Loading...
Header Logo
Keywords
Last Name
Institution

Katherine Ruiz De Luzuriaga MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentProgram in Molecular Medicine
AddressUniversity of Massachusetts Medical School
373 Plantation Street, Two Biotech, Suite 318
Worcester MA 01605
Phone508-856-6282
vCardDownload vCard
    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionInfectious Diseases And Immunology

    InstitutionUMMS - School of Medicine
    DepartmentPediatrics
    DivisionPediatric Immunology & Infectious Diseases

    InstitutionUMMS - School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentClinical Population Health Research

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentImmunology and Virology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMasters in Clinical Investigation

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology


    Collapse Biography 
    Collapse education and training
    Massachusetts Institute of Technology, Cambridge, MA, United StatesBSApplied Biology
    Massachusetts Institute of Technology, Cambridge, MA, United StatesMSNutritional Biochemistry
    Tufts University School of Medicine, Boston, MA, United StatesMD

    Collapse Overview 
    Collapse overview

    Academic Background

    S.B., S.M. - Massachusetts Institute of Technology

    M.D. (1984) Tufts University

    Professor,
    Department of Pediatrics and Program in Molecular Medicine

    Virus-Host Dynamics in Persistent Viral Infections

    Dr. Luzuriaga

    Research in my laboratory is focused on the viral and immunopathogenesis of persistent viral infections in humans, including human immunodeficiency virus (HIV), Epstein Barr virus (EBV), and cytomegalovirus (CMV). Ongoing studies are focused on: 1) examining the relationship between viral replication/viral gene expression and the development of the antiviral CD4+ and CD8+ T cell repertoires from acute through chronic infection; 2) characterization of the ontogeny of cell-mediated immune responses to viral infections in infants and children; and 3) the development of prophylactic and therapeutic vaccine strategies for HIV.



    Collapse Rotation Projects

    Potential Rotation Projects:

    Contact Dr. Luzuriaga for project details.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Brumme Z, Sudderuddin H, Ziemniak C, Luzuriaga K, Jones BR, Joy JB, Cunningham CK, Greenough T, Persaud D. Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth. AIDS. 2018 Oct 15. PMID: 30325763.
      View in: PubMed
    2. Brese RL, Gonzalez-Perez MP, Koch M, O'Connell O, Luzuriaga K, Somasundaran M, Clapham PR, Dollar JJ, Nolan DJ, Rose R, Lamers SL. Ultradeep single-molecule real-time sequencing of HIV envelope reveals complete compartmentalization of highly macrophage-tropic R5 proviral variants in brain and CXCR4-using variants in immune and peripheral tissues. J Neurovirol. 2018 Apr 23. PMID: 29687407.
      View in: PubMed
    3. Quitadamo B, Peters PJ, Repik A, O'Connell O, Mou Z, Koch M, Somasundaran M, Brody R, Luzuriaga K, Wallace A, Wang S, Lu S, McCauley S, Luban J, Duenas-Decamp M, Gonzalez-Perez MP, Clapham PR. HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded. J Virol. 2018 Jan 15; 92(2). PMID: 29118121.
      View in: PubMed
    4. Aslan N, Watkin LB, Gil A, Mishra R, Clark FG, Welsh RM, Ghersi D, Luzuriaga K, Selin LK. Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires. MBio. 2017 Dec 05; 8(6). PMID: 29208744.
      View in: PubMed
    5. Weiss ER, Lamers SL, Henderson JL, Melnikov A, Somasundaran M, Garber M, Selin L, Nusbaum C, Luzuriaga K. Early EBV genomic diversity and convergence towards the B95.8 genome in primary infection. J Virol. 2017 Nov 01. PMID: 29093087.
      View in: PubMed
    6. Gonzalez-Perez MP, Peters PJ, O'Connell O, Silva N, Harbison C, Cummings Macri S, Kaliyaperumal S, Luzuriaga K, Clapham PR. Identification of Emerging Macrophage-Tropic HIV-1 R5 Variants in Brain Tissue of AIDS Patients without Severe Neurological Complications. J Virol. 2017 Oct 15; 91(20). PMID: 28768859.
      View in: PubMed
    7. Watkin LB, Mishra R, Gil A, Aslan N, Ghersi D, Luzuriaga K, Selin LK. Unique Influenza A crossreactive memory CD8 TCR repertoire has a potential to protect against Epstein Barr virus seroconversion. J Allergy Clin Immunol. 2017 Jun 16. PMID: 28629751.
      View in: PubMed
    8. Rainwater-Lovett K, Ziemniak C, Watson D, Luzuriaga K, Siberry G, Petru A, Chen Y, Uprety P, McManus M, Ho YC, Lamers SL, Persaud D. Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection. PLoS One. 2017; 12(2):e0170548. PMID: 28178277.
      View in: PubMed
    9. Calvin-Naylor NA, Jones CT, Wartak MM, Blackwell K, Davis JM, Divecha R, Ellerbeck EF, Kieburtz K, Koziel MJ, Luzuriaga K, Maddox J, Needler NA, Murphy S, Pemberton K, Radovich C, Rubinstein EP, Selker HP, Tenaerts P, Unsworth K, Wilson K, Wright JE, Barohn R, Shanley TP. Education and training of clinical and translational study investigators and research coordinators: A competency-based approach. J Clin Transl Sci. 2017 Feb; 1(1):16-25. PMID: 28480054.
      View in: PubMed
    10. Weiss ER, Alter G, Ogembo JG, Henderson JL, Tabak B, Bakis Y, Somasundaran M, Garber M, Selin L, Luzuriaga K. High Epstein-Barr Virus Load and Genomic Diversity Are Associated with Generation of gp350-Specific Neutralizing Antibodies following Acute Infectious Mononucleosis. J Virol. 2017 Jan 01; 91(1). PMID: 27733645.
      View in: PubMed
    11. Luzuriaga K, Persaud D. Treatment interruption after early-treated perinatal HIV-1 infection. AIDS. 2016 09 24; 30(15):2381-3. PMID: 27603162.
      View in: PubMed
    12. Luzuriaga K, Mofenson LM. Eliminating Pediatric HIV-1 Infection. N Engl J Med. 2016 07 14; 375(2):193-4. PMID: 27410941.
      View in: PubMed
    13. McManus M, Mick E, Hudson R, Mofenson LM, Sullivan JL, Somasundaran M, Luzuriaga K. Early Combination Antiretroviral Therapy Limits Exposure to HIV-1 Replication and Cell-Associated HIV-1 DNA Levels in Infants. PLoS One. 2016; 11(4):e0154391. PMID: 27104621.
      View in: PubMed
    14. Luzuriaga K, Mofenson LM. Challenges in the Elimination of Pediatric HIV-1 Infection. N Engl J Med. 2016 Feb 25; 374(8):761-70. PMID: 26933850.
      View in: PubMed
    15. Luzuriaga K. Early Combination Antiretroviral Therapy Limits HIV-1 Persistence in Children. Annu Rev Med. 2016; 67:201-13. PMID: 26768239.
      View in: PubMed
    16. Sanborn KB, Somasundaran M, Luzuriaga K, Leitner T. Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission. Retrovirology. 2015 Nov 16; 12:96. PMID: 26573574.
      View in: PubMed
    17. Greenough TC, Straubhaar JR, Kamga L, Weiss ER, Brody RM, McManus MM, Lambrecht LK, Somasundaran M, Luzuriaga KF. A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection. J Immunol. 2015 Nov 01; 195(9):4185-97. PMID: 26416268.
      View in: PubMed
    18. Uprety P, Chadwick EG, Rainwater-Lovett K, Ziemniak C, Luzuriaga K, Capparelli EV, Yenokyan G, Persaud D. Cell-Associated HIV-1 DNA and RNA Decay Dynamics During Early Combination Antiretroviral Therapy in HIV-1-Infected Infants. Clin Infect Dis. 2015 Dec 15; 61(12):1862-70. PMID: 26270687.
      View in: PubMed
    19. Gibson L, Barysauskas CM, McManus M, Dooley S, Lilleri D, Fisher D, Srivastava T, Diamond DJ, Luzuriaga K. Reduced frequencies of polyfunctional CMV-specific T cell responses in infants with congenital CMV infection. J Clin Immunol. 2015 Apr; 35(3):289-301. PMID: 25712611.
      View in: PubMed
    20. Luzuriaga K, Gay H, Ziemniak C, Sanborn KB, Somasundaran M, Rainwater-Lovett K, Mellors JW, Rosenbloom D, Persaud D. Viremic relapse after HIV-1 remission in a perinatally infected child. N Engl J Med. 2015 Feb 19; 372(8):786-8. PMID: 25693029.
      View in: PubMed
    21. Rainwater-Lovett K, Luzuriaga K, Persaud D. Very early combination antiretroviral therapy in infants: prospects for cure. Curr Opin HIV AIDS. 2015 Jan; 10(1):4-11. PMID: 25402708.
      View in: PubMed
    22. Persaud D, Patel K, Karalius B, Rainwater-Lovett K, Ziemniak C, Ellis A, Chen YH, Richman D, Siberry GK, Van Dyke RB, Burchett S, Seage GR, Luzuriaga K. Influence of age at virologic control on peripheral blood human immunodeficiency virus reservoir size and serostatus in perinatally infected adolescents. JAMA Pediatr. 2014 Dec; 168(12):1138-46. PMID: 25286283.
      View in: PubMed
    23. Luzuriaga K, Tabak B, Garber M, Chen YH, Ziemniak C, McManus MM, Murray D, Strain MC, Richman DD, Chun TW, Cunningham CK, Persaud D. HIV type 1 (HIV-1) proviral reservoirs decay continuously under sustained virologic control in HIV-1-infected children who received early treatment. J Infect Dis. 2014 Nov 15; 210(10):1529-38. PMID: 24850788.
      View in: PubMed
    24. Persaud D, Luzuriaga K. Absence of HIV-1 after treatment cessation in an infant. N Engl J Med. 2014 Feb 13; 370(7):678. PMID: 24521123.
      View in: PubMed
    25. Renzette N, Somasundaran M, Brewster F, Coderre J, Weiss ER, McManus M, Greenough T, Tabak B, Garber M, Kowalik TF, Luzuriaga K. Epstein-Barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids. J Virol. 2014 Apr; 88(7):3744-55. PMID: 24429365.
      View in: PubMed
    26. Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M, Chun TW, Strain M, Richman D, Luzuriaga K. Absence of detectable HIV-1 viremia after treatment cessation in an infant. N Engl J Med. 2013 Nov 07; 369(19):1828-35. PMID: 24152233.
      View in: PubMed
    27. Wang S, Kishko M, Wan S, Wang Y, Brewster F, Gray GE, Violari A, Sullivan JL, Somasundaran M, Luzuriaga K, Lu S. Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates. Hum Vaccin Immunother. 2012 Nov 1; 8(11):1638-47. PMID: 23151449.
      View in: PubMed
    28. Tracy SI, Kakalacheva K, L√ľnemann JD, Luzuriaga K, Middeldorp J, Thorley-Lawson DA. Persistence of Epstein-Barr virus in self-reactive memory B cells. J Virol. 2012 Nov; 86(22):12330-40. PMID: 22951828.
      View in: PubMed
    29. Persaud D, Palumbo PE, Ziemniak C, Hughes MD, Alvero CG, Luzuriaga K, Yogev R, Capparelli EV, Chadwick EG. Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age. AIDS. 2012 Jul 31; 26(12):1483-90. PMID: 22555165.
      View in: PubMed
    30. Kishko M, Somasundaran M, Brewster F, Sullivan JL, Clapham PR, Luzuriaga K. Genotypic and functional properties of early infant HIV-1 envelopes. Retrovirology. 2011 Aug 15; 8:67. PMID: 21843318.
      View in: PubMed
    31. Clute SC, Naumov YN, Watkin LB, Aslan N, Sullivan JL, Thorley-Lawson DA, Luzuriaga K, Welsh RM, Puzone R, Celada F, Selin LK. Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes. J Immunol. 2010 Dec 1; 185(11):6753-64. PMID: 21048112.
      View in: PubMed
    32. Greenough TC, Campellone SC, Brody R, Jain S, Sanchez-Merino V, Somasundaran M, Luzuriaga K. Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage. PLoS One. 2010 Sep 23; 5(9):e12926. PMID: 20886079.
      View in: PubMed
    33. Luzuriaga K, Sullivan JL. Infectious mononucleosis. N Engl J Med. 2010 May 27; 362(21):1993-2000. PMID: 20505178.
      View in: PubMed
    34. Mehta N, Cunningham CK, Flynn P, Pepe J, Obaro S, Kapogiannis BG, Bethel J, Luzuriaga K. Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination. Vaccine. 2010 May 7; 28(21):3672-8. PMID: 20356567.
      View in: PubMed
    35. Shiu C, Cunningham CK, Greenough T, Muresan P, Sanchez-Merino V, Carey V, Jackson JB, Ziemniak C, Fox L, Belzer M, Ray SC, Luzuriaga K, Persaud D. Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy. J Virol. 2009 Oct; 83(19):9731-42. PMID: 19605490.
      View in: PubMed
    36. Mehta N, Trzmielina S, Nonyane BA, Eliot MN, Lin R, Foulkes AS, McNeal K, Ammann A, Eulalievyolo V, Sullivan JL, Luzuriaga K, Somasundaran M. Low-cost HIV-1 diagnosis and quantification in dried blood spots by real time PCR. PLoS One. 2009 Jun 05; 4(6):e5819. PMID: 19503790.
      View in: PubMed
    37. Sanchez-Merino V, Farrow MA, Brewster F, Somasundaran M, Luzuriaga K. Identification and characterization of HIV-1 CD8+ T cell escape variants with impaired fitness. J Infect Dis. 2008 Jan 15; 197(2):300-8. PMID: 18177249.
      View in: PubMed
    38. Hadinoto V, Shapiro M, Greenough TC, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. Blood. 2008 Feb 1; 111(3):1420-7. PMID: 17991806.
      View in: PubMed
    39. Luzuriaga K. Mother-to-child transmission of HIV: a global perspective. Curr Infect Dis Rep. 2007 Nov; 9(6):511-7. PMID: 17999887.
      View in: PubMed
    40. Duca KA, Shapiro M, Delgado-Eckert E, Hadinoto V, Jarrah AS, Laubenbacher R, Lee K, Luzuriaga K, Polys NF, Thorley-Lawson DA. A virtual look at Epstein-Barr virus infection: biological interpretations. PLoS Pathog. 2007 Oct 19; 3(10):1388-400. PMID: 17953479.
      View in: PubMed
    41. Souza TA, Stollar BD, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. Influence of EBV on the peripheral blood memory B cell compartment. J Immunol. 2007 Sep 1; 179(5):3153-60. PMID: 17709530.
      View in: PubMed
    42. Luzuriaga K, Newell ML, Dabis F, Excler JL, Sullivan JL. Vaccines to prevent transmission of HIV-1 via breastmilk: scientific and logistical priorities. Lancet. 2006 Aug 5; 368(9534):511-21. PMID: 16890838.
      View in: PubMed
    43. Souza TA, Stollar BD, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18093-8. PMID: 16330748.
      View in: PubMed
    44. Clute SC, Watkin LB, Cornberg M, Naumov YN, Sullivan JL, Luzuriaga K, Welsh RM, Selin LK. Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis. J Clin Invest. 2005 Dec; 115(12):3602-12. PMID: 16308574.
      View in: PubMed
    45. Sanchez-Merino V, Nie S, Luzuriaga K. HIV-1-specific CD8+ T cell responses and viral evolution in women and infants. J Immunol. 2005 Nov 15; 175(10):6976-86. PMID: 16272358.
      View in: PubMed
    46. Luzuriaga K, McManus M, Mofenson L, Britto P, Graham B, Sullivan JL. A trial of three antiretroviral regimens in HIV-1-infected children. N Engl J Med. 2004 Jun 10; 350(24):2471-80. PMID: 15190139.
      View in: PubMed
    47. Hochberg D, Souza T, Catalina M, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. Acute infection with Epstein-Barr virus targets and overwhelms the peripheral memory B-cell compartment with resting, latently infected cells. J Virol. 2004 May; 78(10):5194-204. PMID: 15113901.
      View in: PubMed
    48. Hochberg D, Middeldorp JM, Catalina M, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo. Proc Natl Acad Sci U S A. 2004 Jan 6; 101(1):239-44. PMID: 14688409.
      View in: PubMed
    49. Luzuriaga K, Sullivan JL. Pediatric HIV-1 infection: advances and remaining challenges. AIDS Rev. 2002 Jan-Mar; 4(1):21-6. PMID: 11998780.
      View in: PubMed
    50. Luzuriaga K, McManus M, Catalina M, Mayack S, Sharkey M, Stevenson M, Sullivan JL. Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responses. J Virol. 2000 Aug; 74(15):6984-91. PMID: 10888637.
      View in: PubMed
    For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
    Ruiz De Luzuriaga's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _