 Elizabeth J Luna PhD
| Title | Professor Emeritus |
|---|
| Institution | University of Massachusetts Medical School |
|---|
| Department | Radiology |
|---|
| Address | University of Massachusetts Medical School
377 Plantation Street
Worcester MA 01605
|
|---|
| Phone | 508-856-8661 |
|---|
| vCard | Download vCard |
|---|
|
|
|
|
| Institution | UMMS - School of Medicine |
|---|
| Department | Radiology |
|---|
|
|
|---|
|
| Institution | UMMS - Graduate School of Biomedical Sciences |
|---|
| Department | Cell Biology |
|---|
|
|
|---|
|
| Institution | UMMS - Graduate School of Biomedical Sciences |
|---|
| Department | Immunology and Virology |
|---|
|
|
|---|
|
| Institution | UMMS - Graduate School of Biomedical Sciences |
|---|
| Department | Interdisciplinary Graduate Program |
|---|
|
|
|---|
|
| Institution | UMMS - Programs, Centers and Institutes |
|---|
| Department | Cancer Center |
|---|
|
|
|---|
|
 Biography | Southern Illinois University Carbondale, Carbondale, IL, United States | BA | | Chemistry | | Stanford University, Palo Alto, CA, United States | PH D | | Physical Chemistry |
Overview
Academic Background
B.A., Chemistry, Southern Illinois University at Carbondale. 1972
Ph.D., Physical Chemistry, Stanford University, 1977.
NIH postdoctoral fellow, Cell and Molecular Biology, The Biological Laboratories,Harvard University, 1977-81
Princeton University, Biology Department, 1981-88
The Worcester Foundation for Experimental Biology, 1988-97
University of Massachusetts Medical School,1989-present
Mechanochemical Signal Transduction, Muscular Dystrophy
Cells modulate their internal stiffness (cortical tension) in response to external forces, such as the stiffness or chemical composition of their extracellular environment. Poorly understood signaling pathways downstream of mechanical stimulation regulate cell growth, survival and differentiation. Increased stiffness of the extracellular matrix (ECM) can promote tumor growth or lead to increased size (hypertrophy) of muscles. Cross-talk between these growth and survival pathways is limits some cancer treatments, resulting in choices between cancer reoccurrence and heart failure.
Our laboratory is interested in how the signaling and cytoskeletal proteins at the plasma membrane transduce signals arising from extracellular force into cellular responses. We have linked membrane proteins known for their roles in muscular dystrophies to signaling pathways understood best for their roles during tumor cell growth and migration. We are finding both similarities and differences between these pathways in tumor and other nonmuscle cells versus skeletal muscle and heart cells. We aim to both increase our basic understanding of stiffness-sensing biochemical sensing and to identify cell type-specific interactions that can be targeted for chemotherapeutics and muscular dystrophies.
Lab Members
Kay Son, Ph.D.
Tara Smith, M.S.
Potential Rotation Projects
Elizabeth Luna is not accepting new graduate students, but welcomes students interested in learning specific techniques for functional screen for cell motility, adhesion, contractility, or the formation and function of matrix-invading structures (podosomes, invadopodia, invadosomes). Other techniques under development include mechanochemical and signaling dysfunctions in isolated cells and tissues.
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
Faculty can login to make corrections and additions.
-
Luna EJ. Unconventional myosins muscle into myofibrils. J Biol Chem. 2019 May 03; 294(18):7219-7220. PMID: 31053679.
-
Smith TC, Saul RG, Barton ER, Luna EJ. Generation and characterization of monoclonal antibodies that recognize human and murine supervillin protein isoforms. PLoS One. 2018; 13(10):e0205910. PMID: 30332471.
-
Pollock LM, Gupta N, Chen X, Luna EJ, McDermott BM. Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells. PLoS One. 2016; 11(7):e0158349. PMID: 27415442.
-
Son K, Smith TC, Luna EJ. Supervillin binds the Rac/Rho-GEF Trio and increases Trio-mediated Rac1 activation. Cytoskeleton (Hoboken). 2015 Jan; 72(1):47-64. PMID: 25655724.
-
Spinazzola JM, Smith TC, Liu M, Luna EJ, Barton ER. Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle. Hum Mol Genet. 2015 May 1; 24(9):2470-81. PMID: 25605665.
-
Lawlor MW, Viola MG, Meng H, Edelstein RV, Liu F, Yan K, Luna EJ, Lerch-Gaggl A, Hoffmann RG, Pierson CR, Buj-Bello A, Lachey JL, Pearsall S, Yang L, Hillard CJ, Beggs AH. Differential muscle hypertrophy is associated with satellite cell numbers and Akt pathway activation following activin type IIB receptor inhibition in Mtm1 p.R69C mice. Am J Pathol. 2014 Jun; 184(6):1831-42. PMID: 24726641.
-
Smith TC, Fridy PC, Li Y, Basil S, Arjun S, Friesen RM, Leszyk J, Chait BT, Rout MP, Luna EJ. Supervillin binding to myosin II and synergism with anillin are required for cytokinesis. Mol Biol Cell. 2013 Dec; 24(23):3603-19. PMID: 24088567.
-
Fang Z, Luna EJ. Supervillin-mediated suppression of p53 protein enhances cell survival. J Biol Chem. 2013 Mar 15; 288(11):7918-29. PMID: 23382381.
-
Fedechkin SO, Brockerman J, Luna EJ, Lobanov MY, Galzitskaya OV, Smirnov SL. An N-terminal, 830 residues intrinsically disordered region of the cytoskeleton-regulatory protein supervillin contains Myosin II- and F-actin-binding sites. J Biomol Struct Dyn. 2013 Oct; 31(10):1150-9. PMID: 23075227.
-
Edelstein LC, Luna EJ, Gibson IB, Bray M, Jin Y, Kondkar A, Nagalla S, Hadjout-Rabi N, Smith TC, Covarrubias D, Jones SN, Ahmad F, Stolla M, Kong X, Fang Z, Bergmeier W, Shaw C, Leal SM, Bray PF. Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress. Circulation. 2012 Jun 5; 125(22):2762-71. PMID: 22550155.
-
Bhuwania R, Cornfine S, Fang Z, Krüger M, Luna EJ, Linder S. Supervillin couples myosin-dependent contractility to podosomes and enables their turnover. J Cell Sci. 2012 May 1; 125(Pt 9):2300-14. PMID: 22344260.
-
Smith TC, Fang Z, Luna EJ. Novel interactors and a role for supervillin in early cytokinesis. Cytoskeleton (Hoboken). 2010 Jun; 67(6):346-64. PMID: 20309963.
-
Fang Z, Takizawa N, Wilson KA, Smith TC, Delprato A, Davidson MW, Lambright DG, Luna EJ. The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility. Traffic. 2010 Jun; 11(6):782-99. PMID: 20331534.
-
Crowley JL, Smith TC, Fang Z, Takizawa N, Luna EJ. Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency. Mol Biol Cell. 2009 Feb; 20(3):948-62. PMID: 19109420.
-
Takizawa N, Ikebe R, Ikebe M, Luna EJ. Supervillin slows cell spreading by facilitating myosin II activation at the cell periphery. J Cell Sci. 2007 Nov 1; 120(Pt 21):3792-803. PMID: 17925381.
-
Takizawa N, Smith TC, Nebl T, Crowley JL, Palmieri SJ, Lifshitz LM, Ehrhardt AG, Hoffman LM, Beckerle MC, Luna EJ. Supervillin modulation of focal adhesions involving TRIP6/ZRP-1. J Cell Biol. 2006 Jul 31; 174(3):447-58. PMID: 16880273.
-
Peterman TK, Ohol YM, McReynolds LJ, Luna EJ. Patellin1, a novel Sec14-like protein, localizes to the cell plate and binds phosphoinositides. Plant Physiol. 2004 Oct; 136(2):3080-94; discussion 3001-2. PMID: 15466235.
-
Gangopadhyay SS, Takizawa N, Gallant C, Barber AL, Je HD, Smith TC, Luna EJ, Morgan KG. Smooth muscle archvillin: a novel regulator of signaling and contractility in vascular smooth muscle. J Cell Sci. 2004 Oct 1; 117(Pt 21):5043-57. PMID: 15383618.
-
Chen Y, Takizawa N, Crowley JL, Oh SW, Gatto CL, Kambara T, Sato O, Li XD, Ikebe M, Luna EJ. F-actin and myosin II binding domains in supervillin. J Biol Chem. 2003 Nov 14; 278(46):46094-106. PMID: 12917436.
-
Oh SW, Pope RK, Smith KP, Crowley JL, Nebl T, Lawrence JB, Luna EJ. Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton. J Cell Sci. 2003 Jun 1; 116(Pt 11):2261-75. PMID: 12711699.
-
Nebl T, Pestonjamasp KN, Leszyk JD, Crowley JL, Oh SW, Luna EJ. Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. J Biol Chem. 2002 Nov 8; 277(45):43399-409. PMID: 12202484.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
To see the data from this visualization as text, click here.
| Year | Publications |
|---|
| 2002 | 1 | | 2003 | 2 | | 2004 | 2 | | 2006 | 1 | | 2007 | 1 | | 2008 | 1 | | 2010 | 2 | | 2012 | 3 | | 2013 | 2 | | 2014 | 1 | | 2015 | 2 | | 2016 | 1 | | 2018 | 1 | | 2019 | 1 |
To return to the timeline, click here.
For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
|
Luna's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts  Derived automatically from this person's publications. _
Co-Authors People in Profiles who have published with this person. _
Similar People People who share similar concepts with this person. _
Same Department
People who are also in this person's primary department.
Physical Neighbors People whose addresses are nearby this person. _
|