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Last Name
Institution

Giles Whalen MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentSurgery
AddressUMass Memorial Medical Center
119 Belmont Street
Worcester MA 01605
Phone508-334-5404
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentSurgery
    DivisionSurgical Oncology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCancer Biology


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA, United StatesBABiology
    Duke University, Durham, NC, United StatesMD

    Collapse Overview 
    Collapse overview


    Research Interests:



    Dr. Whalen's clinical interests include GI tract tumors (gastroesophageal, hepatobilliary, pancreatic, colorectal),  endcocrine tumors (thyroid, parathyroid, adrenal), melanoma and sarcoma.



    In particular, the patterns, processes and control of metastases from solid tumors are of interest to Dr. Whalen. Areas of potential research collaboration also include studies of patient outcomes, particularly QOL for surgical cancer “cures” and survivorship surveillance strategies.



    Other research areas for Dr. Whalen include adjuvant immunotherapy for surgically treated cancers and palliative surgical care. 




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Shaw SM, Middleton J, Wigglesworth K, Charlemagne A, Schulz O, Glossop MS, Whalen GF, Old R, Westby M, Pickford C, Tabakman R, Carmi-Levy I, Vainstein A, Sorani E, Zur AA, Kristian SA. AGI-134: a fully synthetic a-Gal glycolipid that converts tumors into in situ autologous vaccines, induces anti-tumor immunity and is synergistic with an anti-PD-1 antibody in mouse melanoma models. Cancer Cell Int. 2019; 19:346. PMID: 31889898.
      View in: PubMed
    2. Sakhdari A, Moghaddam PA, Ok CY, Walter O, Tomaszewicz K, Caporelli ML, Meng X, LaFemina J, Whalen G, Belkin E, Zivny J, Wassef W, Woda BA, Hutchinson LM, Cosar EF. Somatic molecular analysis augments cytologic evaluation of pancreatic cyst fluids as a diagnostic tool. Oncotarget. 2019 Jun 18; 10(40):4026-4037. PMID: 31258847.
      View in: PubMed
    3. Whalen G. Invited Commentary. J Am Coll Surg. 2018 Jun; 226(6):986-987. PMID: 29803257.
      View in: PubMed
    4. Whalen G. Invited Commentary. J Am Coll Surg. 2018 Jun; 226(6):1043-1044. PMID: 29803244.
      View in: PubMed
    5. Barth RJ, Mills JB, Suriawinata AA, Putra J, Tosteson TD, Axelrod D, Freeman R, Whalen GF, LaFemina J, Tarczewski SM, Kinlaw WB. Short-term Preoperative Diet Decreases Bleeding After Partial Hepatectomy: Results From a Multi-institutional Randomized Controlled Trial. Ann Surg. 2018 Feb 27. PMID: 29489484.
      View in: PubMed
    6. Dinh KH, Harris AF, LaFemina J, Whalen GF, Sullivan M, Licho R, Hill T, Lambert LA. Advantages of day-before lymphoscintigraphy and undiluted methylene blue dye injections for sentinel lymph node biopsies for melanoma. J Surg Oncol. 2016 Dec; 114(8):947-950. PMID: 27634654.
      View in: PubMed
    7. Whalen G, Sullivan M, Maranda L, Quinlan R, Larkin A. Randomized trial of a short course of preoperative potassium iodide in patients undergoing thyroidectomy for Graves' disease. Am J Surg. 2016 Aug 4. PMID: 27769543.
      View in: PubMed
    8. Albertini MR, Ranheim EA, Zuleger CL, Sondel PM, Hank JA, Bridges A, Newton MA, McFarland T, Collins J, Clements E, Henry MB, Neuman HB, Weber S, Whalen G, Galili U. Phase I study to evaluate toxicity and feasibility of intratumoral injection of a-gal glycolipids in patients with advanced melanoma. Cancer Immunol Immunother. 2016 Aug; 65(8):897-907. PMID: 27207605.
      View in: PubMed
    9. Lim PW, Dinh KH, Sullivan M, Wassef WY, Zivny J, Whalen GF, LaFemina J. Thirty-day outcomes underestimate endocrine and exocrine insufficiency after pancreatic resection. HPB (Oxford). 2016 Apr; 18(4):360-6. PMID: 27037206.
      View in: PubMed
    10. Flores K, Dinh K, Rouleau E, Whalen G, Wassef W, LaFemina J. Identification of genetic risk for pancreatic adenocarcinoma. Cancer Genet. 2015 Nov; 208(11):559-63. PMID: 26481832.
      View in: PubMed
    11. Rajeshkumar BR, Paliwal S, Lambert L, Grossman SR, Whalen GF. Treatment of peritoneal carcinomatosis with intraperitoneal administration of Ad-hARF. J Surg Res. 2015 Jul; 197(1):85-90. PMID: 25935465.
      View in: PubMed
    12. Collins CE, Cherng N, McDade T, Movahedi B, Emhoff TA, Whalen GF, LaFemina J, Dorfman JD. Improving patient notification of solid abdominal viscera incidental findings with a standardized protocol. J Trauma Manag Outcomes. 2015; 9(1):1. PMID: 25670964.
      View in: PubMed
    13. Furman MJ, Picotte RJ, Wante MJ, Rajeshkumar BR, Whalen GF, Lambert LA. Higher flow rates improve heating during hyperthermic intraperitoneal chemoperfusion. J Surg Oncol. 2014 Dec; 110(8):970-5. PMID: 25171494.
      View in: PubMed
    14. Rao SN, Swami A, Khan A, Toke M, Whalen G, Fischer A, Torres MS. Metastatic mesothelioma to the thyroid. Cytojournal. 2014; 11:11. PMID: 24987442.
      View in: PubMed
    15. Arous EJ, McDade TP, Smith JK, Ng SC, Sullivan ME, Zottola RJ, Ranauro PJ, Shah SA, Whalen GF, Tseng JF. Electronic medical record: research tool for pancreatic cancer? J Surg Res. 2014 Apr; 187(2):466-70. PMID: 24326179.
      View in: PubMed
    16. Furman MJ, Lambert LA, Sullivan ME, Whalen GF. Reply to S. Senthi et al. J Clin Oncol. 2013 Oct 1; 31(28):3608. PMID: 24002498.
      View in: PubMed
    17. Cetin V, Piperdi B, Bathini V, Walsh WV, Yunus S, Tseng JF, Whalen GF, Wassef WY, Kadish SP, Fitzgerald TJ, Mikule C, Wang Y, Grossman SR. A Phase II Trial of Cetuximab, Gemcitabine, 5-Fluorouracil, and Radiation Therapy in Locally Advanced Nonmetastatic Pancreatic Adenocarcinoma. Gastrointest Cancer Res. 2013 Jul; 6(4 Suppl 1):S2-9. PMID: 24312684.
      View in: PubMed
    18. Furman MJ, Lambert LA, Sullivan ME, Whalen GF. Rational follow-up after curative cancer resection. J Clin Oncol. 2013 Mar 20; 31(9):1130-3. PMID: 23358986.
      View in: PubMed
    19. Whalen GF, Sullivan M, Piperdi B, Wasseff W, Galili U. Cancer immunotherapy by intratumoral injection of a-gal glycolipids. Anticancer Res. 2012 Sep; 32(9):3861-8. PMID: 22993330.
      View in: PubMed
    20. Furman MJ, Whalen GF, Shah SA, Kadish SP. Gastric perforation following stereotactic body radiation therapy of hepatic metastasis from colon cancer. Pract Radiat Oncol. 2013 Jan-Mar; 3(1):40-4. PMID: 24674262.
      View in: PubMed
    21. Straza MW, Paliwal S, Kovi RC, Rajeshkumar B, Trenh P, Parker D, Whalen GF, Lyle S, Schiffer CA, Grossman SR. Therapeutic targeting of C-terminal binding protein in human cancer. Cell Cycle. 2010 Sep 15; 9(18):3740-50. PMID: 20930544.
      View in: PubMed
    22. Larkin AC, Cahan MA, Whalen G, Hatem D, Starr S, Haley HL, Litwin D, Sullivan K, Quirk M. Human Emotion and Response in Surgery (HEARS): a simulation-based curriculum for communication skills, systems-based practice, and professionalism in surgical residency training. J Am Coll Surg. 2010 Aug; 211(2):285-92. PMID: 20670869.
      View in: PubMed
    23. Hayward J, Alvarez SA, Ruiz C, Sullivan M, Tseng J, Whalen G. Machine learning of clinical performance in a pancreatic cancer database. Artif Intell Med. 2010 Jul; 49(3):187-95. PMID: 20483571.
      View in: PubMed
    24. Galili U, Albertini MR, Sondel PM, Wigglesworth K, Sullivan M, Whalen GF. In Situ Conversion of Melanoma Lesions into Autologous Vaccine by Intratumoral Injections of a-gal Glycolipids. Cancers (Basel). 2010; 2(2):773-93. PMID: 23087817.
      View in: PubMed
    25. Zhou Z, McDade TP, Simons JP, Ng SC, Lambert LA, Whalen GF, Shah SA, Tseng JF. Surgery and radiotherapy for retroperitoneal and abdominal sarcoma: both necessary and sufficient. Arch Surg. 2010 May; 145(5):426-31. PMID: 20479339.
      View in: PubMed
    26. Piperdi M, McDade TP, Shim JK, Piperdi B, Kadish SP, Sullivan ME, Whalen GF, Tseng JF. A neoadjuvant strategy for pancreatic adenocarcinoma increases the likelihood of receiving all components of care: lessons from a single-institution database. HPB (Oxford). 2010 Apr; 12(3):204-10. PMID: 20590888.
      View in: PubMed
    27. Murphy MM, Witkowski ER, Ng SC, McDade TP, Hill JS, Larkin AC, Whalen GF, Litwin DE, Tseng JF. Trends in adrenalectomy: a recent national review. Surg Endosc. 2010 Oct; 24(10):2518-26. PMID: 20336320.
      View in: PubMed
    28. Hill JS, Zhou Z, Simons JP, Ng SC, McDade TP, Whalen GF, Tseng JF. A simple risk score to predict in-hospital mortality after pancreatic resection for cancer. Ann Surg Oncol. 2010 Jul; 17(7):1802-7. PMID: 20155401.
      View in: PubMed
    29. Simons JP, Hill JS, Ng SC, Shah SA, Zhou Z, Whalen GF, Tseng JF. Perioperative mortality for management of hepatic neoplasm: a simple risk score. Ann Surg. 2009 Dec; 250(6):929-34. PMID: 19855257.
      View in: PubMed
    30. Murphy MM, Simons JP, Hill JS, McDade TP, Chau Ng S, Whalen GF, Shah SA, Harrison LH, Tseng JF. Pancreatic resection: a key component to reducing racial disparities in pancreatic adenocarcinoma. Cancer. 2009 Sep 1; 115(17):3979-90. PMID: 19514091.
      View in: PubMed
    31. Hill JS, McPhee JT, Whalen GF, Sullivan ME, Warshaw AL, Tseng JF. In-hospital mortality after pancreatic resection for chronic pancreatitis: population-based estimates from the nationwide inpatient sample. J Am Coll Surg. 2009 Oct; 209(4):468-76. PMID: 19801320.
      View in: PubMed
    32. Jaffar R, Pechet L, Whalen GF, Banner BF. Spontaneous hepatic hemorrhage secondary to prolonged use of oral contraceptives. Pathol Res Pract. 2010 May 15; 206(5):318-21. PMID: 19577854.
      View in: PubMed
    33. Gammon DC, Dutton T, Piperdi B, Zybert J, Wolfe SH, Nguyen E, Sbat D, Pillarisetty VG, Sullivan M, Whalen GF. Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy in the treatment of peritoneal carcinomatosis. Am J Health Syst Pharm. 2009 Jul 1; 66(13):1186-90. PMID: 19535657.
      View in: PubMed
    34. Simons JP, Ng SC, Shah SA, McDade TP, Whalen GF, Tseng JF. Malignant intraductal papillary mucinous neoplasm: are we doing the right thing? J Surg Res. 2011 May 15; 167(2):251-7. PMID: 19765732.
      View in: PubMed
    35. Simons JP, Shah SA, Ng SC, Whalen GF, Tseng JF. National complication rates after pancreatectomy: beyond mere mortality. J Gastrointest Surg. 2009 Oct; 13(10):1798-805. PMID: 19506975.
      View in: PubMed
    36. Hill JS, McPhee JT, McDade TP, Zhou Z, Sullivan ME, Whalen GF, Tseng JF. Pancreatic neuroendocrine tumors: the impact of surgical resection on survival. Cancer. 2009 Feb 15; 115(4):741-51. PMID: 19130464.
      View in: PubMed
    37. Jiang NY, Woda BA, Banner BF, Whalen GF, Dresser KA, Lu D. Sp1, a new biomarker that identifies a subset of aggressive pancreatic ductal adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2008 Jul; 17(7):1648-52. PMID: 18628415.
      View in: PubMed
    38. Bruner DW, Bryan CJ, Aaronson N, Blackmore CC, Brundage M, Cella D, Ganz PA, Gotay C, Hinds PS, Kornblith AB, Movsas B, Sloan J, Wenzel L, Whalen G. Issues and challenges with integrating patient-reported outcomes in clinical trials supported by the National Cancer Institute-sponsored clinical trials networks. J Clin Oncol. 2007 Nov 10; 25(32):5051-7. PMID: 17991920.
      View in: PubMed
    39. McPhee JT, Hill JS, Whalen GF, Zayaruzny M, Litwin DE, Sullivan ME, Anderson FA, Tseng JF. Perioperative mortality for pancreatectomy: a national perspective. Ann Surg. 2007 Aug; 246(2):246-53. PMID: 17667503.
      View in: PubMed
    40. Whalen GF, Kutner J, Byock I, Gerard D, Stovall E, Sieverding P, Ganz PA, Krouse RS. Implementing palliative care studies. J Pain Symptom Manage. 2007 Jul; 34(1 Suppl):S40-8. PMID: 17544245.
      View in: PubMed
    41. Sharma V, Cui H, Whalen G, Khan A, Torres M. A case of trabecular adenoma of the thyroid with black pigmentation. Thyroid. 2007 Jun; 17(6):593-4. PMID: 17614784.
      View in: PubMed
    42. Smith JK, McPhee JT, Hill JS, Whalen GF, Sullivan ME, Litwin DE, Anderson FA, Tseng JF. National outcomes after gastric resection for neoplasm. Arch Surg. 2007 Apr; 142(4):387-93. PMID: 17441293.
      View in: PubMed
    43. Shankar S, Bhargava P, Habib F, Desai M, Tyagi G, Whalen G. Transpulmonary CT-guided radiofrequency ablation of liver metastasis. Cardiovasc Intervent Radiol. 2005 Jul-Aug; 28(4):481-4. PMID: 16001134.
      View in: PubMed
    44. Yantiss RK, Woda BA, Fanger GR, Kalos M, Whalen GF, Tada H, Andersen DK, Rock KL, Dresser K. KOC (K homology domain containing protein overexpressed in cancer): a novel molecular marker that distinguishes between benign and malignant lesions of the pancreas. Am J Surg Pathol. 2005 Feb; 29(2):188-95. PMID: 15644775.
      View in: PubMed
    45. Sidiropoulos N, Vento J, Malchoff C, Whalen G. Radioguided tumorectomy in the management of parathyroid adenomas. Arch Surg. 2003 Jul; 138(7):716-20. PMID: 12860751.
      View in: PubMed
    46. MacGillivray DC, Whalen GF, Malchoff CD, Oppenheim DS, Shichman SJ. Laparoscopic resection of large adrenal tumors. Ann Surg Oncol. 2002 Jun; 9(5):480-5. PMID: 12052760.
      View in: PubMed
    47. Whalen GF, Ferrans CE. Quality of life as an outcome in clinical trials and cancer care: a primer for surgeons. J Surg Oncol. 2001 Aug; 77(4):270-6. PMID: 11473376.
      View in: PubMed
    48. Whalen GF, Bird I, Tanski W, Russell JC, Clive J. Laparoscopic cholecystectomy does not demonstrably decrease survival of patients with serendipitously treated gallbladder cancer. J Am Coll Surg. 2001 Feb; 192(2):189-95. PMID: 11220719.
      View in: PubMed
    49. Malchoff CD, Sarfarazi M, Tendler B, Forouhar F, Whalen G, Joshi V, Arnold A, Malchoff DM. Papillary thyroid carcinoma associated with papillary renal neoplasia: genetic linkage analysis of a distinct heritable tumor syndrome. J Clin Endocrinol Metab. 2000 May; 85(5):1758-64. PMID: 10843148.
      View in: PubMed
    50. Malchoff CD, Sarfarazi M, Tendler B, Forouhar F, Whalen G, Malchoff DM. Familial papillary thyroid carcinoma is genetically distinct from familial adenomatous polyposis coli. Thyroid. 1999 Mar; 9(3):247-52. PMID: 10211600.
      View in: PubMed
    51. Gendreau KM, Whalen GF. What can we learn from the phenomenon of preferential lymph node metastasis in carcinoma? J Surg Oncol. 1999 Mar; 70(3):199-204. PMID: 10102353.
      View in: PubMed
    52. Shichman SJ, Herndon CD, Sosa RE, Whalen GF, MacGillivray DC, Malchoff CD, Vaughan ED. Lateral transperitoneal laparoscopic adrenalectomy. World J Urol. 1999 Feb; 17(1):48-53. PMID: 10096151.
      View in: PubMed
    53. Fox SH, Whalen GF, Sanders MM, Burleson JA, Jennings K, Kurtzman S, Kreutzer D. Angiogenesis in normal tissue adjacent to colon cancer. J Surg Oncol. 1998 Dec; 69(4):230-4. PMID: 9881940.
      View in: PubMed
    54. Woolfson RG, Jennings K, Whalen GF. Management of bowel obstruction in patients with abdominal cancer. Arch Surg. 1997 Oct; 132(10):1093-7. PMID: 9336507.
      View in: PubMed
    55. Hyacinthe LM, Jarrett TW, Gordon CS, Vaughan ED, Whalen GF. Inhibition of bladder tumor cell implantation in cauterized urothelium, without inhibition of healing, by a fibronectin-related peptide (GRGDS). Ann Surg Oncol. 1995 Sep; 2(5):450-6. PMID: 7496842.
      View in: PubMed
    56. Fong Y, Whalen GF, Hariri RJ, Barie PS. Utility of routine chest radiographs in the surgical intensive care unit. A prospective study. Arch Surg. 1995 Jul; 130(7):764-8. PMID: 7611867.
      View in: PubMed
    57. Whalen GF, Gordon C, Yeshion C, Juers D, Yurt R. Influence of a lymph node environment on invasiveness of metastatic tumor cells. J Am Coll Surg. 1994 Aug; 179(2):145-50. PMID: 8044382.
      View in: PubMed
    58. Dyce M, Sharif SF, Whalen GF. Search for anti-metastatic therapy: effects of phenytoin on B16 melanoma metastasis. J Surg Oncol. 1992 Feb; 49(2):107-12. PMID: 1738231.
      View in: PubMed
    59. Whalen GF, Sharif SF. Locally increased metastatic efficiency as a reason for preferential metastasis of solid tumors to lymph nodes. Ann Surg. 1992 Feb; 215(2):166-71. PMID: 1546903.
      View in: PubMed
    60. Whalen GF, Ingber DE. Inhibition of tumor-cell attachment to extracellular matrix as a method for preventing tumor recurrence in a surgical wound. Ann Surg. 1989 Dec; 210(6):758-64. PMID: 2686568.
      View in: PubMed
    61. Whalen G, Robbs JV. Penetrating wounds of the heart: the aftermath. J R Coll Surg Edinb. 1987 Jun; 32(3):139-41. PMID: 3656234.
      View in: PubMed
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