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Chad E Darling MD

TitleAssociate Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentEmergency Medicine
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-421-1400
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentEmergency Medicine

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentClinical Population Health Research

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMasters in Clinical Investigation

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program


    Collapse Biography 
    Collapse education and training
    University of Pittsburgh, Pittsburgh, PA, United StatesBSBiology/Chemistry
    Dartmouth College, Hanover, NH, United StatesMDMedicine

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Darling CE, Martindale JL, Hiestand BC, Bonnell M, Colvin M, DeFilippis EM, Elliott Rn T. An Emergency-Medicine Focused Summary of the HFSA/SAEM/ISHLT Clinical Consensus Document on the Emergency Management of Patients with Ventricular Assist Devices. Acad Emerg Med. 2020 Mar 16. PMID: 32176420.
      View in: PubMed
    2. Kapoor A, Bloomstone S, Javed S, Silva M, Lynch A, Yogaratnam D, Carlone B, Springer K, Maheswaran A, Chen X, Nagy A, Elhag R, Markaddy E, Aungst T, Bartlett D, Houng D, Darling C, McManus D, Herzig SJ, Barton B, Mazor K. Reducing Hospitalizations and Emergency Department Visits in Patients With Venous Thromboembolism Using a Multicomponent Care Transition Intervention. Inquiry. 2020 Jan-Dec; 57:46958019900080. PMID: 31965873.
      View in: PubMed
    3. Givertz MM, DeFilippis EM, Colvin M, Darling CE, Elliott T, Hamad E, Hiestand BC, Martindale JL, Pinney SP, Shah KB, Vierecke J, Bonnell M. HFSA/SAEM/ISHLT clinical expert consensus document on the emergency management of patients with ventricular assist devices. J Heart Lung Transplant. 2019 Jul; 38(7):677-698. PMID: 31272557.
      View in: PubMed
    4. Givertz MM, DeFilippis EM, Colvin M, Darling CE, Elliott T, Hamad E, Hiestand BC, Martindale JL, Pinney SP, Shah KB, Vierecke J, Bonnell M. HFSA/SAEM/ISHLT clinical expert consensus document on the emergency management of patients with ventricular assist devices. J Card Fail. 2019 Jun 25. PMID: 31271866.
      View in: PubMed
    5. Tran HV, Ash AS, Gore JM, Darling CE, Kiefe CI, Goldberg RJ. Twenty-five year trends (1986-2011) in hospital incidence and case-fatality rates of ventricular tachycardia and ventricular fibrillation complicating acute myocardial infarction. Am Heart J. 2018 Nov 01; 208:1-10. PMID: 30471486.
      View in: PubMed
    6. Tran HV, Gore JM, Darling CE, Ash AS, Kiefe CI, Goldberg RJ. Hyperglycemia and risk of ventricular tachycardia among patients hospitalized with acute myocardial infarction. Cardiovasc Diabetol. 2018 Oct 19; 17(1):136. PMID: 30340589.
      View in: PubMed
    7. Tran HV, Gore JM, Darling CE, Ash AS, Kiefe CI, Goldberg RJ. Clinically significant ventricular arrhythmias and progression of depression and anxiety following an acute coronary syndrome. J Psychosom Res. 2018 Oct 19. PMID: 30482494.
      View in: PubMed
    8. Waring ME, McManus DD, Amante DJ, Darling CE, Kiefe CI. Online health information seeking by adults hospitalized for acute coronary syndromes: Who looks for information, and who discusses it with healthcare providers? Patient Educ Couns. 2018 Nov; 101(11):1973-1981. PMID: 30305253.
      View in: PubMed
    9. Reljin N, Zimmer G, Malyuta Y, Shelley K, Mendelson Y, Blehar DJ, Darling CE, Chon KH. Using support vector machines on photoplethysmographic signals to discriminate between hypovolemia and euvolemia. PLoS One. 2018; 13(3):e0195087. PMID: 29596477.
      View in: PubMed
    10. Darling CE, Sun JE, Goldberg J, Pang P, Baugh CW, Lessard D, McManus DD. A Historical Perspective on Presentations of Hypertensive Acute Heart Failure. J Cardiovasc Dis Diagn. 2017 May; 5(3). PMID: 28824930.
      View in: PubMed
    11. Darling CE, Dovancescu S, Saczynski JS, Riistama J, Sert Kuniyoshi F, Rock J, Meyer TE, McManus DD. Bioimpedance-Based Heart Failure Deterioration Prediction Using a Prototype Fluid Accumulation Vest-Mobile Phone Dyad: An Observational Study. JMIR Cardio. 2017 Mar 13; 1(1):e1. PMID: 31758769.
      View in: PubMed
    12. Dao D, Salehizadeh SM, Noj Y, Chong JW, Cho C, Mcmanus D, Darling CE, Mendelson Y, Chon KH. A Robust Motion Artifact Detection Algorithm for Accurate Detection of Heart Rates from Photoplethysmographic Signals using Time-Frequency Spectral Features. IEEE J Biomed Health Inform. 2016 Oct 21. PMID: 28113791.
      View in: PubMed
    13. Kundu A, O'Day K, Shaikh AY, Lessard DM, Saczynski JS, Yarzebski J, Darling CE, Thabet R, Akhter MW, Floyd KC, Goldberg RJ, McManus DD. Relation of Atrial Fibrillation in Acute Myocardial Infarction to In-Hospital Complications and Early Hospital Readmission. Am J Cardiol. 2016 Apr 15; 117(8):1213-8. PMID: 26874548.
      View in: PubMed
    14. Coles AH, Tisminetzky M, Yarzebski J, Lessard D, Gore JM, Darling CE, Goldberg RJ. Magnitude of and Prognostic Factors Associated With 1-Year Mortality After Hospital Discharge for Acute Decompensated Heart Failure Based on Ejection Fraction Findings. J Am Heart Assoc. 2015 Dec 23; 4(12). PMID: 26702084.
      View in: PubMed
    15. Chai PR, Castillo-Mancilla J, Buffkin E, Darling C, Rosen RK, Horvath KJ, Boudreaux ED, Robbins GK, Hibberd PL, Boyer EW. Utilizing an Ingestible Biosensor to Assess Real-Time Medication Adherence. J Med Toxicol. 2015 Dec; 11(4):439-44. PMID: 26245878.
      View in: PubMed
    16. McMANUS DD, Chong JW, Soni A, Saczynski JS, Esa N, Napolitano C, Darling CE, Boyer E, Rosen RK, Floyd KC, Chon KH. PULSE-SMART: Pulse-Based Arrhythmia Discrimination Using a Novel Smartphone Application. J Cardiovasc Electrophysiol. 2016 Jan; 27(1):51-7. PMID: 26391728.
      View in: PubMed
    17. Dovancescu S, Saczynski JS, Darling CE, Riistama J, Sert Kuniyoshi F, Meyer T, Goldberg R, McManus DD. Detecting Heart Failure Decompensation by Measuring Transthoracic Bioimpedance in the Outpatient Setting: Rationale and Design of the SENTINEL-HF Study. JMIR Res Protoc. 2015 Oct 09; 4(4):e121. PMID: 26453479.
      View in: PubMed
    18. Reznek MA, Kotkowski KA, Arce MW, Jepson ZK, Bird SB, Darling CE. Patient safety incident capture resulting from incident reports: a comparative observational analysis. BMC Emerg Med. 2015; 15:6. PMID: 25880446.
      View in: PubMed
    19. Fisher KA, Stefan MS, Darling C, Lessard D, Goldberg RJ. Impact of COPD on the mortality and treatment of patients hospitalized with acute decompensated heart failure: the Worcester Heart Failure Study. Chest. 2015 Mar; 147(3):637-45. PMID: 25188234.
      View in: PubMed
    20. Levin SN, Hajduk AM, McManus DD, Darling CE, Gurwitz JH, Spencer FA, Goldberg RJ, Saczynski JS. Cognitive status in patients hospitalized with acute decompensated heart failure. Am Heart J. 2014 Dec; 168(6):917-23. PMID: 25458656.
      View in: PubMed
    21. Jepson ZK, Darling CE, Kotkowski KA, Bird SB, Arce MW, Volturo GA, Reznek MA. Emergency department patient safety incident characterization: an observational analysis of the findings of a standardized peer review process. BMC Emerg Med. 2014; 14:20. PMID: 25106803.
      View in: PubMed
    22. Chong JW, Dao DK, Salehizadeh SM, McManus DD, Darling CE, Chon KH, Mendelson Y. Photoplethysmograph signal reconstruction based on a novel hybrid motion artifact detection-reduction approach. Part I: Motion and noise artifact detection. Ann Biomed Eng. 2014 Nov; 42(11):2238-50. PMID: 25092422.
      View in: PubMed
    23. Coles AH, Fisher K, Darling C, Yarzebski J, McManus DD, Gore JM, Lessard D, Goldberg RJ. Long-term survival for patients with acute decompensated heart failure according to ejection fraction findings. Am J Cardiol. 2014 Sep 15; 114(6):862-8. PMID: 25092194.
      View in: PubMed
    24. Mullen M, Cerri G, Murray R, Talbot A, Sanseverino A, McCahill P, Mangolds V, Volturo J, Darling C, Restuccia M. Use of point-of-care lactate in the prehospital aeromedical environment. Prehosp Disaster Med. 2014 Apr; 29(2):200-3. PMID: 24642116.
      View in: PubMed
    25. Tisminetzky M, Joffe S, McManus DD, Darling C, Gore JM, Yarzebski J, Lessard D, Goldberg RJ. Decade-long trends in the characteristics, management and hospital outcomes of diabetic patients with ST-segment elevation myocardial infarction. Diab Vasc Dis Res. 2014 May; 11(3):182-9. PMID: 24618530.
      View in: PubMed
    26. Tisminetzky M, Coukos JA, McManus DD, Darling CE, Joffe S, Gore J, Lessard D, Goldberg RJ. Decade-long trends in the magnitude, treatment, and outcomes of patients aged 30 to 54 years hospitalized with ST-segment elevation and non-ST-segment elevation myocardial infarction. Am J Cardiol. 2014 May 15; 113(10):1606-10. PMID: 24666616.
      View in: PubMed
    27. Darling CE, Sala Mercado JA, Quiroga-Castro W, Tecco GF, Zelaya FR, Conci EC, Sala JP, Smith CS, Michelson AD, Whittaker P, Welch RD, Przyklenk K. Point-of-care assessment of platelet reactivity in the emergency department may facilitate rapid rule-out of acute coronary syndromes: a prospective cohort pilot feasibility study. BMJ Open. 2014 Jan 17; 4(1):e003883. PMID: 24441051.
      View in: PubMed
    28. Darling CE, Fisher KA, McManus DD, Coles AH, Spencer FA, Gore JM, Goldberg RJ. Survival after hospital discharge for ST-segment elevation and non-ST-segment elevation acute myocardial infarction: a population-based study. Clin Epidemiol. 2013; 5:229-36. PMID: 23901296.
      View in: PubMed
    29. Joffe SW, Webster K, McManus DD, Kiernan MS, Lessard D, Yarzebski J, Darling C, Gore JM, Goldberg RJ. Improved survival after heart failure: a community-based perspective. J Am Heart Assoc. 2013 May 15; 2(3):e000053. PMID: 23676294.
      View in: PubMed
    30. Darling C, Saczynski JS, McManus DD, Lessard D, Spencer FA, Goldberg RJ. Delayed hospital presentation in acute decompensated heart failure: clinical and patient reported factors. Heart Lung. 2013 Jul-Aug; 42(4):281-6. PMID: 23474108.
      View in: PubMed
    31. Darling CE, Smith CS, Sun JE, Klaucke CG, Lerner J, Cyr J, Paige PG, Paige P, Bird SB. Cost reductions associated with a quality improvement initiative for patients with ST-elevation myocardial infarction. Jt Comm J Qual Patient Saf. 2013 Jan; 39(1):16-21. PMID: 23367648.
      View in: PubMed
    32. Coles AH, Fisher KA, Darling C, McManus D, Maitas O, Yarzebski J, Gore JM, Lessard D, Goldberg RJ. Recent trends in post-discharge mortality among patients with an initial acute myocardial infarction. Am J Cardiol. 2012 Oct 15; 110(8):1073-7. PMID: 22762720.
      View in: PubMed
    33. Kiefer CR, Stock RE, Flanagan SS, Darling CE, Smith CS, Snyder LM. Early verification of myocardial ischemia with a novel biomarker of acute tissue damage: C-reactive protein fractional forms. Clin Chim Acta. 2012 Oct 9; 413(19-20):1536-41. PMID: 22735342.
      View in: PubMed
    34. McManus DD, Saczynski JS, Ward JA, Jaggi K, Bourrell P, Darling C, Goldberg RJ. The Relationship Between Atrial Fibrillation and Chronic Kidney Disease : Epidemiologic and Pathophysiologic Considerations for a Dual Epidemic. J Atr Fibrillation. 2012 Jun-Jul; 5(1):442. PMID: 28496745.
      View in: PubMed
    35. Goldberg RJ, Lamusta J, Darling C, DeWolf M, Saczynski JS, Lessard D, Ward J, Gore JM. Community trends in the use and characteristics of persons with acute myocardial infarction who are transported by emergency medical services. Heart Lung. 2012 Jul-Aug; 41(4):323-31. PMID: 22436968.
      View in: PubMed
    36. Park D, McManus D, Darling C, Goldberg JH, Gore JM, Lessard D, Goldberg RJ. Recent trends in the characteristics and prognosis of patients hospitalized with acute heart failure. Clin Epidemiol. 2011; 3:295-303. PMID: 22253547.
      View in: PubMed
    37. Weibrecht K, Dayno M, Darling C, Bird SB. Liver aminotransferases are elevated with rhabdomyolysis in the absence of significant liver injury. J Med Toxicol. 2010 Sep; 6(3):294-300. PMID: 20407858.
      View in: PubMed
    38. Weisberg S, Fitch J, Towner D, Darling CE. Transporting without infusions: effect on door-to-needle time for acute coronary syndrome patients. Prehosp Emerg Care. 2010 Apr-Jun; 14(2):159-63. PMID: 20095829.
      View in: PubMed
    39. Saczynski JS, Darling CE, Spencer FA, Lessard D, Gore JM, Goldberg RJ. Clinical features, treatment practices, and hospital and long-term outcomes of older patients hospitalized with decompensated heart failure: The Worcester Heart Failure Study. J Am Geriatr Soc. 2009 Sep; 57(9):1587-94. PMID: 19682131.
      View in: PubMed
    40. Goldberg RJ, Darling C, Joseph B, Saczynski J, Chinali M, Lessard D, Pezzella S, Spencer FA. Epidemiology of decompensated heart failure in a single community in the northeastern United States. Am J Cardiol. 2009 Aug 1; 104(3):377-82. PMID: 19616671.
      View in: PubMed
    41. Darling CE, Michelson AD, Volturo GA, Przyklenk K. Platelet reactivity and the identification of acute coronary syndromes in the emergency department. J Thromb Thrombolysis. 2009 Jul; 28(1):31-7. PMID: 18600429.
      View in: PubMed
    42. Przyklenk K, Maynard M, Darling CE, Whittaker P. Aging mouse hearts are refractory to infarct size reduction with post-conditioning. J Am Coll Cardiol. 2008 Apr 8; 51(14):1393-8. PMID: 18387442.
      View in: PubMed
    43. Darling CE, Solari PB, Smith CS, Furman MI, Przyklenk K. 'Postconditioning' the human heart: multiple balloon inflations during primary angioplasty may confer cardioprotection. Basic Res Cardiol. 2007 May; 102(3):274-8. PMID: 17235447.
      View in: PubMed
    44. Darling CE, Jiang R, Maynard M, Whittaker P, Vinten-Johansen J, Przyklenk K. Postconditioning via stuttering reperfusion limits myocardial infarct size in rabbit hearts: role of ERK1/2. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1618-26. PMID: 15937101.
      View in: PubMed
    45. Przyklenk K, Maynard M, Darling CE, Whittaker P. Pretreatment with D-myo-inositol trisphosphate reduces infarct size in rabbit hearts: role of inositol trisphosphate receptors and gap junctions in triggering protection. J Pharmacol Exp Ther. 2005 Sep; 314(3):1386-92. PMID: 15919762.
      View in: PubMed
    46. Dickson EW, Whittaker P, Darling CE, Hirsch DJ, Blehar DJ, Przyklenk K. Brief apnea induces myocardial ischemic tolerance by an opioid-insensitive mechanism. Cardiovasc Pathol. 2004 Jul-Aug; 13(4):225-9. PMID: 15210139.
      View in: PubMed
    47. Przyklenk K, Darling CE, Dickson EW, Whittaker P. Cardioprotection 'outside the box'--the evolving paradigm of remote preconditioning. Basic Res Cardiol. 2003 May; 98(3):149-57. PMID: 12883832.
      View in: PubMed
    48. Dickson EW, Tubbs RJ, Porcaro WA, Lee WJ, Blehar DJ, Carraway RE, Darling CE, Przyklenk K. Myocardial preconditioning factors evoke mesenteric ischemic tolerance via opioid receptors and K(ATP) channels. Am J Physiol Heart Circ Physiol. 2002 Jul; 283(1):H22-8. PMID: 12063270.
      View in: PubMed
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