Loading...
Header Logo
Keywords
Last Name
Institution

Francis Ka Ming Chan PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentPathology
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-1664
vCardDownload vCard
    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentPathology
    DivisionAcademic Pathology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentImmunology and Virology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentCenter for AIDS Research


    Collapse Biography 
    Collapse education and training
    University of California, San Diego, San Diego, CA, United StatesBABiochemistry & Cell Biology
    University of California, Berkeley, Berkeley, CA, United StatesPHDMolecular & Cell Biology

    Collapse Overview 
    Collapse overview

    Academic Background

    Education:

    1991B.A.University of California, San Diego (Summa Cum Laude)
    1996Ph.D.University of California, Berkeley
    Dr. Francis Chan

    The Role of Programmed Cell Death in Immune Functions and Diseases

    Cell death plays an essential role in metazoan homeostasis. Members of the tumor necrosis factor (TNF) and TNF receptor (TNFR) family are crucial regulators of cell death. Our lab is interested in how cell death contributes to the induction of immune responses. One of the ways by which cell death can modulate immune responses is through the induction of programmed necrosis. Necrotic cell death is distinguished from apoptosis by extensive cell and organelle swelling, the early rupture of plasma membrane, and the lack of caspase activation. The release of endogenous cellular adjuvants can cause inflammation and stimulate immune responses. Our long-term goal is to understand the biochemical regulation of programmed necrosis and the role programmed necrosis plays in inflammation, virus infections, autoimmune diseases and cancers.

    Current projects:

    1. Molecular regulation of programmed necrosis

    Using RNA interference, we have recently identified several kinases including RIP1 and RIP3 that critically regulate programmed necrosis. We show that a pro-necrotic signaling complex containing RIP1 and RIP3 are critically required for the induction of programmed necrosis. We are currently investigating how the assembly of this RIP1-RIP3 complex is regulated. Moreover, we are interested in identifying the downstream substrates for the RIP1-RIP3 kinase complex, and the effector mechanism that causes necrotic cell injury.

    2. Programmed necrosis in anti-viral immunity

    One of the physiological situations in which necrosis plays an important role is during viral infections. Using vaccinia virus infections in mice as models, we have demonstrated a critical role for RIP3-dependent programmed necrosis in virus-induced inflammation and innate immune responses. We are currently examining whether programmed necrosis and the subsequent inflammation it causes may also impact the induction of adaptive immune responses. In addition, we are evaluating the role of programmed necrosis in other virus infections.

    3. How do viruses inhibit host cell death?

    Inhibition of host cell death is widely touted as an immune evasion strategy employed by viruses. In support of this hypothesis, many viruses encode inhibitors against the host cell death machinery. We have recently identified several classes of viral inhibitors that potently inhibits programmed necrosis. One of the challenges in the future will be to identify the molecular mechanisms by which viral inhibitors modulate the pro-necrotic signaling pathway.

    4. Regulation of TRAIL signaling in immune cells

    TRAIL (TNF-related apoptosis inducing ligand) is a TNF-like cytokine with potent cytotoxicity against many tumor cells, but are generally non-toxic to normal cells. Of the five identified TRAIL receptors, two are termed “decoys” due to their ability to negatively regulate the apoptotic function of other TRAIL receptors. We have found that signaling by TRAIL is in part regulated at the level of assembly of “pre-ligand complexes” between death receptors and the decoy receptors. Current and future efforts will focus on understanding how the assembly of different TRAIL receptor complexes regulates death and non-death signaling in immune cells and cancer cells.

    Figure 1

    Figure 1: Electron micrograph of a vaccinia virus infected cell undergoing programmed necrosis. Note that the dying cell exhibits extensive intracellular vacuolation and mitochondrial swelling.

    Figure 2

    Figure 2: Electron micrograph of a necrotic cell exhibiting extensive loss of plasma membrane integrity.

    Figure 3

    Figure 3: A cartoon representation of how necrotic cell injury can trigger inflammation and stimulation immune responses during virus infections.



    Collapse Rotation Projects

    Potential Rotation Projects

    1. Examining TRAIL-induced apoptosis in cancer and normal cells.
      We have found that primary CD8+ T-cellsare resistant towhile most of the cancer cells are sensitive to TRAIL-induced apoptosis. However, werecently found that certain stimulation to the cells can reverse the cellular sensitivity to TRAIL. In this rotation project, the student will examine the molecular signals that controlcellular sensitivity to TRAIL-induced apoptosis.Specifically, the students will examine the role of lipid rafts and protein kinase C in regulating TRAIL response. The student will learn standard biochemical and molecular biology techniques in this project. In addition, the student willbe exposed to concepts relating to receptor signal transduction, cell death and TNF receptor biology.

    2. Molecular regulation of programmed necrosis.
      TNF stimulation through TNF receptors activates a myriad of biological responses ranging from cell death to inflammation. Interestingly, apoptosisis a dominant cell death pathway over programmed necrosis. Thus, inhibition of caspases, which is an essential step during apoptosis,is crucial for the induction of programmed necrosis. In this rotation project, the student will examine the signals that control the induction of apoptosis versus programmed necrosis. Specifically, the student will examine the role of several TNF receptor signaling molecules such as caspase-8, RIP and TRAF2 in this process.The students will learn about cell death and TNF receptor biology in this project.

    3. TNF-induced programmed necrosis in viral infections.
      We have identified several viral proteins termed vFLIPs that are potent inhibitors of TNF-indcued apoptosis and programmed necrosis. This finding strongly suggests that apoptosis and programmed necrosis play central role in host defense against viral infections.Inthis rotation project, the student will examinetransgenic mice that express a potent cell death inhibitor for their immune response to viral infections.The student will learn different immunological techniques and concepts in this rotation project.


    Collapse Post Docs

    A postdoctoral position is available
    to study in this laboratory.
    Contact Dr. Chan for additional details.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. DeSouza-Vieira T, Chan FK. Bacterial pathogenesis: Pathogenic bacteria attack RHIM. Nat Microbiol. 2017 Mar 28; 2:17042. PMID: 28349936.
      View in: PubMed
    2. Moriwaki K, Balaji S, Bertin J, Gough PJ, Chan FK. Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair. Cell Rep. 2017 Mar 07; 18(10):2441-2451. PMID: 28273458.
      View in: PubMed
    3. Qian Y, Wong CC, Xu J, Chen H, Zhang Y, Kang W, Wang H, Zhang L, Li W, Chu ESH, Go MYY, Chiu PWY, Ng EKW, Chan FKL, Sung JJY, Si J, Yu J. Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation. Cancer Res. 2017 Apr 15; 77(8):1968-1982. PMID: 28202509.
      View in: PubMed
    4. Orlowski GM, Sharma S, Colbert JD, Bogyo M, Robertson SA, Kataoka H, Chan FK, Rock KL. Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1ß activation. J Leukoc Biol. 2017 Jan 13. PMID: 28087651.
      View in: PubMed
    5. Moriwaki K, Chan FK. The Inflammatory Signal Adaptor RIPK3: Functions Beyond Necroptosis. Int Rev Cell Mol Biol. 2017; 328:253-275. PMID: 28069136.
      View in: PubMed
    6. Chan FK. RIPK3 Slams the Brake on Leukemogenesis. Cancer Cell. 2016 Jul 11; 30(1):7-9. PMID: 27411581.
      View in: PubMed
    7. Moriwaki K, Balaji S, Chan FK. Border Security: The Role of RIPK3 in Epithelium Homeostasis. Front Cell Dev Biol. 2016; 4:70. PMID: 27446921.
      View in: PubMed
    8. Farias Luz N, Balaji S, Okuda K, Barreto AS, Bertin J, Gough PJ, Gazzinelli R, Almeida RP, Bozza MT, Borges VM, Chan FK. RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms. J Immunol. 2016 Jun 15; 196(12):5056-63. PMID: 27183605.
      View in: PubMed
    9. Shi HY, Chan FK, Leung WK, Li MK, Leung CM, Sze SF, Ching JY, Lo FH, Tsang SW, Shan EH, Mak LY, Lam BC, Hui AJ, Chow WH, Wong MT, Hung IF, Hui YT, Chan YK, Chan KH, Loo CK, Ng CK, Lao WC, Harbord M, Wu JC, Sung JJ, Ng SC. Low-dose azathioprine is effective in maintaining remission in steroid-dependent ulcerative colitis: results from a territory-wide Chinese population-based IBD registry. Therap Adv Gastroenterol. 2016 Jul; 9(4):449-56. PMID: 27366213.
      View in: PubMed
    10. Moriwaki K, Chan FK. Necroptosis-independent signaling by the RIP kinases in inflammation. Cell Mol Life Sci. 2016 Jun; 73(11-12):2325-34. PMID: 27048814.
      View in: PubMed
    11. Ananthakrishnan AN, Shi HY, Tang W, Law CC, Sung JJ, Chan FK, Ng SC. Systematic Review and Meta-analysis: Phenotype and Clinical Outcomes of Older-onset Inflammatory Bowel Disease. J Crohns Colitis. 2016 Oct; 10(10):1224-36. PMID: 26928965.
      View in: PubMed
    12. Zhang L, Wu WK, Gallo RL, Fang EF, Hu W, Ling TK, Shen J, Chan RL, Lu L, Luo XM, Li MX, Chan KM, Yu J, Wong VW, Ng SC, Wong SH, Chan FK, Sung JJ, Chan MT, Cho CH. Critical Role of Antimicrobial Peptide Cathelicidin for Controlling Helicobacter pylori Survival and Infection. J Immunol. 2016 Feb 15; 196(4):1799-809. PMID: 26800870.
      View in: PubMed
    13. Moriwaki K, Chan FK. Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome. J Biol Chem. 2016 Mar 11; 291(11):5948-59. PMID: 26786097.
      View in: PubMed
    14. Moriwaki K, Farias Luz N, Balaji S, De Rosa MJ, O'Donnell CL, Gough PJ, Bertin J, Welsh RM, Chan FK. The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages. J Immunol. 2016 Jan 01; 196(1):407-15. PMID: 26582950.
      View in: PubMed
    15. Luo MX, Wong SH, Chan MT, Yu L, Yu SS, Wu F, Xiao Z, Wang X, Zhang L, Cheng AS, Ng SS, Chan FK, Cho CH, Yu J, Sung JJ, Wu WK. Autophagy Mediates HBx-Induced Nuclear Factor-?B Activation and Release of IL-6, IL-8, and CXCL2 in Hepatocytes. J Cell Physiol. 2015 Oct; 230(10):2382-9. PMID: 25708728.
      View in: PubMed
    16. Moriwaki K, Bertin J, Gough PJ, Orlowski GM, Chan FK. Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death. Cell Death Dis. 2015 Feb 12; 6:e1636. PMID: 25675296; PMCID: PMC4669795.
    17. Moriwaki K, Bertin J, Gough PJ, Chan FK. A RIPK3-caspase 8 complex mediates atypical pro-IL-1ß processing. J Immunol. 2015 Feb 15; 194(4):1938-44. PMID: 25567679.
      View in: PubMed
    18. Chan FK, Luz NF, Moriwaki K. Programmed necrosis in the cross talk of cell death and inflammation. Annu Rev Immunol. 2015; 33:79-106. PMID: 25493335.
      View in: PubMed
    19. Mandal P, Berger SB, Pillay S, Moriwaki K, Huang C, Guo H, Lich JD, Finger J, Kasparcova V, Votta B, Ouellette M, King BW, Wisnoski D, Lakdawala AS, DeMartino MP, Casillas LN, Haile PA, Sehon CA, Marquis RW, Upton J, Daley-Bauer LP, Roback L, Ramia N, Dovey CM, Carette JE, Chan FK, Bertin J, Gough PJ, Mocarski ES, Kaiser WJ. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20; 56(4):481-95. PMID: 25459880.
      View in: PubMed
    20. Wong SH, Ip M, Tang W, Lin Z, Kee C, Hung E, Lui G, Lee N, Chan FK, Wu JC, Sung JJ, Ng SC. Performance of interferon-gamma release assay for tuberculosis screening in inflammatory bowel disease patients. Inflamm Bowel Dis. 2014 Nov; 20(11):2067-72. PMID: 25159454.
      View in: PubMed
    21. Moriwaki K, Balaji S, McQuade T, Malhotra N, Kang J, Chan FK. The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair. Immunity. 2014 Oct 16; 41(4):567-78. PMID: 25367573.
      View in: PubMed
    22. Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015 Jan; 22(1):58-73. PMID: 25236395.
      View in: PubMed
    23. Chan FK. Cell biology: A guardian angel of cell integrity. Nature. 2014 Sep 4; 513(7516):38-40. PMID: 25186894.
      View in: PubMed
    24. Polykratis A, Hermance N, Zelic M, Roderick J, Kim C, Van TM, Lee TH, Chan FK, Pasparakis M, Kelliher MA. Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo. J Immunol. 2014 Aug 15; 193(4):1539-43. PMID: 25015821.
      View in: PubMed
    25. Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, Mocarski ES, Pouliot K, Chan FK, Kelliher MA, Harris PA, Bertin J, Gough PJ, Shayakhmetov DM, Goguen JD, Fitzgerald KA, Silverman N, Lien E. Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7391-6. PMID: 24799678.
      View in: PubMed
    26. Upton JW, Chan FK. Staying alive: cell death in antiviral immunity. Mol Cell. 2014 Apr 24; 54(2):273-80. PMID: 24766891.
      View in: PubMed
    27. Zhang J, Chan FK. Cell biology. RIPK3 takes another deadly turn. Science. 2014 Mar 21; 343(6177):1322-3. PMID: 24653026.
      View in: PubMed
    28. Moriwaki K, Chan FK. Necrosis-dependent and independent signaling of the RIP kinases in inflammation. Cytokine Growth Factor Rev. 2014 Apr; 25(2):167-74. PMID: 24412261.
      View in: PubMed
    29. McQuade T, Cho Y, Chan FK. Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis. Biochem J. 2013 Dec 15; 456(3):409-15. PMID: 24059293.
      View in: PubMed
    30. Moquin DM, McQuade T, Chan FK. CYLD deubiquitinates RIP1 in the TNFa-induced necrosome to facilitate kinase activation and programmed necrosis. PLoS One. 2013; 8(10):e76841. PMID: 24098568.
      View in: PubMed
    31. Moriwaki K, Chan FK. RIP3: a molecular switch for necrosis and inflammation. Genes Dev. 2013 Aug 1; 27(15):1640-9. PMID: 23913919.
      View in: PubMed
    32. Wang XJ, Yu J, Wong SH, Cheng AS, Chan FK, Ng SS, Cho CH, Sung JJ, Wu WK. A novel crosstalk between two major protein degradation systems: regulation of proteasomal activity by autophagy. Autophagy. 2013 Oct; 9(10):1500-8. PMID: 23934082.
      View in: PubMed
    33. Sosna J, Voigt S, Mathieu S, Lange A, Thon L, Davarnia P, Herdegen T, Linkermann A, Rittger A, Chan FK, Kabelitz D, Schütze S, Adam D. TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. Cell Mol Life Sci. 2014 Jan; 71(2):331-48. PMID: 23760205.
      View in: PubMed
    34. Dong Y, Zhao J, Wu CW, Zhang L, Liu X, Kang W, Leung WW, Zhang N, Chan FK, Sung JJ, Ng SS, Yu J. Tumor suppressor functions of miR-133a in colorectal cancer. Mol Cancer Res. 2013 Sep; 11(9):1051-60. PMID: 23723074.
      View in: PubMed
    35. Chan FK, Moriwaki K, De Rosa MJ. Detection of necrosis by release of lactate dehydrogenase activity. Methods Mol Biol. 2013; 979:65-70. PMID: 23397389.
      View in: PubMed
    36. Kim CK, Toft JE, Papenfus M, Verutes G, Guerry AD, Ruckelshaus MH, Arkema KK, Guannel G, Wood SA, Bernhardt JR, Tallis H, Plummer ML, Halpern BS, Pinsky ML, Beck MW, Chan F, Chan KM, Levin PS, Polasky S. Catching the right wave: evaluating wave energy resources and potential compatibility with existing marine and coastal uses. PLoS One. 2012; 7(11):e47598. PMID: 23144824.
      View in: PubMed
    37. Chan FK. Fueling the flames: Mammalian programmed necrosis in inflammatory diseases. Cold Spring Harb Perspect Biol. 2012 Nov 01; 4(11). PMID: 23125016.
      View in: PubMed
    38. Ren SX, Cheng AS, To KF, Tong JH, Li MS, Shen J, Shen J, Wong CC, Zhang L, Chan RL, Wang XJ, Ng SS, Chiu LC, Marquez VE, Gallo RL, Chan FK, Yu J, Sung JJ, Wu WK, Cho CH. Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res. 2012 Dec 15; 72(24):6512-23. PMID: 23100468.
      View in: PubMed
    39. Cheng AS, Li MS, Kang W, Cheng VY, Chou JL, Lau SS, Go MY, Lee CC, Ling TK, Ng EK, Yu J, Huang TH, To KF, Chan MW, Sung JJ, Chan FK. Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis. Gastroenterology. 2013 Jan; 144(1):122-133.e9. PMID: 23058321.
      View in: PubMed
    40. Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H. The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell. 2012 Jul 20; 150(2):339-50. PMID: 22817896.
      View in: PubMed
    41. Chan FK, Baehrecke EH. RIP3 finds partners in crime. Cell. 2012 Jan 20; 148(1-2):17-8. PMID: 22265396.
      View in: PubMed
    42. Fortes GB, Alves LS, de Oliveira R, Dutra FF, Rodrigues D, Fernandez PL, Souto-Padron T, De Rosa MJ, Kelliher M, Golenbock D, Chan FK, Bozza MT. Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. Blood. 2012 Mar 8; 119(10):2368-75. PMID: 22262768.
      View in: PubMed
    43. Cho Y, McQuade T, Zhang H, Zhang J, Chan FK. RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. PLoS One. 2011; 6(8):e23209. PMID: 21853090.
      View in: PubMed
    44. Steindler L, Schwalbach MS, Smith DP, Chan F, Giovannoni SJ. Energy starved Candidatus Pelagibacter ubique substitutes light-mediated ATP production for endogenous carbon respiration. PLoS One. 2011; 6(5):e19725. PMID: 21573025.
      View in: PubMed
    45. Zhang H, Zhou X, McQuade T, Li J, Chan FK, Zhang J. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature. 2011 Mar 17; 471(7338):373-6. PMID: 21368761.
      View in: PubMed
    46. Cho Y, Challa S, Chan FK. A RNA interference screen identifies RIP3 as an essential inducer of TNF-induced programmed necrosis. Adv Exp Med Biol. 2011; 691:589-93. PMID: 21153365.
      View in: PubMed
    47. Challa S, Woelfel M, Guildford M, Moquin D, Chan FK. Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection. J Virol. 2010 Oct; 84(20):10467-76. PMID: 20702623.
      View in: PubMed
    48. Challa S, Chan FK. Going up in flames: necrotic cell injury and inflammatory diseases. Cell Mol Life Sci. 2010 Oct; 67(19):3241-53. PMID: 20532807.
      View in: PubMed
    49. Cho YS, Challa S, Clancy L, Chan FK. Lipopolysaccharide-induced expression of TRAIL promotes dendritic cell differentiation. Immunology. 2010 Aug; 130(4):504-15. PMID: 20406302.
      View in: PubMed
    50. Cho YS, Park SY, Shin HS, Chan FK. Physiological consequences of programmed necrosis, an alternative form of cell demise. Mol Cells. 2010 Apr; 29(4):327-32. PMID: 20390367.
      View in: PubMed
    51. Moquin D, Chan FK. The molecular regulation of programmed necrotic cell injury. Trends Biochem Sci. 2010 Aug; 35(8):434-41. PMID: 20346680.
      View in: PubMed
    52. Liu X, Wang X, Zhang J, Lam EK, Shin VY, Cheng AS, Yu J, Chan FK, Sung JJ, Jin HC. Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis. Oncogene. 2010 Jan 21; 29(3):442-50. PMID: 19881551.
      View in: PubMed
    53. Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell. 2009 Jun 12; 137(6):1112-23. PMID: 19524513.
      View in: PubMed
    54. Wang LJ, Jin HC, Wang X, Lam EK, Zhang JB, Liu X, Chan FK, Si JM, Sung JJ. ZIC1 is downregulated through promoter hypermethylation in gastric cancer. Biochem Biophys Res Commun. 2009 Feb 20; 379(4):959-63. PMID: 19135984.
      View in: PubMed
    55. Yu J, Cheng YY, Tao Q, Cheung KF, Lam CN, Geng H, Tian LW, Wong YP, Tong JH, Ying JM, Jin H, To KF, Chan FK, Sung JJ. Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer. Gastroenterology. 2009 Feb; 136(2):640-51.e1. PMID: 19084528.
      View in: PubMed
    56. Cheng YY, Yu J, Wong YP, Man EP, To KF, Jin VX, Li J, Tao Q, Sung JJ, Chan FK, Leung WK. Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer. Br J Cancer. 2007 Oct 8; 97(7):895-901. PMID: 17848950.
      View in: PubMed
    57. Chan FK. Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling. Cytokine. 2007 Feb; 37(2):101-7. PMID: 17449269.
      View in: PubMed
    58. Woelfel M, Bixby J, Brehm MA, Chan FK. Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity. J Immunol. 2006 Sep 15; 177(6):3814-20. PMID: 16951343.
      View in: PubMed
    59. Sedger LM, Osvath SR, Xu XM, Li G, Chan FK, Barrett JW, McFadden G. Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death. J Virol. 2006 Sep; 80(18):9300-9. PMID: 16940541.
      View in: PubMed
    60. Leung DT, van Maren WW, Chan FK, Chan WS, Lo AW, Ma CH, Tam FC, To KF, Chan PK, Sung JJ, Lim PL. Extremely low exposure of a community to severe acute respiratory syndrome coronavirus: false seropositivity due to use of bacterially derived antigens. J Virol. 2006 Sep; 80(18):8920-8. PMID: 16940504.
      View in: PubMed
    61. Zheng L, Bidere N, Staudt D, Cubre A, Orenstein J, Chan FK, Lenardo M. Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. Mol Cell Biol. 2006 May; 26(9):3505-13. PMID: 16611992.
      View in: PubMed
    62. Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FK. Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18099-104. PMID: 16319225.
      View in: PubMed
    63. Deng GM, Zheng L, Chan FK, Lenardo M. Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. Nat Med. 2005 Oct; 11(10):1066-72. PMID: 16170321.
      View in: PubMed
    64. To KF, Chan MW, Leung WK, Ng EK, Yu J, Bai AH, Lo AW, Chu SH, Tong JH, Lo KW, Sung JJ, Chan FK. Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line. Br J Cancer. 2004 Oct 04; 91(7):1335-41. PMID: 15354212; PMCID: PMC2409891.
    65. Grantham BA, Chan F, Nielsen KJ, Fox DS, Barth JA, Huyer A, Lubchenco J, Menge BA. Upwelling-driven nearshore hypoxia signals ecosystem and oceanographic changes in the northeast Pacific. Nature. 2004 Jun 17; 429(6993):749-54. PMID: 15201908.
      View in: PubMed
    66. Chan FK, Holmes KL. Flow cytometric analysis of fluorescence resonance energy transfer: a tool for high-throughput screening of molecular interactions in living cells. Methods Mol Biol. 2004; 263:281-92. PMID: 14976372.
      View in: PubMed
    67. Chan FK. Monitoring molecular interactions in living cells using flow cytometric analysis of fluorescence resonance energy transfer. Methods Mol Biol. 2004; 261:371-82. PMID: 15064470.
      View in: PubMed
    68. Chan FK, Shisler J, Bixby JG, Felices M, Zheng L, Appel M, Orenstein J, Moss B, Lenardo MJ. A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. J Biol Chem. 2003 Dec 19; 278(51):51613-21. PMID: 14532286.
      View in: PubMed
    69. Chan FK, Lenardo MJ. Tumor Necrosis Factor Family Ligands and Receptors in the Immune System: Targets for Future Pharmaceuticals. Drug News Perspect. 2002 Oct; 15(8):483-490. PMID: 12677186.
      View in: PubMed
    70. Chan FK, Siegel RM, Zacharias D, Swofford R, Holmes KL, Tsien RY, Lenardo MJ. Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein. Cytometry. 2001 Aug 1; 44(4):361-8. PMID: 11500853.
      View in: PubMed
    71. Siegel RM, Chan FK, Chun HJ, Lenardo MJ. The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Nat Immunol. 2000 Dec; 1(6):469-74. PMID: 11101867.
      View in: PubMed
    72. Chan FK. The pre-ligand binding assembly domain: a potential target of inhibition of tumour necrosis factor receptor function. Ann Rheum Dis. 2000 Nov; 59 Suppl 1:i50-3. PMID: 11053089.
      View in: PubMed
    73. Chan FK, Chun HJ, Zheng L, Siegel RM, Bui KL, Lenardo MJ. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science. 2000 Jun 30; 288(5475):2351-4. PMID: 10875917.
      View in: PubMed
    74. Siegel RM, Frederiksen JK, Zacharias DA, Chan FK, Johnson M, Lynch D, Tsien RY, Lenardo MJ. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science. 2000 Jun 30; 288(5475):2354-7. PMID: 10875918.
      View in: PubMed
    75. Siegel RM, Chan FK, Zacharias DA, Swofford R, Holmes KL, Tsien RY, Lenardo MJ. Measurement of molecular interactions in living cells by fluorescence resonance energy transfer between variants of the green fluorescent protein. Sci STKE. 2000 Jun 27; 2000(38):pl1. PMID: 11752595.
      View in: PubMed
    76. Chan FK, Lenardo MJ. A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes. Eur J Immunol. 2000 Feb; 30(2):652-60. PMID: 10671223.
      View in: PubMed
    77. Wang J, Zheng L, Lobito A, Chan FK, Dale J, Sneller M, Yao X, Puck JM, Straus SE, Lenardo MJ. Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell. 1999 Jul 9; 98(1):47-58. PMID: 10412980.
      View in: PubMed
    78. Brunner MC, Chambers CA, Chan FK, Hanke J, Winoto A, Allison JP. CTLA-4-Mediated inhibition of early events of T cell proliferation. J Immunol. 1999 May 15; 162(10):5813-20. PMID: 10229815.
      View in: PubMed
    79. Chan FK, Chen A, Winoto A. Thymic expression of the transcription factor Nur77 rescues the T cell but not the B cell abnormality of gld/gld mice. J Immunol. 1998 Oct 15; 161(8):4252-6. PMID: 9780200.
      View in: PubMed
    80. Cheng LE, Chan FK, Cado D, Winoto A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 1997 Apr 15; 16(8):1865-75. PMID: 9155013.
      View in: PubMed
    81. Calnan BJ, Szychowski S, Chan FK, Cado D, Winoto A. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity. 1995 Sep; 3(3):273-82. PMID: 7552993.
      View in: PubMed
    82. Chan FK, Zhang J, Cheng L, Shapiro DN, Winoto A. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol. 1995 May; 15(5):2682-8. PMID: 7739548.
      View in: PubMed
    83. Itano A, Cado D, Chan FK, Robey E. A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection. Immunity. 1994 Jul; 1(4):287-90. PMID: 7889416.
      View in: PubMed
    For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
    Chan's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _