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Hardy Kornfeld MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-2646
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionPulmonary, Allergy And Critical Care Medicine

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentImmunology and Virology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program


    Collapse Biography 
    Collapse education and training
    Bennington College, North Bennington, VT, United StatesBALiberal Arts
    Boston University School of Medicine, Boston, MA, United StatesMD

    Collapse Overview 
    Collapse overview

    The Kornfeld Laboratory Link

    Education

    Medical School: Boston University School of Medicine, Boston, MA, 1978.
    Medical Residency: University Hospital, Boston, MA, 1980.
    St Luke's Hospital, NY, NY, 1981.
    Infectious Disease Fellowship: St Luke's-Roosevelt Hospital Center, NY, NY, 1982.
    Pulmonary Fellowship: Boston University School of Medicine, Boston, MA, 1985.
    Molecular virology Fellowship: Harvard School of Public Health, Boston, MA, 1987.

    Clinical, educational, scientific interests

    Tuberculosis
    Immunology
    Host defense against respiratory pathogens
    Impact of metabolic disorders on host defense
    Critical care

    Research Activities:

    1. Role of macrophage apoptosis in TB defense
    2. Impact of diabetes and hyperlipidemia on TB defense
    3. Role of IL-16 in protective immunity
    4. Heterologous immunity between viruses and mycobacteria




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kumar NP, Moideen K, Nancy A, Viswanathan V, Shruthi BS, Sivakumar S, Natarajan M, Kornfeld H, Babu S. Heterogeneity in the cytokine profile of tuberculosis - diabetes co-morbidity. Cytokine. 2019 Aug 28; 125:154824. PMID: 31472402.
      View in: PubMed
    2. Kumar NP, Fukutani KF, Shruthi BS, Alves T, Silveira-Mattos PS, Rocha MS, West K, Natarajan M, Viswanathan V, Babu S, Andrade BB, Kornfeld H. Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity. Elife. 2019 Jul 04; 8. PMID: 31271354.
      View in: PubMed
    3. Martinez N, Cheng CY, Ketheesan N, Cullen A, Tang Y, Lum J, West K, Poidinger M, Guertin DA, Singhal A, Kornfeld H. mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis. EBioMedicine. 2019 Jul 03. PMID: 31279779.
      View in: PubMed
    4. Martinez N, Kornfeld H. Tuberculosis and diabetes: from bench to bedside and back. Int J Tuberc Lung Dis. 2019 Jun 01; 23(6):669-677. PMID: 31315698.
      View in: PubMed
    5. Magee MJ, Salindri AD, Kornfeld H, Singhal A. Reduced prevalence of latent tuberculosis infection in diabetes patients using metformin and statins. Eur Respir J. 2019 Mar; 53(3). PMID: 30523163.
      View in: PubMed
    6. Kumar NP, Moideen K, Bhootra Y, Nancy A, Viswanathan V, Shruthi BS, Sivakumar S, Natarajan M, Kornfeld H, Babu S. Elevated circulating levels of monocyte activation markers among tuberculosis patients with diabetes co-morbidity. Immunology. 2018 Nov 14. PMID: 30427060.
      View in: PubMed
    7. Kumar NP, Moideen K, Viswanathan V, Shruthi BS, Sivakumar S, Menon PA, Kornfeld H, Babu S. Elevated levels of matrix metalloproteinases reflect severity and extent of disease in tuberculosis-diabetes co-morbidity and are predominantly reversed following standard anti-tuberculosis or metformin treatment. BMC Infect Dis. 2018 Jul 25; 18(1):345. PMID: 30045688.
      View in: PubMed
    8. Dai Y, Wen Z, Ye T, Deng G, Zhang M, Deng Q, Yang Q, Shan W, Kornfeld H, Cai Y, Chen X. Empirical treatment with non-anti-tuberculosis antibiotics decreased microbiological detection in cervical tuberculous lymphadenitis. Diagn Microbiol Infect Dis. 2018 Jun 20. PMID: 30076042.
      View in: PubMed
    9. Kornfeld H, Singhal A. Enlisting the Host to Fight TB. Chest. 2018 Jun; 153(6):1292-1293. PMID: 29884247.
      View in: PubMed
    10. Liu X, Hou XF, Gao L, Deng GF, Zhang MX, Deng QY, Ye TS, Yang QT, Zhou BP, Wen ZH, Liu HY, Kornfeld H, Chen XC. Indicators for prediction of Mycobacterium tuberculosis positivity detected with bronchoalveolar lavage fluid. Infect Dis Poverty. 2018 Mar 24; 7(1):22. PMID: 29580276.
      View in: PubMed
    11. Ravimohan S, Kornfeld H, Weissman D, Bisson GP. Tuberculosis and lung damage: from epidemiology to pathophysiology. Eur Respir Rev. 2018 Mar 31; 27(147). PMID: 29491034.
      View in: PubMed
    12. Kumar NP, Moideen K, Viswanathan V, Sivakumar S, Menon PA, Kornfeld H, Babu S. Heightened circulating levels of antimicrobial peptides in tuberculosis-Diabetes co-morbidity and reversal upon treatment. PLoS One. 2017; 12(9):e0184753. PMID: 28910369.
      View in: PubMed
    13. Prada-Medina CA, Fukutani KF, Pavan Kumar N, Gil-Santana L, Babu S, Lichtenstein F, West K, Sivakumar S, Menon PA, Viswanathan V, Andrade BB, Nakaya HI, Kornfeld H. Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications. Sci Rep. 2017 May 17; 7(1):1999. PMID: 28515464.
      View in: PubMed
    14. Boggiano C, Eichelberg K, Ramachandra L, Shea J, Ramakrishnan L, Behar S, Ernst JD, Porcelli SA, Maeurer M, Kornfeld H. "The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report. Vaccine. 2017 May 02. PMID: 28476627.
      View in: PubMed
    15. Ronacher K, van Crevel R, Critchley J, Bremer AA, Schlesinger LS, Kapur A, Basaraba R, Kornfeld H, Restrepo BI. Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 2: Underlying biological mechanisms. Chest. 2017 Apr 19. PMID: 28434937.
      View in: PubMed
    16. Critchley JA, Restrepo BI, Ronacher K, Kapur A, Bremer AA, Schlesinger LS, Basaraba R, Kornfeld H, van Crevel R. Defining a research agenda to address the converging epidemics of tuberculosis and diabetes. Part 1: Epidemiology and clinical management. Chest. 2017 Apr 19. PMID: 28434936.
      View in: PubMed
    17. Cheng CY, Gutierrez NM, Marzuki MB, Lu X, Foreman TW, Paleja B, Lee B, Balachander A, Chen J, Tsenova L, Kurepina N, Teng KWW, West K, Mehra S, Zolezzi F, Poidinger M, Kreiswirth B, Kaushal D, Kornfeld H, Newell EW, Singhal A. Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis. Sci Immunol. 2017 Mar; 2(9). PMID: 28707004.
      View in: PubMed
    18. Cheekatla SS, Tripathi D, Venkatasubramanian S, Nathella PK, Paidipally P, Ishibashi M, Welch E, Tvinnereim AR, Ikebe M, Valluri VL, Babu S, Kornfeld H, Vankayalapati R. NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection. PLoS Pathog. 2016 Oct; 12(10):e1005972. PMID: 27783671.
      View in: PubMed
    19. Kumar NP, Moideen K, Sivakumar S, Menon PA, Viswanathan V, Kornfeld H, Babu S. Modulation of dendritic cell and monocyte subsets in tuberculosis-diabetes co-morbidity upon standard tuberculosis treatment. Tuberculosis (Edinb). 2016 Dec; 101:191-200. PMID: 27865391.
      View in: PubMed
    20. Kumar NP, Moideen K, Sivakumar S, Menon PA, Viswanathan V, Kornfeld H, Babu S. Tuberculosis-diabetes co-morbidity is characterized by heightened systemic levels of circulating angiogenic factors. J Infect. 2017 Jan; 74(1):10-21. PMID: 27717783.
      View in: PubMed
    21. Smith CM, Proulx MK, Olive AJ, Laddy D, Mishra BB, Moss C, Gutierrez NM, Bellerose MM, Barreira-Silva P, Phuah JY, Baker RE, Behar SM, Kornfeld H, Evans TG, Beamer G, Sassetti CM. Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype. MBio. 2016 Sep 20; 7(5). PMID: 27651361.
      View in: PubMed
    22. Martinez N, Ketheesan N, West K, Vallerskog T, Kornfeld H. Impaired Recognition of Mycobacterium tuberculosis by Alveolar Macrophages From Diabetic Mice. J Infect Dis. 2016 Dec 01; 214(11):1629-1637. PMID: 27630197.
      View in: PubMed
    23. Kumar NP, Moideen K, Viswanathan V, Kornfeld H, Babu S. Effect of standard tuberculosis treatment on naive, memory and regulatory T-cell homeostasis in tuberculosis-diabetes co-morbidity. Immunology. 2016 Sep; 149(1):87-97. PMID: 27289086.
      View in: PubMed
    24. Martinez N, Ketheesan N, Martens GW, West K, Lien E, Kornfeld H. Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice. Microbes Infect. 2016 Oct; 18(10):649-655. PMID: 27256462.
      View in: PubMed
    25. Almeida-Junior JL, Gil-Santana L, Oliveira CA, Castro S, Cafezeiro AS, Daltro C, Netto EM, Kornfeld H, Andrade BB. Glucose Metabolism Disorder Is Associated with Pulmonary Tuberculosis in Individuals with Respiratory Symptoms from Brazil. PLoS One. 2016; 11(4):e0153590. PMID: 27078026.
      View in: PubMed
    26. Kornfeld H, West K, Kane K, Kumpatla S, Zacharias RR, Martinez-Balzano C, Li W, Viswanathan V. High Prevalence and Heterogeneity of Diabetes in Patients With TB in South India: A Report from the Effects of Diabetes on Tuberculosis Severity (EDOTS) Study. Chest. 2016 Jun; 149(6):1501-8. PMID: 26973015.
      View in: PubMed
    27. Ní Cheallaigh C, Sheedy FJ, Harris J, Muñoz-Wolf N, Lee J, West K, McDermott EP, Smyth A, Gleeson LE, Coleman M, Martinez N, Hearnden CH, Tynan GA, Carroll EC, Jones SA, Corr SC, Bernard NJ, Hughes MM, Corcoran SE, O'Sullivan M, Fallon CM, Kornfeld H, Golenbock D, Gordon SV, O'Neill LA, Lavelle EC, Keane J. A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling. Immunity. 2016 Feb 16; 44(2):368-79. PMID: 26885859.
      View in: PubMed
    28. Gil-Santana L, Almeida-Junior JL, Oliveira CA, Hickson LS, Daltro C, Castro S, Kornfeld H, Netto EM, Andrade BB. Diabetes Is Associated with Worse Clinical Presentation in Tuberculosis Patients from Brazil: A Retrospective Cohort Study. PLoS One. 2016; 11(1):e0146876. PMID: 26752596.
      View in: PubMed
    29. Yang Q, Xu Q, Chen Q, Li J, Zhang M, Cai Y, Liu H, Zhou Y, Deng G, Deng Q, Zhou B, Kornfeld H, Chen X. Discriminating Active Tuberculosis from Latent Tuberculosis Infection by flow cytometric measurement of CD161-expressing T cells. Sci Rep. 2015 Dec 08; 5:17918. PMID: 26643453.
      View in: PubMed
    30. Lee J, Martinez N, West K, Kornfeld H. Differential adjuvant activities of TLR7 and TLR9 agonists inversely correlate with nitric oxide and PGE2 production. PLoS One. 2015; 10(4):e0123165. PMID: 25875128.
      View in: PubMed
    31. Repasy T, Martinez N, Lee J, West K, Li W, Kornfeld H. Bacillary replication and macrophage necrosis are determinants of neutrophil recruitment in tuberculosis. Microbes Infect. 2015 Aug; 17(8):564-74. PMID: 25862076.
      View in: PubMed
    32. Moraco AH, Kornfeld H. Cell death and autophagy in tuberculosis. Semin Immunol. 2014 Dec; 26(6):497-511. PMID: 25453227.
      View in: PubMed
    33. Yang Q, Cai Y, Zhao W, Wu F, Zhang M, Luo K, Zhang Y, Liu H, Zhou B, Kornfeld H, Chen X. IP-10 and MIG are compartmentalized at the site of disease during pleural and meningeal tuberculosis and are decreased after antituberculosis treatment. Clin Vaccine Immunol. 2014 Dec; 21(12):1635-44. PMID: 25274803.
      View in: PubMed
    34. Martinez N, Vallerskog T, West K, Nunes-Alves C, Lee J, Martens GW, Behar SM, Kornfeld H. Chromatin decondensation and T cell hyperresponsiveness in diabetes-associated hyperglycemia. J Immunol. 2014 Nov 1; 193(9):4457-68. PMID: 25246495.
      View in: PubMed
    35. Martinez N, Kornfeld H. Diabetes and immunity to tuberculosis. Eur J Immunol. 2014 Mar; 44(3):617-26. PMID: 24448841.
      View in: PubMed
    36. Lee J, Brehm MA, Greiner D, Shultz LD, Kornfeld H. Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice. BMC Immunol. 2013 Dec 07; 14:53. PMID: 24313934.
      View in: PubMed
    37. Reed GW, Choi H, Lee SY, Lee M, Kim Y, Park H, Lee J, Zhan X, Kang H, Hwang S, Carroll M, Cai Y, Cho SN, Barry CE, Via LE, Kornfeld H. Impact of diabetes and smoking on mortality in tuberculosis. PLoS One. 2013; 8(2):e58044. PMID: 23469139.
      View in: PubMed
    38. Repasy T, Lee J, Marino S, Martinez N, Kirschner DE, Hendricks G, Baker S, Wilson AA, Kotton DN, Kornfeld H. Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo. PLoS Pathog. 2013 Feb; 9(2):e1003190. PMID: 23436998.
      View in: PubMed
    39. Mishra BB, Rathinam VA, Martens GW, Martinot AJ, Kornfeld H, Fitzgerald KA, Sassetti CM. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1ß. Nat Immunol. 2013 Jan; 14(1):52-60. PMID: 23160153.
      View in: PubMed
    40. Richmond JM, Lee J, Green DS, Kornfeld H, Cruikshank WW. Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells. J Immunol. 2012 Dec 15; 189(12):5886-95. PMID: 23129756.
      View in: PubMed
    41. Richmond JM, Duffy ER, Lee J, Kaboli K, Kim YS, Remick DG, Kornfeld H, Cruikshank WW. Mannose-capped Lipoarabinomannan from Mycobacterium tuberculosis induces soluble tumor necrosis factor receptor production through tumor necrosis factor alpha-converting enzyme activation. Infect Immun. 2012 Nov; 80(11):3858-68. PMID: 22927046.
      View in: PubMed
    42. Narayan K, Sylvia KE, Malhotra N, Yin CC, Martens G, Vallerskog T, Kornfeld H, Xiong N, Cohen NR, Brenner MB, Berg LJ, Kang J. Intrathymic programming of effector fates in three molecularly distinct ?d T cell subtypes. Nat Immunol. 2012 Apr 01; 13(5):511-8. PMID: 22473038.
      View in: PubMed
    43. Martens GW, Vallerskog T, Kornfeld H. Hypercholesterolemic LDL receptor-deficient mice mount a neutrophilic response to tuberculosis despite the timely expression of protective immunity. J Leukoc Biol. 2012 Jun; 91(6):849-57. PMID: 22227965.
      View in: PubMed
    44. Kimura N, Itoh S, Nakae S, Axtell RC, Velotta JB, Bos EJ, Merk DR, Gong Y, Okamura H, Nagamine CM, Adachi H, Kornfeld H, Robbins RC, Fischbein MP. Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model. J Heart Lung Transplant. 2011 Dec; 30(12):1409-17. PMID: 22055099.
      View in: PubMed
    45. Hartman ML, Kornfeld H. Interactions between naïve and infected macrophages reduce Mycobacterium tuberculosis viability. PLoS One. 2011; 6(11):e27972. PMID: 22125644.
      View in: PubMed
    46. Lee J, Repasy T, Papavinasasundaram K, Sassetti C, Kornfeld H. Mycobacterium tuberculosis induces an atypical cell death mode to escape from infected macrophages. PLoS One. 2011 Mar 31; 6(3):e18367. PMID: 21483832.
      View in: PubMed
    47. Harris J, Hartman M, Roche C, Zeng SG, O'Shea A, Sharp FA, Lambe EM, Creagh EM, Golenbock DT, Tschopp J, Kornfeld H, Fitzgerald KA, Lavelle EC. Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem. 2011 Mar 18; 286(11):9587-97. PMID: 21228274.
      View in: PubMed
    48. Ghigo E, Barry AO, Pretat L, Al Moussawi K, Desnues B, Capo C, Kornfeld H, Mege JL. IL-16 promotes T. whipplei replication by inhibiting phagosome conversion and modulating macrophage activation. PLoS One. 2010; 5(10):e13561. PMID: 21042409.
      View in: PubMed
    49. Vallerskog T, Martens GW, Kornfeld H. Diabetic mice display a delayed adaptive immune response to Mycobacterium tuberculosis. J Immunol. 2010 Jun 1; 184(11):6275-82. PMID: 20421645.
      View in: PubMed
    50. Lee J, Kornfeld H. Interferon-? Regulates the Death of M. tuberculosis-Infected Macrophages. J Cell Death. 2010 Mar 3; 3:1-11. PMID: 21072140.
      View in: PubMed
    51. Kashino SS, Vallerskog T, Martens G, Troudt J, Keyser A, Taylor J, Izzo A, Kornfeld H, Campos-Neto A. Initiation of acquired immunity in the lungs of mice lacking lymph nodes after infection with aerosolized Mycobacterium tuberculosis. Am J Pathol. 2010 Jan; 176(1):198-204. PMID: 20008132.
      View in: PubMed
    52. Han R, Kornfeld H, Martens G. Is hypercholesterolemia a friend or a foe of tuberculosis? Infect Immun. 2009 Aug; 77(8):3514; author reply 3514-5. PMID: 19617455.
      View in: PubMed
    53. Lee J, Hartman M, Kornfeld H. Macrophage apoptosis in tuberculosis. Yonsei Med J. 2009 Feb 28; 50(1):1-11. PMID: 19259342.
      View in: PubMed
    54. Mathurin KS, Martens GW, Kornfeld H, Welsh RM. CD4 T-cell-mediated heterologous immunity between mycobacteria and poxviruses. J Virol. 2009 Apr; 83(8):3528-39. PMID: 19193795.
      View in: PubMed
    55. Friedline RH, Brown DS, Nguyen H, Kornfeld H, Lee J, Zhang Y, Appleby M, Der SD, Kang J, Chambers CA. CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med. 2009 Feb 16; 206(2):421-34. PMID: 19188497.
      View in: PubMed
    56. Gan H, Lee J, Ren F, Chen M, Kornfeld H, Remold HG. Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence. Nat Immunol. 2008 Oct; 9(10):1189-97. PMID: 18794848.
      View in: PubMed
    57. Martens GW, Arikan MC, Lee J, Ren F, Vallerskog T, Kornfeld H. Hypercholesterolemia impairs immunity to tuberculosis. Infect Immun. 2008 Aug; 76(8):3464-72. PMID: 18505807.
      View in: PubMed
    58. Kornfeld H. An ounce of tuberculosis prevention. Chest. 2008 Apr; 133(4):835-6. PMID: 18398110.
      View in: PubMed
    59. Ernst JD, Lewinsohn DM, Behar S, Blythe M, Schlesinger LS, Kornfeld H, Sette A. Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database. Tuberculosis (Edinb). 2008 Jul; 88(4):366-70. PMID: 18068490.
      View in: PubMed
    60. Moise L, McMurry J, Rivera DS, Carter EJ, Lee J, Kornfeld H, Martin WD, De Groot AS. Progress towards a genome-derived, epitope-driven vaccine for latent TB infection. Med Health R I. 2007 Oct; 90(10):301-3. PMID: 18019185.
      View in: PubMed
    61. Martens GW, Arikan MC, Lee J, Ren F, Greiner D, Kornfeld H. Tuberculosis susceptibility of diabetic mice. Am J Respir Cell Mol Biol. 2007 Nov; 37(5):518-24. PMID: 17585110.
      View in: PubMed
    62. Morgan RK, McAllister B, Cross L, Green DS, Kornfeld H, Center DM, Cruikshank WW. Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J Immunol. 2007 Jun 15; 178(12):8081-9. PMID: 17548646.
      View in: PubMed
    63. McMurry JA, Kimball S, Lee JH, Rivera D, Martin W, Weiner DB, Kutzler M, Sherman DR, Kornfeld H, De Groot AS. Epitope-driven TB vaccine development: a streamlined approach using immuno-informatics, ELISpot assays, and HLA transgenic mice. Curr Mol Med. 2007 Jun; 7(4):351-68. PMID: 17584075.
      View in: PubMed
    64. Lee J, Remold HG, Ieong MH, Kornfeld H. Macrophage apoptosis in response to high intracellular burden of Mycobacterium tuberculosis is mediated by a novel caspase-independent pathway. J Immunol. 2006 Apr 1; 176(7):4267-74. PMID: 16547264.
      View in: PubMed
    65. El Bassam S, Pinsonneault S, Kornfeld H, Ren F, Menezes J, Laberge S. Interleukin-16 inhibits interleukin-13 production by allergen-stimulated blood mononuclear cells. Immunology. 2006 Jan; 117(1):89-96. PMID: 16423044.
      View in: PubMed
    66. Stabile E, Kinnaird T, la Sala A, Hanson SK, Watkins C, Campia U, Shou M, Zbinden S, Fuchs S, Kornfeld H, Epstein SE, Burnett MS. CD8+ T lymphocytes regulate the arteriogenic response to ischemia by infiltrating the site of collateral vessel development and recruiting CD4+ mononuclear cells through the expression of interleukin-16. Circulation. 2006 Jan 3; 113(1):118-24. PMID: 16380545.
      View in: PubMed
    67. Wilson KC, Cattel DJ, Wan Z, Rahangdale S, Ren F, Kornfeld H, Sullivan BA, Cruikshank WW, Center DM. Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes. Cell Immunol. 2005 Sep; 237(1):17-27. PMID: 16289056.
      View in: PubMed
    68. Gan H, He X, Duan L, Mirabile-Levens E, Kornfeld H, Remold HG. Enhancement of antimycobacterial activity of macrophages by stabilization of inner mitochondrial membrane potential. J Infect Dis. 2005 Apr 15; 191(8):1292-300. PMID: 15776376.
      View in: PubMed
    69. Ren F, Zhan X, Martens G, Lee J, Center D, Hanson SK, Kornfeld H. Pro-IL-16 regulation in activated murine CD4+ lymphocytes. J Immunol. 2005 Mar 1; 174(5):2738-45. PMID: 15728482.
      View in: PubMed
    70. Spira A, Carroll JD, Liu G, Aziz Z, Shah V, Kornfeld H, Keane J. Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: a pivotal role for tumor necrosis factor. Am J Respir Cell Mol Biol. 2003 Nov; 29(5):545-51. PMID: 12748057.
      View in: PubMed
    71. Little FF, de Bie J, van Oosterhout A, Kornfeld H, Center DM, Cruikshank WW. Immunomodulatory effect of interleukin-16 on allergic airway inflammation. Chest. 2003 Mar; 123(3 Suppl):431S-2S. PMID: 12629022.
      View in: PubMed
    72. Riendeau CJ, Kornfeld H. THP-1 cell apoptosis in response to Mycobacterial infection. Infect Immun. 2003 Jan; 71(1):254-9. PMID: 12496173.
      View in: PubMed
    73. Saukkonen JJ, Bazydlo B, Thomas M, Strieter RM, Keane J, Kornfeld H. Beta-chemokines are induced by Mycobacterium tuberculosis and inhibit its growth. Infect Immun. 2002 Apr; 70(4):1684-93. PMID: 11895930.
      View in: PubMed
    74. Zhang Y, Kornfeld H, Cruikshank WW, Kim S, Reardon CC, Center DM. Nuclear translocation of the N-terminal prodomain of interleukin-16. J Biol Chem. 2001 Jan 12; 276(2):1299-303. PMID: 11032842.
      View in: PubMed
    75. Ieong MH, Reardon CC, Levitz SM, Kornfeld H. Human immunodeficiency virus type 1 infection of alveolar macrophages impairs their innate fungicidal activity. Am J Respir Crit Care Med. 2000 Sep; 162(3 Pt 1):966-70. PMID: 10988114.
      View in: PubMed
    76. Cruikshank WW, Kornfeld H, Center DM. Interleukin-16. J Leukoc Biol. 2000 Jun; 67(6):757-66. PMID: 10857846.
      View in: PubMed
    77. Liu Y, Cruikshank WW, O'Loughlin T, O'Reilly P, Center DM, Kornfeld H. Identification of a CD4 domain required for interleukin-16 binding and lymphocyte activation. J Biol Chem. 1999 Aug 13; 274(33):23387-95. PMID: 10438516.
      View in: PubMed
    78. Zhang Y, Center DM, Wu DM, Cruikshank WW, Yuan J, Andrews DW, Kornfeld H. Processing and activation of pro-interleukin-16 by caspase-3. J Biol Chem. 1998 Jan 9; 273(2):1144-9. PMID: 9422780.
      View in: PubMed
    79. Fenton MJ, Vermeulen MW, Kim S, Burdick M, Strieter RM, Kornfeld H. Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis. Infect Immun. 1997 Dec; 65(12):5149-56. PMID: 9393809.
      View in: PubMed
    80. Saukkonen JJ, Furfaro S, Mahoney KM, Strieter RM, Burdick M, Wright EA, Kornfeld H, Berman JS. In vitro transendothelial migration of blood T lymphocytes from HIV-infected individuals. AIDS. 1997 Nov; 11(13):1595-601. PMID: 9365764.
      View in: PubMed
    81. Cruikshank WW, Doctrow SR, Falvo MS, Huffman K, Maciaszek J, Viglianti G, Raina J, Kornfeld H, Malfroy B. A lipidated anti-Tat antibody enters living cells and blocks HIV-1 viral replication. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Mar 1; 14(3):193-203. PMID: 9117450.
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    82. Keane J, Balcewicz-Sablinska MK, Remold HG, Chupp GL, Meek BB, Fenton MJ, Kornfeld H. Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis. Infect Immun. 1997 Jan; 65(1):298-304. PMID: 8975927.
      View in: PubMed
    83. Maciaszek JW, Parada NA, Cruikshank WW, Center DM, Kornfeld H, Viglianti GA. IL-16 represses HIV-1 promoter activity. J Immunol. 1997 Jan 1; 158(1):5-8. PMID: 8977168.
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    84. Reardon CC, Kim SJ, Wagner RP, Kornfeld H. Interferon-gamma reduces the capacity of human alveolar macrophages to inhibit growth of Cryptococcus neoformans in vitro. Am J Respir Cell Mol Biol. 1996 Dec; 15(6):711-5. PMID: 8969264.
      View in: PubMed
    85. Cruikshank WW, Long A, Tarpy RE, Kornfeld H, Carroll MP, Teran L, Holgate ST, Center DM. Early identification of interleukin-16 (lymphocyte chemoattractant factor) and macrophage inflammatory protein 1 alpha (MIP1 alpha) in bronchoalveolar lavage fluid of antigen-challenged asthmatics. Am J Respir Cell Mol Biol. 1995 Dec; 13(6):738-47. PMID: 7576712.
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    86. Ryan TC, Cruikshank WW, Kornfeld H, Collins TL, Center DM. The CD4-associated tyrosine kinase p56lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migration. J Biol Chem. 1995 Jul 21; 270(29):17081-6. PMID: 7615501.
      View in: PubMed
    87. Center DM, Kornfeld H, Wu MJ, Falvo M, Theodore AC, Bernardo J, Berman JS, Cruikshank WW, Djukanovic R, Teran L, et al. Cytokine binding to CD4+ inflammatory cells: implications for asthma. Am J Respir Crit Care Med. 1994 Nov; 150(5 Pt 2):S59-62. PMID: 7952594.
      View in: PubMed
    88. Graven KK, Troxler RF, Kornfeld H, Panchenko MV, Farber HW. Regulation of endothelial cell glyceraldehyde-3-phosphate dehydrogenase expression by hypoxia. J Biol Chem. 1994 Sep 30; 269(39):24446-53. PMID: 7929107.
      View in: PubMed
    89. Theodore AC, Kornfeld H, Wallace RP, Cruikshank WW. CD4 modulation of noninfected human T lymphocytes by HIV-1 envelope glycoprotein gp120: contribution to the immunosuppression seen in HIV-1 infection by induction of CD4 and CD3 unresponsiveness. J Acquir Immune Defic Syndr. 1994 Sep; 7(9):899-907. PMID: 7914230.
      View in: PubMed
    90. Saukkonen JJ, Kornfeld H, Berman JS. Expansion of a CD8+CD28- cell population in the blood and lung of HIV-positive patients. J Acquir Immune Defic Syndr. 1993 Nov; 6(11):1194-204. PMID: 8229654.
      View in: PubMed
    91. Tarpy SP, Kornfeld H, Moroz K, Lazar HL. Unusual presentation of a large tension bronchogenic cyst in an adult. Thorax. 1993 Sep; 48(9):951-2. PMID: 8236082.
      View in: PubMed
    92. Oh SK, Cruikshank WW, Raina J, Blanchard GC, Adler WH, Walker J, Kornfeld H. Identification of HIV-1 envelope glycoprotein in the serum of AIDS and ARC patients. J Acquir Immune Defic Syndr. 1992; 5(3):251-6. PMID: 1740750.
      View in: PubMed
    93. Berman JS, Cruikshank WW, Beer DJ, Kornfeld H, Bernardo J, Theodore AC, Center DM. Lymphocyte motility and lymphocyte chemoattractant factors. Immunol Invest. 1988 Nov-Dec; 17(8-9):625-77. PMID: 3068125.
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    94. Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM. Lymphocyte activation by HIV-1 envelope glycoprotein. Nature. 1988 Sep 29; 335(6189):445-8. PMID: 2843775.
      View in: PubMed
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