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Steven Reppert MD

TitleDistinguished Professor Emeritus
InstitutionUMass Chan Medical School
DepartmentNeurobiology
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-6148
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentNeurobiology


    Collapse Biography 
    Collapse education and training
    University of Nebraska, Omaha, Omaha, NE, United StatesBSMedical Sciences
    Harvard University, Cambridge, MA, United StatesMAHonorary
    University of Nebraska, Omaha, Omaha, NE, United StatesMD

    Collapse Overview 
    Collapse overview

    • B.S., University of Nebraska    1973

    • M.D. with Distinction, University of Nebraska    1973

    • M.S., Harvard University (Honorary)    1993

    • Pediatric Residency, Mass General Hosp /Harvard Medical School    1973-1976

    • Post-Doctoral Fellow, NIH    1976-1979

    • Charles King Trust Research Fellow    1979-1981

    • Instructor to Associate Professor, Harvard Medical School    1979-1993

    • Basil O'Connor Early Scholar Award    1981-1984

    • Director, Laboratory of Developmental Chronobiology, Mass General Hosp   1983-2001

    • Established Investigatorship of American Heart Association    1986-1991

    • Member, American Association for Clinical Investigation    1987-

    • E. Mead Johnson Award for Outstanding Research    1991

    • NIH-NICHD MERIT Award    1992-2002

    • Professor, Harvard Medical School    1993-2001

    • Chair, Gordon Conference on Pineal Cell Biology    1998

    • Higgins Family Professor of Neuroscience, UMass Med    2001-

    • Professor & Chair, Dept Neurobiology, UMass Med    2001-

    • President, Society for Research on Biological Rhythms    2002-2004

    • Fellow, American Association for the Advancement of Science    2011-

    • G.J. Mendel Medal from the Czech Academy of Sciences    2012

    • Chancellor's Medal for Distinguished Scholarship, UMass Med    2016


    Molecular Neuroethology


    In an integrated set of studies, our laboratory is using anatomical, cellular, molecular, electrophysiological, genetic and behavioral approaches to more fully understand the biological basis of monarch butterfly (Danaus plexippus) migration, with a focus on the butterfly's navigational abilities and its ancestral circadian clock. For details see the Reppert Lab link



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sehadova H, Guerra PA, Sauman I, Reppert SM. A re-evaluation of silk measurement by the cecropia caterpillar (Hyalophora cecropia) during cocoon construction reveals use of a silk odometer that is temporally regulated. PLoS One. 2020; 15(2):e0228453. PMID: 32074121.
      Citations: 3     Fields:    Translation:Animals
    2. Reppert SM, de Roode JC. Demystifying Monarch Butterfly Migration. Curr Biol. 2018 09 10; 28(17):R1009-R1022. PMID: 30205052.
      Citations: 20     Fields:    Translation:Animals
    3. Guerra PA, Reppert SM. Dimorphic cocoons of the cecropia moth (Hyalophora cecropia): Morphological, behavioral, and biophysical differences. PLoS One. 2017; 12(3):e0174023. PMID: 28329006.
      Citations: 4     Fields:    Translation:Animals
    4. Shlizerman E, Phillips-Portillo J, Forger DB, Reppert SM. Neural Integration Underlying a Time-Compensated Sun Compass in the Migratory Monarch Butterfly. Cell Rep. 2016 Apr 26; 15(4):683-691. PMID: 27149852.
      Citations: 5     Fields:    
    5. Markert MJ, Zhang Y, Enuameh MS, Reppert SM, Wolfe SA, Merlin C. Genomic Access to Monarch Migration Using TALEN and CRISPR/Cas9-Mediated Targeted Mutagenesis. G3 (Bethesda). 2016 04 07; 6(4):905-15. PMID: 26837953.
      Citations: 31     Fields:    Translation:AnimalsCells
    6. Reppert SM, Guerra PA, Merlin C. Neurobiology of Monarch Butterfly Migration. Annu Rev Entomol. 2016; 61:25-42. PMID: 26473314.
      Citations: 27     Fields:    Translation:Animals
    7. Guerra PA, Reppert SM. Sensory basis of lepidopteran migration: focus on the monarch butterfly. Curr Opin Neurobiol. 2015 Oct; 34:20-8. PMID: 25625216.
      Citations: 5     Fields:    Translation:HumansAnimals
    8. Zhan S, Zhang W, Niitepõld K, Hsu J, Haeger JF, Zalucki MP, Altizer S, de Roode JC, Reppert SM, Kronforst MR. The genetics of monarch butterfly migration and warning colouration. Nature. 2014 Oct 16; 514(7522):317-21. PMID: 25274300.
      Citations: 71     Fields:    Translation:Animals
    9. Guerra PA, Gegear RJ, Reppert SM. A magnetic compass aids monarch butterfly migration. Nat Commun. 2014 Jun 24; 5:4164. PMID: 24960099.
      Citations: 36     Fields:    Translation:Animals
    10. Oberhauser KS, Taylor OR, Reppert SM, Dingle H, Nail KR, Pyle RM, Stenoien C. Are monarch butterflies true navigators? The jury is still out. Proc Natl Acad Sci U S A. 2013 Sep 24; 110(39):E3680. PMID: 23983267.
      Citations: 2     Fields:    Translation:Animals
    11. Guerra PA, Reppert SM. Coldness triggers northward flight in remigrant monarch butterflies. Curr Biol. 2013 Mar 04; 23(5):419-23. PMID: 23434279.
      Citations: 17     Fields:    Translation:Animals
    12. Heinze S, Florman J, Asokaraj S, El Jundi B, Reppert SM. Anatomical basis of sun compass navigation II: the neuronal composition of the central complex of the monarch butterfly. J Comp Neurol. 2013 Feb 01; 521(2):267-98. PMID: 22886450.
      Citations: 44     Fields:    Translation:AnimalsCells
    13. Zhan S, Reppert SM. MonarchBase: the monarch butterfly genome database. Nucleic Acids Res. 2013 Jan; 41(Database issue):D758-63. PMID: 23143105.
      Citations: 45     Fields:    Translation:Animals
    14. Merlin C, Beaver LE, Taylor OR, Wolfe SA, Reppert SM. Efficient targeted mutagenesis in the monarch butterfly using zinc-finger nucleases. Genome Res. 2013 Jan; 23(1):159-68. PMID: 23009861.
      Citations: 30     Fields:    Translation:AnimalsCells
    15. Guerra PA, Merlin C, Gegear RJ, Reppert SM. Discordant timing between antennae disrupts sun compass orientation in migratory monarch butterflies. Nat Commun. 2012 Jul 17; 3:958. PMID: 22805565.
      Citations: 18     Fields:    Translation:Animals
    16. Heinze S, Reppert SM. Anatomical basis of sun compass navigation I: the general layout of the monarch butterfly brain. J Comp Neurol. 2012 Jun 01; 520(8):1599-628. PMID: 22473804.
      Citations: 39     Fields:    Translation:AnimalsCells
    17. Merlin C, Heinze S, Reppert SM. Unraveling navigational strategies in migratory insects. Curr Opin Neurobiol. 2012 Apr; 22(2):353-61. PMID: 22154565.
      Citations: 18     Fields:    Translation:Animals
    18. Zhan S, Merlin C, Boore JL, Reppert SM. The monarch butterfly genome yields insights into long-distance migration. Cell. 2011 Nov 23; 147(5):1171-85. PMID: 22118469.
      Citations: 195     Fields:    Translation:AnimalsCells
    19. Foley LE, Gegear RJ, Reppert SM. Human cryptochrome exhibits light-dependent magnetosensitivity. Nat Commun. 2011 Jun 21; 2:356. PMID: 21694704.
      Citations: 56     Fields:    Translation:HumansAnimals
    20. Heinze S, Reppert SM. Sun compass integration of skylight cues in migratory monarch butterflies. Neuron. 2011 Jan 27; 69(2):345-58. PMID: 21262471.
      Citations: 77     Fields:    Translation:AnimalsCells
    21. Reppert SM, Gegear RJ, Merlin C. Navigational mechanisms of migrating monarch butterflies. Trends Neurosci. 2010 Sep; 33(9):399-406. PMID: 20627420.
      Citations: 50     Fields:    Translation:Animals
    22. Gegear RJ, Foley LE, Casselman A, Reppert SM. Animal cryptochromes mediate magnetoreception by an unconventional photochemical mechanism. Nature. 2010 Feb 11; 463(7282):804-7. PMID: 20098414.
      Citations: 89     Fields:    Translation:AnimalsCells
    23. Merlin C, Gegear RJ, Reppert SM. Antennal circadian clocks coordinate sun compass orientation in migratory monarch butterflies. Science. 2009 Sep 25; 325(5948):1700-4. PMID: 19779201.
      Citations: 54     Fields:    Translation:AnimalsCells
    24. Bradley TJ, Briscoe AD, Brady SG, Contreras HL, Danforth BN, Dudley R, Grimaldi D, Harrison JF, Kaiser JA, Merlin C, Reppert SM, Vandenbrooks JM, Yanoviak SP. Episodes in insect evolution. Integr Comp Biol. 2009 Nov; 49(5):590-606. PMID: 21665843.
      Citations: 14     Fields:    
    25. Etchegaray JP, Machida KK, Noton E, Constance CM, Dallmann R, Di Napoli MN, DeBruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009 Jul; 29(14):3853-66. PMID: 19414593.
      Citations: 103     Fields:    Translation:AnimalsCells
    26. Zhu H, Gegear RJ, Casselman A, Kanginakudru S, Reppert SM. Defining behavioral and molecular differences between summer and migratory monarch butterflies. BMC Biol. 2009 Mar 31; 7:14. PMID: 19335876.
      Citations: 34     Fields:    Translation:Animals
    27. Gegear RJ, Casselman A, Waddell S, Reppert SM. Cryptochrome mediates light-dependent magnetosensitivity in Drosophila. Nature. 2008 Aug 21; 454(7207):1014-8. PMID: 18641630.
      Citations: 135     Fields:    Translation:Animals
    28. Zhu H, Casselman A, Reppert SM. Chasing migration genes: a brain expressed sequence tag resource for summer and migratory monarch butterflies (Danaus plexippus). PLoS One. 2008 Jan 09; 3(1):e1345. PMID: 18183285.
      Citations: 15     Fields:    Translation:AnimalsCells
    29. Zhu H, Sauman I, Yuan Q, Casselman A, Emery-Le M, Emery P, Reppert SM. Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation. PLoS Biol. 2008 Jan; 6(1):e4. PMID: 18184036.
      Citations: 86     Fields:    Translation:AnimalsCells
    30. DeBruyne JP, Weaver DR, Reppert SM. Peripheral circadian oscillators require CLOCK. Curr Biol. 2007 Jul 17; 17(14):R538-9. PMID: 17637349.
      Citations: 71     Fields:    Translation:Animals
    31. Song SH, Oztürk N, Denaro TR, Arat NO, Kao YT, Zhu H, Zhong D, Reppert SM, Sancar A. Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly. J Biol Chem. 2007 Jun 15; 282(24):17608-12. PMID: 17459876.
      Citations: 38     Fields:    Translation:AnimalsCells
    32. DeBruyne JP, Weaver DR, Reppert SM. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci. 2007 May; 10(5):543-5. PMID: 17417633.
      Citations: 183     Fields:    Translation:Animals
    33. Yuan Q, Metterville D, Briscoe AD, Reppert SM. Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocks. Mol Biol Evol. 2007 Apr; 24(4):948-55. PMID: 17244599.
      Citations: 128     Fields:    Translation:AnimalsCells
    34. Etchegaray JP, Yang X, DeBruyne JP, Peters AHFM, Weaver DR, Jenuwein T, Reppert SM. The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28; 281(30):21209-21215. PMID: 16717091.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    35. Debruyne JP, Noton E, Lambert CM, Maywood ES, Weaver DR, Reppert SM. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron. 2006 May 04; 50(3):465-77. PMID: 16675400.
      Citations: 173     Fields:    Translation:AnimalsCells
    36. Reppert SM. A colorful model of the circadian clock. Cell. 2006 Jan 27; 124(2):233-6. PMID: 16439193.
      Citations: 23     Fields:    Translation:Animals
    37. Zhu H, Yuan Q, Briscoe AD, Froy O, Casselman A, Reppert SM. The two CRYs of the butterfly. Curr Biol. 2005 Dec 06; 15(23):R953-4. PMID: 16332522.
      Citations: 78     Fields:    Translation:AnimalsCells
    38. Sauman I, Briscoe AD, Zhu H, Shi D, Froy O, Stalleicken J, Yuan Q, Casselman A, Reppert SM. Connecting the navigational clock to sun compass input in monarch butterfly brain. Neuron. 2005 May 05; 46(3):457-67. PMID: 15882645.
      Citations: 48     Fields:    Translation:AnimalsCells
    39. Emery P, Reppert SM. A rhythmic Ror. Neuron. 2004 Aug 19; 43(4):443-6. PMID: 15312644.
      Citations: 46     Fields:    Translation:HumansAnimals
    40. Reppert SM, Zhu H, White RH. Polarized light helps monarch butterflies navigate. Curr Biol. 2004 Jan 20; 14(2):155-8. PMID: 14738739.
      Citations: 41     Fields:    Translation:AnimalsCells
    41. Lee C, Weaver DR, Reppert SM. Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004 Jan; 24(2):584-94. PMID: 14701732.
      Citations: 61     Fields:    Translation:AnimalsCells
    42. Chang DC, McWatters HG, Williams JA, Gotter AL, Levine JD, Reppert SM. Constructing a feedback loop with circadian clock molecules from the silkmoth, Antheraea pernyi. J Biol Chem. 2003 Oct 03; 278(40):38149-58. PMID: 12869551.
      Citations: 21     Fields:    Translation:AnimalsCells
    43. Froy O, Gotter AL, Casselman AL, Reppert SM. Illuminating the circadian clock in monarch butterfly migration. Science. 2003 May 23; 300(5623):1303-5. PMID: 12764200.
      Citations: 46     Fields:    Translation:Animals
    44. Chang DC, Reppert SM. A novel C-terminal domain of drosophila PERIOD inhibits dCLOCK:CYCLE-mediated transcription. Curr Biol. 2003 Apr 29; 13(9):758-62. PMID: 12725734.
      Citations: 45     Fields:    Translation:AnimalsCells
    45. Jin X, von Gall C, Pieschl RL, Gribkoff VK, Stehle JH, Reppert SM, Weaver DR. Targeted disruption of the mouse Mel(1b) melatonin receptor. Mol Cell Biol. 2003 Feb; 23(3):1054-60. PMID: 12529409.
      Citations: 65     Fields:    Translation:AnimalsCells
    46. Etchegaray JP, Lee C, Wade PA, Reppert SM. Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature. 2003 Jan 09; 421(6919):177-82. PMID: 12483227.
      Citations: 259     Fields:    Translation:AnimalsCells
    47. Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002 Aug 29; 418(6901):935-41. PMID: 12198538.
      Citations: 1370     Fields:    Translation:AnimalsCells
    48. Travnickova-Bendova Z, Cermakian N, Reppert SM, Sassone-Corsi P. Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7728-33. PMID: 12032351.
      Citations: 202     Fields:    Translation:HumansAnimalsCells
    49. Froy O, Chang DC, Reppert SM. Redox potential: differential roles in dCRY and mCRY1 functions. Curr Biol. 2002 Jan 22; 12(2):147-52. PMID: 11818067.
      Citations: 33     Fields:    Translation:AnimalsCells
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