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David Paydarfar MD

TitleAdjunct Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentNeurology
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-1658
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeurology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Duke University, Durham, NC, United StatesBSPhysics
    University of North Carolina Chapel Hill, Chapel Hill, NC, United StatesMD

    Collapse Overview 
    Collapse overview

    My research is devoted to understanding the neural control of autonomic functions. Specific areas of interest are the genesis of respiratory rhythm, the coordination of breathing and swallowing, and the maintenance of circulation during upright posture. The major goal is to understand how normal control mechanisms break down and lead to certain common disease states: central apnea, neurogenic aspiration, and neurally mediated syncope.

    More Information Coming Soon




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Santoso LF, Kim DY, Paydarfar D. Sensory dysphagia: A case series and proposed classification of an under recognized swallowing disorder. Head Neck. 2019 Jan 08. PMID: 30620442.
      View in: PubMed
    2. Zuzarte I, Indic P, Sternad D, Paydarfar D. Quantifying Movement in Preterm Infants Using Photoplethysmography. Ann Biomed Eng. 2018 Sep 25. PMID: 30255214.
      View in: PubMed
    3. Chang J, Paydarfar D. Optimizing stimulus waveforms for electroceuticals. Biol Cybern. 2018 Aug 11. PMID: 30099589.
      View in: PubMed
    4. Chang J, Paydarfar D. Author Correction: Evolution of extrema features reveals optimal stimuli for biological state transitions. Sci Rep. 2018 Jul 18; 8(1):11177. PMID: 30022084.
      View in: PubMed
    5. Chang J, Paydarfar D. Optimizing stimulus waveforms for suppressing epileptic activity reveals a counterbalancing mechanism. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul; 2018:2226-2229. PMID: 30440848.
      View in: PubMed
    6. Gee AH, Chang J, Ghosh J, Paydarfar D. Bayesian Online Changepoint Detection Of Physiological Transitions. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul; 2018:45-48. PMID: 30440337.
      View in: PubMed
    7. Chang J, Paydarfar D. Evolution of extrema features reveals optimal stimuli for biological state transitions. Sci Rep. 2018 Feb 21; 8(1):3403. PMID: 29467377.
      View in: PubMed
    8. Zuzarte I, Indic P, Barton B, Paydarfar D, Bednarek F, Bloch-Salisbury E. Vibrotactile stimulation: A non-pharmacological intervention for opioid-exposed newborns. PLoS One. 2017; 12(4):e0175981. PMID: 28426726.
      View in: PubMed
    9. Ghasemi M, Riaz N, Bjornsdottir A, Paydarfar D. Isolated pseudoabducens palsy in acute thalamic stroke. Clin Imaging. 2017 Feb 01; 43:28-31. PMID: 28167284.
      View in: PubMed
    10. Gee AH, Barbieri R, Paydarfar D, Indic P. Predicting Bradycardia in Preterm Infants Using Point Process Analysis of Heart Rate. IEEE Trans Biomed Eng. 2016 Nov 24. PMID: 27898379.
      View in: PubMed
    11. Gee AH, Barbieri R, Paydarfar D, Indic P. Improving heart rate estimation in preterm infants with bivariate point process analysis of heart rate and respiration. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug; 2016:920-923. PMID: 28268474.
      View in: PubMed
    12. Smith VC, Kelty-Stephen D, Qureshi Ahmad M, Mao W, Cakert K, Osborne J, Paydarfar D. Stochastic Resonance Effects on Apnea, Bradycardia, and Oxygenation: A Randomized Controlled Trial. Pediatrics. 2015 Dec; 136(6):e1561-8. PMID: 26598451.
      View in: PubMed
    13. Gee AH, Barbieri R, Paydarfar D, Indic P. Uncovering statistical features of bradycardia severity in premature infants using a point process model. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug; 2015:5855-8. PMID: 26737623.
      View in: PubMed
    14. Chang J, Paydarfar D. Optimal stimulus waveforms for eliciting a spike: How close is the spike-triggered average? Int IEEE EMBS Conf Neural Eng. 2015 Apr; 2015:414-417. PMID: 28163829.
      View in: PubMed
    15. Cachia D, Smith T, Paydarfar D, Pomorska G. A case of early-onset rapidly progressive dementia. JAMA Neurol. 2014 Nov; 71(11):1445-9. PMID: 25265527.
      View in: PubMed
    16. Bloch-Salisbury E, Zuzarte I, Indic P, Bednarek F, Paydarfar D. Kangaroo care: cardio-respiratory relationships between the infant and caregiver. Early Hum Dev. 2014 Dec; 90(12):843-50. PMID: 25463830.
      View in: PubMed
    17. Bodová K, Paydarfar D, Forger DB. Characterizing spiking in noisy type II neurons. J Theor Biol. 2015 Jan 21; 365:40-54. PMID: 25311908.
      View in: PubMed
    18. Chang J, Paydarfar D. Switching neuronal state: optimal stimuli revealed using a stochastically-seeded gradient algorithm. J Comput Neurosci. 2014 Dec; 37(3):569-82. PMID: 25145955.
      View in: PubMed
    19. Gaspari RJ, Paydarfar D. Pulmonary effects of intravenous atropine induce ventilation perfusion mismatch. Can J Physiol Pharmacol. 2014 May; 92(5):399-404. PMID: 24773405.
      View in: PubMed
    20. Zuzarte I, Temple C, Indic P, Paydarfar D. Transforming artifact to signal: A wavelet-based algorithm for quantifying neonatal movement. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:5466-9. PMID: 25571231.
      View in: PubMed
    21. Kheradmand A, Fisher M, Paydarfar D. Ischemic stroke in evolution: predictive value of perfusion computed tomography. J Stroke Cerebrovasc Dis. 2014 May-Jun; 23(5):836-43. PMID: 23954606.
      View in: PubMed
    22. Williamson JR, Bliss DW, Paydarfar D. Forecasting respiratory collapse: theory and practice for averting life-threatening infant apneas. Respir Physiol Neurobiol. 2013 Nov 1; 189(2):223-31. PMID: 23735485.
      View in: PubMed
    23. Indic P, Paydarfar D, Barbieri R. Point process modeling of interbreath interval: a new approach for the assessment of instability of breathing in neonates. IEEE Trans Biomed Eng. 2013 Oct; 60(10):2858-66. PMID: 23739777.
      View in: PubMed
    24. Clay JR, Forger DB, Paydarfar D. Ionic mechanism underlying optimal stimuli for neuronal excitation: role of Na+ channel inactivation. PLoS One. 2012; 7(9):e45983. PMID: 23049913.
      View in: PubMed
    25. Gaspari RJ, Paydarfar D. Respiratory recovery following organophosphate poisoning in a rat model is suppressed by isolated hypoxia at the point of apnea. Toxicology. 2012 Dec 16; 302(2-3):242-7. PMID: 22906926.
      View in: PubMed
    26. McFarland DH, Paydarfar D. Proceedings of the Integrative Neural Systems Underlying Vital Aerodigestive Tract Functions Conference, June 17-19, 2010: work group summary and call to action. Head Neck. 2011 Oct; 33 Suppl 1:S54-7. PMID: 21901782.
      View in: PubMed
    27. Paydarfar D. Protecting the airway during swallowing: what is the role for afferent surveillance? Head Neck. 2011 Oct; 33 Suppl 1:S26-9. PMID: 21901781.
      View in: PubMed
    28. Forger DB, Paydarfar D, Clay JR. Optimal stimulus shapes for neuronal excitation. PLoS Comput Biol. 2011 Jul; 7(7):e1002089. PMID: 21760759.
      View in: PubMed
    29. Paydarfar D, Schwartz WJ. A piece of my mind. Dear provider. JAMA. 2011 May 25; 305(20):2046-7. PMID: 21610229.
      View in: PubMed
    30. Indic P, Bloch-Salisbury E, Bednarek F, Brown EN, Paydarfar D, Barbieri R. Assessment of cardio-respiratory interactions in preterm infants by bivariate autoregressive modeling and surrogate data analysis. Early Hum Dev. 2011 Jul; 87(7):477-87. PMID: 21511413.
      View in: PubMed
    31. Gaspari RJ, Paydarfar D. Dichlorvos-induced central apnea: effects of selective brainstem exposure in the rat. Neurotoxicology. 2011 Mar; 32(2):206-14. PMID: 21241738.
      View in: PubMed
    32. Indic P, Paydarfar D, Barbieri R. A point process model of respiratory dynamics in early physiological development. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:3804-7. PMID: 22255168.
      View in: PubMed
    33. Bloch-Salisbury E, Hall MH, Sharma P, Boyd T, Bednarek F, Paydarfar D. Heritability of apnea of prematurity: a retrospective twin study. Pediatrics. 2010 Oct; 126(4):e779-87. PMID: 20837586.
      View in: PubMed
    34. Marcus CL, Smith RJ, Mankarious LA, Arens R, Mitchell GS, Elluru RG, Forte V, Goudy S, Jabs EW, Kane AA, Katz E, Paydarfar D, Pereira K, Reeves RH, Richtsmeier JT, Ruiz RL, Thach BT, Tunkel DE, Whitsett JA, Wootton D, Blaisdell CJ. Developmental aspects of the upper airway: report from an NHLBI Workshop, March 5-6, 2009. Proc Am Thorac Soc. 2009 Sep 15; 6(6):513-20. PMID: 19741259.
      View in: PubMed
    35. Bloch-Salisbury E, Indic P, Bednarek F, Paydarfar D. Stabilizing immature breathing patterns of preterm infants using stochastic mechanosensory stimulation. J Appl Physiol (1985). 2009 Oct; 107(4):1017-27. PMID: 19608934.
      View in: PubMed
    36. Adams L, Lansing RW, O'Donnell CR, Paydarfar D, Banzett RB. No evidence for reduction in dyspnea following lesions of the right insula. Am J Respir Crit Care Med. 2009 Apr 1; 179(7):623; author reply 623-4. PMID: 19318545.
      View in: PubMed
    37. Gaspari RJ, Paydarfar D. Respiratory failure induced by acute organophosphate poisoning in rats: effects of vagotomy. Neurotoxicology. 2009 Mar; 30(2):298-304. PMID: 19428503.
      View in: PubMed
    38. Clay JR, Paydarfar D, Forger DB. A simple modification of the Hodgkin and Huxley equations explains type 3 excitability in squid giant axons. J R Soc Interface. 2008 Dec 6; 5(29):1421-8. PMID: 18544505.
      View in: PubMed
    39. Indic P, Salisbury E, Paydarfar D, Brown E, Barbieri R. Interaction between Heart Rate Variability and Respiration in Preterm Infants. Comput Cardiol. 2008 Sep; 35:57-60. PMID: 20333264.
      View in: PubMed
    40. Indic P, Schwartz WJ, Paydarfar D. Design principles for phase-splitting behaviour of coupled cellular oscillators: clues from hamsters with 'split' circadian rhythms. J R Soc Interface. 2008 Aug 6; 5(25):873-83. PMID: 18077247.
      View in: PubMed
    41. Gaspari RJ, Paydarfar D. Pathophysiology of respiratory failure following acute dichlorvos poisoning in a rodent model. Neurotoxicology. 2007 May; 28(3):664-71. PMID: 17350689.
      View in: PubMed
    42. Paydarfar D, Forger DB, Clay JR. Noisy inputs and the induction of on-off switching behavior in a neuronal pacemaker. J Neurophysiol. 2006 Dec; 96(6):3338-48. PMID: 16956993.
      View in: PubMed
    43. Forger DB, Paydarfar D. Starting, stopping, and resetting biological oscillators: in search of optimum perturbations. J Theor Biol. 2004 Oct 21; 230(4):521-32. PMID: 15363673.
      View in: PubMed
    44. Jafari S, Prince RA, Kim DY, Paydarfar D. Sensory regulation of swallowing and airway protection: a role for the internal superior laryngeal nerve in humans. J Physiol. 2003 Jul 1; 550(Pt 1):287-304. PMID: 12754311.
      View in: PubMed
    45. Binks AP, Paydarfar D, Schachter SC, Guz A, Banzett RB. High strength stimulation of the vagus nerve in awake humans: a lack of cardiorespiratory effects. Respir Physiol. 2001 Sep; 127(2-3):125-33. PMID: 11504585.
      View in: PubMed
    46. Paydarfar D, Schwartz WJ. An algorithm for discovery. Science. 2001 Apr 6; 292(5514):13. PMID: 11283352.
      View in: PubMed
    47. Paydarfar D, Krieger D, Dib N, Blair RH, Pastore JO, Stetz JJ, Symes JF. In vivo magnetic resonance imaging and surgical histopathology of intracardiac masses: distinct features of subacute thrombi. Cardiology. 2001; 95(1):40-7. PMID: 11385191.
      View in: PubMed
    48. Banzett RB, Guz A, Paydarfar D, Shea SA, Schachter SC, Lansing RW. Cardiorespiratory variables and sensation during stimulation of the left vagus in patients with epilepsy. Epilepsy Res. 1999 May; 35(1):1-11. PMID: 10232789.
      View in: PubMed
    49. Paydarfar D, Eldridge FL, Paydarfar JA. Phase resetting of the respiratory oscillator by carotid sinus nerve stimulation in cats. J Physiol. 1998 Jan 15; 506 ( Pt 2):515-28. PMID: 9490875.
      View in: PubMed
    50. Paydarfar D, Buerkel DM. Sporadic apnea: paradoxical transformation to eupnea by perturbations that inhibit inspiration. Med Hypotheses. 1997 Jul; 49(1):19-26. PMID: 9247902.
      View in: PubMed
    51. Paydarfar D, Buerkel DM. Dysrhythmias of the respiratory oscillator. Chaos. 1995 Mar; 5(1):18-29. PMID: 12780150.
      View in: PubMed
    52. Paydarfar D, Gilbert RJ, Poppel CS, Nassab PF. Respiratory phase resetting and airflow changes induced by swallowing in humans. J Physiol. 1995 Feb 15; 483 ( Pt 1):273-88. PMID: 7776238.
      View in: PubMed
    53. Shea SA, Andres LP, Paydarfar D, Banzett RB, Shannon DC. Effect of mental activity on breathing in congenital central hypoventilation syndrome. Respir Physiol. 1993 Dec; 94(3):251-63. PMID: 8108605.
      View in: PubMed
    54. Eldridge FL, Paydarfar D. Desynchronized respiratory rhythms and their interactions in cats with split brain stems. J Physiol. 1989 Mar; 410:513-32. PMID: 2507779.
      View in: PubMed
    55. Eldridge FL, Kiley JP, Paydarfar D. Dynamics of medullary hydrogen ion and respiratory responses to square-wave change of arterial carbon dioxide in cats. J Physiol. 1987 Apr; 385:627-42. PMID: 3116211.
      View in: PubMed
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