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Julie A Jonassen PhD

TitleProfessor Emeritus
InstitutionUniversity of Massachusetts Medical School
DepartmentMicrobiology and Physiological Systems
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-5808
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - School of Medicine
    DepartmentRadiology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience


    Collapse Biography 
    Collapse education and training
    University of Michigan, Ann Arbor, Ann Arbor, MI, United StatesBSZoology
    University of Michigan, Ann Arbor, Ann Arbor, MI, United StatesPHDCell & Molecular Biology

    Collapse Overview 
    Collapse overview

    Academic Background

    B.S. University of Michigan, 1974;
    Ph.D. University of Michigan, 1980.

    Julie

    Regulation of the Growth, Differentiation and Death of Epithelial Cells.

    Research in our laboratory focuses on regulation of the growth, differentiation and death of epithelial cells. The goal of our current studies is to define mechanisms by which a variety of growth factors, free radicals and hormones mediate signal transduction and gene expression in human and animal renal epithelial cells. Particular emphasis is placed on elucidating the roles played by free radicals in mediating both proliferation and death of renal epithelial cells in kidney disease. I am also actively involved in research in medical education, participating in the development, implementation and assessment of new and innovative medical curricula.



    Collapse Rotation Projects

    Potential Rotation Projects

    Project #1: Analysis of gene expression in kidney stone disease. Student will be involved in isolating kidney RNA from patients with kidney stone disease and using DNA microarray to achieve expression profiling in normal and diseased kidney.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Desai PB, San Agustin JT, Stuck MW, Jonassen JA, Bates CM, Pazour GJ. Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Mech Dev. 2018 Apr 04. PMID: 29626631.
      View in: PubMed
    2. San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ. Erratum: Genetic link between renal birth defects and congenital heart disease. Nat Commun. 2016 Jun 08; 7:11910. PMID: 27273704.
      View in: PubMed
    3. San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ. Genetic link between renal birth defects and congenital heart disease. Nat Commun. 2016 Mar 22; 7:11103. PMID: 27002738.
      View in: PubMed
    4. Eguether T, San Agustin JT, Keady BT, Jonassen JA, Liang Y, Francis R, Tobita K, Johnson CA, Abdelhamed ZA, Lo CW, Pazour GJ. IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment. Dev Cell. 2014 Nov 10; 31(3):279-90. PMID: 25446516.
      View in: PubMed
    5. Follit JA, San Agustin JT, Jonassen JA, Huang T, Rivera-Perez JA, Tremblay KD, Pazour GJ. Arf4 is required for Mammalian development but dispensable for ciliary assembly. PLoS Genet. 2014 Feb; 10(2):e1004170. PMID: 24586199.
      View in: PubMed
    6. Keady BT, Samtani R, Tobita K, Tsuchya M, San Agustin JT, Follit JA, Jonassen JA, Subramanian R, Lo CW, Pazour GJ. IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport. Dev Cell. 2012 May 15; 22(5):940-51. PMID: 22595669.
      View in: PubMed
    7. Jonassen JA, SanAgustin J, Baker SP, Pazour GJ. Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation. J Am Soc Nephrol. 2012 Apr; 23(4):641-51. PMID: 22282595.
      View in: PubMed
    8. Follit JA, San Agustin JT, Xu F, Jonassen JA, Samtani R, Lo CW, Pazour GJ. The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex. PLoS Genet. 2008 Dec; 4(12):e1000315. PMID: 19112494.
      View in: PubMed
    9. Jonassen JA, San Agustin J, Follit JA, Pazour GJ. Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol. 2008 Nov 3; 183(3):377-84. PMID: 18981227.
      View in: PubMed
    10. Jonassen JA, Kohjimoto Y, Scheid CR, Schmidt M. Oxalate toxicity in renal cells. Urol Res. 2005 Nov; 33(5):329-39. PMID: 16284883.
      View in: PubMed
    11. Cao LC, Honeyman TW, Cooney R, Kennington L, Scheid CR, Jonassen JA. Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity. Kidney Int. 2004 Nov; 66(5):1890-900. PMID: 15496160.
      View in: PubMed
    12. Jonassen JA, Cao LC, Honeyman T, Scheid CR. Intracellular events in the initiation of calcium oxalate stones. Nephron Exp Nephrol. 2004; 98(2):e61-4. PMID: 15499209.
      View in: PubMed
    13. Scheid CR, Cao LC, Honeyman T, Jonassen JA. How elevated oxalate can promote kidney stone disease: changes at the surface and in the cytosol of renal cells that promote crystal adherence and growth. Front Biosci. 2004 Jan 1; 9:797-808. PMID: 14766409.
      View in: PubMed
    14. Jonassen JA, Mazor KM. Identification of physician and patient attributes that influence the likelihood of screening for intimate partner violence. Acad Med. 2003 Oct; 78(10 Suppl):S20-3. PMID: 14557085.
      View in: PubMed
    15. Jonassen JA, Cao LC, Honeyman T, Scheid CR. Mechanisms mediating oxalate-induced alterations in renal cell functions. Crit Rev Eukaryot Gene Expr. 2003; 13(1):55-72. PMID: 12839097.
      View in: PubMed
    16. Matthews J, Kadish W, Barrett SV, Mazor K, Field D, Jonassen J. The impact of a brief interclerkship about substance abuse on medical students' skills. Acad Med. 2002 May; 77(5):419-26. PMID: 12010703.
      View in: PubMed
    17. Jonassen JA, Mazor K, Sefton L. Identification of factors that influence the likelihood of screening for domestic violence by medical students and residents. Acad Med. 2001 May; 76(5):529. PMID: 11346572.
      View in: PubMed
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