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Hira Lal Goel PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUMass Chan Medical School
364 Plantation Street LRB
Worcester MA 01605
Phone508-856-1936
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionT.H. Chan School of Medicine
    DepartmentRadiation Oncology


    Collapse Biography 
    Collapse education and training
    Kurukshetra University, Kurukshetra, HR, IndiaM SMicrobiology
    National Institute of Pharmaceutical Education & Research, Punjab, , IndiaPH DBiotechnology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kumar A, Kishimoto K, Goel HL, Wisniewski CA, Li R, Pacheco B, Zhu LJ, Flavahan WA, Mercurio AM. Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism. bioRxiv. 2025 Feb 25. PMID: 40060410.
      Citations:    
    2. Wang M, Prachyathipsakul T, Wisniewski CA, Xiong C, Goel S, Goel HL, Karner ER, Mukhopadhyay D, Gupta P, Majee A, Thayumanavan S, Mercurio AM. Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates. Cell Chem Biol. 2024 Dec 19; 31(12):2039-2051.e6. PMID: 39603241.
      Citations:    
    3. Kumar A, Goel HL, Wisniewski CA, Wang T, Geng Y, Wang M, Goel S, Hu K, Li R, Zhu LJ, Clark JL, Ferreira LM, Brehm MA, FitzGerald TJ, Mercurio AM. Neuropilin-2-expressing breast cancer cells mitigate radiation-induced oxidative stress through nitric oxide signaling. J Clin Invest. 2024 Oct 01; 134(22). PMID: 39352757.
      Citations:    
    4. Goel HL, Karner ER, Kumar A, Mukhopadhyay D, Goel S, Mercurio AM. YAP/TAZ-mediated regulation of laminin 332 is enabled by ?4 integrin repression of ZEB1 to promote ferroptosis resistance. J Biol Chem. 2024 04; 300(4):107202. PMID: 38508310.
      Citations:    
    5. Mukhopadhyay D, Goel HL, Xiong C, Goel S, Kumar A, Li R, Zhu LJ, Clark JL, Brehm MA, Mercurio AM. The calcium channel TRPC6 promotes chemotherapy-induced persistence by regulating integrin a6 mRNA splicing. Cell Rep. 2023 11 28; 42(11):113347. PMID: 37910503.
      Citations: 1     Fields:    
    6. Doshi MB, Lee N, Tseyang T, Ponomarova O, Goel HL, Spears M, Li R, Zhu LJ, Ashwood C, Simin K, Jang C, Mercurio AM, Walhout AJM, Spinelli JB, Kim D. Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells. Nature. 2023 Nov; 623(7987):625-632. PMID: 37880368.
      Citations: 1     Fields:    Translation:HumansCells
    7. Wang M, Wisniewski CA, Xiong C, Chhoy P, Goel HL, Kumar A, Zhu LJ, Li R, St Louis PA, Ferreira LM, Pakula H, Xu Z, Loda M, Jiang Z, Brehm MA, Mercurio AM. Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer. Sci Transl Med. 2023 05 03; 15(694):eade5855. PMID: 37134151.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    8. Xu Z, Goel HL, Burkart C, Burman L, Chong YE, Barber AG, Geng Y, Zhai L, Wang M, Kumar A, Menefee A, Polizzi C, Eide L, Rauch K, Rahman J, Hamel K, Fogassy Z, Klopp-Savino S, Paz S, Zhang M, Cubitt A, Nangle LA, Mercurio AM. Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer. Sci Transl Med. 2023 05 03; 15(694):eadf1128. PMID: 37134152.
      Citations: 2     Fields:    Translation:HumansCells
    9. Walker MR, Goel HL, Mukhopadhyay D, Chhoy P, Karner ER, Clark JL, Liu H, Li R, Zhu JL, Chen S, Mahal LK, Bensing BA, Mercurio AM. O-linked a2,3 sialylation defines stem cell populations in breast cancer. Sci Adv. 2022 Jan 07; 8(1):eabj9513. PMID: 34995107.
      Citations: 5     Fields:    
    10. Geng Y, Amante JJ, Goel HL, Zhang X, Walker MR, Luther DC, Mercurio AM, Rotello VM. Differentiation of Cancer Stem Cells through Nanoparticle Surface Engineering. ACS Nano. 2020 11 24; 14(11):15276-15285. PMID: 33164505.
      Citations: 8     Fields:    Translation:HumansCells
    11. Walker MR, Amante JJ, Li J, Liu H, Zhu LJ, Feltri ML, Goel HL, Mercurio AM. Alveolar progenitor cells in the mammary gland are dependent on the ?4 integrin. Dev Biol. 2020 01 01; 457(1):13-19. PMID: 31586558.
      Citations: 2     Fields:    Translation:AnimalsCells
    12. Elaimy AL, Wang M, Sheel A, Brown CW, Walker MR, Amante JJ, Xue W, Chan A, Baer CE, Goel HL, Mercurio AM. Real-time imaging of integrin ?4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing. J Cell Sci. 2019 07 31; 132(15). PMID: 31262785.
      Citations: 7     Fields:    Translation:Humans
    13. Elaimy AL, Amante JJ, Zhu LJ, Wang M, Walmsley CS, FitzGerald TJ, Goel HL, Mercurio AM. The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):14174-14180. PMID: 31235595.
      Citations: 22     Fields:    Translation:HumansCells
    14. Zhang H, Brown RL, Wei Y, Zhao P, Liu S, Liu X, Deng Y, Hu X, Zhang J, Gao XD, Kang Y, Mercurio AM, Goel HL, Cheng C. CD44 splice isoform switching determines breast cancer stem cell state. Genes Dev. 2019 02 01; 33(3-4):166-179. PMID: 30692202.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    15. Wang T, Huang J, Vue M, Alavian MR, Goel HL, Altieri DC, Languino LR, FitzGerald TJ. av?3 Integrin Mediates Radioresistance of Prostate Cancer Cells through Regulation of Survivin. Mol Cancer Res. 2019 02; 17(2):398-408. PMID: 30266752.
      Citations: 15     Fields:    Translation:HumansCells
    16. Geng Y, Goel HL, Le NB, Yoshii T, Mout R, Tonga GY, Amante JJ, Mercurio AM, Rotello VM. Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays. Nanomedicine. 2018 08; 14(6):1931-1939. PMID: 29778888.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    17. Elaimy AL, Guru S, Chang C, Ou J, Amante JJ, Zhu LJ, Goel HL, Mercurio AM. VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP ?2-chimaerin. Sci Signal. 2018 05 01; 11(528). PMID: 29717062.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    18. Brown CW, Amante JJ, Goel HL, Mercurio AM. The a6?4 integrin promotes resistance to ferroptosis. J Cell Biol. 2017 12 04; 216(12):4287-4297. PMID: 28972104.
      Citations: 76     Fields:    Translation:HumansCells
    19. Goel HL, Pursell B, Shultz LD, Greiner DL, Brekken RA, Vander Kooi CW, Mercurio AM. P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer. Cell Rep. 2016 Mar 08; 14(9):2193-2208. PMID: 26923603.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    20. Liu X, Li H, Rajurkar M, Li Q, Cotton JL, Ou J, Zhu LJ, Goel HL, Mercurio AM, Park JS, Davis RJ, Mao J. Tead and AP1 Coordinate Transcription and Motility. Cell Rep. 2016 Feb 09; 14(5):1169-1180. PMID: 26832411.
      Citations: 118     Fields:    Translation:HumansCells
    21. Yoshii T, Geng Y, Le ND, Goel HL, Mercurio AM, Rotello VM. Highlights from the latest articles in nanomaterial-based therapies for targeting cancer stem cells. Nanomedicine (Lond). 2015; 10(23):3427-9. PMID: 26606862.
      Citations: 1     Fields:    
    22. Parker MW, Linkugel AD, Goel HL, Wu T, Mercurio AM, Vander Kooi CW. Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form. Structure. 2015 Apr 07; 23(4):677-87. PMID: 25752543.
      Citations: 27     Fields:    Translation:HumansCells
    23. Chang C, Goel HL, Gao H, Pursell B, Shultz LD, Greiner DL, Ingerpuu S, Patarroyo M, Cao S, Lim E, Mao J, McKee KK, Yurchenco PD, Mercurio AM. A laminin 511 matrix is regulated by TAZ and functions as the ligand for the a6B?1 integrin to sustain breast cancer stem cells. Genes Dev. 2015 Jan 01; 29(1):1-6. PMID: 25561492.
      Citations: 67     Fields:    Translation:HumansCells
    24. Goel HL, Gritsko T, Pursell B, Chang C, Shultz LD, Greiner DL, Norum JH, Toftgard R, Shaw LM, Mercurio AM. Regulated splicing of the a6 integrin cytoplasmic domain determines the fate of breast cancer stem cells. Cell Rep. 2014 May 08; 7(3):747-61. PMID: 24767994.
      Citations: 68     Fields:    Translation:HumansCells
    25. Goel HL, Mercurio AM. VEGF targets the tumour cell. Nat Rev Cancer. 2013 Dec; 13(12):871-82. PMID: 24263190.
      Citations: 530     Fields:    Translation:HumansAnimalsCells
    26. Goel HL, Sayeed A, Breen M, Zarif MJ, Garlick DS, Leav I, Davis RJ, Fitzgerald TJ, Morrione A, Hsieh CC, Liu Q, Dicker AP, Altieri DC, Languino LR. ?1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1. J Cell Physiol. 2013 Jul; 228(7):1601-9. PMID: 23359252.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    27. Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM. GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med. 2013 Apr; 5(4):488-508. PMID: 23436775.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    28. Goel HL, Mercurio AM. Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology. Cell Adh Migr. 2012 Nov-Dec; 6(6):554-60. PMID: 23076131.
      Citations: 19     Fields:    Translation:HumansCells
    29. Goel HL, Chang C, Pursell B, Leav I, Lyle S, Xi HS, Hsieh CC, Adisetiyo H, Roy-Burman P, Coleman IM, Nelson PS, Vessella RL, Davis RJ, Plymate SR, Mercurio AM. VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer. Cancer Discov. 2012 Oct; 2(10):906-21. PMID: 22777769.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    30. Goel HL, Pursell B, Standley C, Fogarty K, Mercurio AM. Neuropilin-2 regulates a6?1 integrin in the formation of focal adhesions and signaling. J Cell Sci. 2012 Jan 15; 125(Pt 2):497-506. PMID: 22302985.
      Citations: 39     Fields:    Translation:HumansCells
    31. Goel HL, Bae D, Pursell B, Gouvin LM, Lu S, Mercurio AM. Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland. Development. 2011 Jul; 138(14):2969-76. PMID: 21693513.
      Citations: 12     Fields:    Translation:AnimalsCells
    32. Goel HL, Underwood JM, Nickerson JA, Hsieh CC, Languino LR. Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1. J Cell Physiol. 2010 Jul; 224(1):210-7. PMID: 20333644.
      Citations: 25     Fields:    Translation:HumansCells
    33. Trerotola M, Rathore S, Goel HL, Li J, Alberti S, Piantelli M, Adams D, Jiang Z, Languino LR. CD133, Trop-2 and alpha2beta1 integrin surface receptors as markers of putative human prostate cancer stem cells. Am J Transl Res. 2010 Mar 15; 2(2):135-44. PMID: 20407603.
      Citations:    
    34. Leav I, Plescia J, Goel HL, Li J, Jiang Z, Cohen RJ, Languino LR, Altieri DC. Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. Am J Pathol. 2010 Jan; 176(1):393-401. PMID: 19948822.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    35. Goel HL, Moro L, Murphy-Ullrich JE, Hsieh CC, Wu CL, Jiang Z, Languino LR. Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1. Cancer Res. 2009 Jul 01; 69(13):5374-82. PMID: 19549894.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    36. Goel HL, Alam N, Johnson IN, Languino LR. Integrin signaling aberrations in prostate cancer. Am J Transl Res. 2009 Apr 20; 1(3):211-20. PMID: 19956432.
      Citations:    
    37. Wang T, Alavian MR, Goel HL, Languino LR, Fitzgerald TJ. Bicalutamide inhibits androgen-mediated adhesion of prostate cancer cells exposed to ionizing radiation. Prostate. 2008 Dec 01; 68(16):1734-42. PMID: 18729104.
      Citations: 5     Fields:    Translation:HumansCells
    38. Goel HL, Li J, Kogan S, Languino LR. Integrins in prostate cancer progression. Endocr Relat Cancer. 2008 Sep; 15(3):657-64. PMID: 18524948.
      Citations: 94     Fields:    Translation:HumansAnimals
    39. Fitzgerald TJ, Wang T, Goel HL, Huang J, Stein G, Lian J, Davis RJ, Doxsey S, Balaji KC, Aronowitz J, Languino LR. Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention. Expert Rev Anticancer Ther. 2008 Jun; 8(6):967-74. PMID: 18533806.
      Citations: 15     Fields:    Translation:Humans
    40. Alam N, Goel HL, Zarif MJ, Butterfield JE, Perkins HM, Sansoucy BG, Sawyer TK, Languino LR. The integrin-growth factor receptor duet. J Cell Physiol. 2007 Dec; 213(3):649-53. PMID: 17886260.
      Citations: 88     Fields:    Translation:HumansAnimals
    41. Goel HL, Moro L, King M, Teider N, Centrella M, McCarthy TL, Holgado-Madruga M, Wong AJ, Marra E, Languino LR. Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment. Cancer Res. 2006 Jan 01; 66(1):331-42. PMID: 16397247.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    42. Goel HL, Breen M, Zhang J, Das I, Aznavoorian-Cheshire S, Greenberg NM, Elgavish A, Languino LR. beta1A integrin expression is required for type 1 insulin-like growth factor receptor mitogenic and transforming activities and localization to focal contacts. Cancer Res. 2005 Aug 01; 65(15):6692-700. PMID: 16061650.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    43. Simon EL, Goel HL, Teider N, Wang T, Languino LR, Fitzgerald TJ. High dose fractionated ionizing radiation inhibits prostate cancer cell adhesion and beta(1) integrin expression. Prostate. 2005 Jun 15; 64(1):83-91. PMID: 15651037.
      Citations: 7     Fields:    Translation:HumansCells
    44. Goel HL, Fornaro M, Moro L, Teider N, Rhim JS, King M, Languino LR. Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins. J Cell Biol. 2004 Aug 02; 166(3):407-18. PMID: 15289498.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    45. Goel HL, Languino LR. Integrin signaling in cancer. Cancer Treat Res. 2004; 119:15-31. PMID: 15164871.
      Citations: 12     Fields:    Translation:HumansCells
    46. Goel HL, Dey CS. Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, phosphatidylinositol 3-kinase and extracellular signal regulated kinases. J Cell Physiol. 2002 Nov; 193(2):187-98. PMID: 12384996.
      Citations: 6     Fields:    Translation:AnimalsCells
    47. Goel HL, Dey CS. PKC-regulated myogenesis is associated with increased tyrosine phosphorylation of FAK, Cas, and paxillin, formation of Cas-CRK complex, and JNK activation. Differentiation. 2002 Aug; 70(6):257-71. PMID: 12190987.
      Citations: 10     Fields:    Translation:AnimalsCells
    48. Goel HL, Dey CS. Role of protein kinase C during insulin mediated skeletal muscle cell spreading. J Muscle Res Cell Motil. 2002; 23(4):269-77. PMID: 12630700.
      Citations: 1     Fields:    Translation:AnimalsCells
    49. Goel HL, Dey CS. Insulin-mediated tyrosine phosphorylation of myosin heavy chain and concomitant enhanced association of C-terminal SRC kinase during skeletal muscle differentiation. Cell Biol Int. 2002; 26(6):557-61. PMID: 12119182.
      Citations: 5     Fields:    Translation:AnimalsCells
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