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Ann R Rittenhouse PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences

    Collapse Biography 
    Collapse education and training
    Mount Holyoke College, South Hadley, MA, United StatesABBiology
    Boston University, Boston, MA, United StatesPHDBiology

    Collapse Overview 
    Collapse Summary
    Focus: Voltage-Gated Calcium channels and neuronal plasticity
    Collapse overview

    Calcium Channels and Neuronal Plasticity

    My laboratory is interested in understanding the role that voltage-gated Ca2+ channel (VGCC) subunits play in both health and disease. In neurons, influx of Ca2+ through these channels serves the critical function of interfacing electrical signals with biochemical and transcriptional changes. Variability in their level of expression, cell-surface location and activity has profound effects on how much and where Ca2+ enters a nerve cell. This in turn influences neurotransmitter release, the strength of synaptic contacts as well as cellular and transcriptional processes, which ultimately affect learning and behavior. At the cellular level, my lab has focused on understanding how neuro­trans­mitters, small lipid molecules, and cytoplasmic proteins modulate postsynaptic neuronal VGCC activity and also VGCC activity in pancreatic beta cells that regulates insulin secretion. These basic questions about VGCC function overlap with our interest in understanding the cellular basis of schizophrenia. Explore the lab webpage to learn more about the lab’s research interests. 



    Collapse Rotation Projects

    Rotation Projects

    Please contact me if you are interested in hearing more about current lab projects and potential rotation projects: ann.rittenhouse@umassmed.edu.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rittenhouse AR, Ortiz-Miranda S, Jurczyk A. Mutations in DISC1 alter IP3R and voltage-gated Ca2+ channel functioning, implications for major mental illness. Neuronal Signal. 2021 Dec; 5(4):NS20180122. PMID: 34956649.
    2. Redick SD, Leehy L, Rittenhouse AR, Blodgett DM, Derr AG, Kucukural A, Garber MG, Shultz LD, Greiner DL, Wang JP, Harlan DM, Bortell R, Jurczyk A. Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice. FASEB J. 2020 01; 34(1):1901-1911. PMID: 31914605.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    3. Liu L, Bonventre JV, Rittenhouse AR. cPLA2a-/- sympathetic neurons exhibit increased membrane excitability and loss of N-Type Ca2+ current inhibition by M1 muscarinic receptor signaling. PLoS One. 2018; 13(12):e0201322. PMID: 30557348.
      Citations:    Fields:    Translation:AnimalsCells
    4. Roberts-Crowley ML, Rittenhouse AR. Modulation of CaV1.3b L-type calcium channels by M1 muscarinic receptors varies with CaV? subunit expression. BMC Res Notes. 2018 Sep 27; 11(1):681. PMID: 30261922.
      Citations: 2     Fields:    Translation:HumansCells
    5. Ortiz-Miranda S, Ji R, Jurczyk A, Aryee KE, Mo S, Fletcher T, Shaffer SA, Greiner DL, Bortell R, Gregg RG, Cheng A, Hennings LJ, Rittenhouse AR. A novel transgenic mouse model of lysosomal storage disorder. Am J Physiol Gastrointest Liver Physiol. 2016 11 01; 311(5):G903-G919. PMID: 27659423.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Jurczyk A, Nowosielska A, Przewozniak N, Aryee KE, DiIorio P, Blodgett D, Yang C, Campbell-Thompson M, Atkinson M, Shultz L, Rittenhouse A, Harlan D, Greiner D, Bortell R. Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ?-cell function via glycogen synthase kinase-3?. FASEB J. 2016 Feb; 30(2):983-93. PMID: 26546129.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    7. Roberts-Crowley ML, Rittenhouse AR. Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels. PLoS One. 2015; 10(7):e0132469. PMID: 26147123.
      Citations: 2     Fields:    Translation:AnimalsCells
    8. Huang F, Bladon J, Lagoy RC, Shorrock PN, Hronik-Tupaj M, Zoto CA, Connors RE, Grant McGimpsey W, Molnar P, Lambert S, Rittenhouse AR, Lambert CR. A photosensitive surface capable of inducing electrophysiological changes in NG108-15 neurons. Acta Biomater. 2015 Jan; 12:42-50. PMID: 25449922.
      Citations: 5     Fields:    Translation:HumansCells
    9. diIorio P, Rittenhouse AR, Bortell R, Jurczyk A. Role of cilia in normal pancreas function and in diseased states. Birth Defects Res C Embryo Today. 2014 Jun; 102(2):126-38. PMID: 24861006.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    10. Rittenhouse AR. Novel coupling is painless. J Gen Physiol. 2014 Apr; 143(4):443-7. PMID: 24688017.
      Citations:    Fields:    Translation:HumansAnimals
    11. Gabriel L, Lvov A, Orthodoxou D, Rittenhouse AR, Kobertz WR, Melikian HE. The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3?-dependent, protein kinase C (PKC)-mediated endocytic trafficking. J Biol Chem. 2012 Sep 21; 287(39):32354-66. PMID: 22846993.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    12. Heneghan JF, Mitra-Ganguli T, Stanish LF, Liu L, Zhao R, Rittenhouse AR. The Ca2+ channel beta subunit determines whether stimulation of Gq-coupled receptors enhances or inhibits N current. J Gen Physiol. 2009 Nov; 134(5):369-84. PMID: 19858357.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    13. Mitra-Ganguli T, Vitko I, Perez-Reyes E, Rittenhouse AR. Orientation of palmitoylated CaVbeta2a relative to CaV2.2 is critical for slow pathway modulation of N-type Ca2+ current by tachykinin receptor activation. J Gen Physiol. 2009 Nov; 134(5):385-96. PMID: 19858358.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    14. Roberts-Crowley ML, Mitra-Ganguli T, Liu L, Rittenhouse AR. Regulation of voltage-gated Ca2+ channels by lipids. Cell Calcium. 2009 Jun; 45(6):589-601. PMID: 19419761.
      Citations: 36     Fields:    
    15. Roberts-Crowley ML, Rittenhouse AR. Arachidonic acid inhibition of L-type calcium (CaV1.3b) channels varies with accessory CaVbeta subunits. J Gen Physiol. 2009 Apr; 133(4):387-403. PMID: 19332620.
      Citations: 19     Fields:    Translation:HumansCells
    16. Liu L, Heneghan JF, Michael GJ, Stanish LF, Egertov? M, Rittenhouse AR. L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity. J Cell Physiol. 2008 Jul; 216(1):91-100. PMID: 18247369.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    17. Rittenhouse AR. PIP2 PIP2 hooray for maxi K+. J Gen Physiol. 2008 Jul; 132(1):5-8. PMID: 18562503.
      Citations: 3     Fields:    Translation:AnimalsCells
    18. Liu L, Heneghan JF, Mitra-Ganguli T, Roberts-Crowley ML, Rittenhouse AR. Role of PIP2 in regulating versus modulating Ca2+ channel activity. J Physiol. 2007 Sep 15; 583(Pt 3):1165-6; author reply 1167. PMID: 17673503.
      Citations: 1     Fields:    Translation:AnimalsCells
    19. Zhao R, Liu L, Rittenhouse AR. Ca2+ influx through both L- and N-type Ca2+ channels increases c-fos expression by electrical stimulation of sympathetic neurons. Eur J Neurosci. 2007 Feb; 25(4):1127-35. PMID: 17331208.
      Citations: 15     Fields:    Translation:AnimalsCells
    20. Liu L, Zhao R, Bai Y, Stanish LF, Evans JE, Sanderson MJ, Bonventre JV, Rittenhouse AR. M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades. J Neurosci. 2006 Nov 08; 26(45):11588-98. PMID: 17093080.
      Citations: 27     Fields:    Translation:AnimalsCells
    21. Liu L, Roberts ML, Rittenhouse AR. Phospholipid metabolism is required for M1 muscarinic inhibition of N-type calcium current in sympathetic neurons. Eur Biophys J. 2004 May; 33(3):255-64. PMID: 15004729.
      Citations: 17     Fields:    Translation:AnimalsCells
    22. Liu L, Gonzalez PK, Barrett CF, Rittenhouse AR. The calcium channel ligand FPL 64176 enhances L-type but inhibits N-type neuronal calcium currents. Neuropharmacology. 2003 Aug; 45(2):281-92. PMID: 12842134.
      Citations: 12     Fields:    Translation:AnimalsCells
    23. Liu L, Rittenhouse AR. Pharmacological discrimination between muscarinic receptor signal transduction cascades with bethanechol chloride. Br J Pharmacol. 2003 Apr; 138(7):1259-70. PMID: 12711626.
      Citations: 13     Fields:    Translation:AnimalsCells
    24. Liu L, Rittenhouse AR. Arachidonic acid mediates muscarinic inhibition and enhancement of N-type Ca2+ current in sympathetic neurons. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):295-300. PMID: 12496347.
      Citations: 32     Fields:    Translation:AnimalsCells
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