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Steven Reppert MD

TitleDistinguished Professor Emeritus
InstitutionUniversity of Massachusetts Medical School
DepartmentNeurobiology
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-6148
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeurobiology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience


    Collapse Biography 
    Collapse education and training
    University of Nebraska, Omaha, Omaha, NE, United StatesBS
    Harvard University, Cambridge, MA, United StatesMAHonorary
    University of Nebraska, Omaha, Omaha, NE, United StatesMD

    Collapse Overview 
    Collapse overview

    • B.S., University of Nebraska    1973

    • M.D. with Distinction, University of Nebraska    1973

    • M.S., Harvard University (Honorary)    1993

    • Pediatric Residency, Mass General Hosp /Harvard Medical School    1973-1976

    • Post-Doctoral Fellow, NIH    1976-1979

    • Charles King Trust Research Fellow    1979-1981

    • Instructor to Associate Professor, Harvard Medical School    1979-1993

    • Basil O'Connor Early Scholar Award    1981-1984

    • Director, Laboratory of Developmental Chronobiology, Mass General Hosp   1983-2001

    • Established Investigatorship of American Heart Association    1986-1991

    • Member, American Association for Clinical Investigation    1987-

    • E. Mead Johnson Award for Outstanding Research    1991

    • NIH-NICHD MERIT Award    1992-2002

    • Professor, Harvard Medical School    1993-2001

    • Chair, Gordon Conference on Pineal Cell Biology    1998

    • Higgins Family Professor of Neuroscience, UMass Med    2001-

    • Professor & Chair, Dept Neurobiology, UMass Med    2001-

    • President, Society for Research on Biological Rhythms    2002-2004

    • Fellow, American Association for the Advancement of Science    2011-

    • G.J. Mendel Medal from the Czech Academy of Sciences    2012

    • Chancellor's Medal for Distinguished Scholarship, UMass Med    2016


    Molecular Neuroethology


    In an integrated set of studies, our laboratory is using anatomical, cellular, molecular, electrophysiological, genetic and behavioral approaches to more fully understand the biological basis of monarch butterfly (Danaus plexippus) migration, with a focus on the butterfly's navigational abilities and its ancestral circadian clock. For details see the Reppert Lab link




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Guerra PA, Reppert SM. Dimorphic cocoons of the cecropia moth (Hyalophora cecropia): Morphological, behavioral, and biophysical differences. PLoS One. 2017; 12(3):e0174023. PMID: 28329006.
      View in: PubMed
    2. Shlizerman E, Phillips-Portillo J, Forger DB, Reppert SM. Neural Integration Underlying a Time-Compensated Sun Compass in the Migratory Monarch Butterfly. Cell Rep. 2016 Apr 13. PMID: 27149852.
      View in: PubMed
    3. Markert MJ, Zhang Y, Enuameh MS, Reppert SM, Wolfe SA, Merlin C. Genomic Access to Monarch Migration Using TALEN and CRISPR/Cas9-Mediated Targeted Mutagenesis. G3 (Bethesda). 2016 Apr 07; 6(4):905-15. PMID: 26837953.
      View in: PubMed
    4. Reppert SM, Guerra PA, Merlin C. Neurobiology of Monarch Butterfly Migration. Annu Rev Entomol. 2016; 61:25-42. PMID: 26473314.
      View in: PubMed
    5. Guerra PA, Reppert SM. Sensory basis of lepidopteran migration: focus on the monarch butterfly. Curr Opin Neurobiol. 2015 Oct; 34:20-8. PMID: 25625216.
      View in: PubMed
    6. Zhan S, Zhang W, Niitepõld K, Hsu J, Haeger JF, Zalucki MP, Altizer S, de Roode JC, Reppert SM, Kronforst MR. The genetics of monarch butterfly migration and warning colouration. Nature. 2014 Oct 16; 514(7522):317-21. PMID: 25274300.
      View in: PubMed
    7. Guerra PA, Gegear RJ, Reppert SM. A magnetic compass aids monarch butterfly migration. Nat Commun. 2014; 5:4164. PMID: 24960099.
      View in: PubMed
    8. Oberhauser KS, Taylor OR, Reppert SM, Dingle H, Nail KR, Pyle RM, Stenoien C. Are monarch butterflies true navigators? The jury is still out. Proc Natl Acad Sci U S A. 2013 Sep 24; 110(39):E3680. PMID: 23983267.
      View in: PubMed
    9. Guerra PA, Reppert SM. Coldness triggers northward flight in remigrant monarch butterflies. Curr Biol. 2013 Mar 4; 23(5):419-23. PMID: 23434279.
      View in: PubMed
    10. Heinze S, Florman J, Asokaraj S, El Jundi B, Reppert SM. Anatomical basis of sun compass navigation II: the neuronal composition of the central complex of the monarch butterfly. J Comp Neurol. 2013 Feb 1; 521(2):267-98. PMID: 22886450.
      View in: PubMed
    11. Zhan S, Reppert SM. MonarchBase: the monarch butterfly genome database. Nucleic Acids Res. 2013 Jan; 41(Database issue):D758-63. PMID: 23143105.
      View in: PubMed
    12. Merlin C, Beaver LE, Taylor OR, Wolfe SA, Reppert SM. Efficient targeted mutagenesis in the monarch butterfly using zinc-finger nucleases. Genome Res. 2013 Jan; 23(1):159-68. PMID: 23009861.
      View in: PubMed
    13. Guerra PA, Merlin C, Gegear RJ, Reppert SM. Discordant timing between antennae disrupts sun compass orientation in migratory monarch butterflies. Nat Commun. 2012 Jul 17; 3:958. PMID: 22805565.
      View in: PubMed
    14. Heinze S, Reppert SM. Anatomical basis of sun compass navigation I: the general layout of the monarch butterfly brain. J Comp Neurol. 2012 Jun 1; 520(8):1599-628. PMID: 22473804.
      View in: PubMed
    15. Merlin C, Heinze S, Reppert SM. Unraveling navigational strategies in migratory insects. Curr Opin Neurobiol. 2012 Apr; 22(2):353-61. PMID: 22154565.
      View in: PubMed
    16. Zhan S, Merlin C, Boore JL, Reppert SM. The monarch butterfly genome yields insights into long-distance migration. Cell. 2011 Nov 23; 147(5):1171-85. PMID: 22118469.
      View in: PubMed
    17. Foley LE, Gegear RJ, Reppert SM. Human cryptochrome exhibits light-dependent magnetosensitivity. Nat Commun. 2011 Jun 21; 2:356. PMID: 21694704.
      View in: PubMed
    18. Heinze S, Reppert SM. Sun compass integration of skylight cues in migratory monarch butterflies. Neuron. 2011 Jan 27; 69(2):345-58. PMID: 21262471.
      View in: PubMed
    19. Reppert SM, Gegear RJ, Merlin C. Navigational mechanisms of migrating monarch butterflies. Trends Neurosci. 2010 Sep; 33(9):399-406. PMID: 20627420.
      View in: PubMed
    20. Gegear RJ, Foley LE, Casselman A, Reppert SM. Animal cryptochromes mediate magnetoreception by an unconventional photochemical mechanism. Nature. 2010 Feb 11; 463(7282):804-7. PMID: 20098414.
      View in: PubMed
    21. Merlin C, Gegear RJ, Reppert SM. Antennal circadian clocks coordinate sun compass orientation in migratory monarch butterflies. Science. 2009 Sep 25; 325(5948):1700-4. PMID: 19779201.
      View in: PubMed
    22. Bradley TJ, Briscoe AD, Brady SG, Contreras HL, Danforth BN, Dudley R, Grimaldi D, Harrison JF, Kaiser JA, Merlin C, Reppert SM, Vandenbrooks JM, Yanoviak SP. Episodes in insect evolution. Integr Comp Biol. 2009 Nov; 49(5):590-606. PMID: 21665843.
      View in: PubMed
    23. Etchegaray JP, Machida KK, Noton E, Constance CM, Dallmann R, Di Napoli MN, DeBruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009 Jul; 29(14):3853-66. PMID: 19414593.
      View in: PubMed
    24. Zhu H, Gegear RJ, Casselman A, Kanginakudru S, Reppert SM. Defining behavioral and molecular differences between summer and migratory monarch butterflies. BMC Biol. 2009 Mar 31; 7:14. PMID: 19335876.
      View in: PubMed
    25. Gegear RJ, Casselman A, Waddell S, Reppert SM. Cryptochrome mediates light-dependent magnetosensitivity in Drosophila. Nature. 2008 Aug 21; 454(7207):1014-8. PMID: 18641630.
      View in: PubMed
    26. Zhu H, Casselman A, Reppert SM. Chasing migration genes: a brain expressed sequence tag resource for summer and migratory monarch butterflies (Danaus plexippus). PLoS One. 2008 Jan 09; 3(1):e1345. PMID: 18183285.
      View in: PubMed
    27. Zhu H, Sauman I, Yuan Q, Casselman A, Emery-Le M, Emery P, Reppert SM. Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation. PLoS Biol. 2008 Jan; 6(1):e4. PMID: 18184036.
      View in: PubMed
    28. DeBruyne JP, Weaver DR, Reppert SM. Peripheral circadian oscillators require CLOCK. Curr Biol. 2007 Jul 17; 17(14):R538-9. PMID: 17637349.
      View in: PubMed
    29. Song SH, Oztürk N, Denaro TR, Arat NO, Kao YT, Zhu H, Zhong D, Reppert SM, Sancar A. Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly. J Biol Chem. 2007 Jun 15; 282(24):17608-12. PMID: 17459876.
      View in: PubMed
    30. DeBruyne JP, Weaver DR, Reppert SM. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci. 2007 May; 10(5):543-5. PMID: 17417633.
      View in: PubMed
    31. Yuan Q, Metterville D, Briscoe AD, Reppert SM. Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocks. Mol Biol Evol. 2007 Apr; 24(4):948-55. PMID: 17244599.
      View in: PubMed
    32. Etchegaray JP, Yang X, DeBruyne JP, Peters AH, Weaver DR, Jenuwein T, Reppert SM. The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28; 281(30):21209-15. PMID: 16717091.
      View in: PubMed
    33. Debruyne JP, Noton E, Lambert CM, Maywood ES, Weaver DR, Reppert SM. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron. 2006 May 4; 50(3):465-77. PMID: 16675400.
      View in: PubMed
    34. Reppert SM. A colorful model of the circadian clock. Cell. 2006 Jan 27; 124(2):233-6. PMID: 16439193.
      View in: PubMed
    35. Zhu H, Yuan Q, Briscoe AD, Froy O, Casselman A, Reppert SM. The two CRYs of the butterfly. Curr Biol. 2005 Dec 6; 15(23):R953-4. PMID: 16332522.
      View in: PubMed
    36. Sauman I, Briscoe AD, Zhu H, Shi D, Froy O, Stalleicken J, Yuan Q, Casselman A, Reppert SM. Connecting the navigational clock to sun compass input in monarch butterfly brain. Neuron. 2005 May 5; 46(3):457-67. PMID: 15882645.
      View in: PubMed
    37. Emery P, Reppert SM. A rhythmic Ror. Neuron. 2004 Aug 19; 43(4):443-6. PMID: 15312644.
      View in: PubMed
    38. Reppert SM, Zhu H, White RH. Polarized light helps monarch butterflies navigate. Curr Biol. 2004 Jan 20; 14(2):155-8. PMID: 14738739.
      View in: PubMed
    39. Lee C, Weaver DR, Reppert SM. Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004 Jan; 24(2):584-94. PMID: 14701732.
      View in: PubMed
    40. Chang DC, McWatters HG, Williams JA, Gotter AL, Levine JD, Reppert SM. Constructing a feedback loop with circadian clock molecules from the silkmoth, Antheraea pernyi. J Biol Chem. 2003 Oct 3; 278(40):38149-58. PMID: 12869551.
      View in: PubMed
    41. Froy O, Gotter AL, Casselman AL, Reppert SM. Illuminating the circadian clock in monarch butterfly migration. Science. 2003 May 23; 300(5623):1303-5. PMID: 12764200.
      View in: PubMed
    42. Chang DC, Reppert SM. A novel C-terminal domain of drosophila PERIOD inhibits dCLOCK:CYCLE-mediated transcription. Curr Biol. 2003 Apr 29; 13(9):758-62. PMID: 12725734.
      View in: PubMed
    43. Jin X, von Gall C, Pieschl RL, Gribkoff VK, Stehle JH, Reppert SM, Weaver DR. Targeted disruption of the mouse Mel(1b) melatonin receptor. Mol Cell Biol. 2003 Feb; 23(3):1054-60. PMID: 12529409.
      View in: PubMed
    44. Etchegaray JP, Lee C, Wade PA, Reppert SM. Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature. 2003 Jan 9; 421(6919):177-82. PMID: 12483227.
      View in: PubMed
    45. Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002 Aug 29; 418(6901):935-41. PMID: 12198538.
      View in: PubMed
    46. Travnickova-Bendova Z, Cermakian N, Reppert SM, Sassone-Corsi P. Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7728-33. PMID: 12032351.
      View in: PubMed
    47. Froy O, Chang DC, Reppert SM. Redox potential: differential roles in dCRY and mCRY1 functions. Curr Biol. 2002 Jan 22; 12(2):147-52. PMID: 11818067.
      View in: PubMed
    48. Godson C, Reppert SM. The Mel1a Melatonin Receptor Is Coupled to Parallel Signal Transduction Pathways 1. Endocrinology. 1997 Jan 01; 138(1):397-404. PMID: 28204267.
      View in: PubMed
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