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Gang Han PhD

InstitutionUMass Chan Medical School
DepartmentBiochemistry and Molecular Biotechnology
AddressUMass Chan Medical School
364 Plantation Street LRB 806
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    Collapse Biography 
    Collapse education and training
    Nanjing University, Nanjing, , ChinaBSChemistry
    Nanjing University, Nanjing, , ChinaMSInorganic Chemistry
    University of Massachusetts Amherst, Amherst, MA, United StatesPHDChemistry
    Collapse awards and honors
    2011 - 2012Worcester Foundation Mel Cutler Award, The Hudson Hoagland Society
    2013 - 20142013 Commercial Ventures and Intellectual Property Award (UMass), University of Massachusetts
    2013 - 2017Exceptional Unconventional Research Enabling Knowledge Acceleration (EUREKA) Award, NIH
    2014the Human Frontier Science Program Award, HFSP
    2014UMASS Clinical and Translational Science Award (UMCCTS) Pilot Award, University of Massachusetts
    2014 - 2016Alex’s Lemonade Stand Foundation Innovation Award, Alex’s Lemonade Stand Foundation for Childhood Cancer
    2014Materials Horizons Symposia Award, Royal Society of Chemistry
    2016OTCV Technology development Fund , University of Massachusetts

    Collapse Overview 
    Collapse overview

    Nanomaterials for Neuroscience, Biomolecule Imaging and Therapy

    email: gang.han@umassmed.edu

    B.S. Nanjing University,Ph.D. University of Massachusetts-Amherst ,Postdoctoral Fellow. The Molecule Foundry, Lawrence Berkeley Lab. Phone: 508-856-3297


    My research is at the intersection between nanotechnology, neuroscience, bioimaging and therapy. We focus on developing both small and bright tools for biology, that is, designing synthetic/semi-synthetic nanomaterials or small molecules with unique programmable physical properties for basic science and biomedical applications.  These tools will be developed using a synergetic multidisciplinary approach, including synthetic chemistry, materials science, biochemistry, and cell biology.  In particular, we are most interested in developing optically active nanomaterials/molecules for probing signal transduction pathways, single-molecule imaging, sptiotemperol activation of neurons as well as diagnosis and drug delivery.

    Contact: email: gang.han@umassmed.edu Phone : 508-856-3297

    People in Lab:

    Postdoctoral fellows:Yuanwei Zhang, Zhanjun Li, Jie Shen,  Graduate student: Xiang Wu,LWA/MQP student : Amol Punjabi, Hyungseok Alex Lee, George Han, Andrew Seto,  Rohit Maudgal


    Postdoctoral fellows Yekui Zou (  2010- 2012, MIT)

    Graduate students: Liang Zhao (2012 , Lecturer, Dalian University of Technology)

    LWA students :Samuel J. Kesseli (2010-2013,  now MD student at Dartmouth Geisel School of Medicine)

    Lucas J. Brutvan, (2011, Process Engineer at 3M),

    Anne-Marie Vu (2013, Tufts University)

    Steven Buchholz (2011, Product Analyst at Boston Scientific)

    El-rifai, Mahmoud (2013-1014 Massachusetts Eye and Ear, Harvard Medical School), Amira Tokatli-Apollon(2013-2014  Design Assurance Engineer, HOLOGIC)

     Erin May Laroche; Rachael M. Matty; Babeu, Amy Monique; Cardoso, Marlisa Anne(2013 WPI)

    Ayers, Brian Christopher (2013, MD/MBA Student - University of Rochester)

    Luis Figueroa(2014, UMASS-Amherst)

    Past rotation students: Xizhe Gao (2011, now Ph.D student at University of Maryland Baltimore School of Pharmacy), Artem Kutikov, (2011, Ph.D student at UMMS ), Lejie Zhang( 2013, Ph. D student at UMMS)


    Collapse Rotation Projects

    Rotation projects

    (1) Specific cell membrane component labeling using bioconjugated nanoparticles

    (2) To develop tools for targeted and traceable siRNA delivery

    (3) To synthesize functional nanomaterials for detecting biomarkers in biological fluids

    Collapse Post Docs

    Positions for  postdoctoral fellows are available in the laboratory of Dr. Gang Han at the Department of Biochemistry and Molecular Pharmacology of The University of Massachusetts- Medical School.

    Research will focus on developing   novel small molecule/ nanoparticle approaches for translational biomedical sciences and molecular imaging.

    Qualifications: Candidates have a Ph.D degree in (1)Organic Chemistry/polymer synthesis , (2) Molecular cell biology , (3) Biophysics or (4) Biochemistry. A solid training and substantial organic synthesis, animal experiments,  spectroscopy and  microscopy are desired.  Candidates need to have strong work ethic, creativity, and enthusiasm with proven ability to work independently and collaboratively.

    To apply: Applicants should submit their CV including a full publication list and sources of three reference letters by email to gang.han@umassmed.edu

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zeng L, Huang L, Lin W, Jiang LH, Han G. Red light-driven electron sacrificial agents-free photoreduction of inert aryl halides via triplet-triplet annihilation. Nat Commun. 2023 Feb 27; 14(1):1102. PMID: 36843133.
      Citations: 7     Fields:    
    2. Zeng L, Jiang LH, Li JY, Huang L, Chen Y, Yu N, Wang L, Huang K, Peng J, Han G. Metal-Free Far-Red Light-Driven Photolysis via Triplet Fusion to Enhance Checkpoint Blockade Immunotherapy. Angew Chem Int Ed Engl. 2023 03 06; 62(11):e202218341. PMID: 36634030.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Zeng L, Huang L, Han J, Han G. Enhancing Triplet-Triplet Annihilation Upconversion: From Molecular Design to Present Applications. Acc Chem Res. 2022 Sep 20; 55(18):2604-2615. PMID: 36074952.
      Citations: 6     Fields:    
    4. Huang K, Liu X, Han G, Zhou Y. Nano-optogenetic immunotherapy. Clin Transl Med. 2022 09; 12(9):e1020. PMID: 36101937.
      Citations: 6     Fields:    Translation:HumansCells
    5. Zeng L, Huang L, Han G. Dye Doped Metal-Organic Frameworks for Enhanced Phototherapy. Adv Drug Deliv Rev. 2022 Oct; 189:114479. PMID: 35932906.
      Citations:    Fields:    Translation:Humans
    6. Huang K, Le N, Wang JS, Huang L, Zeng L, Xu WC, Li Z, Li Y, Han G. Designing Next Generation of Persistent Luminescence: Recent Advances in Uniform Persistent Luminescence Nanoparticles. Adv Mater. 2022 Apr; 34(14):e2107962. PMID: 34877721.
      Citations: 5     Fields:    
    7. Huang K, Li Z, Li Y, Yu N, Gao X, Huang L, Lim SF, Han G. Three-Dimensional Colloidal Controlled Growth of Core-Shell Heterostructured Persistent Luminescence Nanocrystals. Nano Lett. 2021 06 23; 21(12):4903-4910. PMID: 34100617.
      Citations: 2     Fields:    
    8. Li Z, Zhao Y, Huang K, Huang L, Zhang Y, Yang H, Han G. Enhancing Rechargeable Persistent Luminescence via Organic Dye Sensitization. Angew Chem Int Ed Engl. 2021 07 12; 60(29):15886-15890. PMID: 33860576.
      Citations: 2     Fields:    
    9. Huang L, Le T, Huang K, Han G. Enzymatic enhancing of triplet-triplet annihilation upconversion by breaking oxygen quenching for background-free biological sensing. Nat Commun. 2021 03 26; 12(1):1898. PMID: 33772017.
      Citations: 6     Fields:    Translation:HumansCells
    10. Huang L, Zeng L, Chen Y, Yu N, Wang L, Huang K, Zhao Y, Han G. Long wavelength single photon like driven photolysis via triplet triplet annihilation. Nat Commun. 2021 01 05; 12(1):122. PMID: 33402702.
      Citations: 5     Fields:    
    11. Li Z, Yu N, Zhou J, Li Y, Zhang Y, Huang L, Huang K, Zhao Y, Kelmar S, Yang J, Han G. Coloring Afterglow Nanoparticles for High-Contrast Time-Gating-Free Multiplex Luminescence Imaging. Adv Mater. 2020 Dec; 32(49):e2003881. PMID: 33145880.
      Citations: 7     Fields:    
    12. Huang L, Wu W, Li Y, Huang K, Zeng L, Lin W, Han G. Highly Effective Near-Infrared Activating Triplet-Triplet Annihilation Upconversion for Photoredox Catalysis. J Am Chem Soc. 2020 10 28; 142(43):18460-18470. PMID: 33074671.
      Citations: 14     Fields:    
    13. Zhou Y, Zhang Y, Lin W, Kesseli SJ, Huang L, Zhao Y, Yao X, Huang K, Han G. Wavelength-Selective Light-Controlled Stepwise Photolysis from Single Gold Nanoparticles. Adv Healthc Mater. 2021 03; 10(5):e2000321. PMID: 33034955.
      Citations:    Fields:    Translation:Cells
    14. Lin W, Colombani-Garay D, Huang L, Duan C, Han G. Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 07; 12(4):e1627. PMID: 32164043.
      Citations: 3     Fields:    Translation:HumansAnimals
    15. Lin W, Zhang W, Liu S, Li Z, Hu X, Xie Z, Duan C, Han G. Engineering pH-Responsive BODIPY Nanoparticles for Tumor Selective Multimodal Imaging and Phototherapy. ACS Appl Mater Interfaces. 2019 Nov 27; 11(47):43928-43935. PMID: 31682101.
      Citations: 6     Fields:    Translation:HumansAnimals
    16. Huang L, Kakadiaris E, Vaneckova T, Huang K, Vaculovicova M, Han G. Designing next generation of photon upconversion: Recent advances in organic triplet-triplet annihilation upconversion nanoparticles. Biomaterials. 2019 05; 201:77-86. PMID: 30802685.
      Citations: 13     Fields:    Translation:Cells
    17. Yu N, Huang L, Zhou Y, Xue T, Chen Z, Han G. Near-Infrared-Light Activatable Nanoparticles for Deep-Tissue-Penetrating Wireless Optogenetics. Adv Healthc Mater. 2019 03; 8(6):e1801132. PMID: 30633858.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    18. Huang L, Han G. Near Infrared Boron Dipyrromethene Nanoparticles for Optotheranostics. Small Methods. 2018 Sep 11; 2(9). PMID: 31872045.
      Citations: 7     Fields:    
    19. Ma G, Liu J, Ke Y, Liu X, Li M, Wang F, Han G, Huang Y, Wang Y, Zhou Y. Optogenetic Control of Voltage-Gated Calcium Channels. Angew Chem Int Ed Engl. 2018 06 11; 57(24):7019-7022. PMID: 29569306.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    20. Wang M, Deng K, L? W, Deng X, Li K, Shi Y, Ding B, Cheng Z, Xing B, Han G, Hou Z, Lin J. Rational Design of Multifunctional Fe@?-Fe2 O3 @H-TiO2 Nanocomposites with Enhanced Magnetic and Photoconversion Effects for Wide Applications: From Photocatalysis to Imaging-Guided Photothermal Cancer Therapy. Adv Mater. 2018 Mar; 30(13):e1706747. PMID: 29441613.
      Citations: 10     Fields:    Translation:Humans
    21. Ling Huang,Zhanxian Gao,Gang Han. Photoswitchable Near-Infrared-Emitting Boron-dipyrromethene (BODIPY) Nanoparticles. Particle & particle systems characterization. 2017. View Publication.
    22. Huang L, Zhao Y, Zhang H, Huang K, Yang J, Han G. Expanding Anti-Stokes Shifting in Triplet-Triplet Annihilation Upconversion for In Vivo Anticancer Prodrug Activation. Angew Chem Int Ed Engl. 2017 11 13; 56(46):14400-14404. PMID: 28875533.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    23. Ling Huang, Yang Zhao, He Zhang, Kai Huang, Jingyi Yang, and Gang Han. Expanding Anti-Stokes Shifting in Triplet-triplet Annihilation Upconversion for In Vivo Anticancer Prodrug Activation. Angewandte Chemie International Edition (online accepted article). 2017. View Publication.
    24. Zhao Y, Peng J, Li J, Huang L, Yang J, Huang K, Li H, Jiang N, Zheng S, Zhang X, Niu Y, Han G. Tumor-Targeted and Clearable Human Protein-Based MRI Nanoprobes. Nano Lett. 2017 07 12; 17(7):4096-4100. PMID: 28581764.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    25. Liang Zhao, Xiang Wu, Xiaofeng Wang, Chunying Duan, Hongyan Wang, Amol Punjabi, Yang Zhao, Yuanwei Zhang, Zuoshang Xu, Haifeng Gao, Gang Han. Development of Excipient-Free Freeze-Dryable Unimolecular Hyperstar Polymers for Efficient siRNA Silencing. ACS Macro Letters. 2017; (6):700. View Publication.
    26. Zhao L, Wu X, Wang X, Duan C, Wang H, Punjabi A, Zhao Y, Zhang Y, Xu Z, Gao H, Han G. Development of Excipient-Free Freeze-Dryable Unimolecular Hyperstar Polymers for Efficient siRNA Silencing. ACS Macro Lett. 2017 Jul 18; 6(7):700-704. PMID: 35650873.
      Citations:    Fields:    
    27. Lihua Li, Xianfeng Yang, Xiaoming Hu, Yao Lu, Liping Wang, Mingying Peng, Hong Xia, Qingshui Yin, Yu Zhang and Gang Han. Multifunctional Cu39S28 Hollow Nanopeanuts for In Vivo Targeted Photothermal Chemotherapy. Journal of Materials Chemistry B. 2017. View Publication.
    28. Huang L, Li Z, Zhao Y, Yang J, Yang Y, Pendharkar AI, Zhang Y, Kelmar S, Chen L, Wu W, Zhao J, Han G. Enhancing Photodynamic Therapy through Resonance Energy Transfer Constructed Near-Infrared Photosensitized Nanoparticles. Adv Mater. 2017 07; 29(28). PMID: 28586102.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    29. Zhanjun Li, Ling Huang, Yuanwei Zhang, Yang Zhao, Hong Yang, and Gang Han. Near-infrared light activated persistent luminescence nanoparticles via upconversion. Nano Research. 2017. View Publication.
    30. Zhang Y, Yang H, Zhou Z, Huang K, Yang S, Han G. Recent Advances on Magnetic Relaxation Switching Assay-Based Nanosensors. Bioconjug Chem. 2017 Apr 19; 28(4):869-879. PMID: 28205434.
      Citations: 8     Fields:    Translation:HumansAnimalsPHPublic Health
    31. Zhang H, Dasbiswas K, Ludwig NB, Han G, Lee B, Vaikuntanathan S, Talapin DV. Stable colloids in molten inorganic salts. Nature. 2017 02 15; 542(7641):328-331. PMID: 28202966.
      Citations: 21     Fields:    Translation:Cells
    32. Xie X, Li Z, Zhang Y, Guo S, Pendharkar AI, Lu M, Huang L, Huang W, Han G. Emerging ?800 nm Excited Lanthanide-Doped Upconversion Nanoparticles. Small. 2017 Feb; 13(6). PMID: 27982542.
      Citations: 13     Fields:    Translation:HumansAnimals
    33. Han G, Xie J. Light-Mediated Deep-Tissue Theranostics. Theranostics. 2016; 6(13):2292-2294. PMID: 27877234.
      Citations: 2     Fields:    Translation:HumansAnimals
    34. Zhanjun Li, Yuanwei Zhang, Ling Huang, Yuchen Yang, Yang Zhao, Ghida El-Banna, Gang Han. Nanoscale “fluorescent stone”: Luminescent Calcium Fluoride Nanoparticles as Theranostic Platforms. Theranostics. 2016; 6(13):2380-2393. View Publication.
    35. Peng Tan, Lian He, Gang Han*, Yubin Zhou*. Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity. Trends in Biotechnology. 2016.
    36. Regino Mercado-Lubo, Yuanwei Zhang, Liang Zhao, Kyle Rossi, Xiang Wu, Yekui Zou, Antonio Castillo, Jack Leonard, Rita Bortell, Dale Greiner, Leonard D. Shultz, Gang Han*, and Beth McCormick*. Salmonella Nanoparticle Mimic Overcomes Multidrug Resistance in Tumors. Nature Communications. 2016; 7(12).
    37. Zhang Y, Huang L, Li Z, Ma G, Zhou Y, Han G. Illuminating Cell Signaling with Near-Infrared Light-Responsive Nanomaterials. ACS Nano. 2016 04 26; 10(4):3881-3885. PMID: 27077481.
      Citations: 22     Fields:    Translation:Animals
    38. Ling Huang, Ran Duan, Zhanjun Li, Yuanwei Zhang, Jianzhang Zhao and Gang Han. BODIPY-Based Nanomicelles as Near-Infrared Fluorescent “Turn-On” Sensors for Biogenic Thiols (Selected as Front cover article) DOI: 10.1002/cnma.201600019. ChemNanoMat. 2016. View Publication.
    39. Wu X, Zhang Y, Takle K, Bilsel O, Li Z, Lee H, Zhang Z, Li D, Fan W, Duan C, Chan EM, Lois C, Xiang Y, Han G. Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. ACS Nano. 2016 Jan 26; 10(1):1060-6. PMID: 26736013.
      Citations: 69     Fields:    Translation:AnimalsCells
    40. Lian He, Yuanwei Zhang, Guolin Ma, Peng Tan, Zhanjun Li, Shengbing Zhang, Xiang Wu, Ji Jing, Shaohai Fang, Lijuan Zhou, Youjun Wang, Yun Huang, Patrick Hogan, Gang Han*, Yubin Zhou* (*Corresponding Authors). Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation. eLife 2015;4:e10024. 2015. View Publication.
    41. Zhanjun Li,Yuanwei Zhang, Hieu La,Richard Zhu,Ghida El-Banna ,Yuzou Wei ,Gang Han . Upconverting NIR Photons for Bioimaging. Nanomaterials. 2015; 4(5):2148-2168. View Publication.
    42. Li Z, Zhang Y, La H, Zhu R, El-Banna G, Wei Y, Han G. Upconverting NIR Photons for Bioimaging. Nanomaterials (Basel). 2015 Dec 04; 5(4):2148-2168. PMID: 28347113.
    43. Wu X, Lee H, Bilsel O, Zhang Y, Li Z, Chen T, Liu Y, Duan C, Shen J, Punjabi A, Han G. Tailoring dye-sensitized upconversion nanoparticle excitation bands towards excitation wavelength selective imaging. Nanoscale. 2015 Nov 28; 7(44):18424-8. PMID: 26499208.
      Citations: 10     Fields:    
    44. Chen G, Damasco J, Qiu H, Shao W, Ohulchanskyy TY, Valiev RR, Wu X, Han G, Wang Y, Yang C, ?gren H, Prasad PN. Energy-Cascaded Upconversion in an Organic Dye-Sensitized Core/Shell Fluoride Nanocrystal. Nano Lett. 2015 Nov 11; 15(11):7400-7. PMID: 26487489.
      Citations: 42     Fields:    
    45. Zhanjun Li, Yuanwei Zhang, Xiang Wu, Ling Huang, Dongsheng Li, Wei Fan,Gang Han. Direct Aqueous-Phase Synthesis of Sub-10 nm “Luminous Pearls” with Enhanced in Vivo Renewable Near-Infrared Persistent Luminescence (Selected as ACS Editors' Choice Article and JACS Spotlight Article). Journal of the American Chemical Society Apr 29; 137(16):5304-7. 2015.
    46. Kutikov AB, Skelly JD, Ayers DC, Song J. Templated repair of long bone defects in rats with bioactive spiral-wrapped electrospun amphiphilic polymer/hydroxyapatite scaffolds. ACS Appl Mater Interfaces. 2015 Mar 04; 7(8):4890-901. PMID: 27786443.
      Citations: 38     Fields:    Translation:HumansCells
    47. Li Z, Zhang Y, Wu X, Wu X, Maudgal R, Zhang H, Han G. In Vivo Repeatedly Charging Near-Infrared-Emitting Mesoporous SiO2/ZnGa2O4:Cr3+ Persistent Luminescence Nanocomposites. Adv Sci (Weinh). 2015 Mar; 2(3). PMID: 27419003.
      Citations: 18     Fields:    
    48. Zhanjun Li, Yuanwei Zhang, Xiang Wu, Xiaoqiong Wu, Rohit Maudgal, Hongwu Zhang and Gang Han. In Vivo Repeatedly Charging Near-Infrared-Emitting Mesoporous SiO2/ZnGa2O4:Cr3+ Persistent Luminescence Nanocomposites (Cover feature). Advanced Science. 2015; 2(3):1500001. View Publication.
    49. Bogdanov AA, Gupta S, Koshkina N, Corr SJ, Zhang S, Curley SA, Han G. Gold nanoparticles stabilized with MPEG-grafted poly(l-lysine): in vitro and in vivo evaluation of a potential theranostic agent. Bioconjug Chem. 2015 Jan 21; 26(1):39-50. PMID: 25496453.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    50. Wu X, Chen G, Shen J, Li Z, Zhang Y, Han G. Upconversion nanoparticles: a versatile solution to multiscale biological imaging. Bioconjug Chem. 2015 Feb 18; 26(2):166-75. PMID: 25254658.
      Citations: 46     Fields:    Translation:HumansAnimals
    51. Punjabi A, Wu X, Tokatli-Apollon A, El-Rifai M, Lee H, Zhang Y, Wang C, Liu Z, Chan EM, Duan C, Han G. Amplifying the red-emission of upconverting nanoparticles for biocompatible clinically used prodrug-induced photodynamic therapy. ACS Nano. 2014 Oct 28; 8(10):10621-30. PMID: 25291544.
      Citations: 38     Fields:    Translation:HumansCells
    52. Jie Shen, Guanying Chen, Anne-Marie Vu, Wei Fan, Osman S Bilsel, Chun-Chih Chang and Gang Han. Engineering the Upconversion Nanoparticle Excitation Wavelength: Cascade Sensitization of Tri-doped Upconversion Colloidal Nanoparticles at 800nm. Advanced Optical Materials. 2013; 9(1):644-650. View Publication.
    53. Shen J, Chen G, Ohulchanskyy TY, Kesseli SJ, Buchholz S, Li Z, Prasad PN, Han G. Tunable near infrared to ultraviolet upconversion luminescence enhancement in (a-NaYF4 :Yb,Tm)/CaF2 core/shell nanoparticles for in situ real-time recorded biocompatible photoactivation. Small. 2013 Oct 11; 9(19):3213-7. PMID: 23696330.
      Citations: 29     Fields:    
    54. Han G, Chen G. Theranostic upconversion nanoparticles (II). Theranostics. 2013; 3(5):354-5. PMID: 23650482.
      Citations: 2     Fields:    Translation:Humans
    55. Chen G, Han G. Theranostic upconversion nanoparticles (I). Theranostics. 2013; 3(4):289-91. PMID: 23606916.
      Citations: 3     Fields:    
    56. Liang Zhao, Artem Kutikov, Jie Shen, Chunying Duan, Jie Song and Gang Han . Stem Cell Labeling using Polyethylenimine Conjugated (a-NaYbF4:Tm3+)/CaF2 Upconversion Nanoparticles. Theranostics (featured on cover). 2013; 4(3):249-257. View Publication.
    57. Guanying Chen, Hailong Qiu, Rongwei Fan, Shuwei Hao, Shuo Tan, Chunhui Yang, and Gang Han. Lanthanide-Doped Ultrasmall Yttrium Fluoride Nanoparticles with Enhanced Multicolor Upconversion Photoluminescence. J. Mater. Chem.,( featured on front cover). 2012; 38(22):20190 - 20196 . View Publication.
    58. Chen G, Shen J, Ohulchanskyy TY, Patel NJ, Kutikov A, Li Z, Song J, Pandey RK, Agren H, Prasad PN, Han G. (a-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging. ACS Nano. 2012 Sep 25; 6(9):8280-7. PMID: 22928629.
      Citations: 95     Fields:    Translation:AnimalsCells
    59. Chan EM, Han G, Goldberg JD, Gargas DJ, Ostrowski AD, Schuck PJ, Cohen BE, Milliron DJ. Combinatorial discovery of lanthanide-doped nanocrystals with spectrally pure upconverted emission. Nano Lett. 2012 Jul 11; 12(7):3839-45. PMID: 22713101.
      Citations: 23     Fields:    
    60. Shen J, Zhao L, Han G. Lanthanide-doped upconverting luminescent nanoparticle platforms for optical imaging-guided drug delivery and therapy. Adv Drug Deliv Rev. 2013 May; 65(5):744-55. PMID: 22626980.
      Citations: 50     Fields:    Translation:HumansAnimals
    61. Ostrowski AD, Chan EM, Gargas DJ, Katz EM, Han G, Schuck PJ, Milliron DJ, Cohen BE. Controlled synthesis and single-particle imaging of bright, sub-10 nm lanthanide-doped upconverting nanocrystals. ACS Nano. 2012 Mar 27; 6(3):2686-92. PMID: 22339653.
      Citations: 47     Fields:    
    62. Zhang X, Jing X, Liu T, Han G, Li H, Duan C. Dual-functional gadolinium-based copper(II) probe for selective magnetic resonance imaging and fluorescence sensing. Inorg Chem. 2012 Feb 20; 51(4):2325-31. PMID: 22316302.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    63. Qiu, H., Chen, Sun,L., Hao, S., Han, G * and Yang, C.* .(* co- corresponding authors). Ethylenediaminetetraacetic acid (EDTA)-Controlled Synthesis of Multicolor Lanthanide Doped BaYF5 Upconversion Nanocrystals. J Mater Chem. 2011; (21):17202-17208. View Publication.
    64. Liang X, Chen T, Jung YS, Miyamoto Y, Han G, Cabrini S, Ma B, Olynick DL. Nanoimprint-induced molecular stacking and pattern stabilization in a solution-processed subphthalocyanine film. ACS Nano. 2010 May 25; 4(5):2627-34. PMID: 20411983.
      Citations:    Fields:    
    65. Chan EM, Xu C, Mao AW, Han G, Owen JS, Cohen BE, Milliron DJ. Reproducible, high-throughput synthesis of colloidal nanocrystals for optimization in multidimensional parameter space. Nano Lett. 2010 May 12; 10(5):1874-85. PMID: 20387807.
      Citations: 15     Fields:    Translation:Cells
    66. Kim B, Han G, Toley BJ, Kim CK, Rotello VM, Forbes NS. Tuning payload delivery in tumour cylindroids using gold nanoparticles. Nat Nanotechnol. 2010 Jun; 5(6):465-72. PMID: 20383126.
      Citations: 140     Fields:    Translation:HumansCells
    67. Jordan BJ, Hong R, Han G, Rana S, Rotello VM. Modulation of enzyme-substrate selectivity using tetraethylene glycol functionalized gold nanoparticles. Nanotechnology. 2009 Oct 28; 20(43):434004. PMID: 19801753.
      Citations: 4     Fields:    Translation:AnimalsCells
    68. Wu S*, Han G*, Milliron DJ, Aloni S, Altoe V, Talapin DV, Cohen BE, Schuck PJ. (co-first authors) . Non-blinking and photostable upconverted luminescence from single lanthanide-doped nanocrystals. Proc Natl Acad Sci U S A. 2009; 106(27):10917-21. View Publication.
    69. Han G, Mokari T, Ajo-Franklin C, Cohen BE. Caged quantum dots. J Am Chem Soc. 2008 Nov 26; 130(47):15811-3. PMID: 18983148.
      Citations: 15     Fields:    Translation:AnimalsCells
    70. Ghosh PS, Kim CK, Han G, Forbes NS, Rotello VM. Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles. ACS Nano. 2008 Nov 25; 2(11):2213-8. PMID: 19206385.
      Citations: 98     Fields:    Translation:AnimalsCells
    71. Chompoosor A, Han G, Rotello VM. Charge dependence of ligand release and monolayer stability of gold nanoparticles by biogenic thiols. Bioconjug Chem. 2008 Jul; 19(7):1342-5. PMID: 18553895.
      Citations: 19     Fields:    Translation:Cells
    72. Ghosh P, Han G, De M, Kim CK, Rotello VM. Gold nanoparticles in delivery applications. Adv Drug Deliv Rev. 2008 Aug 17; 60(11):1307-1315. PMID: 18555555.
      Citations: 528     Fields:    Translation:HumansAnimals
    73. Ghosh PS, Han G, Erdogan B, Rosado O, Rotello VM. Binding of nanoparticle receptors to peptide alpha-helices using amino acid-functionalized nanoparticles. J Pept Sci. 2008 Feb; 14(2):134-8. PMID: 17973336.
      Citations: 1     Fields:    Translation:Cells
    74. Leroueil PR, Berry SA, Duthie K, Han G, Rotello VM, McNerny DQ, Baker JR, Orr BG, Holl MM. Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers. Nano Lett. 2008 Feb; 8(2):420-4. PMID: 18217783.
      Citations: 116     Fields:    Translation:Cells
    75. Ghosh PS, Han G, Erdogan B, Rosado O, Krovi SA, Rotello VM. Nanoparticles featuring amino acid-functionalized side chains as DNA receptors. Chem Biol Drug Des. 2007 Jul; 70(1):13-8. PMID: 17630990.
      Citations: 9     Fields:    Translation:Cells
    76. Han G, Ghosh P, Rotello VM. Functionalized gold nanoparticles for drug delivery. Nanomedicine (Lond). 2007 Feb; 2(1):113-23. PMID: 17716197.
      Citations: 80     Fields:    
    77. Srivastava, S.; Samanta, B.; Arumugam, P.; Han, G. Rotello, V. M. . Journal of Material chemistry. Influence of DNA on Spacing and Magnetic Properties of Iron Platinum (Fe-Pt) Nanoparticles. 2007; 17(1):52-55.
    78. Nakade H, Jordan BJ, Xu H, Han G, Srivastava S, Arvizo RR, Cooke G, Rotello VM. Chiral translation and cooperative self-assembly of discrete helical structures using molecular recognition dyads. J Am Chem Soc. 2006 Nov 22; 128(46):14924-9. PMID: 17105303.
      Citations:    Fields:    Translation:Cells
    79. Vanderpuije BN, Han G, Rotello VM, Vachet RW. Mixed monolayer-protected gold nanoclusters as selective peptide extraction agents for MALDI-MS analysis. Anal Chem. 2006 Aug 01; 78(15):5491-6. PMID: 16878887.
      Citations: 6     Fields:    
    80. Han G, You CC, Kim BJ, Turingan RS, Forbes NS, Martin CT, Rotello VM. Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles. Angew Chem Int Ed Engl. 2006 May 05; 45(19):3165-9. PMID: 16572498.
      Citations: 52     Fields:    Translation:Cells
    81. Goodman CM, Chari NS, Han G, Hong R, Ghosh P, Rotello VM. DNA-binding by functionalized gold nanoparticles: mechanism and structural requirements. Chem Biol Drug Des. 2006 Apr; 67(4):297-304. PMID: 16629827.
      Citations: 18     Fields:    Translation:Cells
    82. Hong R, Han G, Fern?ndez JM, Kim BJ, Forbes NS, Rotello VM. Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers. J Am Chem Soc. 2006 Feb 01; 128(4):1078-9. PMID: 16433515.
      Citations: 131     Fields:    
    83. Han G, Martin CT, Rotello VM. Stability of gold nanoparticle-bound DNA toward biological, physical, and chemical agents. Chem Biol Drug Des. 2006 Jan; 67(1):78-82. PMID: 16492152.
      Citations: 37     Fields:    Translation:Cells
    84. Han G, Chari NS, Verma A, Hong R, Martin CT, Rotello VM. Controlled recovery of the transcription of nanoparticle-bound DNA by intracellular concentrations of glutathione. Bioconjug Chem. 2005 Nov-Dec; 16(6):1356-9. PMID: 16287230.
      Citations: 27     Fields:    Translation:Cells
    85. You CC, De M, Han G, Rotello VM. Tunable inhibition and denaturation of alpha-chymotrypsin with amino acid-functionalized gold nanoparticles. J Am Chem Soc. 2005 Sep 21; 127(37):12873-81. PMID: 16159281.
      Citations: 49     Fields:    Translation:Cells
    86. Chen, G ; Ou, SJ; Bai, ZP ; Han, G; Duan, CY . Synthesis, crystal structure and electrochemistry of biferrocene palladium complex. CHINESE JOURNAL OF INORGANIC CHEMISTRY. 2003; 19(5):501-505.
    87. Dong G, Gang H, Chun-ying D, Ke-liang P, Qing-jin M. Novel ferrocene-containing helical triangular macrocycle achieved via an exchange reaction. Chem Commun (Camb). 2002 May 21; (10):1096-7. PMID: 12122682.
      Citations:    Fields:    
    88. Gang, H ; Dong, G ; Duan, CY ; Hong, M ; Meng, QJ . Self-assembly of a novel mixed-valence tetranuclear molecular square [(Fe3FeL2)-Fe-II-L-III(HL)(2)](3+) and [M(HL)](4)(4+) squares (M = Ni, Zn and Cd) {H2L = bis(2-acetylpyridine) thiocarbazone}. NEW JOURNAL OF CHEMISTRY. 2002; 26(10):1371-1377. View Publication.
    89. Fang, CJ ; Duan, CY ; He, C; Han, G ; Meng, QJ . A supramolecular analog of cyclohexane sustained by aromatic C-H center dot center dot center dot pi interactions between ferrocene moieties: molecular packing of ferrocene-containing thiosemicarbazato metal complexes. NEW JOURNAL OF CHEMISTRY. 2000; 24(9):697-701. View Publication.
    90. Fang, CJ ; Han, G ; Liu, YJ ; Duan, CY; Meng, QJ . Acetylferrocene thiosemicarbazone. 1999; 55 :2058-2060. View Publication.
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