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Hira Lal Goel PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUniversity of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-1936
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionUMMS - School of Medicine
    DepartmentRadiation Oncology


    Collapse Biography 
    Collapse education and training
    Kurukshetra University, Kurukshetra, HR, IndiaM SMicrobiology
    National Institute of Pharmaceutical Education & Research, Punjab, , IndiaPH DBiotechnology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Elaimy AL, Sheel A, Brown CW, Walker MR, Wang M, Amante JJ, Xue W, Chan A, Baer CE, Goel HL, Mercurio AM. Real-time imaging of integrin ß4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing. J Cell Sci. 2019 Jul 01. PMID: 31262785.
      View in: PubMed
    2. Elaimy AL, Amante JJ, Zhu LJ, Wang M, Walmsley CS, FitzGerald TJ, Goel HL, Mercurio AM. The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression. Proc Natl Acad Sci U S A. 2019 Jun 24. PMID: 31235595.
      View in: PubMed
    3. Zhang H, Brown RL, Wei Y, Zhao P, Liu S, Liu X, Deng Y, Hu X, Zhang J, Gao XD, Kang Y, Mercurio AM, Goel HL, Cheng C. CD44 splice isoform switching determines breast cancer stem cell state. Genes Dev. 2019 Feb 01; 33(3-4):166-179. PMID: 30692202.
      View in: PubMed
    4. Wang T, Huang J, Vue M, Alavian MR, Goel HL, Altieri DC, Languino LR, Fitzgerald TJ. avß3 INTEGRIN MEDIATES RADIORESISTANCE OF PROSTATE CANCER CELLS THROUGH REGULATION OF SURVIVIN. Mol Cancer Res. 2018 Sep 28. PMID: 30266752.
      View in: PubMed
    5. Geng Y, Goel HL, Le NB, Yoshii T, Mout R, Tonga GY, Amante JJ, Mercurio AM, Rotello VM. Rapid phenotyping of cancer stem cells using multichannel nanosensor arrays. Nanomedicine. 2018 May 17. PMID: 29778888.
      View in: PubMed
    6. Elaimy AL, Guru S, Chang C, Ou J, Amante JJ, Zhu LJ, Goel HL, Mercurio AM. VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP ß2-chimaerin. Sci Signal. 2018 May 01; 11(528). PMID: 29717062.
      View in: PubMed
    7. Brown CW, Amante JJ, Goel HL, Mercurio AM. The a6ß4 integrin promotes resistance to ferroptosis. J Cell Biol. 2017 12 04; 216(12):4287-4297. PMID: 28972104.
      View in: PubMed
    8. Goel HL, Pursell B, Shultz LD, Greiner DL, Brekken RA, Vander Kooi CW, Mercurio AM. P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer. Cell Rep. 2016 Mar 08; 14(9):2193-208. PMID: 26923603.
      View in: PubMed
    9. Liu X, Li H, Rajurkar M, Li Q, Cotton JL, Ou J, Zhu LJ, Goel HL, Mercurio AM, Park JS, Davis RJ, Mao J. Tead and AP1 Coordinate Transcription and Motility. Cell Rep. 2016 Feb 09; 14(5):1169-80. PMID: 26832411.
      View in: PubMed
    10. Yoshii T, Geng Y, Le ND, Goel HL, Mercurio AM, Rotello VM. Highlights from the latest articles in nanomaterial-based therapies for targeting cancer stem cells. Nanomedicine (Lond). 2015; 10(23):3427-9. PMID: 26606862.
      View in: PubMed
    11. Parker MW, Linkugel AD, Goel HL, Wu T, Mercurio AM, Vander Kooi CW. Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form. Structure. 2015 Apr 7; 23(4):677-87. PMID: 25752543.
      View in: PubMed
    12. Chang C, Goel HL, Gao H, Pursell B, Shultz LD, Greiner DL, Ingerpuu S, Patarroyo M, Cao S, Lim E, Mao J, McKee KK, Yurchenco PD, Mercurio AM. A laminin 511 matrix is regulated by TAZ and functions as the ligand for the a6Bß1 integrin to sustain breast cancer stem cells. Genes Dev. 2015 Jan 01; 29(1):1-6. PMID: 25561492.
      View in: PubMed
    13. Goel HL, Gritsko T, Pursell B, Chang C, Shultz LD, Greiner DL, Norum JH, Toftgard R, Shaw LM, Mercurio AM. Regulated splicing of the a6 integrin cytoplasmic domain determines the fate of breast cancer stem cells. Cell Rep. 2014 May 8; 7(3):747-61. PMID: 24767994.
      View in: PubMed
    14. Goel HL, Mercurio AM. VEGF targets the tumour cell. Nat Rev Cancer. 2013 Dec; 13(12):871-82. PMID: 24263190.
      View in: PubMed
    15. Goel HL, Sayeed A, Breen M, Zarif MJ, Garlick DS, Leav I, Davis RJ, Fitzgerald TJ, Morrione A, Hsieh CC, Liu Q, Dicker AP, Altieri DC, Languino LR. ß1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1. J Cell Physiol. 2013 Jul; 228(7):1601-9. PMID: 23359252.
      View in: PubMed
    16. Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM. GLI1 regulates a novel neuropilin-2/a6ß1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med. 2013 Apr; 5(4):488-508. PMID: 23436775.
      View in: PubMed
    17. Goel HL, Mercurio AM. Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology. Cell Adh Migr. 2012 Nov-Dec; 6(6):554-60. PMID: 23076131.
      View in: PubMed
    18. Goel HL, Chang C, Pursell B, Leav I, Lyle S, Xi HS, Hsieh CC, Adisetiyo H, Roy-Burman P, Coleman IM, Nelson PS, Vessella RL, Davis RJ, Plymate SR, Mercurio AM. VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer. Cancer Discov. 2012 Oct; 2(10):906-21. PMID: 22777769.
      View in: PubMed
    19. Goel HL, Pursell B, Standley C, Fogarty K, Mercurio AM. Neuropilin-2 regulates a6ß1 integrin in the formation of focal adhesions and signaling. J Cell Sci. 2012 Jan 15; 125(Pt 2):497-506. PMID: 22302985.
      View in: PubMed
    20. Goel HL, Bae D, Pursell B, Gouvin LM, Lu S, Mercurio AM. Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland. Development. 2011 Jul; 138(14):2969-76. PMID: 21693513.
      View in: PubMed
    21. Goel HL, Underwood JM, Nickerson JA, Hsieh CC, Languino LR. Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1. J Cell Physiol. 2010 Jul; 224(1):210-7. PMID: 20333644.
      View in: PubMed
    22. Trerotola M, Rathore S, Goel HL, Li J, Alberti S, Piantelli M, Adams D, Jiang Z, Languino LR. CD133, Trop-2 and alpha2beta1 integrin surface receptors as markers of putative human prostate cancer stem cells. Am J Transl Res. 2010 Mar 15; 2(2):135-44. PMID: 20407603.
      View in: PubMed
    23. Leav I, Plescia J, Goel HL, Li J, Jiang Z, Cohen RJ, Languino LR, Altieri DC. Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. Am J Pathol. 2010 Jan; 176(1):393-401. PMID: 19948822.
      View in: PubMed
    24. Goel HL, Moro L, Murphy-Ullrich JE, Hsieh CC, Wu CL, Jiang Z, Languino LR. Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1. Cancer Res. 2009 Jul 1; 69(13):5374-82. PMID: 19549894.
      View in: PubMed
    25. Goel HL, Alam N, Johnson IN, Languino LR. Integrin signaling aberrations in prostate cancer. Am J Transl Res. 2009 Apr 20; 1(3):211-20. PMID: 19956432.
      View in: PubMed
    26. Wang T, Alavian MR, Goel HL, Languino LR, Fitzgerald TJ. Bicalutamide inhibits androgen-mediated adhesion of prostate cancer cells exposed to ionizing radiation. Prostate. 2008 Dec 1; 68(16):1734-42. PMID: 18729104.
      View in: PubMed
    27. Goel HL, Li J, Kogan S, Languino LR. Integrins in prostate cancer progression. Endocr Relat Cancer. 2008 Sep; 15(3):657-64. PMID: 18524948.
      View in: PubMed
    28. Fitzgerald TJ, Wang T, Goel HL, Huang J, Stein G, Lian J, Davis RJ, Doxsey S, Balaji KC, Aronowitz J, Languino LR. Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention. Expert Rev Anticancer Ther. 2008 Jun; 8(6):967-74. PMID: 18533806.
      View in: PubMed
    29. Alam N, Goel HL, Zarif MJ, Butterfield JE, Perkins HM, Sansoucy BG, Sawyer TK, Languino LR. The integrin-growth factor receptor duet. J Cell Physiol. 2007 Dec; 213(3):649-53. PMID: 17886260.
      View in: PubMed
    30. Goel HL, Moro L, King M, Teider N, Centrella M, McCarthy TL, Holgado-Madruga M, Wong AJ, Marra E, Languino LR. Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment. Cancer Res. 2006 Jan 1; 66(1):331-42. PMID: 16397247.
      View in: PubMed
    31. Goel HL, Breen M, Zhang J, Das I, Aznavoorian-Cheshire S, Greenberg NM, Elgavish A, Languino LR. beta1A integrin expression is required for type 1 insulin-like growth factor receptor mitogenic and transforming activities and localization to focal contacts. Cancer Res. 2005 Aug 1; 65(15):6692-700. PMID: 16061650.
      View in: PubMed
    32. Simon EL, Goel HL, Teider N, Wang T, Languino LR, Fitzgerald TJ. High dose fractionated ionizing radiation inhibits prostate cancer cell adhesion and beta(1) integrin expression. Prostate. 2005 Jun 15; 64(1):83-91. PMID: 15651037.
      View in: PubMed
    33. Goel HL, Fornaro M, Moro L, Teider N, Rhim JS, King M, Languino LR. Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins. J Cell Biol. 2004 Aug 02; 166(3):407-18. PMID: 15289498.
      View in: PubMed
    34. Goel HL, Languino LR. Integrin signaling in cancer. Cancer Treat Res. 2004; 119:15-31. PMID: 15164871.
      View in: PubMed
    35. Goel HL, Dey CS. Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, phosphatidylinositol 3-kinase and extracellular signal regulated kinases. J Cell Physiol. 2002 Nov; 193(2):187-98. PMID: 12384996.
      View in: PubMed
    36. Goel HL, Dey CS. PKC-regulated myogenesis is associated with increased tyrosine phosphorylation of FAK, Cas, and paxillin, formation of Cas-CRK complex, and JNK activation. Differentiation. 2002 Aug; 70(6):257-71. PMID: 12190987.
      View in: PubMed
    37. Goel HL, Dey CS. Role of protein kinase C during insulin mediated skeletal muscle cell spreading. J Muscle Res Cell Motil. 2002; 23(4):269-77. PMID: 12630700.
      View in: PubMed
    38. Goel HL, Dey CS. Insulin-mediated tyrosine phosphorylation of myosin heavy chain and concomitant enhanced association of C-terminal SRC kinase during skeletal muscle differentiation. Cell Biol Int. 2002; 26(6):557-61. PMID: 12119182.
      View in: PubMed
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