Steven Reppert MD
Title | Distinguished Professor Emeritus |
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Institution | University of Massachusetts Medical School |
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Department | Neurobiology |
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Address | University of Massachusetts Medical School 364 Plantation Street, LRB Worcester MA 01605
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Phone | 508-856-6148 |
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vCard | Download vCard |
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Institution | UMMS - School of Medicine |
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Department | Neurobiology |
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Institution | UMMS - Graduate School of Biomedical Sciences |
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Department | Interdisciplinary Graduate Program |
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Institution | UMMS - Graduate School of Biomedical Sciences |
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Department | MD/PhD Program |
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Institution | UMMS - Graduate School of Biomedical Sciences |
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Department | Neuroscience |
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Biography University of Nebraska, Omaha, Omaha, NE, United States | BS | | Medical Sciences | Harvard University, Cambridge, MA, United States | MA | | Honorary | University of Nebraska, Omaha, Omaha, NE, United States | MD | | |
Overview
- B.S., University of Nebraska 1973
- M.D. with Distinction, University of Nebraska 1973
- M.S., Harvard University (Honorary) 1993
- Pediatric Residency, Mass General Hosp /Harvard Medical School 1973-1976
- Post-Doctoral Fellow, NIH 1976-1979
- Charles King Trust Research Fellow 1979-1981
- Instructor to Associate Professor, Harvard Medical School 1979-1993
- Basil O'Connor Early Scholar Award 1981-1984
- Director, Laboratory of Developmental Chronobiology, Mass General Hosp 1983-2001
- Established Investigatorship of American Heart Association 1986-1991
- Member, American Association for Clinical Investigation 1987-
- E. Mead Johnson Award for Outstanding Research 1991
- NIH-NICHD MERIT Award 1992-2002
- Professor, Harvard Medical School 1993-2001
- Chair, Gordon Conference on Pineal Cell Biology 1998
- Higgins Family Professor of Neuroscience, UMass Med 2001-
- Professor & Chair, Dept Neurobiology, UMass Med 2001-
- President, Society for Research on Biological Rhythms 2002-2004
- Fellow, American Association for the Advancement of Science 2011-
- G.J. Mendel Medal from the Czech Academy of Sciences 2012
- Chancellor's Medal for Distinguished Scholarship, UMass Med 2016
Molecular NeuroethologyIn an integrated set of studies, our laboratory is using anatomical, cellular, molecular, electrophysiological, genetic and behavioral approaches to more fully understand the biological basis of monarch butterfly (Danaus plexippus) migration, with a focus on the butterfly's navigational abilities and its ancestral circadian clock. For details see the Reppert Lab link Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
Faculty can login to make corrections and additions.
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Sehadova H, Guerra PA, Sauman I, Reppert SM. A re-evaluation of silk measurement by the cecropia caterpillar (Hyalophora cecropia) during cocoon construction reveals use of a silk odometer that is temporally regulated. PLoS One. 2020; 15(2):e0228453. PMID: 32074121.
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Reppert SM, de Roode JC. Demystifying Monarch Butterfly Migration. Curr Biol. 2018 Sep 10; 28(17):R1009-R1022. PMID: 30205052.
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Guerra PA, Reppert SM. Dimorphic cocoons of the cecropia moth (Hyalophora cecropia): Morphological, behavioral, and biophysical differences. PLoS One. 2017; 12(3):e0174023. PMID: 28329006.
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Shlizerman E, Phillips-Portillo J, Forger DB, Reppert SM. Neural Integration Underlying a Time-Compensated Sun Compass in the Migratory Monarch Butterfly. Cell Rep. 2016 Apr 13. PMID: 27149852.
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Markert MJ, Zhang Y, Enuameh MS, Reppert SM, Wolfe SA, Merlin C. Genomic Access to Monarch Migration Using TALEN and CRISPR/Cas9-Mediated Targeted Mutagenesis. G3 (Bethesda). 2016 Apr 07; 6(4):905-15. PMID: 26837953.
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Reppert SM, Guerra PA, Merlin C. Neurobiology of Monarch Butterfly Migration. Annu Rev Entomol. 2016; 61:25-42. PMID: 26473314.
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Guerra PA, Reppert SM. Sensory basis of lepidopteran migration: focus on the monarch butterfly. Curr Opin Neurobiol. 2015 Oct; 34:20-8. PMID: 25625216.
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Zhan S, Zhang W, Niitepõld K, Hsu J, Haeger JF, Zalucki MP, Altizer S, de Roode JC, Reppert SM, Kronforst MR. The genetics of monarch butterfly migration and warning colouration. Nature. 2014 Oct 16; 514(7522):317-21. PMID: 25274300.
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Guerra PA, Gegear RJ, Reppert SM. A magnetic compass aids monarch butterfly migration. Nat Commun. 2014; 5:4164. PMID: 24960099.
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Oberhauser KS, Taylor OR, Reppert SM, Dingle H, Nail KR, Pyle RM, Stenoien C. Are monarch butterflies true navigators? The jury is still out. Proc Natl Acad Sci U S A. 2013 Sep 24; 110(39):E3680. PMID: 23983267.
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Guerra PA, Reppert SM. Coldness triggers northward flight in remigrant monarch butterflies. Curr Biol. 2013 Mar 4; 23(5):419-23. PMID: 23434279.
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Heinze S, Florman J, Asokaraj S, El Jundi B, Reppert SM. Anatomical basis of sun compass navigation II: the neuronal composition of the central complex of the monarch butterfly. J Comp Neurol. 2013 Feb 1; 521(2):267-98. PMID: 22886450.
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Zhan S, Reppert SM. MonarchBase: the monarch butterfly genome database. Nucleic Acids Res. 2013 Jan; 41(Database issue):D758-63. PMID: 23143105.
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Merlin C, Beaver LE, Taylor OR, Wolfe SA, Reppert SM. Efficient targeted mutagenesis in the monarch butterfly using zinc-finger nucleases. Genome Res. 2013 Jan; 23(1):159-68. PMID: 23009861.
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Guerra PA, Merlin C, Gegear RJ, Reppert SM. Discordant timing between antennae disrupts sun compass orientation in migratory monarch butterflies. Nat Commun. 2012 Jul 17; 3:958. PMID: 22805565.
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Heinze S, Reppert SM. Anatomical basis of sun compass navigation I: the general layout of the monarch butterfly brain. J Comp Neurol. 2012 Jun 1; 520(8):1599-628. PMID: 22473804.
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Merlin C, Heinze S, Reppert SM. Unraveling navigational strategies in migratory insects. Curr Opin Neurobiol. 2012 Apr; 22(2):353-61. PMID: 22154565.
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Zhan S, Merlin C, Boore JL, Reppert SM. The monarch butterfly genome yields insights into long-distance migration. Cell. 2011 Nov 23; 147(5):1171-85. PMID: 22118469.
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Foley LE, Gegear RJ, Reppert SM. Human cryptochrome exhibits light-dependent magnetosensitivity. Nat Commun. 2011 Jun 21; 2:356. PMID: 21694704.
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Heinze S, Reppert SM. Sun compass integration of skylight cues in migratory monarch butterflies. Neuron. 2011 Jan 27; 69(2):345-58. PMID: 21262471.
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Reppert SM, Gegear RJ, Merlin C. Navigational mechanisms of migrating monarch butterflies. Trends Neurosci. 2010 Sep; 33(9):399-406. PMID: 20627420.
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Gegear RJ, Foley LE, Casselman A, Reppert SM. Animal cryptochromes mediate magnetoreception by an unconventional photochemical mechanism. Nature. 2010 Feb 11; 463(7282):804-7. PMID: 20098414.
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Merlin C, Gegear RJ, Reppert SM. Antennal circadian clocks coordinate sun compass orientation in migratory monarch butterflies. Science. 2009 Sep 25; 325(5948):1700-4. PMID: 19779201.
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Bradley TJ, Briscoe AD, Brady SG, Contreras HL, Danforth BN, Dudley R, Grimaldi D, Harrison JF, Kaiser JA, Merlin C, Reppert SM, Vandenbrooks JM, Yanoviak SP. Episodes in insect evolution. Integr Comp Biol. 2009 Nov; 49(5):590-606. PMID: 21665843.
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Etchegaray JP, Machida KK, Noton E, Constance CM, Dallmann R, Di Napoli MN, DeBruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009 Jul; 29(14):3853-66. PMID: 19414593.
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Zhu H, Gegear RJ, Casselman A, Kanginakudru S, Reppert SM. Defining behavioral and molecular differences between summer and migratory monarch butterflies. BMC Biol. 2009 Mar 31; 7:14. PMID: 19335876.
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Gegear RJ, Casselman A, Waddell S, Reppert SM. Cryptochrome mediates light-dependent magnetosensitivity in Drosophila. Nature. 2008 Aug 21; 454(7207):1014-8. PMID: 18641630.
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Zhu H, Casselman A, Reppert SM. Chasing migration genes: a brain expressed sequence tag resource for summer and migratory monarch butterflies (Danaus plexippus). PLoS One. 2008 Jan 09; 3(1):e1345. PMID: 18183285.
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Zhu H, Sauman I, Yuan Q, Casselman A, Emery-Le M, Emery P, Reppert SM. Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation. PLoS Biol. 2008 Jan; 6(1):e4. PMID: 18184036.
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DeBruyne JP, Weaver DR, Reppert SM. Peripheral circadian oscillators require CLOCK. Curr Biol. 2007 Jul 17; 17(14):R538-9. PMID: 17637349.
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Song SH, Oztürk N, Denaro TR, Arat NO, Kao YT, Zhu H, Zhong D, Reppert SM, Sancar A. Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly. J Biol Chem. 2007 Jun 15; 282(24):17608-12. PMID: 17459876.
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DeBruyne JP, Weaver DR, Reppert SM. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci. 2007 May; 10(5):543-5. PMID: 17417633.
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Yuan Q, Metterville D, Briscoe AD, Reppert SM. Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocks. Mol Biol Evol. 2007 Apr; 24(4):948-55. PMID: 17244599.
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Etchegaray JP, Yang X, DeBruyne JP, Peters AH, Weaver DR, Jenuwein T, Reppert SM. The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28; 281(30):21209-15. PMID: 16717091.
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Debruyne JP, Noton E, Lambert CM, Maywood ES, Weaver DR, Reppert SM. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron. 2006 May 4; 50(3):465-77. PMID: 16675400.
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Reppert SM. A colorful model of the circadian clock. Cell. 2006 Jan 27; 124(2):233-6. PMID: 16439193.
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Zhu H, Yuan Q, Briscoe AD, Froy O, Casselman A, Reppert SM. The two CRYs of the butterfly. Curr Biol. 2005 Dec 6; 15(23):R953-4. PMID: 16332522.
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Sauman I, Briscoe AD, Zhu H, Shi D, Froy O, Stalleicken J, Yuan Q, Casselman A, Reppert SM. Connecting the navigational clock to sun compass input in monarch butterfly brain. Neuron. 2005 May 5; 46(3):457-67. PMID: 15882645.
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Emery P, Reppert SM. A rhythmic Ror. Neuron. 2004 Aug 19; 43(4):443-6. PMID: 15312644.
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Reppert SM, Zhu H, White RH. Polarized light helps monarch butterflies navigate. Curr Biol. 2004 Jan 20; 14(2):155-8. PMID: 14738739.
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Lee C, Weaver DR, Reppert SM. Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004 Jan; 24(2):584-94. PMID: 14701732.
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Chang DC, McWatters HG, Williams JA, Gotter AL, Levine JD, Reppert SM. Constructing a feedback loop with circadian clock molecules from the silkmoth, Antheraea pernyi. J Biol Chem. 2003 Oct 3; 278(40):38149-58. PMID: 12869551.
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Froy O, Gotter AL, Casselman AL, Reppert SM. Illuminating the circadian clock in monarch butterfly migration. Science. 2003 May 23; 300(5623):1303-5. PMID: 12764200.
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Chang DC, Reppert SM. A novel C-terminal domain of drosophila PERIOD inhibits dCLOCK:CYCLE-mediated transcription. Curr Biol. 2003 Apr 29; 13(9):758-62. PMID: 12725734.
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Jin X, von Gall C, Pieschl RL, Gribkoff VK, Stehle JH, Reppert SM, Weaver DR. Targeted disruption of the mouse Mel(1b) melatonin receptor. Mol Cell Biol. 2003 Feb; 23(3):1054-60. PMID: 12529409.
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Etchegaray JP, Lee C, Wade PA, Reppert SM. Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature. 2003 Jan 9; 421(6919):177-82. PMID: 12483227.
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Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002 Aug 29; 418(6901):935-41. PMID: 12198538.
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Travnickova-Bendova Z, Cermakian N, Reppert SM, Sassone-Corsi P. Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7728-33. PMID: 12032351.
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Froy O, Chang DC, Reppert SM. Redox potential: differential roles in dCRY and mCRY1 functions. Curr Biol. 2002 Jan 22; 12(2):147-52. PMID: 11818067.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2002 | 4 | 2003 | 4 | 2004 | 3 | 2005 | 2 | 2006 | 3 | 2007 | 4 | 2008 | 3 | 2009 | 4 | 2010 | 2 | 2011 | 4 | 2012 | 4 | 2013 | 3 | 2014 | 2 | 2015 | 2 | 2016 | 2 | 2017 | 1 | 2018 | 1 | 2020 | 1 |
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