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Julie A Jonassen PhD

TitleProfessor Emeritus
InstitutionUMass Chan Medical School
DepartmentMicrobiology
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-5808
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology

    InstitutionT.H. Chan School of Medicine
    DepartmentRadiology


    Collapse Biography 
    Collapse education and training
    University of Michigan, Ann Arbor, Ann Arbor, MI, United StatesBSZoology
    University of Michigan, Ann Arbor, Ann Arbor, MI, United StatesPHDCell & Molecular Biology

    Collapse Overview 
    Collapse overview

    Academic Background

    B.S. University of Michigan, 1974;
    Ph.D. University of Michigan, 1980.

    Julie

    Regulation of the Growth, Differentiation and Death of Epithelial Cells.

    Research in our laboratory focuses on regulation of the growth, differentiation and death of epithelial cells. The goal of our current studies is to define mechanisms by which a variety of growth factors, free radicals and hormones mediate signal transduction and gene expression in human and animal renal epithelial cells. Particular emphasis is placed on elucidating the roles played by free radicals in mediating both proliferation and death of renal epithelial cells in kidney disease. I am also actively involved in research in medical education, participating in the development, implementation and assessment of new and innovative medical curricula.


    Collapse Rotation Projects

    Potential Rotation Projects

    Project #1: Analysis of gene expression in kidney stone disease. Student will be involved in isolating kidney RNA from patients with kidney stone disease and using DNA microarray to achieve expression profiling in normal and diseased kidney.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Smith AO, Frantz WT, Preval KM, Edwards YJK, Ceol CJ, Jonassen JA, Pazour GJ. The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in cystic epithelial cells revealing a potential new target for polycystic kidney disease. PLoS Genet. 2024 Dec; 20(12):e1011510. PMID: 39666736.
      Citations:    
    2. Francis RJB, San Agustin JT, Szabo Rogers HL, Cui C, Jonassen JA, Eguether T, Follit JA, Lo CW, Pazour GJ. Autonomous and non-cell autonomous role of cilia in structural birth defects in mice. PLoS Biol. 2023 Dec; 21(12):e3002425. PMID: 38079449.
      Citations:    Fields:    Translation:AnimalsCells
    3. Smith AO, Frantz WT, Preval KM, Edwards YJK, Ceol CJ, Jonassen JA, Pazour GJ. The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in pre-cystic epithelial cells revealing a new target for polycystic kidney disease. medRxiv. 2023 Dec 04. PMID: 38106222.
      Citations:    
    4. Bakey Z, Cabrera OA, Hoefele J, Antony D, Wu K, Stuck MW, Micha D, Eguether T, Smith AO, van der Wel NN, Wagner M, Strittmatter L, Beales PL, Jonassen JA, Thiffault I, Cadieux-Dion M, Boyes L, Sharif S, T?ys?z B, Dunstheimer D, Niessen HWM, Devine W, Lo CW, Mitchison HM, Schmidts M, Pazour GJ. IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans. PLoS Genet. 2023 06; 19(6):e1010796. PMID: 37315079.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    5. Francis R, San Agustin JT, Szabo Rogers HL, Cui C, Jonassen JA, Eguether T, Follit JA, Lo CW, Pazour GJ. Autonomous and non-cell autonomous etiology of ciliopathy associated structural birth defects. bioRxiv. 2023 Jun 07. PMID: 37333142.
      Citations:    
    6. Bakey Z, Cabrera OA, Hoefele J, Antony D, Wu K, Stuck MW, Micha D, Eguether T, Smith AO, van der Wel NN, Wagner M, Strittmatter L, Beales PL, Jonassen JA, Thiffault I, Cadieux-Dion M, Boyes L, Sharif S, T?ys?z B, Dunstheimer D, Niessen HWM, Devine W, Lo CW, Mitchison HM, Schmidts M, Pazour GJ. IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans. medRxiv. 2023 Feb 26. PMID: 36865301.
      Citations:    
    7. Smith AO, Jonassen JA, Preval KM, Davis RJ, Pazour GJ. c-JUN n-Terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease. J Cell Signal. 2022; 3(1):62-78. PMID: 35253003.
      Citations:    
    8. Smith AO, Jonassen JA, Preval KM, Davis RJ, Pazour GJ. c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease. PLoS Genet. 2021 12; 17(12):e1009711. PMID: 34962918.
      Citations: 4     Fields:    Translation:HumansCells
    9. Desai PB, San Agustin JT, Stuck MW, Jonassen JA, Bates CM, Pazour GJ. Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Mech Dev. 2018 06; 151:10-17. PMID: 29626631.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    10. San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ. Erratum: Genetic link between renal birth defects and congenital heart disease. Nat Commun. 2016 06 08; 7:11910. PMID: 27273704.
      Citations: 1     Fields:    
    11. San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine W, Strittmatter L, Jonassen JA, Liu X, Lo CW, Pazour GJ. Genetic link between renal birth defects and congenital heart disease. Nat Commun. 2016 Mar 22; 7:11103. PMID: 27002738.
      Citations: 29     Fields:    Translation:HumansAnimals
    12. Eguether T, San Agustin JT, Keady BT, Jonassen JA, Liang Y, Francis R, Tobita K, Johnson CA, Abdelhamed ZA, Lo CW, Pazour GJ. IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment. Dev Cell. 2014 Nov 10; 31(3):279-290. PMID: 25446516.
      Citations: 140     Fields:    Translation:AnimalsCells
    13. Follit JA, San Agustin JT, Jonassen JA, Huang T, Rivera-Perez JA, Tremblay KD, Pazour GJ. Arf4 is required for Mammalian development but dispensable for ciliary assembly. PLoS Genet. 2014 Feb; 10(2):e1004170. PMID: 24586199.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    14. Keady BT, Samtani R, Tobita K, Tsuchya M, San Agustin JT, Follit JA, Jonassen JA, Subramanian R, Lo CW, Pazour GJ. IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport. Dev Cell. 2012 May 15; 22(5):940-51. PMID: 22595669.
      Citations: 134     Fields:    Translation:AnimalsCells
    15. Jonassen JA, SanAgustin J, Baker SP, Pazour GJ. Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation. J Am Soc Nephrol. 2012 Apr; 23(4):641-51. PMID: 22282595.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    16. Follit JA, San Agustin JT, Xu F, Jonassen JA, Samtani R, Lo CW, Pazour GJ. The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex. PLoS Genet. 2008 Dec; 4(12):e1000315. PMID: 19112494.
      Citations: 105     Fields:    Translation:AnimalsCells
    17. Jonassen JA, San Agustin J, Follit JA, Pazour GJ. Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol. 2008 Nov 03; 183(3):377-84. PMID: 18981227.
      Citations: 159     Fields:    Translation:AnimalsCells
    18. Jonassen JA, Kohjimoto Y, Scheid CR, Schmidt M. Oxalate toxicity in renal cells. Urol Res. 2005 Nov; 33(5):329-39. PMID: 16284883.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    19. Cao LC, Honeyman TW, Cooney R, Kennington L, Scheid CR, Jonassen JA. Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity. Kidney Int. 2004 Nov; 66(5):1890-900. PMID: 15496160.
      Citations: 49     Fields:    Translation:AnimalsCells
    20. Jonassen JA, Cao LC, Honeyman T, Scheid CR. Intracellular events in the initiation of calcium oxalate stones. Nephron Exp Nephrol. 2004; 98(2):e61-4. PMID: 15499209.
      Citations: 10     Fields:    Translation:HumansCells
    21. Scheid CR, Cao LC, Honeyman T, Jonassen JA. How elevated oxalate can promote kidney stone disease: changes at the surface and in the cytosol of renal cells that promote crystal adherence and growth. Front Biosci. 2004 Jan 01; 9:797-808. PMID: 14766409.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    22. Jonassen JA, Mazor KM. Identification of physician and patient attributes that influence the likelihood of screening for intimate partner violence. Acad Med. 2003 Oct; 78(10 Suppl):S20-3. PMID: 14557085.
      Citations: 5     Fields:    Translation:HumansPHPublic Health
    23. Jonassen JA, Cao LC, Honeyman T, Scheid CR. Mechanisms mediating oxalate-induced alterations in renal cell functions. Crit Rev Eukaryot Gene Expr. 2003; 13(1):55-72. PMID: 12839097.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    24. Matthews J, Kadish W, Barrett SV, Mazor K, Field D, Jonassen J. The impact of a brief interclerkship about substance abuse on medical students' skills. Acad Med. 2002 May; 77(5):419-26. PMID: 12010703.
      Citations: 10     Fields:    Translation:Humans
    25. Jonassen JA, Mazor K, Sefton L. Identification of factors that influence the likelihood of screening for domestic violence by medical students and residents. Acad Med. 2001 May; 76(5):529. PMID: 11346572.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
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