McManus DD, Brooke CB. Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution. Open Forum Infect Dis. 2022 Jul; 9(7):ofac192. PMID: 35791353.
      Citations:    
    13. Flotte TR, Cataltepe O, Puri A, Batista AR, Moser R, McKenna-Yasek D, Douthwright C, Gernoux G, Blackwood M, Mueller C, Tai PWL, Jiang X, Bateman S, Spanakis SG, Parzych J, Keeler AM, Abayazeed A, Rohatgi S, Gibson L, Finberg R, Barton BA, Vardar Z, Shazeeb MS, Gounis M, Tifft CJ, Eichler FS, Brown RH, Martin DR, Gray-Edwards HL, Sena-Esteves M. AAV gene therapy for Tay-Sachs disease. Nat Med. 2022 02; 28(2):251-259. PMID: 35145305.
      Citations: 28     Fields:    Translation:HumansCells
    14. Robinson ML, Mirza A, Gallagher N, Boudreau A, Garcia L, Yu T, Norton J, Luo CH, Conte A, Zhou R, Kafka K, Hardick J, McManus DD, Gibson LL, Pekosz A, Mostafa H, Manabe YC. Limitations of molecular and antigen test performance for SARS-CoV-2 in symptomatic and asymptomatic COVID-19 contacts. medRxiv. 2022 Feb 07. PMID: 35169814.
      Citations:    
    15. Smith RL, Gibson LL, Martinez PP, Ke R, Mirza A, Conte M, Gallagher N, Conte A, Wang L, Fredrickson R, Edmonson DC, Baughman ME, Chiu KK, Choi H, Jensen TW, Scardina KR, Bradley S, Gloss SL, Reinhart C, Yedetore J, Owens AN, Broach J, Barton B, Lazar P, Henness D, Young T, Dunnett A, Robinson ML, Mostafa HH, Pekosz A, Manabe YC, Heetderks WJ, McManus DD, Brooke CB. Longitudinal Assessment of Diagnostic Test Performance Over the Course of Acute SARS-CoV-2 Infection. J Infect Dis. 2021 09 17; 224(6):976-982. PMID: 34191025.
      Citations: 69     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    16. Ke R, Martinez PP, Smith RL, Gibson LL, Achenbach CJ, McFall S, Qi C, Jacob J, Dembele E, Bundy C, Simons LM, Ozer EA, Hultquist JF, Lorenzo-Redondo R, Opdycke AK, Hawkins C, Murphy RL, Mirza A, Conte M, Gallagher N, Luo CH, Jarrett J, Conte A, Zhou R, Farjo M, Rendon G, Fields CJ, Wang L, Fredrickson R, Baughman ME, Chiu KK, Choi H, Scardina KR, Owens AN, Broach J, Barton B, Lazar P, Robinson ML, Mostafa HH, Manabe YC, Pekosz A, McManus DD, Brooke CB. Longitudinal analysis of SARS-CoV-2 vaccine breakthrough infections reveal limited infectious virus shedding and restricted tissue distribution. medRxiv. 2021 Sep 02. PMID: 34494028.
      Citations:    
    17. Gibson L. An Interferon-? Release Assay for Evaluation of Cell-mediated Immunity in Infants With Congenital Cytomegalovirus Infection. Clin Infect Dis. 2021 08 02; 73(3):374-375. PMID: 32504089.
      Citations: 1     Fields:    Translation:Humans
    18. Ke R, Martinez PP, Smith RL, Gibson LL, Mirza A, Conte M, Gallagher N, Luo CH, Jarrett J, Conte A, Liu T, Farjo M, Walden KKO, Rendon G, Fields CJ, Wang L, Fredrickson R, Edmonson DC, Baughman ME, Chiu KK, Choi H, Scardina KR, Bradley S, Gloss SL, Reinhart C, Yedetore J, Quicksall J, Owens AN, Broach J, Barton B, Lazar P, Heetderks WJ, Robinson ML, Mostafa HH, Manabe YC, Pekosz A, McManus DD, Brooke CB. Daily sampling of early SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness. medRxiv. 2021 Jul 12. PMID: 34282424.
      Citations:    
    19. Gibson L, Fahey N, Hafer N, Buchholz B, Dunlap D, Murphy R, Achenbach C, Stone C, Cleeton R, O'Neal J, Frediani J, Vos M, Brand O, Nayee R, Wells L, Lam W, Martin G, Manabe Y, Robinson M, Broach J, Olgin J, Barton B, Lemon S, Blodgett A, McManus D. The RADx Tech Clinical Studies Core: A Model for Academic Based Clinical Studies. IEEE Open J Eng Med Biol. 2021; 2:152-157. PMID: 34192287.
      Citations:    
    20. Smith RL, Gibson LL, Martinez PP, Ke R, Mirza A, Conte M, Gallagher N, Conte A, Wang L, Fredrickson R, Edmonson DC, Baughman ME, Chiu KK, Choi H, Jensen TW, Scardina KR, Bradley S, Gloss SL, Reinhart C, Yedetore J, Owens AN, Broach J, Barton B, Lazar P, Henness D, Young T, Dunnett A, Robinson ML, Mostafa HH, Pekosz A, Manabe YC, Heetderks WJ, McManus DD, Brooke CB. Longitudinal assessment of diagnostic test performance over the course of acute SARS-CoV-2 infection. medRxiv. 2021 Mar 22. PMID: 33791719.
      Citations:    
    21. Materne EC, Lilleri D, Garofoli F, Lombardi G, Furione M, Zavattoni M, Gibson L. Cytomegalovirus-Specific T Cell Epitope Recognition in Congenital Cytomegalovirus Mother-Infant Pairs. Front Immunol. 2020; 11:568217. PMID: 33329532.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    22. Theodoropoulos NM, Bolstorff B, Bozorgzadeh A, Brandeburg C, Cumming M, Daly JS, Ellison RT, Forsberg K, Gade L, Gibson L, Greenough T, Litvintseva AP, Mack DA, Madoff L, Martins PN, McHale E, Melvin Z, Movahedi B, Stiles T, Vallabhaneni S, Levitz SM. Candida auris outbreak involving liver transplant recipients in a surgical intensive care unit. Am J Transplant. 2020 12; 20(12):3673-3679. PMID: 32530145.
      Citations: 12     Fields:    Translation:HumansAnimalsPHPublic Health
    23. Krueger S, Rork J, Lee J, Cornejo K, Gibson L, Daly JS, Levin NA. Mycobacterium haemophilum infection in a renal transplant patient with inflammatory bowel disease. Dermatol Online J. 2017 Sep 15; 23(9). PMID: 29469723.
      Citations:    Fields:    Translation:HumansCells
    24. Renzette N, Pokalyuk C, Gibson L, Bhattacharjee B, Schleiss MR, Hamprecht K, Yamamoto AY, Mussi-Pinhata MM, Britt WJ, Jensen JD, Kowalik TF. Limits and patterns of cytomegalovirus genomic diversity in humans. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4120-8. PMID: 26150505.
      Citations: 66     Fields:    Translation:HumansCells
    25. Gibson L, Barysauskas CM, McManus M, Dooley S, Lilleri D, Fisher D, Srivastava T, Diamond DJ, Luzuriaga K. Reduced frequencies of polyfunctional CMV-specific T cell responses in infants with congenital CMV infection. J Clin Immunol. 2015 Apr; 35(3):289-301. PMID: 25712611.
      Citations: 14     Fields:    Translation:HumansCells
    26. Becerra A, Gibson L, Stern LJ, Calvo-Calle JM. Immune response to HHV-6 and implications for immunotherapy. Curr Opin Virol. 2014 Dec; 9:154-61. PMID: 25462448.
      Citations: 16     Fields:    Translation:HumansCells
    27. Renzette N, Gibson L, Jensen JD, Kowalik TF. Human cytomegalovirus intrahost evolution-a new avenue for understanding and controlling herpesvirus infections. Curr Opin Virol. 2014 Oct; 8:109-15. PMID: 25154343.
      Citations: 41     Fields:    Translation:HumansCells
    28. Tan AS, Gibson L, Zafar HM, Gray SW, Hornik RC, Armstrong K. Associations between cancer-related information seeking and receiving PET imaging for routine cancer surveillance--an analysis of longitudinal survey data. Cancer Epidemiol Biomarkers Prev. 2014 Mar; 23(3):481-9. PMID: 24550351.
      Citations:    Fields:    Translation:Humans
    29. Renzette N, Gibson L, Bhattacharjee B, Fisher D, Schleiss MR, Jensen JD, Kowalik TF. Rapid intrahost evolution of human cytomegalovirus is shaped by demography and positive selection. PLoS Genet. 2013; 9(9):e1003735. PMID: 24086142.
      Citations: 95     Fields:    Translation:HumansCells
    30. Gil A, Shen S, Coley S, Gibson L, Diamond DJ, Wang S, Lu S. DNA vaccine prime followed by boost with live attenuated virus significantly improves antigen-specific T cell responses against human cytomegalovirus. Hum Vaccin Immunother. 2013 Oct; 9(10):2120-32. PMID: 24051429.
      Citations: 6     Fields:    Translation:AnimalsCells
    31. Nastke MD, Becerra A, Yin L, Dominguez-Amorocho O, Gibson L, Stern LJ, Calvo-Calle JM. Human CD4+ T cell response to human herpesvirus 6. J Virol. 2012 May; 86(9):4776-92. PMID: 22357271.
      Citations: 32     Fields:    Translation:HumansCells
    32. Renzette N, Bhattacharjee B, Jensen JD, Gibson L, Kowalik TF. Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants. PLoS Pathog. 2011 May; 7(5):e1001344. PMID: 21625576.
      Citations: 124     Fields:    Translation:HumansCells
    33. Gibson L, Dooley S, Trzmielina S, Somasundaran M, Fisher D, Revello MG, Luzuriaga K. Cytomegalovirus (CMV) IE1- and pp65-specific CD8+ T cell responses broaden over time after primary CMV infection in infants. J Infect Dis. 2007 Jun 15; 195(12):1789-98. PMID: 17492595.
      Citations: 17     Fields:    Translation:HumansCells
    34. Gibson L, Piccinini G, Lilleri D, Revello MG, Wang Z, Markel S, Diamond DJ, Luzuriaga K. Human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for CD8+ T cell responses in children with congenital or postnatal human cytomegalovirus infection. J Immunol. 2004 Feb 15; 172(4):2256-64. PMID: 14764694.
      Citations: 39     Fields:    Translation:HumansCells
    35. Scott ZA, Chadwick EG, Gibson LL, Catalina MD, McManus MM, Yogev R, Palumbo P, Sullivan JL, Britto P, Gay H, Luzuriaga K. Infrequent detection of HIV-1-specific, but not cytomegalovirus-specific, CD8(+) T cell responses in young HIV-1-infected infants. J Immunol. 2001 Dec 15; 167(12):7134-40. PMID: 11739536.
      Citations:    
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