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Giles Whalen MD

InstitutionUMass Chan Medical School
AddressUMass Memorial Medical Center
119 Belmont Street
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionSurgical Oncology

    Collapse Biography 
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    Harvard University, Cambridge, MA, United StatesBABiology
    Duke University, Durham, NC, United StatesMD

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    Research Interests:

    Dr. Whalen's clinical interests include GI tract tumors (gastroesophageal, hepatobilliary, pancreatic, colorectal),  endcocrine tumors (thyroid, parathyroid, adrenal), melanoma and sarcoma.

    In particular, the patterns, processes and control of metastases from solid tumors are of interest to Dr. Whalen. Areas of potential research collaboration also include studies of patient outcomes, particularly QOL for surgical cancer “cures” and survivorship surveillance strategies.

    Other research areas for Dr. Whalen include adjuvant immunotherapy for surgically treated cancers and palliative surgical care. 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chung SK, Bludevich B, Cherng N, Zhang T, Crawford A, Maxfield MW, Whalen G, Uy K, Perugini RA. Paraconduit Hiatal Hernia Following Esophagectomy: Incidence, Risk Factors, Outcomes and Repair. J Surg Res. 2021 12; 268:276-283. PMID: 34392181.
      Citations: 1     Fields:    Translation:Humans
    2. Narain AS, Kitto AZ, Braun B, Poorman MJ, Curtin P, Slavin J, Whalen G, DiPaola CP, Connolly PJ, Stauff MP. Does the ACS NSQIP Surgical Risk Calculator Accurately Predict Complications Rates After Anterior Lumbar Interbody Fusion Procedures? Spine (Phila Pa 1976). 2021 Jun 15; 46(12):E655-E662. PMID: 33337678.
      Citations:    Fields:    Translation:Humans
    3. McIntosh LJ, Rosen MP, Mittal K, Whalen GF, Bathini VG, Ali T, Edmiston KL, Walsh WV, Gerber JM. Coordination and optimization of FDG PET/CT and COVID-19 vaccination; Lessons learned in the early stages of mass vaccination. Cancer Treat Rev. 2021 Jul; 98:102220. PMID: 34029956.
      Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
    4. Bai S, Lindberg J, Whalen G, Bathini V, Zou J, Yang MX. Utility of HNF-1B and a panel of lineage-specific biomarkers to optimize the diagnosis of pancreatic ductal adenocarcinoma. Am J Cancer Res. 2021; 11(3):858-865. PMID: 33791159.
    5. Fong ZV, Lim PW, Hendrix R, Castillo CF, Nipp RD, Lindberg JM, Whalen GF, Kastrinakis W, Qadan M, Ferrone CR, Warshaw AL, Lillemoe KD, Chang DC, Traeger LN. Patient and Caregiver Considerations and Priorities When Selecting Hospitals for Complex Cancer Care. Ann Surg Oncol. 2021 Aug; 28(8):4183-4192. PMID: 33415563.
      Citations: 1     Fields:    Translation:Humans
    6. Whalen GF. Invited Commentary. J Am Coll Surg. 2020 06; 230(6):942-943. PMID: 32451053.
      Citations:    Fields:    
    7. Shaw SM, Middleton J, Wigglesworth K, Charlemagne A, Schulz O, Glossop MS, Whalen GF, Old R, Westby M, Pickford C, Tabakman R, Carmi-Levy I, Vainstein A, Sorani E, Zur AA, Kristian SA. AGI-134: a fully synthetic ?-Gal glycolipid that converts tumors into in situ autologous vaccines, induces anti-tumor immunity and is synergistic with an anti-PD-1 antibody in mouse melanoma models. Cancer Cell Int. 2019; 19:346. PMID: 31889898.
    8. Sakhdari A, Moghaddam PA, Ok CY, Walter O, Tomaszewicz K, Caporelli ML, Meng X, LaFemina J, Whalen G, Belkin E, Zivny J, Wassef W, Woda BA, Hutchinson LM, Cosar EF. Somatic molecular analysis augments cytologic evaluation of pancreatic cyst fluids as a diagnostic tool. Oncotarget. 2019 Jun 18; 10(40):4026-4037. PMID: 31258847.
      Citations: 2     Fields:    
    9. Barth RJ, Mills JB, Suriawinata AA, Putra J, Tosteson TD, Axelrod D, Freeman R, Whalen GF, LaFemina J, Tarczewski SM, Kinlaw WB. Short-term Preoperative Diet Decreases Bleeding After Partial Hepatectomy: Results From a Multi-institutional Randomized Controlled Trial. Ann Surg. 2019 01; 269(1):48-52. PMID: 29489484.
      Citations: 7     Fields:    Translation:Humans
    10. Whalen G. Invited Commentary. J Am Coll Surg. 2018 06; 226(6):986-987. PMID: 29803257.
      Citations:    Fields:    Translation:Humans
    11. Whalen G. Invited Commentary. J Am Coll Surg. 2018 06; 226(6):1043-1044. PMID: 29803244.
      Citations:    Fields:    
    12. Dinh KH, Harris AF, LaFemina J, Whalen GF, Sullivan M, Licho R, Hill T, Lambert LA. Advantages of day-before lymphoscintigraphy and undiluted methylene blue dye injections for sentinel lymph node biopsies for melanoma. J Surg Oncol. 2016 Dec; 114(8):947-950. PMID: 27634654.
      Citations:    Fields:    Translation:Humans
    13. Whalen G, Sullivan M, Maranda L, Quinlan R, Larkin A. Randomized trial of a short course of preoperative potassium iodide in patients undergoing thyroidectomy for Graves' disease. Am J Surg. 2017 Apr; 213(4):805-809. PMID: 27769543.
      Citations: 4     Fields:    Translation:Humans
    14. Albertini MR, Ranheim EA, Zuleger CL, Sondel PM, Hank JA, Bridges A, Newton MA, McFarland T, Collins J, Clements E, Henry MB, Neuman HB, Weber S, Whalen G, Galili U. Phase I study to evaluate toxicity and feasibility of intratumoral injection of ?-gal glycolipids in patients with advanced melanoma. Cancer Immunol Immunother. 2016 08; 65(8):897-907. PMID: 27207605.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    15. Lim PW, Dinh KH, Sullivan M, Wassef WY, Zivny J, Whalen GF, LaFemina J. Thirty-day outcomes underestimate endocrine and exocrine insufficiency after pancreatic resection. HPB (Oxford). 2016 Apr; 18(4):360-6. PMID: 27037206.
      Citations: 11     Fields:    Translation:Humans
    16. Flores K, Dinh K, Rouleau E, Whalen G, Wassef W, LaFemina J. Identification of genetic risk for pancreatic adenocarcinoma. Cancer Genet. 2015 Nov; 208(11):559-63. PMID: 26481832.
      Citations: 1     Fields:    Translation:Humans
    17. Rajeshkumar BR, Paliwal S, Lambert L, Grossman SR, Whalen GF. Treatment of peritoneal carcinomatosis with intraperitoneal administration of Ad-hARF. J Surg Res. 2015 Jul; 197(1):85-90. PMID: 25935465.
      Citations:    Fields:    Translation:HumansAnimalsCells
    18. Collins CE, Cherng N, McDade T, Movahedi B, Emhoff TA, Whalen GF, LaFemina J, Dorfman JD. Improving patient notification of solid abdominal viscera incidental findings with a standardized protocol. J Trauma Manag Outcomes. 2015; 9(1):1. PMID: 25670964.
    19. Furman MJ, Picotte RJ, Wante MJ, Rajeshkumar BR, Whalen GF, Lambert LA. Higher flow rates improve heating during hyperthermic intraperitoneal chemoperfusion. J Surg Oncol. 2014 Dec; 110(8):970-5. PMID: 25171494.
      Citations: 5     Fields:    Translation:HumansAnimals
    20. Rao SN, Swami A, Khan A, Toke M, Whalen G, Fischer A, Torres MS. Metastatic mesothelioma to the thyroid. Cytojournal. 2014; 11:11. PMID: 24987442.
    21. Arous EJ, McDade TP, Smith JK, Ng SC, Sullivan ME, Zottola RJ, Ranauro PJ, Shah SA, Whalen GF, Tseng JF. Electronic medical record: research tool for pancreatic cancer? J Surg Res. 2014 Apr; 187(2):466-70. PMID: 24326179.
      Citations: 4     Fields:    Translation:Humans
    22. Furman MJ, Lambert LA, Sullivan ME, Whalen GF. Reply to S. Senthi et al. J Clin Oncol. 2013 Oct 01; 31(28):3608. PMID: 24002498.
      Citations:    Fields:    Translation:Humans
    23. Cetin V, Piperdi B, Bathini V, Walsh WV, Yunus S, Tseng JF, Whalen GF, Wassef WY, Kadish SP, Fitzgerald TJ, Mikule C, Wang Y, Grossman SR. A Phase II Trial of Cetuximab, Gemcitabine, 5-Fluorouracil, and Radiation Therapy in Locally Advanced Nonmetastatic Pancreatic Adenocarcinoma. Gastrointest Cancer Res. 2013 Jul; 6(4 Suppl 1):S2-9. PMID: 24312684.
    24. Furman MJ, Lambert LA, Sullivan ME, Whalen GF. Rational follow-up after curative cancer resection. J Clin Oncol. 2013 Mar 20; 31(9):1130-3. PMID: 23358986.
      Citations: 11     Fields:    Translation:Humans
    25. Whalen GF, Sullivan M, Piperdi B, Wasseff W, Galili U. Cancer immunotherapy by intratumoral injection of ?-gal glycolipids. Anticancer Res. 2012 Sep; 32(9):3861-8. PMID: 22993330.
      Citations: 12     Fields:    Translation:HumansCellsCTClinical Trials
    26. Furman MJ, Whalen GF, Shah SA, Kadish SP. Gastric perforation following stereotactic body radiation therapy of hepatic metastasis from colon cancer. Pract Radiat Oncol. 2013 Jan-Mar; 3(1):40-44. PMID: 24674262.
      Citations: 4     Fields:    
    27. Straza MW, Paliwal S, Kovi RC, Rajeshkumar B, Trenh P, Parker D, Whalen GF, Lyle S, Schiffer CA, Grossman SR. Therapeutic targeting of C-terminal binding protein in human cancer. Cell Cycle. 2010 Sep 15; 9(18):3740-50. PMID: 20930544.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    28. Larkin AC, Cahan MA, Whalen G, Hatem D, Starr S, Haley HL, Litwin D, Sullivan K, Quirk M. Human Emotion and Response in Surgery (HEARS): a simulation-based curriculum for communication skills, systems-based practice, and professionalism in surgical residency training. J Am Coll Surg. 2010 Aug; 211(2):285-92. PMID: 20670869.
      Citations: 16     Fields:    Translation:Humans
    29. Hayward J, Alvarez SA, Ruiz C, Sullivan M, Tseng J, Whalen G. Machine learning of clinical performance in a pancreatic cancer database. Artif Intell Med. 2010 Jul; 49(3):187-95. PMID: 20483571.
      Citations: 10     Fields:    Translation:Humans
    30. Galili U, Albertini MR, Sondel PM, Wigglesworth K, Sullivan M, Whalen GF. In Situ Conversion of Melanoma Lesions into Autologous Vaccine by Intratumoral Injections of ?-gal Glycolipids. Cancers (Basel). 2010; 2(2):773-93. PMID: 23087817.
    31. Zhou Z, McDade TP, Simons JP, Ng SC, Lambert LA, Whalen GF, Shah SA, Tseng JF. Surgery and radiotherapy for retroperitoneal and abdominal sarcoma: both necessary and sufficient. Arch Surg. 2010 May; 145(5):426-31. PMID: 20479339.
      Citations: 19     Fields:    Translation:Humans
    32. Piperdi M, McDade TP, Shim JK, Piperdi B, Kadish SP, Sullivan ME, Whalen GF, Tseng JF. A neoadjuvant strategy for pancreatic adenocarcinoma increases the likelihood of receiving all components of care: lessons from a single-institution database. HPB (Oxford). 2010 Apr; 12(3):204-10. PMID: 20590888.
      Citations: 9     Fields:    Translation:Humans
    33. Murphy MM, Witkowski ER, Ng SC, McDade TP, Hill JS, Larkin AC, Whalen GF, Litwin DE, Tseng JF. Trends in adrenalectomy: a recent national review. Surg Endosc. 2010 Oct; 24(10):2518-26. PMID: 20336320.
      Citations: 31     Fields:    Translation:Humans
    34. Hill JS, Zhou Z, Simons JP, Ng SC, McDade TP, Whalen GF, Tseng JF. A simple risk score to predict in-hospital mortality after pancreatic resection for cancer. Ann Surg Oncol. 2010 Jul; 17(7):1802-7. PMID: 20155401.
      Citations: 37     Fields:    Translation:Humans
    35. Simons JP, Hill JS, Ng SC, Shah SA, Zhou Z, Whalen GF, Tseng JF. Perioperative mortality for management of hepatic neoplasm: a simple risk score. Ann Surg. 2009 Dec; 250(6):929-34. PMID: 19855257.
      Citations: 14     Fields:    Translation:Humans
    36. Murphy MM, Simons JP, Hill JS, McDade TP, Chau Ng S, Whalen GF, Shah SA, Harrison LH, Tseng JF. Pancreatic resection: a key component to reducing racial disparities in pancreatic adenocarcinoma. Cancer. 2009 Sep 01; 115(17):3979-90. PMID: 19514091.
      Citations: 32     Fields:    Translation:Humans
    37. Hill JS, McPhee JT, Whalen GF, Sullivan ME, Warshaw AL, Tseng JF. In-hospital mortality after pancreatic resection for chronic pancreatitis: population-based estimates from the nationwide inpatient sample. J Am Coll Surg. 2009 Oct; 209(4):468-76. PMID: 19801320.
      Citations: 11     Fields:    Translation:Humans
    38. Jaffar R, Pechet L, Whalen GF, Banner BF. Spontaneous hepatic hemorrhage secondary to prolonged use of oral contraceptives. Pathol Res Pract. 2010 May 15; 206(5):318-21. PMID: 19577854.
      Citations:    Fields:    Translation:Humans
    39. Gammon DC, Dutton T, Piperdi B, Zybert J, Wolfe SH, Nguyen E, Sbat D, Pillarisetty VG, Sullivan M, Whalen GF. Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy in the treatment of peritoneal carcinomatosis. Am J Health Syst Pharm. 2009 Jul 01; 66(13):1186-90. PMID: 19535657.
      Citations: 1     Fields:    Translation:Humans
    40. Simons JP, Ng SC, Shah SA, McDade TP, Whalen GF, Tseng JF. Malignant intraductal papillary mucinous neoplasm: are we doing the right thing? J Surg Res. 2011 May 15; 167(2):251-7. PMID: 19765732.
      Citations: 7     Fields:    Translation:Humans
    41. Simons JP, Shah SA, Ng SC, Whalen GF, Tseng JF. National complication rates after pancreatectomy: beyond mere mortality. J Gastrointest Surg. 2009 Oct; 13(10):1798-805. PMID: 19506975.
      Citations: 44     Fields:    Translation:Humans
    42. Hill JS, McPhee JT, McDade TP, Zhou Z, Sullivan ME, Whalen GF, Tseng JF. Pancreatic neuroendocrine tumors: the impact of surgical resection on survival. Cancer. 2009 Feb 15; 115(4):741-51. PMID: 19130464.
      Citations: 113     Fields:    Translation:Humans
    43. Jiang NY, Woda BA, Banner BF, Whalen GF, Dresser KA, Lu D. Sp1, a new biomarker that identifies a subset of aggressive pancreatic ductal adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2008 Jul; 17(7):1648-52. PMID: 18628415.
      Citations: 74     Fields:    Translation:Humans
    44. Bruner DW, Bryan CJ, Aaronson N, Blackmore CC, Brundage M, Cella D, Ganz PA, Gotay C, Hinds PS, Kornblith AB, Movsas B, Sloan J, Wenzel L, Whalen G. Issues and challenges with integrating patient-reported outcomes in clinical trials supported by the National Cancer Institute-sponsored clinical trials networks. J Clin Oncol. 2007 Nov 10; 25(32):5051-7. PMID: 17991920.
      Citations: 31     Fields:    Translation:Humans
    45. McPhee JT, Hill JS, Whalen GF, Zayaruzny M, Litwin DE, Sullivan ME, Anderson FA, Tseng JF. Perioperative mortality for pancreatectomy: a national perspective. Ann Surg. 2007 Aug; 246(2):246-53. PMID: 17667503.
      Citations: 143     Fields:    Translation:Humans
    46. Whalen GF, Kutner J, Byock I, Gerard D, Stovall E, Sieverding P, Ganz PA, Krouse RS. Implementing palliative care studies. J Pain Symptom Manage. 2007 Jul; 34(1 Suppl):S40-8. PMID: 17544245.
      Citations:    Fields:    Translation:Humans
    47. Sharma V, Cui H, Whalen G, Khan A, Torres M. A case of trabecular adenoma of the thyroid with black pigmentation. Thyroid. 2007 Jun; 17(6):593-4. PMID: 17614784.
      Citations:    Fields:    Translation:Humans
    48. Smith JK, McPhee JT, Hill JS, Whalen GF, Sullivan ME, Litwin DE, Anderson FA, Tseng JF. National outcomes after gastric resection for neoplasm. Arch Surg. 2007 Apr; 142(4):387-93. PMID: 17441293.
      Citations: 41     Fields:    Translation:Humans
    49. Shankar S, Bhargava P, Habib F, Desai M, Tyagi G, Whalen G. Transpulmonary CT-guided radiofrequency ablation of liver metastasis. Cardiovasc Intervent Radiol. 2005 Jul-Aug; 28(4):481-4. PMID: 16001134.
      Citations: 2     Fields:    Translation:Humans
    50. Yantiss RK, Woda BA, Fanger GR, Kalos M, Whalen GF, Tada H, Andersen DK, Rock KL, Dresser K. KOC (K homology domain containing protein overexpressed in cancer): a novel molecular marker that distinguishes between benign and malignant lesions of the pancreas. Am J Surg Pathol. 2005 Feb; 29(2):188-95. PMID: 15644775.
      Citations: 42     Fields:    Translation:HumansAnimals
    51. Sidiropoulos N, Vento J, Malchoff C, Whalen G. Radioguided tumorectomy in the management of parathyroid adenomas. Arch Surg. 2003 Jul; 138(7):716-20. PMID: 12860751.
      Citations: 3     Fields:    Translation:Humans
    52. MacGillivray DC, Whalen GF, Malchoff CD, Oppenheim DS, Shichman SJ. Laparoscopic resection of large adrenal tumors. Ann Surg Oncol. 2002 Jun; 9(5):480-5. PMID: 12052760.
      Citations: 33     Fields:    Translation:Humans
    53. Whalen GF, Ferrans CE. Quality of life as an outcome in clinical trials and cancer care: a primer for surgeons. J Surg Oncol. 2001 Aug; 77(4):270-6. PMID: 11473376.
      Citations: 6     Fields:    Translation:Humans
    54. Whalen GF, Bird I, Tanski W, Russell JC, Clive J. Laparoscopic cholecystectomy does not demonstrably decrease survival of patients with serendipitously treated gallbladder cancer. J Am Coll Surg. 2001 Feb; 192(2):189-95. PMID: 11220719.
      Citations: 13     Fields:    Translation:Humans
    55. Veillette G, MacGillivray D, Whalen G. Practical experience with the Stoppa repair of ventral/incisional hernias. Conn Med. 2001 Feb; 65(2):67-70. PMID: 11265603.
      Citations: 3     Fields:    Translation:Humans
    56. Malchoff CD, Sarfarazi M, Tendler B, Forouhar F, Whalen G, Joshi V, Arnold A, Malchoff DM. Papillary thyroid carcinoma associated with papillary renal neoplasia: genetic linkage analysis of a distinct heritable tumor syndrome. J Clin Endocrinol Metab. 2000 May; 85(5):1758-64. PMID: 10843148.
      Citations: 59     Fields:    Translation:HumansCells
    57. Malchoff CD, Sarfarazi M, Tendler B, Forouhar F, Whalen G, Malchoff DM. Familial papillary thyroid carcinoma is genetically distinct from familial adenomatous polyposis coli. Thyroid. 1999 Mar; 9(3):247-52. PMID: 10211600.
      Citations: 8     Fields:    Translation:Humans
    58. Gendreau KM, Whalen GF. What can we learn from the phenomenon of preferential lymph node metastasis in carcinoma? J Surg Oncol. 1999 Mar; 70(3):199-204. PMID: 10102353.
      Citations: 6     Fields:    Translation:Humans
    59. Shichman SJ, Herndon CD, Sosa RE, Whalen GF, MacGillivray DC, Malchoff CD, Vaughan ED. Lateral transperitoneal laparoscopic adrenalectomy. World J Urol. 1999 Feb; 17(1):48-53. PMID: 10096151.
      Citations: 10     Fields:    Translation:Humans
    60. Fox SH, Whalen GF, Sanders MM, Burleson JA, Jennings K, Kurtzman S, Kreutzer D. Angiogenesis in normal tissue adjacent to colon cancer. J Surg Oncol. 1998 Dec; 69(4):230-4. PMID: 9881940.
      Citations: 20     Fields:    Translation:Humans
    61. Woolfson RG, Jennings K, Whalen GF. Management of bowel obstruction in patients with abdominal cancer. Arch Surg. 1997 Oct; 132(10):1093-7. PMID: 9336507.
      Citations: 13     Fields:    Translation:HumansCTClinical Trials
    62. Hyacinthe LM, Jarrett TW, Gordon CS, Vaughan ED, Whalen GF. Inhibition of bladder tumor cell implantation in cauterized urothelium, without inhibition of healing, by a fibronectin-related peptide (GRGDS). Ann Surg Oncol. 1995 Sep; 2(5):450-6. PMID: 7496842.
      Citations:    Fields:    Translation:AnimalsCells
    63. Fong Y, Whalen GF, Hariri RJ, Barie PS. Utility of routine chest radiographs in the surgical intensive care unit. A prospective study. Arch Surg. 1995 Jul; 130(7):764-8. PMID: 7611867.
      Citations: 12     Fields:    Translation:HumansCTClinical Trials
    64. Whalen GF, Gordon C, Yeshion C, Juers D, Yurt R. Influence of a lymph node environment on invasiveness of metastatic tumor cells. J Am Coll Surg. 1994 Aug; 179(2):145-50. PMID: 8044382.
      Citations: 1     Fields:    Translation:AnimalsCells
    65. Dyce M, Sharif SF, Whalen GF. Search for anti-metastatic therapy: effects of phenytoin on B16 melanoma metastasis. J Surg Oncol. 1992 Feb; 49(2):107-12. PMID: 1738231.
      Citations: 2     Fields:    Translation:Animals
    66. Whalen GF, Sharif SF. Locally increased metastatic efficiency as a reason for preferential metastasis of solid tumors to lymph nodes. Ann Surg. 1992 Feb; 215(2):166-71. PMID: 1546903.
      Citations: 2     Fields:    Translation:AnimalsCells
    67. Whalen GF, Ingber DE. Inhibition of tumor-cell attachment to extracellular matrix as a method for preventing tumor recurrence in a surgical wound. Ann Surg. 1989 Dec; 210(6):758-64. PMID: 2686568.
      Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    68. Whalen G, Robbs JV. Penetrating wounds of the heart: the aftermath. J R Coll Surg Edinb. 1987 Jun; 32(3):139-41. PMID: 3656234.
      Citations: 1     Fields:    Translation:Humans
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