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Jeanmarie Houghton MD, PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-6441
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionGastroenterology

    InstitutionUMMS - School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMolecular Genetics and Microbiology


    Collapse Biography 
    Collapse education and training
    Rutgers University New Brunswick, New Brunswick, NJ, United StatesBABiology
    University of Medicine and Dentistry of New Jersey, Newark, NJ, United StatesMD
    University of Medicine and Dentistry of New Jersey, Newark, NJ, United StatesPHD

    Collapse Overview 
    Collapse overview

    Academic Background

    Education:
    B. A., Rutgers University, New Brunswick, NJ
    MD,UMDNJ-New Jersey Medical School, Newark, NJ
    PhD, UMDNJ-Graduate School of Biological Sciences, Newark, NJ

    Post-Graduate Training:
    UMDNJ-University Hospital, Newark, New Jersey
    Internal Medicine Residency

    UMDNJ-University Hospital, Newark, New Jersey
    Chief Medical Resident

    UMDNJ-University Hospital, Newark, New Jersey
    Gastroenterology Fellowship

    Research Interests:


    Host immune response to Helicobacter pylori infection, immune modulation of gastric cell signaling and growth regulation in response to Helicobacter infection.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Maykel J, Liu JH, Li H, Shultz LD, Greiner DL, Houghton J. NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer. Dig Dis Sci. 2014 Jun; 59(6):1169-79. PMID: 24798995.
      View in: PubMed
    2. Donnelly JM, Engevik A, Feng R, Xiao C, Boivin GP, Li J, Houghton J, Zavros Y. Mesenchymal stem cells induce epithelial proliferation within the inflamed stomach. Am J Physiol Gastrointest Liver Physiol. 2014 Jun 15; 306(12):G1075-88. PMID: 24789207.
      View in: PubMed
    3. Donnelly JM, Chawla A, Houghton J, Zavros Y. Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach. PLoS One. 2013; 8(9):e75225. PMID: 24069395.
      View in: PubMed
    4. Stoicov C, Li H, Liu JH, Houghton J. Mesenchymal stem cells utilize CXCR4-SDF-1 signaling for acute, but not chronic, trafficking to gastric mucosal inflammation. Dig Dis Sci. 2013 Sep; 58(9):2466-77. PMID: 23873382.
      View in: PubMed
    5. Houghton JM. Helicobacter species methods and protocols. Introduction. Methods Mol Biol. 2012; 921:1-5. PMID: 23015484.
      View in: PubMed
    6. Moore N, Houghton J, Lyle S. Slow-cycling therapy-resistant cancer cells. Stem Cells Dev. 2012 Jul 1; 21(10):1822-30. PMID: 21973238.
      View in: PubMed
    7. Hutchinson L, Stenstrom B, Chen D, Piperdi B, Levey S, Lyle S, Wang TC, Houghton J. Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant. Stem Cells Dev. 2011 Jan; 20(1):11-7. PMID: 20677919.
      View in: PubMed
    8. Houghton J, Li H, Fan X, Liu Y, Liu JH, Rao VP, Poutahidis T, Taylor CL, Jackson EA, Hewes C, Lyle S, Cerny A, Bowen G, Cerny J, Moore N, Kurt-Jones EA, Erdman SE. Mutations in bone marrow-derived stromal stem cells unmask latent malignancy. Stem Cells Dev. 2010 Aug; 19(8):1153-66. PMID: 20199238.
      View in: PubMed
    9. Martin J, Donnelly JM, Houghton J, Zavros Y. The role of sonic hedgehog reemergence during gastric cancer. Dig Dis Sci. 2010 Jun; 55(6):1516-24. PMID: 20437100.
      View in: PubMed
    10. Cerny J, Trneny M, Slavickova A, Pytlik R, Salkova J, Valkova V, Liu Q, Houghton J, Klener P. Rituximab based therapy followed by autologous stem cell transplantation leads to superior outcome and high rates of PCR negativity in patients with indolent B-cell lymphoproliferative disorders. Hematology. 2009 Aug; 14(4):187-97. PMID: 19635181.
      View in: PubMed
    11. Stoicov C, Fan X, Liu JH, Bowen G, Whary M, Kurt-Jones E, Houghton J. T-bet knockout prevents Helicobacter felis-induced gastric cancer. J Immunol. 2009 Jul 1; 183(1):642-9. PMID: 19535625.
      View in: PubMed
    12. Li H, Fan X, Stoicov C, Liu JH, Zubair S, Tsai E, Ste Marie R, Wang TC, Lyle S, Kurt-Jones E, Houghton J. Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver. Gastroenterology. 2009 Sep; 137(3):934-44, 944.e1-4. PMID: 19524576.
      View in: PubMed
    13. Stoicov C, Saffari R, Houghton J. Green tea inhibits Helicobacter growth in vivo and in vitro. Int J Antimicrob Agents. 2009 May; 33(5):473-8. PMID: 19157800.
      View in: PubMed
    14. Rogers AB, Houghton J. Helicobacter-based mouse models of digestive system carcinogenesis. Methods Mol Biol. 2009; 511:267-95. PMID: 19347301.
      View in: PubMed
    15. Li H, Fan X, Kovi RC, Jo Y, Moquin B, Konz R, Stoicov C, Kurt-Jones E, Grossman SR, Lyle S, Rogers AB, Montrose M, Houghton J. Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice. Cancer Res. 2007 Nov 15; 67(22):10889-98. PMID: 18006834.
      View in: PubMed
    16. Li H, Cai X, Fan X, Moquin B, Stoicov C, Houghton J. Fas Ag-FasL coupling leads to ERK1/2-mediated proliferation of gastric mucosal cells. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G263-75. PMID: 17991709.
      View in: PubMed
    17. Correa P, Houghton J. Carcinogenesis of Helicobacter pylori. Gastroenterology. 2007 Aug; 133(2):659-72. PMID: 17681184.
      View in: PubMed
    18. Li H, Fan X, Houghton J. Tumor microenvironment: the role of the tumor stroma in cancer. J Cell Biochem. 2007 Jul 1; 101(4):805-15. PMID: 17226777.
      View in: PubMed
    19. Houghton J. Bone-marrow-derived cells and cancer--an opportunity for improved therapy. Nat Clin Pract Oncol. 2007 Jan; 4(1):2-3. PMID: 17183348.
      View in: PubMed
    20. Kurt-Jones EA, Cao L, Sandor F, Rogers AB, Whary MT, Nambiar PR, Cerny A, Bowen G, Yan J, Takaishi S, Chi AL, Reed G, Houghton J, Fox JG, Wang TC. Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses. Infect Immun. 2007 Jan; 75(1):471-80. PMID: 17101660.
      View in: PubMed
    21. Cui G, Takaishi S, Ai W, Betz KS, Florholmen J, Koh TJ, Houghton J, Pritchard DM, Wang TC. Gastrin-induced apoptosis contributes to carcinogenesis in the stomach. Lab Invest. 2006 Oct; 86(10):1037-51. PMID: 16894354.
      View in: PubMed
    22. Houghton J, Morozov A, Smirnova I, Wang TC. Stem cells and cancer. Semin Cancer Biol. 2007 Jun; 17(3):191-203. PMID: 16762563.
      View in: PubMed
    23. Li HC, Stoicov C, Rogers AB, Houghton J. Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers. World J Gastroenterol. 2006 Jan 21; 12(3):363-71. PMID: 16489634.
      View in: PubMed
    24. Stoicov C, Li H, Carlson J, Houghton J. Bone marrow cells as the origin of stomach cancer. Future Oncol. 2005 Dec; 1(6):851-62. PMID: 16556065.
      View in: PubMed
    25. Cai X, Stoicov C, Li H, Carlson J, Whary M, Fox JG, Houghton J. Overcoming Fas-mediated apoptosis accelerates Helicobacter-induced gastric cancer in mice. Cancer Res. 2005 Dec 1; 65(23):10912-20. PMID: 16322238.
      View in: PubMed
    26. Stoicov C, Cai X, Li H, Klucevsek K, Carlson J, Saffari R, Houghton J. Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation. Infect Immun. 2005 Oct; 73(10):6311-21. PMID: 16177302.
      View in: PubMed
    27. Cai X, Carlson J, Stoicov C, Li H, Wang TC, Houghton J. Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology. 2005 Jun; 128(7):1937-52. PMID: 15940628.
      View in: PubMed
    28. Takaishi S, Cui G, Frederick DM, Carlson JE, Houghton J, Varro A, Dockray GJ, Ge Z, Whary MT, Rogers AB, Fox JG, Wang TC. Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer. Gastroenterology. 2005 Jun; 128(7):1965-83. PMID: 15940630.
      View in: PubMed
    29. Houghton J, Wang TC. Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology. 2005 May; 128(6):1567-78. PMID: 15887152.
      View in: PubMed
    30. Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TC. Gastric cancer originating from bone marrow-derived cells. Science. 2004 Nov 26; 306(5701):1568-71. PMID: 15567866.
      View in: PubMed
    31. Mandell L, Moran AP, Cocchiarella A, Houghton J, Taylor N, Fox JG, Wang TC, Kurt-Jones EA. Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun. 2004 Nov; 72(11):6446-54. PMID: 15501775.
      View in: PubMed
    32. Stoicov C, Saffari R, Cai X, Hasyagar C, Houghton J. Molecular biology of gastric cancer: Helicobacter infection and gastric adenocarcinoma: bacterial and host factors responsible for altered growth signaling. Gene. 2004 Oct 27; 341:1-17. PMID: 15474284.
      View in: PubMed
    33. Stoicov C, Whary M, Rogers AB, Lee FS, Klucevsek K, Li H, Cai X, Saffari R, Ge Z, Khan IA, Combe C, Luster A, Fox JG, Houghton J. Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections. J Immunol. 2004 Sep 1; 173(5):3329-36. PMID: 15322196.
      View in: PubMed
    34. Koh TJ, Field JK, Varro A, Liloglou T, Fielding P, Cui G, Houghton J, Dockray GJ, Wang TC. Glycine-extended gastrin promotes the growth of lung cancer. Cancer Res. 2004 Jan 1; 64(1):196-201. PMID: 14729624.
      View in: PubMed
    35. Li H, Stoicov C, Cai X, Wang TC, Houghton J. Helicobacter and gastric cancer disease mechanisms: host response and disease susceptibility. Curr Gastroenterol Rep. 2003 Dec; 5(6):459-67. PMID: 14602053.
      View in: PubMed
    36. Zivny J, Wang TC, Yantiss R, Kim KH, Houghton J. Role of therapy or monitoring in preventing progression to gastric cancer. J Clin Gastroenterol. 2003 May-Jun; 36(5 Suppl):S50-60; discussion S61-2. PMID: 12702966.
      View in: PubMed
    37. Houghton J, Fox JG, Wang TC. Gastric cancer: laboratory bench to clinic. J Gastroenterol Hepatol. 2002 Apr; 17(4):495-502. PMID: 11982733.
      View in: PubMed
    38. Houghton J, Ramamoorthy R, Pandya H, Dhirmalani R, Kim KH. Human plasma is directly bacteriocidal against Helicobacter pylori in vitro, potentially explaining the decreased detection of Helicobacter pylori during acute upper GI bleeding. Gastrointest Endosc. 2002 Jan; 55(1):11-6. PMID: 11756907.
      View in: PubMed
    39. Douglass EC, Valentine M, Etcubanas E, Parham D, Webber BL, Houghton PJ, Houghton JA, Green AA. A specific chromosomal abnormality in rhabdomyosarcoma. Cytogenet Cell Genet. 1987; 45(3-4):148-55. PMID: 3691179.
      View in: PubMed
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