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Andrew Karellas PhD

TitleAdjunct Professor
InstitutionUMass Chan Medical School
AddressUniversity of Arizona College of Medicine
1609 N Warren Ave, Building 211, Room 138
Tucson AZ 85724
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    Other Positions
    InstitutionT.H. Chan School of Medicine

    Collapse Biography 
    Collapse education and training
    Worcester State College, Worcester, MA, United StatesBSChemistry
    California State University, Los Angeles, Los Angeles, CA, United StatesPHDMedical Physics
    Collapse awards and honors
    1983Distinguished Scholar Award, University of California, Los Angeles (UCLA)
    1984The Crump (Institute) Prize for Excellence in Medical Engineering, University of California, Los Angeles (UCLA)
    2001Fellow of the American Association of Physicists in Medicine, AAPM
    2003 - 2007• Georgia Cancer Coalition Distinguished Scholar Award, Georgia Cancer Coalition and Emory University
    2008Farrington Daniels Award for the best paper on radiation dosimetry - Co-author, Mentor, American Association of Physicists in Medicine
    2009Reviewer with Distinction, Radiology
    2012Fellow of The American College of Radiology, American College of Radiology
    2014Excellence in Peer Review for Year 2013, Academic Radiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tseng HW, Karellas A, Vedantham S. Dedicated cone-beam breast CT: Data acquisition strategies based on projection angle-dependent normalized glandular dose coefficients. Med Phys. 2023 Mar; 50(3):1406-1417. PMID: 36427332.
      Citations:    Fields:    Translation:Humans
    2. Tseng HW, Karellas A, Vedantham S. Cone-beam breast CT using an offset detector: effect of detector offset and image reconstruction algorithm. Phys Med Biol. 2022 04 07; 67(8). PMID: 35316793.
      Citations:    Fields:    
    3. Vedantham S, Karellas A. Breast Cancer Screening: Opportunities and Challenges with Fully 3D Tomographic X-Ray Imaging. Bridge (Wash D C). 2022; 52(1):33-42. PMID: 35431425.
    4. Tseng HW, Karellas A, Vedantham S. Radiation dosimetry of a clinical prototype dedicated cone-beam breast CT system with offset detector. Med Phys. 2021 Mar; 48(3):1079-1088. PMID: 33501686.
      Citations: 3     Fields:    Translation:Humans
    5. Fu Z, Tseng HW, Vedantham S, Karellas A, Bilgin A. A residual dense network assisted sparse view reconstruction for breast computed tomography. Sci Rep. 2020 12 03; 10(1):21111. PMID: 33273541.
      Citations: 6     Fields:    Translation:Humans
    6. Tseng HW, Karellas A, Vedantham S. Sparse-view, short-scan, dedicated cone-beam breast computed tomography: image quality assessment. Biomed Phys Eng Express. 2020 09 28. PMID: 33377758.
      Citations: 2     Fields:    
    7. Tseng HW, Vedantham S, Karellas A. Cone-beam breast computed tomography using ultra-fast image reconstruction with constrained, total-variation minimization for suppression of artifacts. Phys Med. 2020 May; 73:117-124. PMID: 32361156.
      Citations: 6     Fields:    
    8. Vedantham S, Tseng HW, Konate S, Shi L, Karellas A. Dedicated cone-beam breast CT using laterally-shifted detector geometry: Quantitative analysis of feasibility for clinical translation. J Xray Sci Technol. 2020; 28(3):405-426. PMID: 32333575.
      Citations: 5     Fields:    Translation:Humans
    9. Tseng HW, Vedantham S, Cho SH, Karellas A. Joint Optimization of Collimator and Reconstruction Parameters in X-Ray Fluorescence Computed Tomography Using Analytical Point Spread Function and Model Observer. IEEE Trans Biomed Eng. 2020 09; 67(9):2443-2452. PMID: 31899411.
      Citations: 1     Fields:    Translation:Animals
    10. Karellas A. Challenges in Dosimetry and Radiation Dose Trends. Radiology. 2020 Feb; 294(2):360-361. PMID: 31770079.
      Citations: 1     Fields:    Translation:Humans
    11. Deng L, Yasar S, Ahmed MF, Jayarathna S, Feng P, Wei B, Vedantham S, Karellas A, Cho SH. Investigation of transmission computed tomography (CT) image quality and x-ray dose achievable from an experimental dual-mode benchtop x-ray fluorescence CT and transmission CT system. J Xray Sci Technol. 2019; 27(3):431-442. PMID: 30909268.
      Citations: 1     Fields:    
    12. Shi L, Vedantham S, Karellas A, Zhu L. The role of off-focus radiation in scatter correction for dedicated cone beam breast CT. Med Phys. 2018 Jan; 45(1):191-201. PMID: 29159941.
      Citations: 9     Fields:    Translation:Humans
    13. Vedantham S, Karellas A. Emerging Breast Imaging Technologies on the Horizon. Semin Ultrasound CT MR. 2018 Feb; 39(1):114-121. PMID: 29317033.
      Citations: 1     Fields:    Translation:Humans
    14. O'Connell AM, Karellas A, Vedantham S, Kawakyu-O'Connor DT. Newer Technologies in Breast Cancer Imaging: Dedicated Cone-Beam Breast Computed Tomography. Semin Ultrasound CT MR. 2018 Feb; 39(1):106-113. PMID: 29317032.
      Citations: 13     Fields:    Translation:Humans
    15. Shi L, Vedantham S, Karellas A, Zhu L. X-ray scatter correction for dedicated cone beam breast CT using a forward-projection model. Med Phys. 2017 Jun; 44(6):2312-2320. PMID: 28295375.
      Citations: 14     Fields:    Translation:Humans
    16. Shrestha S, Vedantham S, Karellas A. Towards standardization of x-ray beam filters in digital mammography and digital breast tomosynthesis: Monte Carlo simulations and analytical modelling. Phys Med Biol. 2017 03 07; 62(5):1969-1993. PMID: 28075335.
      Citations: 2     Fields:    Translation:Humans
    17. Michaelsen KE, Krishnaswamy V, Shi L, Vedantham S, Karellas A, Pogue BW, Paulsen KD, Poplack SP. Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography. J Biomed Opt. 2016 09 01; 21(9):91316. PMID: 27677170.
      Citations: 1     Fields:    
    18. Shi L, Vedantham S, Karellas A, Zhu L. Library based x-ray scatter correction for dedicated cone beam breast CT. Med Phys. 2016 Aug; 43(8):4529. PMID: 27487870.
      Citations: 17     Fields:    Translation:Humans
    19. Vedantham S, Shrestha S, Karellas A, Shi L, Gounis MJ, Bellazzini R, Spandre G, Brez A, Minuti M. Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications. Med Phys. 2016 May; 43(5):2118. PMID: 27147324.
      Citations: 3     Fields:    Translation:Humans
    20. Zygmanski P, Shrestha S, Briovio D, Karellas A, Sajo E. Prototypes of self-powered radiation detectors employing intrinsic high-energy current. Med Phys. 2016 Jan; 43(1):16. PMID: 26745895.
      Citations:    Fields:    
    21. Vedantham S, Karellas A, Vijayaraghavan GR, Kopans DB. Digital Breast Tomosynthesis: State of the Art. Radiology. 2015 Dec; 277(3):663-84. PMID: 26599926.
      Citations: 52     Fields:    Translation:Humans
    22. Michaelsen KE, Krishnaswamy V, Shi L, Vedantham S, Poplack SP, Karellas A, Pogue BW, Paulsen KD. Calibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography. Biomed Opt Express. 2015 Dec 01; 6(12):4981-91. PMID: 26713210.
    23. Vedantham S, Shi L, Michaelsen KE, Krishnaswamy V, Pogue BW, Poplack SP, Karellas A, Paulsen KD. Digital Breast Tomosynthesis guided Near Infrared Spectroscopy: Volumetric estimates of fibroglandular fraction and breast density from tomosynthesis reconstructions. Biomed Phys Eng Express. 2015; 1(4). PMID: 26941961.
      Citations: 6     Fields:    
    24. Goertz L, Tsiamas P, Karellas A, Sajo E, Zygmanski P. Monte Carlo simulation of a prototypical patient dosimetry system for fluoroscopic procedures. Phys Med Biol. 2015 Aug 07; 60(15):5891-909. PMID: 26184743.
      Citations:    Fields:    Translation:Humans
    25. Elshahat B, Gill HS, Filipyev I, Shrestha S, Hesser J, Kumar J, Karellas A, Zygmanski P, Sajo E. Technical Note: Nanometric organic photovoltaic thin film detectors for dose monitoring in diagnostic x-ray imaging. Med Phys. 2015 Jul; 42(7):4027-32. PMID: 26133603.
      Citations:    Fields:    
    26. Noo F, Karellas A. Introduction: Advances and trends in image formation in X-ray computed tomography. Med Phys. 2015 May; 42(5):2656. PMID: 25979061.
      Citations:    Fields:    
    27. Zygmanski P, Shrestha S, Elshahat B, Karellas A, Sajo E. Dosimetric properties of high energy current (HEC) detector in keV x-ray beams. Phys Med Biol. 2015 Apr 07; 60(7):N121-9. PMID: 25789488.
      Citations: 1     Fields:    
    28. Vedantham S, O'Connell AM, Shi L, Karellas A, Huston AJ, Skinner KA. Dedicated Breast CT: Feasibility for Monitoring Neoadjuvant Chemotherapy Treatment. J Clin Imaging Sci. 2014; 4:64. PMID: 25558431.
    29. Vedantham S, Shi L, Karellas A. Large-angle x-ray scatter in Talbot-Lau interferometry for breast imaging. Phys Med Biol. 2014 Nov 07; 59(21):6387-400. PMID: 25295630.
      Citations: 3     Fields:    Translation:HumansCells
    30. O'Connell AM, Karellas A, Vedantham S. The potential role of dedicated 3D breast CT as a diagnostic tool: review and early clinical examples. Breast J. 2014 Nov-Dec; 20(6):592-605. PMID: 25199995.
      Citations: 24     Fields:    Translation:HumansCells
    31. Jon AF, Cheema AR, Khan AN, Raptopoulos V, Hauser T, Nasser I, Welty FK, Karellas A, Clouse ME. Assessment of liver fat in an obese patient population using noncontrast CT fat percent index. Clin Imaging. 2014 May-Jun; 38(3):259-64. PMID: 24559751.
      Citations:    Fields:    Translation:Humans
    32. Marya N, Karellas A, Foley A, Roychowdhury A, Cave D. Computerized 3-dimensional localization of a video capsule in the abdominal cavity: validation by digital radiography. Gastrointest Endosc. 2014 Apr; 79(4):669-74. PMID: 24424401.
      Citations: 12     Fields:    Translation:Humans
    33. Vedantham S, Shi L, Karellas A, O'Connell AM, Conover DL. Personalized estimates of radiation dose from dedicated breast CT in a diagnostic population and comparison with diagnostic mammography. Phys Med Biol. 2013 Nov 21; 58(22):7921-36. PMID: 24165162.
      Citations: 23     Fields:    Translation:Humans
    34. St Peter B, Yngvesson S, Siqueira P, Kelly P, Khan A, Glick S, Karellas A. Development and testing of a single frequency terahertz imaging system for breast cancer detection. IEEE J Biomed Health Inform. 2013 Jul; 17(4):785-97. PMID: 25055306.
      Citations: 6     Fields:    Translation:Humans
    35. Vedantham S, Karellas A, Emmons MM, Moss LJ, Hussain S, Baker SP. Dedicated breast CT: geometric design considerations to maximize posterior breast coverage. Phys Med Biol. 2013 Jun 21; 58(12):4099-118. PMID: 23685899.
      Citations: 12     Fields:    Translation:Humans
    36. Vedantham S, Karellas A. X-ray phase contrast imaging of the breast: analysis of tissue simulating materials. Med Phys. 2013 Apr; 40(4):041906. PMID: 23556900.
      Citations: 8     Fields:    Translation:HumansCells
    37. Lange J, Karellas A, Street J, Eck JC, Lapinsky A, Connolly PJ, Dipaola CP. Estimating the effective radiation dose imparted to patients by intraoperative cone-beam computed tomography in thoracolumbar spinal surgery. Spine (Phila Pa 1976). 2013 Mar 01; 38(5):E306-12. PMID: 23238490.
      Citations: 15     Fields:    Translation:Humans
    38. Shi L, Vedantham S, Karellas A, O'Connell AM. Technical note: Skin thickness measurements using high-resolution flat-panel cone-beam dedicated breast CT. Med Phys. 2013 Mar; 40(3):031913. PMID: 23464328.
      Citations: 19     Fields:    Translation:Humans
    39. Noo F, Karellas A. Focus series introduction. X-ray computed tomography: 2012 advances in image formation. Med Phys. 2013 Mar; 40(3):031001. PMID: 23464280.
      Citations:    Fields:    Translation:Humans
    40. Kanal KM, Krupinski E, Berns EA, Geiser WR, Karellas A, Mainiero MB, Martin MC, Patel SB, Rubin DL, Shepard JD, Siegel EL, Wolfman JA, Mian TA, Mahoney MC. ACR-AAPM-SIIM practice guideline for determinants of image quality in digital mammography. J Digit Imaging. 2013 Feb; 26(1):10-25. PMID: 22992865.
      Citations: 7     Fields:    Translation:Humans
    41. Vedantham S, Shi L, Glick SJ, Karellas A. Scaling-law for the energy dependence of anatomic power spectrum in dedicated breast CT. Med Phys. 2013 Jan; 40(1):011901. PMID: 23298092.
      Citations: 8     Fields:    
    42. Vedantham S, Shi L, Karellas A, O'Connell AM. Dedicated breast CT: fibroglandular volume measurements in a diagnostic population. Med Phys. 2012 Dec; 39(12):7317-28. PMID: 23231281.
      Citations: 39     Fields:    Translation:HumansCTClinical Trials
    43. D'Orsi CJ, Getty DJ, Pickett RM, Sechopoulos I, Newell MS, Gundry KR, Bates SR, Nishikawa RM, Sickles EA, Karellas A, D'Orsi EM. Stereoscopic digital mammography: improved specificity and reduced rate of recall in a prospective clinical trial. Radiology. 2013 Jan; 266(1):81-8. PMID: 23150865.
      Citations: 13     Fields:    Translation:Humans
    44. Jones BL, Manohar N, Reynoso F, Karellas A, Cho SH. Experimental demonstration of benchtop x-ray fluorescence computed tomography (XFCT) of gold nanoparticle-loaded objects using lead- and tin-filtered polychromatic cone-beams. Phys Med Biol. 2012 Dec 07; 57(23):N457-67. PMID: 23135315.
      Citations: 32     Fields:    
    45. Karellas A. Photon-counting digital mammography: evaluation of performance under clinically relevant conditions. Acad Radiol. 2012 Aug; 19(8):913-5. PMID: 22770464.
      Citations:    Fields:    Translation:HumansPHPublic Health
    46. Vedantham S, Shi L, Karellas A, Noo F. Dedicated breast CT: radiation dose for circle-plus-line trajectory. Med Phys. 2012 Mar; 39(3):1530-41. PMID: 22380385.
      Citations: 21     Fields:    
    47. Yngvesson SK, St Peter B, Siqueira P, Kelly P, Glick S, Karellas A, Khan A. Feasibility demonstration of frequency domain terahertz imaging in breast cancer margin determination. Proc SPIE Int Soc Opt Eng. 2012 Feb 09; 8221. PMID: 24353380.
    48. Noo F, Karellas A. X-ray computed tomography: advances in image formation. Med Phys. 2011 Jul; 38 Suppl 1:S1. PMID: 21978110.
      Citations:    Fields:    
    49. Vedantham S, Shi L, Karellas A, Michaelsen KE, Krishnaswamy V, Pogue BW, Paulsen KD. Semi-automated segmentation and classification of digital breast tomosynthesis reconstructed images. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:6188-91. PMID: 22255752.
      Citations: 9     Fields:    Translation:HumansCells
    50. Vedantham S, Karellas A. Modeling the performance characteristics of computed radiography (CR) systems. IEEE Trans Med Imaging. 2010 Mar; 29(3):790-806. PMID: 20199915.
      Citations: 1     Fields:    
    51. Karathanasis E, Suryanarayanan S, Balusu SR, McNeeley K, Sechopoulos I, Karellas A, Annapragada AV, Bellamkonda RV. Imaging nanoprobe for prediction of outcome of nanoparticle chemotherapy by using mammography. Radiology. 2009 Feb; 250(2):398-406. PMID: 19188313.
      Citations: 45     Fields:    Translation:Animals
    52. Karellas A, Vedantham S. Breast cancer imaging: a perspective for the next decade. Med Phys. 2008 Nov; 35(11):4878-97. PMID: 19070222.
      Citations: 27     Fields:    Translation:Humans
    53. Sechopoulos I, Vedantham S, Suryanarayanan S, D'Orsi CJ, Karellas A. Monte Carlo and phantom study of the radiation dose to the body from dedicated CT of the breast. Radiology. 2008 Apr; 247(1):98-105. PMID: 18292479.
      Citations: 16     Fields:    Translation:Humans
    54. Karellas A, Lo JY, Orton CG. Point/Counterpoint. Cone beam x-ray CT will be superior to digital x-ray tomosynthesis in imaging the breast and delineating cancer. Med Phys. 2008 Feb; 35(2):409-11. PMID: 18383660.
      Citations: 6     Fields:    Translation:Humans
    55. Sechopoulos I, Suryanarayanan S, Vedantham S, D'Orsi CJ, Karellas A. Radiation dose to organs and tissues from mammography: Monte Carlo and phantom study. Radiology. 2008 Feb; 246(2):434-43. PMID: 18056857.
      Citations: 16     Fields:    Translation:HumansPHPublic Health
    56. Sechopoulos I, Suryanarayanan S, Vedantham S, D'Orsi CJ, Karellas A. Erratum: "Scatter radiation in digital tomosynthesis of the breast" [Med. Phys., - (2007)]. Med Phys. 2007 Sep; 34(9):3697. PMID: 28524954.
      Citations:    Fields:    
    57. Suryanarayanan S, Karellas A, Vedantham S, Sechopoulos I, D'Orsi CJ. Detection of simulated microcalcifications in a phantom with digital mammography: effect of pixel size. Radiology. 2007 Jul; 244(1):130-7. PMID: 17522348.
      Citations: 6     Fields:    Translation:Humans
    58. Karellas A. Mammographic pattern analysis: an emerging risk assessment tool. Acad Radiol. 2007 May; 14(5):511-2. PMID: 17434063.
      Citations: 2     Fields:    Translation:Humans
    59. Sechopoulos I, Suryanarayanan S, Vedantham S, D'Orsi CJ, Karellas A. Scatter radiation in digital tomosynthesis of the breast. Med Phys. 2007 Feb; 34(2):564-76. PMID: 17388174.
      Citations: 35     Fields:    Translation:Humans
    60. Sechopoulos I, Suryanarayanan S, Vedantham S, D'Orsi C, Karellas A. Computation of the glandular radiation dose in digital tomosynthesis of the breast. Med Phys. 2007 Jan; 34(1):221-32. PMID: 17278508.
      Citations: 48     Fields:    Translation:HumansPHPublic Health
    61. Suryanarayanan S, Karellas A, Vedantham S, Sechopoulos I. Theoretical analysis of high-resolution digital mammography. Phys Med Biol. 2006 Jun 21; 51(12):3041-55. PMID: 16757861.
      Citations: 5     Fields:    
    62. Suryanarayanan S, Karellas A, Vedantham S, Onishi SK. High-resolution imager for digital mammography: physical characterization of a prototype sensor. Phys Med Biol. 2005 Sep 07; 50(17):3957-69. PMID: 16177523.
      Citations: 4     Fields:    
    63. Suryanarayanan S, Karellas A, Vedantham S, Waldrop SM, D'Orsi CJ. Detection of simulated lesions on data-compressed digital mammograms. Radiology. 2005 Jul; 236(1):31-6. PMID: 15983071.
      Citations: 4     Fields:    Translation:Humans
    64. Vedantham S, Karellas A, Suryanarayanan S, Onishi SK. Solid-state fluoroscopic imager for high-resolution angiography: physical characteristics of an 8 cm x 8 cm experimental prototype. Med Phys. 2004 Jun; 31(6):1462-72. PMID: 15259649.
      Citations: 6     Fields:    Translation:Humans
    65. Vedantham S, Karellas A, Suryanarayanan S. Solid-state fluoroscopic imager for high-resolution angiography: parallel-cascaded linear systems analysis. Med Phys. 2004 May; 31(5):1258-68. PMID: 15191318.
      Citations: 18     Fields:    
    66. Suryanarayanan S, Karellas A, Vedantham S, Waldrop SM, D'Orsi CJ. A perceptual evaluation of JPEG 2000 image compression for digital mammography: contrast-detail characteristics. J Digit Imaging. 2004 Mar; 17(1):64-70. PMID: 15255520.
      Citations: 4     Fields:    
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