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David Paydarfar MD

TitleAdjunct Professor
InstitutionUMass Chan Medical School
DepartmentNeurology
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-1658
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentNeurology


    Collapse Biography 
    Collapse education and training
    Duke University, Durham, NC, United StatesBSPhysics
    University of North Carolina Chapel Hill, Chapel Hill, NC, United StatesMD

    Collapse Overview 
    Collapse overview

    My research is devoted to understanding the neural control of autonomic functions. Specific areas of interest are the genesis of respiratory rhythm, the coordination of breathing and swallowing, and the maintenance of circulation during upright posture. The major goal is to understand how normal control mechanisms break down and lead to certain common disease states: central apnea, neurogenic aspiration, and neurally mediated syncope.

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Paydarfar DA, Paydarfar D, Mucha PJ, Chang J. Optimizing Emergency Stroke Transport Strategies Using Physiological Models. Stroke. 2021 12; 52(12):4010-4020. PMID: 34407639.
      Citations:    Fields:    Translation:Humans
    2. Zuzarte I, Sternad D, Paydarfar D. Predicting apneic events in preterm infants using cardio-respiratory and movement features. Comput Methods Programs Biomed. 2021 Sep; 209:106321. PMID: 34380078.
      Citations:    Fields:    Translation:Humans
    3. Rao N, Chang J, Paydarfar D. Characterizing the performance of emergency medical transport time metrics in a residentially segregated community. Am J Emerg Med. 2021 Dec; 50:111-119. PMID: 34340164.
      Citations:    Fields:    Translation:Humans
    4. Zuzarte I, Paydarfar D, Sternad D. Effect of spontaneous movement on respiration in preterm infants. Exp Physiol. 2021 05; 106(5):1285-1302. PMID: 33675125.
      Citations: 1     Fields:    Translation:Humans
    5. Tierney WM, Auzenne D, Cook L, Jones BL, Mackert M, Paydarfar D, Ding X, Woods JM, Kahlon M. Importance of Community Impact as the Fourth Academic Mission: A Qualitative Study. Popul Health Manag. 2021 10; 24(5):610-615. PMID: 33709790.
      Citations:    Fields:    Translation:Humans
    6. Chang J, Paydarfar D. Falling off a limit cycle using phase-agnostic stimuli: Applications to clinical oscillopathies. Chaos. 2021 Feb; 31(2):023134. PMID: 33653068.
      Citations:    Fields:    Translation:Humans
    7. Chang J, Sridhar V, Paydarfar D. Falling off a limit cycle using phase-agnostic stimuli: Definitions and conceptual framework. Chaos. 2020 Dec; 30(12):123113. PMID: 33380020.
      Citations:    Fields:    Translation:Humans
    8. Zuzarte I, Gee AH, Sternad D, Paydarfar D. Automated movement detection reveals features of maturation in preterm infants. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:600-603. PMID: 33018060.
      Citations: 2     Fields:    Translation:Humans
    9. Santoso LF, Jafari S, Kim DY, Paydarfar D. The Internal Superior Laryngeal Nerve in Humans: Evidence for Pure Sensory Function. Laryngoscope. 2021 01; 131(1):E207-E211. PMID: 32198941.
      Citations: 2     Fields:    Translation:Humans
    10. Gee AH, Garcia-Olano D, Ghosh J, Paydarfar D. Explaining Deep Classification of Time-Series Data with Learned Prototypes. CEUR Workshop Proc. 2019 Aug; 2429:15-22. PMID: 33867901.
      Citations:    
    11. Santoso LF, Baqai F, Gwozdz M, Lange J, Rosenberger MG, Sulzer J, Paydarfar D. Applying Machine Learning Algorithms for Automatic Detection of Swallowing from Sound. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:2584-2588. PMID: 31946425.
      Citations:    Fields:    Translation:Humans
    12. Santoso LF, Kim DY, Paydarfar D. Sensory dysphagia: A case series and proposed classification of an under recognized swallowing disorder. Head Neck. 2019 05; 41(5):E71-E78. PMID: 30620442.
      Citations: 2     Fields:    Translation:Humans
    13. Zuzarte I, Indic P, Sternad D, Paydarfar D. Quantifying Movement in Preterm Infants Using Photoplethysmography. Ann Biomed Eng. 2019 Feb; 47(2):646-658. PMID: 30255214.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    14. Chang J, Paydarfar D. Optimizing stimulus waveforms for electroceuticals. Biol Cybern. 2019 04; 113(1-2):191-199. PMID: 30099589.
      Citations: 4     Fields:    Translation:Humans
    15. Chang J, Paydarfar D. Author Correction: Evolution of extrema features reveals optimal stimuli for biological state transitions. Sci Rep. 2018 Jul 18; 8(1):11177. PMID: 30022084.
      Citations:    Fields:    
    16. Chang J, Paydarfar D. Optimizing stimulus waveforms for suppressing epileptic activity reveals a counterbalancing mechanism. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:2226-2229. PMID: 30440848.
      Citations:    Fields:    Translation:Humans
    17. Gee AH, Chang J, Ghosh J, Paydarfar D. Bayesian Online Changepoint Detection Of Physiological Transitions. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:45-48. PMID: 30440337.
      Citations:    Fields:    Translation:Humans
    18. Chang J, Paydarfar D. Evolution of extrema features reveals optimal stimuli for biological state transitions. Sci Rep. 2018 02 21; 8(1):3403. PMID: 29467377.
      Citations:    Fields:    
    19. Zuzarte I, Indic P, Barton B, Paydarfar D, Bednarek F, Bloch-Salisbury E. Vibrotactile stimulation: A non-pharmacological intervention for opioid-exposed newborns. PLoS One. 2017; 12(4):e0175981. PMID: 28426726.
      Citations: 5     Fields:    Translation:Humans
    20. Ghasemi M, Riaz N, Bjornsdottir A, Paydarfar D. Isolated pseudoabducens palsy in acute thalamic stroke. Clin Imaging. 2017 May - Jun; 43:28-31. PMID: 28167284.
      Citations: 2     Fields:    Translation:Humans
    21. Gee AH, Barbieri R, Paydarfar D, Indic P. Predicting Bradycardia in Preterm Infants Using Point Process Analysis of Heart Rate. IEEE Trans Biomed Eng. 2017 09; 64(9):2300-2308. PMID: 27898379.
      Citations: 9     Fields:    Translation:Humans
    22. Gee AH, Barbieri R, Paydarfar D, Indic P. Improving heart rate estimation in preterm infants with bivariate point process analysis of heart rate and respiration. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:920-923. PMID: 28268474.
      Citations: 3     Fields:    Translation:Humans
    23. Smith VC, Kelty-Stephen D, Qureshi Ahmad M, Mao W, Cakert K, Osborne J, Paydarfar D. Stochastic Resonance Effects on Apnea, Bradycardia, and Oxygenation: A Randomized Controlled Trial. Pediatrics. 2015 Dec; 136(6):e1561-8. PMID: 26598451.
      Citations: 17     Fields:    Translation:Humans
    24. Gee AH, Barbieri R, Paydarfar D, Indic P. Uncovering statistical features of bradycardia severity in premature infants using a point process model. Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug; 2015:5855-8. PMID: 26737623.
      Citations: 2     Fields:    Translation:Humans
    25. Chang J, Paydarfar D. Optimal stimulus waveforms for eliciting a spike: How close is the spike-triggered average? Int IEEE EMBS Conf Neural Eng. 2015 Apr; 2015:414-417. PMID: 28163829.
      Citations:    
    26. Cachia D, Smith T, Paydarfar D, Pomorska G. A case of early-onset rapidly progressive dementia. JAMA Neurol. 2014 Nov; 71(11):1445-9. PMID: 25265527.
      Citations: 2     Fields:    Translation:Humans
    27. Bloch-Salisbury E, Zuzarte I, Indic P, Bednarek F, Paydarfar D. Kangaroo care: cardio-respiratory relationships between the infant and caregiver. Early Hum Dev. 2014 Dec; 90(12):843-50. PMID: 25463830.
      Citations: 10     Fields:    Translation:Humans
    28. Bo?ová K, Paydarfar D, Forger DB. Characterizing spiking in noisy type II neurons. J Theor Biol. 2015 Jan 21; 365:40-54. PMID: 25311908.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    29. Chang J, Paydarfar D. Switching neuronal state: optimal stimuli revealed using a stochastically-seeded gradient algorithm. J Comput Neurosci. 2014 Dec; 37(3):569-82. PMID: 25145955.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    30. Gaspari RJ, Paydarfar D. Pulmonary effects of intravenous atropine induce ventilation perfusion mismatch. Can J Physiol Pharmacol. 2014 May; 92(5):399-404. PMID: 24773405.
      Citations: 1     Fields:    Translation:Animals
    31. Zuzarte I, Temple C, Indic P, Paydarfar D. Transforming artifact to signal: A wavelet-based algorithm for quantifying neonatal movement. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:5466-9. PMID: 25571231.
      Citations: 3     Fields:    Translation:Humans
    32. Kheradmand A, Fisher M, Paydarfar D. Ischemic stroke in evolution: predictive value of perfusion computed tomography. J Stroke Cerebrovasc Dis. 2014 May-Jun; 23(5):836-43. PMID: 23954606.
      Citations: 4     Fields:    Translation:Humans
    33. Williamson JR, Bliss DW, Paydarfar D. Forecasting respiratory collapse: theory and practice for averting life-threatening infant apneas. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):223-31. PMID: 23735485.
      Citations: 11     Fields:    Translation:Humans
    34. Indic P, Paydarfar D, Barbieri R. Point process modeling of interbreath interval: a new approach for the assessment of instability of breathing in neonates. IEEE Trans Biomed Eng. 2013 Oct; 60(10):2858-66. PMID: 23739777.
      Citations: 2     Fields:    Translation:HumansAnimals
    35. Clay JR, Forger DB, Paydarfar D. Ionic mechanism underlying optimal stimuli for neuronal excitation: role of Na+ channel inactivation. PLoS One. 2012; 7(9):e45983. PMID: 23049913.
      Citations: 9     Fields:    Translation:AnimalsCells
    36. Gaspari RJ, Paydarfar D. Respiratory recovery following organophosphate poisoning in a rat model is suppressed by isolated hypoxia at the point of apnea. Toxicology. 2012 Dec 16; 302(2-3):242-7. PMID: 22906926.
      Citations: 2     Fields:    Translation:Animals
    37. Paydarfar D. Protecting the airway during swallowing: what is the role for afferent surveillance? Head Neck. 2011 Oct; 33 Suppl 1:S26-9. PMID: 21901781.
      Citations: 2     Fields:    Translation:HumansCells
    38. McFarland DH, Paydarfar D. Proceedings of the Integrative Neural Systems Underlying Vital Aerodigestive Tract Functions Conference, June 17-19, 2010: work group summary and call to action. Head Neck. 2011 Oct; 33 Suppl 1:S54-7. PMID: 21901782.
      Citations: 1     Fields:    Translation:Humans
    39. Forger DB, Paydarfar D, Clay JR. Optimal stimulus shapes for neuronal excitation. PLoS Comput Biol. 2011 Jul; 7(7):e1002089. PMID: 21760759.
      Citations: 8     Fields:    Translation:AnimalsCells
    40. Paydarfar D, Schwartz WJ. A piece of my mind. Dear provider. JAMA. 2011 May 25; 305(20):2046-7. PMID: 21610229.
      Citations: 1     Fields:    Translation:Humans
    41. Indic P, Bloch-Salisbury E, Bednarek F, Brown EN, Paydarfar D, Barbieri R. Assessment of cardio-respiratory interactions in preterm infants by bivariate autoregressive modeling and surrogate data analysis. Early Hum Dev. 2011 Jul; 87(7):477-87. PMID: 21511413.
      Citations: 5     Fields:    Translation:Humans
    42. Gaspari RJ, Paydarfar D. Dichlorvos-induced central apnea: effects of selective brainstem exposure in the rat. Neurotoxicology. 2011 Mar; 32(2):206-14. PMID: 21241738.
      Citations: 8     Fields:    Translation:Animals
    43. Indic P, Paydarfar D, Barbieri R. A point process model of respiratory dynamics in early physiological development. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:3804-7. PMID: 22255168.
      Citations: 1     Fields:    Translation:HumansAnimals
    44. Bloch-Salisbury E, Hall MH, Sharma P, Boyd T, Bednarek F, Paydarfar D. Heritability of apnea of prematurity: a retrospective twin study. Pediatrics. 2010 Oct; 126(4):e779-87. PMID: 20837586.
      Citations: 10     Fields:    Translation:Humans
    45. Marcus CL, Smith RJ, Mankarious LA, Arens R, Mitchell GS, Elluru RG, Forte V, Goudy S, Jabs EW, Kane AA, Katz E, Paydarfar D, Pereira K, Reeves RH, Richtsmeier JT, Ruiz RL, Thach BT, Tunkel DE, Whitsett JA, Wootton D, Blaisdell CJ. Developmental aspects of the upper airway: report from an NHLBI Workshop, March 5-6, 2009. Proc Am Thorac Soc. 2009 Sep 15; 6(6):513-20. PMID: 19741259.
      Citations: 7     Fields:    Translation:HumansAnimals
    46. Bloch-Salisbury E, Indic P, Bednarek F, Paydarfar D. Stabilizing immature breathing patterns of preterm infants using stochastic mechanosensory stimulation. J Appl Physiol (1985). 2009 Oct; 107(4):1017-27. PMID: 19608934.
      Citations: 26     Fields:    Translation:HumansCells
    47. Adams L, Lansing RW, O'Donnell CR, Paydarfar D, Banzett RB. No evidence for reduction in dyspnea following lesions of the right insula. Am J Respir Crit Care Med. 2009 Apr 01; 179(7):623; author reply 623-4. PMID: 19318545.
      Citations:    Fields:    Translation:Humans
    48. Gaspari RJ, Paydarfar D. Respiratory failure induced by acute organophosphate poisoning in rats: effects of vagotomy. Neurotoxicology. 2009 Mar; 30(2):298-304. PMID: 19428503.
      Citations: 5     Fields:    Translation:Animals
    49. Clay JR, Paydarfar D, Forger DB. A simple modification of the Hodgkin and Huxley equations explains type 3 excitability in squid giant axons. J R Soc Interface. 2008 Dec 06; 5(29):1421-8. PMID: 18544505.
      Citations: 19     Fields:    Translation:AnimalsCells
    50. Indic P, Salisbury E, Paydarfar D, Brown E, Barbieri R. Interaction between Heart Rate Variability and Respiration in Preterm Infants. Comput Cardiol. 2008 Sep; 35:57-60. PMID: 20333264.
      Citations:    
    51. Indic P, Schwartz WJ, Paydarfar D. Design principles for phase-splitting behaviour of coupled cellular oscillators: clues from hamsters with 'split' circadian rhythms. J R Soc Interface. 2008 Aug 06; 5(25):873-83. PMID: 18077247.
      Citations: 10     Fields:    Translation:Animals
    52. Gaspari RJ, Paydarfar D. Pathophysiology of respiratory failure following acute dichlorvos poisoning in a rodent model. Neurotoxicology. 2007 May; 28(3):664-71. PMID: 17350689.
      Citations: 9     Fields:    Translation:Animals
    53. Paydarfar D, Forger DB, Clay JR. Noisy inputs and the induction of on-off switching behavior in a neuronal pacemaker. J Neurophysiol. 2006 Dec; 96(6):3338-48. PMID: 16956993.
      Citations: 29     Fields:    Translation:AnimalsCells
    54. Forger DB, Paydarfar D. Starting, stopping, and resetting biological oscillators: in search of optimum perturbations. J Theor Biol. 2004 Oct 21; 230(4):521-32. PMID: 15363673.
      Citations: 19     Fields:    Translation:HumansCells
    55. Jafari S, Prince RA, Kim DY, Paydarfar D. Sensory regulation of swallowing and airway protection: a role for the internal superior laryngeal nerve in humans. J Physiol. 2003 Jul 01; 550(Pt 1):287-304. PMID: 12754311.
      Citations: 46     Fields:    Translation:Humans
    56. Paydarfar D, Buerkel DM. Dysrhythmias of the respiratory oscillator. Chaos. 1995 Mar; 5(1):18-29. PMID: 12780150.
      Citations: 11     Fields:    
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