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Nathan Lawson PhD

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentMolecular, Cell and Cancer Biology
AddressUMass Chan Medical School
364 Plantation Street LRB-617
Worcester MA 01605
Phone508-856-1177
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentBioinformatics and Integrative Biology


    Collapse Biography 
    Collapse education and training
    University of Rhode Island, Kingston, RI, United StatesBSZoology
    Yale University, New Haven, CT, United StatesPHDBiology

    Collapse Overview 
    Collapse overview


    Academic Background



    Nathan Lawson received his B.S. in Zoology from the University of Rhode Island in 1994, and his Ph.D. in Biology from Yale University in 1999. From 1999 to 2002, he was a National Research Council Postdoctoral Associate at the National Institutes of Health where he utilized the zebrafish to study developmental angiogenesis.  Dr. Lawson joined the Program in Gene Function and Expression at the University of Massachusetts Medical School as an Assistant Professor in the fall of 2002.



     



     



     






    Developmental angiogenesis and the basis of endothelial heterogeneity



    We utilize the zebrafish as a model system to understand how new blood vessel formation (angiogenesis) is coordinated and patterned in the developing embryo.  We also have an interest in the developmental basis of endothelial differentiation, which is essential to program blood vessel identity in distinct vascular beds in the mature animal.  We have also developed and applied cutting edge knockout technology to establish zebrafish models of vascular disease.  These include models in which deficient neurovascular formation leads to neurodegeneration, as well as models of congenital lymphedema.  These models will serve as excellent platforms for small molecule screens to identify compounds useful in the treatment of vascular diseases.  For more information, see our lab website at lawsonlab.umassmed.edu



     



    Laboratory Personnel



    For a current list of lab personnel, please visit our lab web page.





    Collapse Rotation Projects

    Rotation Projects

    Please contact Nathan Lawson (nathan.lawson@umassmed.edu) for information regarding potential rotation projects. For information concerning recent research in the lab, please see:lawsonlab.umassmed.edu/research.html



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shin M, Yin HM, Shih YH, Nozaki T, Portman D, Toles B, Kolb A, Luk K, Isogai S, Ishida K, Hanasaka T, Parsons MJ, Wolfe SA, Burns CE, Burns CG, Lawson ND. Generation and application of endogenously floxed alleles for cell-specific knockout in zebrafish. Dev Cell. 2023 Nov 20; 58(22):2614-2626.e7. PMID: 37633272.
      Citations: 1     Fields:    Translation:Animals
    2. Ponnienselvan K, Liu P, Nyalile T, Oikemus S, Maitland SA, Lawson ND, Luban J, Wolfe SA. Reducing the inherent auto-inhibitory interaction within the pegRNA enhances prime editing efficiency. Nucleic Acids Res. 2023 07 21; 51(13):6966-6980. PMID: 37246708.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    3. Peng D, Ando K, Hu?mann M, Gloger M, Skoczylas R, Mochizuki N, Betsholtz C, Fukuhara S, Schulte-Merker S, Lawson ND, Koltowska K. Correction: Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells. Elife. 2023 Jun 12; 12. PMID: 37307048.
      Citations:    Fields:    
    4. Hu K, Liu H, Lawson ND, Zhu LJ. scATACpipe: A nextflow pipeline for comprehensive and reproducible analyses of single cell ATAC-seq data. Front Cell Dev Biol. 2022; 10:981859. PMID: 36238687.
      Citations:    
    5. Lawson ND. Decoding the zebrafish genome. Nat Genet. 2022 07; 54(7):917-919. PMID: 35789322.
      Citations: 1     Fields:    Translation:Animals
    6. Leonard EV, Figueroa RJ, Bussmann J, Lawson ND, Amigo JD, Siekmann AF. Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing mural cells and differentially require Pdgfrb signalling for their development. Development. 2022 04 01; 149(7). PMID: 35297968.
      Citations: 6     Fields:    Translation:AnimalsCells
    7. Peng D, Ando K, Hu?mann M, Gloger M, Skoczylas R, Mochizuki N, Betsholtz C, Fukuhara S, Schulte-Merker S, Lawson ND, Koltowska K. Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells. Elife. 2022 03 22; 11. PMID: 35316177.
      Citations: 3     Fields:    Translation:AnimalsCells
    8. Kapuria S, Bai H, Fierros J, Huang Y, Ma F, Yoshida T, Aguayo A, Kok F, Wiens KM, Yip JK, McCain ML, Pellegrini M, Nagashima M, Hitchcock PF, Mochizuki N, Lawson ND, Harrison MMR, Lien CL. Heterogeneous pdgfrb+ cells regulate coronary vessel development and revascularization during heart regeneration. Development. 2022 02 15; 149(4). PMID: 35088848.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Shih YH, Portman D, Idrizi F, Grosse A, Lawson ND. Integrated molecular analysis identifies a conserved pericyte gene signature in zebrafish. Development. 2021 12 01; 148(23). PMID: 34751773.
      Citations: 11     Fields:    Translation:AnimalsCells
    10. Shin M, Lawson ND. Back and forth: History of and new insights on the vertebrate lymphatic valve. Dev Growth Differ. 2021 Dec; 63(9):523-535. PMID: 34716915.
      Citations: 3     Fields:    Translation:AnimalsCells
    11. Ghanta KS, Chen Z, Mir A, Dokshin GA, Krishnamurthy PM, Yoon Y, Gallant J, Xu P, Zhang XO, Ozturk AR, Shin M, Idrizi F, Liu P, Gneid H, Edraki A, Lawson ND, Rivera-P?rez JA, Sontheimer EJ, Watts JK, Mello CC. 5'-Modifications improve potency and efficacy of DNA donors for precision genome editing. Elife. 2021 10 19; 10. PMID: 34665130.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    12. Ando K, Shih YH, Ebarasi L, Grosse A, Portman D, Chiba A, Mattonet K, Gerri C, Stainier DYR, Mochizuki N, Fukuhara S, Betsholtz C, Lawson ND. Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development. Dev Biol. 2021 11; 479:11-22. PMID: 34310924.
      Citations: 10     Fields:    Translation:AnimalsCells
    13. Jerafi-Vider A, Bassi I, Moshe N, Tevet Y, Hen G, Splittstoesser D, Shin M, Lawson ND, Yaniv K. VEGFC/FLT4-induced cell-cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cells. Cell Rep. 2021 06 15; 35(11):109255. PMID: 34133928.
      Citations: 13     Fields:    Translation:AnimalsCells
    14. Peloggia J, M?nch D, Meneses-Giles P, Romero-Carvajal A, Lush ME, Lawson ND, McClain M, Pan YA, Piotrowski T. Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes. Dev Cell. 2021 05 03; 56(9):1296-1312.e7. PMID: 33878346.
      Citations: 8     Fields:    Translation:AnimalsCells
    15. Lawson ND, Li R, Shin M, Grosse A, Yukselen O, Stone OA, Kucukural A, Zhu L. An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes. Elife. 2020 08 24; 9. PMID: 32831172.
      Citations: 27     Fields:    Translation:AnimalsCells
    16. Sissaoui S, Yu J, Yan A, Li R, Yukselen O, Kucukural A, Zhu LJ, Lawson ND. Genomic Characterization of Endothelial Enhancers Reveals a Multifunctional Role for NR2F2 in Regulation of Arteriovenous Gene Expression. Circ Res. 2020 03 27; 126(7):875-888. PMID: 32065070.
      Citations: 17     Fields:    Translation:HumansCells
    17. Shin M, Nozaki T, Idrizi F, Isogai S, Ogasawara K, Ishida K, Yuge S, Roscoe B, Wolfe SA, Fukuhara S, Mochizuki N, Deguchi T, Lawson ND. Valves Are a Conserved Feature of the Zebrafish Lymphatic System. Dev Cell. 2019 11 04; 51(3):374-386.e5. PMID: 31564611.
      Citations: 18     Fields:    Translation:AnimalsCells
    18. Whitesell TR, Chrystal PW, Ryu JR, Munsie N, Grosse A, French CR, Workentine ML, Li R, Zhu LJ, Waskiewicz A, Lehmann OJ, Lawson ND, Childs SJ. foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish. Dev Biol. 2019 09 01; 453(1):34-47. PMID: 31199900.
      Citations: 19     Fields:    Translation:AnimalsCells
    19. Lawson ND. On the Right Track: Meningeal Lymphatics Guide Angiogenesis during Tissue Repair in the Brain. Dev Cell. 2019 06 03; 49(5):655-656. PMID: 31163169.
      Citations:    Fields:    Translation:AnimalsCells
    20. Liu P, Luk K, Shin M, Idrizi F, Kwok S, Roscoe B, Mintzer E, Suresh S, Morrison K, Fraz?o JB, Bolukbasi MF, Ponnienselvan K, Luban J, Zhu LJ, Lawson ND, Wolfe SA. Enhanced Cas12a editing in mammalian cells and zebrafish. Nucleic Acids Res. 2019 May 07; 47(8):4169-4180. PMID: 30892626.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    21. Ou J, Liu H, Yu J, Kelliher MA, Castilla LH, Lawson ND, Zhu LJ. ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data. BMC Genomics. 2018 03 01; 19(1):169. PMID: 29490630.
      Citations: 91     Fields:    Translation:Cells
    22. Stainier DYR, Raz E, Lawson ND, Ekker SC, Burdine RD, Eisen JS, Ingham PW, Schulte-Merker S, Yelon D, Weinstein BM, Mullins MC, Wilson SW, Ramakrishnan L, Amacher SL, Neuhauss SCF, Meng A, Mochizuki N, Panula P, Moens CB. Guidelines for morpholino use in zebrafish. PLoS Genet. 2017 10; 13(10):e1007000. PMID: 29049395.
      Citations: 163     Fields:    Translation:Animals
    23. Janardhan HP, Milstone ZJ, Shin M, Lawson ND, Keaney JF, Trivedi CM. Hdac3 regulates lymphovenous and lymphatic valve formation. J Clin Invest. 2017 Nov 01; 127(11):4193-4206. PMID: 29035278.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    24. Lataniotis L, Albrecht A, Kok FO, Monfries CAL, Benedetti L, Lawson ND, Hughes SM, Steinhofel K, Mayr M, Zampetaki A. CRISPR/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function. Sci Rep. 2017 08 17; 7(1):8585. PMID: 28819307.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    25. Quillien A, Abdalla M, Yu J, Ou J, Zhu LJ, Lawson ND. Robust Identification of Developmentally Active Endothelial Enhancers in Zebrafish Using FANS-Assisted ATAC-Seq. Cell Rep. 2017 07 18; 20(3):709-720. PMID: 28723572.
      Citations: 31     Fields:    Translation:AnimalsCells
    26. Hasan SS, Tsaryk R, Lange M, Wisniewski L, Moore JC, Lawson ND, Wojciechowska K, Schnittler H, Siekmann AF. Endothelial Notch signalling limits angiogenesis via control of artery formation. Nat Cell Biol. 2017 Aug; 19(8):928-940. PMID: 28714969.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    27. Lawson ND. A New Conserved Player in Lymphatic Morphogenesis. Circ Res. 2017 04 14; 120(8):1216-1218. PMID: 28408443.
      Citations:    Fields:    
    28. Shin M, Male I, Beane TJ, Villefranc JA, Kok FO, Zhu LJ, Lawson ND. Correction: Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors. Development. 2017 02 01; 144(3):531. PMID: 28143848.
      Citations: 4     Fields:    
    29. Matsuoka RL, Marass M, Avdesh A, Helker CS, Maischein HM, Grosse AS, Kaur H, Lawson ND, Herzog W, Stainier DY. Radial glia regulate vascular patterning around the developing spinal cord. Elife. 2016 11 17; 5. PMID: 27852438.
      Citations: 39     Fields:    Translation:AnimalsCells
    30. Shin M, Male I, Beane TJ, Villefranc JA, Kok FO, Zhu LJ, Lawson ND. Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors. Development. 2016 10 15; 143(20):3785-3795. PMID: 27621059.
      Citations: 41     Fields:    Translation:AnimalsCells
    31. Shin M, Beane TJ, Quillien A, Male I, Zhu LJ, Lawson ND. Vegfa signals through ERK to promote angiogenesis, but not artery differentiation. Development. 2016 10 15; 143(20):3796-3805. PMID: 27578780.
      Citations: 59     Fields:    Translation:AnimalsCells
    32. Lawson ND. Reverse Genetics in Zebrafish: Mutants, Morphants, and Moving Forward. Trends Cell Biol. 2016 Feb; 26(2):77-79. PMID: 26739910.
      Citations: 19     Fields:    Translation:HumansAnimals
    33. Hen G, Nicenboim J, Mayseless O, Asaf L, Shin M, Busolin G, Hofi R, Almog G, Tiso N, Lawson ND, Yaniv K. Venous-derived angioblasts generate organ-specific vessels during zebrafish embryonic development. Development. 2015 Dec 15; 142(24):4266-78. PMID: 26525671.
      Citations: 39     Fields:    Translation:AnimalsCells
    34. Shmukler BE, Huston NC, Thon JN, Ni CW, Kourkoulis G, Lawson ND, Paw BH, Alper SL. Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia. Haematologica. 2015 Dec; 100(12):e483-5. PMID: 26294733.
      Citations: 8     Fields:    Translation:Animals
    35. Kok FO, Lawson ND. A platform for reverse genetics in endothelial cells. Circ Res. 2015 Jul 03; 117(2):107-8. PMID: 26139853.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    36. Nicenboim J, Malkinson G, Lupo T, Asaf L, Sela Y, Mayseless O, Gibbs-Bar L, Senderovich N, Hashimshony T, Shin M, Jerafi-Vider A, Avraham-Davidi I, Krupalnik V, Hofi R, Almog G, Astin JW, Golani O, Ben-Dor S, Crosier PS, Herzog W, Lawson ND, Hanna JH, Yanai I, Yaniv K. Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature. 2015 Jun 04; 522(7554):56-61. PMID: 25992545.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    37. Butko E, Distel M, Pouget C, Weijts B, Kobayashi I, Ng K, Mosimann C, Poulain FE, McPherson A, Ni CW, Stachura DL, Del Cid N, Esp?n-Palaz?n R, Lawson ND, Dorsky R, Clements WK, Traver D. Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development. 2015 Mar 15; 142(6):1050-61. PMID: 25758220.
      Citations: 73     Fields:    Translation:AnimalsCells
    38. Kok FO, Shin M, Ni CW, Gupta A, Grosse AS, van Impel A, Kirchmaier BC, Peterson-Maduro J, Kourkoulis G, Male I, DeSantis DF, Sheppard-Tindell S, Ebarasi L, Betsholtz C, Schulte-Merker S, Wolfe SA, Lawson ND. Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish. Dev Cell. 2015 Jan 12; 32(1):97-108. PMID: 25533206.
      Citations: 384     Fields:    Translation:Animals
    39. Carroll KJ, Esain V, Garnaas MK, Cortes M, Dovey MC, Nissim S, Frechette GM, Liu SY, Kwan W, Cutting CC, Harris JM, Gorelick DA, Halpern ME, Lawson ND, Goessling W, North TE. Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Dev Cell. 2014 May 27; 29(4):437-53. PMID: 24871948.
      Citations: 22     Fields:    Translation:AnimalsCells
    40. Quillien A, Moore JC, Shin M, Siekmann AF, Smith T, Pan L, Moens CB, Parsons MJ, Lawson ND. Distinct Notch signaling outputs pattern the developing arterial system. Development. 2014 Apr; 141(7):1544-52. PMID: 24598161.
      Citations: 57     Fields:    Translation:AnimalsCells
    41. Kok FO, Gupta A, Lawson ND, Wolfe SA. Construction and application of site-specific artificial nucleases for targeted gene editing. Methods Mol Biol. 2014; 1101:267-303. PMID: 24233786.
      Citations: 7     Fields:    Translation:AnimalsCells
    42. Moore JC, Sheppard-Tindell S, Shestopalov IA, Yamazoe S, Chen JK, Lawson ND. Post-transcriptional mechanisms contribute to Etv2 repression during vascular development. Dev Biol. 2013 Dec 01; 384(1):128-40. PMID: 24036310.
      Citations: 21     Fields:    Translation:AnimalsCells
    43. Sheppard S, Lawson ND, Zhu LJ. Accurate identification of polyadenylation sites from 3' end deep sequencing using a naive Bayes classifier. Bioinformatics. 2013 Oct 15; 29(20):2564-71. PMID: 23962617.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    44. Gupta A, Hall VL, Kok FO, Shin M, McNulty JC, Lawson ND, Wolfe SA. Targeted chromosomal deletions and inversions in zebrafish. Genome Res. 2013 Jun; 23(6):1008-17. PMID: 23478401.
      Citations: 52     Fields:    Translation:AnimalsCells
    45. Villefranc JA, Nicoli S, Bentley K, Jeltsch M, Zarkada G, Moore JC, Gerhardt H, Alitalo K, Lawson ND. A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development. 2013 Apr; 140(7):1497-506. PMID: 23462469.
      Citations: 52     Fields:    Translation:AnimalsCells
    46. Dang LT, Lawson ND, Fish JE. MicroRNA control of vascular endothelial growth factor signaling output during vascular development. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):193-200. PMID: 23325476.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    47. Shin J, Padmanabhan A, de Groh ED, Lee JS, Haidar S, Dahlberg S, Guo F, He S, Wolman MA, Granato M, Lawson ND, Wolfe SA, Kim SH, Solnica-Krezel L, Kanki JP, Ligon KL, Epstein JA, Look AT. Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Dis Model Mech. 2012 Nov; 5(6):881-94. PMID: 22773753.
      Citations: 49     Fields:    Translation:AnimalsCells
    48. Nicoli S, Knyphausen CP, Zhu LJ, Lakshmanan A, Lawson ND. miR-221 is required for endothelial tip cell behaviors during vascular development. Dev Cell. 2012 Feb 14; 22(2):418-29. PMID: 22340502.
      Citations: 84     Fields:    Translation:AnimalsCells
    49. Delaval B, Covassin L, Lawson ND, Doxsey S. Centrin depletion causes cyst formation and other ciliopathy-related phenotypes in zebrafish. Cell Cycle. 2011 Nov 15; 10(22):3964-72. PMID: 22142866.
      Citations: 21     Fields:    Translation:AnimalsCells
    50. Cheung ID, Bagnat M, Ma TP, Datta A, Evason K, Moore JC, Lawson ND, Mostov KE, Moens CB, Stainier DY. Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b. Dev Biol. 2012 Jan 01; 361(1):68-78. PMID: 22020048.
      Citations: 28     Fields:    Translation:AnimalsCells
    51. Zhu C, Smith T, McNulty J, Rayla AL, Lakshmanan A, Siekmann AF, Buffardi M, Meng X, Shin J, Padmanabhan A, Cifuentes D, Giraldez AJ, Look AT, Epstein JA, Lawson ND, Wolfe SA. Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Development. 2011 Oct; 138(20):4555-64. PMID: 21937602.
      Citations: 54     Fields:    Translation:AnimalsCells
    52. Lawson ND, Wolfe SA. Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish. Dev Cell. 2011 Jul 19; 21(1):48-64. PMID: 21763608.
      Citations: 84     Fields:    Translation:Animals
    53. Clements WK, Kim AD, Ong KG, Moore JC, Lawson ND, Traver D. A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature. 2011 Jun 08; 474(7350):220-4. PMID: 21654806.
      Citations: 121     Fields:    Translation:AnimalsCells
    54. Quillien A, Blanco-Sanchez B, Halluin C, Moore JC, Lawson ND, Blader P, Cau E. BMP signaling orchestrates photoreceptor specification in the zebrafish pineal gland in collaboration with Notch. Development. 2011 Jun; 138(11):2293-302. PMID: 21558377.
      Citations: 15     Fields:    Translation:AnimalsCells
    55. Delaval B, Bright A, Lawson ND, Doxsey S. The cilia protein IFT88 is required for spindle orientation in mitosis. Nat Cell Biol. 2011 Apr; 13(4):461-8. PMID: 21441926.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    56. Aday AW, Zhu LJ, Lakshmanan A, Wang J, Lawson ND. Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites. Dev Biol. 2011 Sep 15; 357(2):450-62. PMID: 21435340.
      Citations: 45     Fields:    Translation:AnimalsCells
    57. Gupta A, Meng X, Zhu LJ, Lawson ND, Wolfe SA. Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases. Nucleic Acids Res. 2011 Jan; 39(1):381-92. PMID: 20843781.
      Citations: 66     Fields:    Translation:AnimalsCells
    58. Chapouton P, Skupien P, Hesl B, Coolen M, Moore JC, Madelaine R, Kremmer E, Faus-Kessler T, Blader P, Lawson ND, Bally-Cuif L. Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells. J Neurosci. 2010 Jun 09; 30(23):7961-74. PMID: 20534844.
      Citations: 113     Fields:    Translation:AnimalsCells
    59. Geudens I, Herpers R, Hermans K, Segura I, Ruiz de Almodovar C, Bussmann J, De Smet F, Vandevelde W, Hogan BM, Siekmann A, Claes F, Moore JC, Pistocchi AS, Loges S, Mazzone M, Mariggi G, Bruy?re F, Cotelli F, Kerjaschki D, No?l A, Foidart JM, Gerhardt H, Ny A, Langenberg T, Lawson ND, Duckers HJ, Schulte-Merker S, Carmeliet P, Dewerchin M. Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9):1695-702. PMID: 20466977.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    60. Zhu LJ, Gazin C, Lawson ND, Pag?s H, Lin SM, Lapointe DS, Green MR. ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data. BMC Bioinformatics. 2010 May 11; 11:237. PMID: 20459804.
      Citations: 528     Fields:    Translation:Cells
    61. Cifuentes D, Xue H, Taylor DW, Patnode H, Mishima Y, Cheloufi S, Ma E, Mane S, Hannon GJ, Lawson ND, Wolfe SA, Giraldez AJ. A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science. 2010 Jun 25; 328(5986):1694-8. PMID: 20448148.
      Citations: 457     Fields:    Translation:HumansAnimalsCells
    62. Nicoli S, Standley C, Walker P, Hurlstone A, Fogarty KE, Lawson ND. MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature. 2010 Apr 22; 464(7292):1196-200. PMID: 20364122.
      Citations: 202     Fields:    Translation:AnimalsCells
    63. Lorent K, Moore JC, Siekmann AF, Lawson N, Pack M. Reiterative use of the notch signal during zebrafish intrahepatic biliary development. Dev Dyn. 2010 Mar; 239(3):855-64. PMID: 20108354.
      Citations: 58     Fields:    Translation:AnimalsCells
    64. Padmanabhan A, Lee JS, Ismat FA, Lu MM, Lawson ND, Kanki JP, Look AT, Epstein JA. Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22305-10. PMID: 19966217.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    65. Siekmann AF, Standley C, Fogarty KE, Wolfe SA, Lawson ND. Chemokine signaling guides regional patterning of the first embryonic artery. Genes Dev. 2009 Oct 01; 23(19):2272-7. PMID: 19797767.
      Citations: 62     Fields:    Translation:AnimalsCells
    66. Parsons MJ, Pisharath H, Yusuff S, Moore JC, Siekmann AF, Lawson N, Leach SD. Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas. Mech Dev. 2009 Oct; 126(10):898-912. PMID: 19595765.
      Citations: 212     Fields:    Translation:Animals
    67. Covassin LD, Siekmann AF, Kacergis MC, Laver E, Moore JC, Villefranc JA, Weinstein BM, Lawson ND. A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development. Dev Biol. 2009 May 15; 329(2):212-26. PMID: 19269286.
      Citations: 67     Fields:    Translation:AnimalsCells
    68. Meng X, Noyes MB, Zhu LJ, Lawson ND, Wolfe SA. Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases. Nat Biotechnol. 2008 Jun; 26(6):695-701. PMID: 18500337.
      Citations: 337     Fields:    Translation:AnimalsCells
    69. Siekmann AF, Covassin L, Lawson ND. Modulation of VEGF signalling output by the Notch pathway. Bioessays. 2008 Apr; 30(4):303-13. PMID: 18348190.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    70. Hart DO, Raha T, Lawson ND, Green MR. Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3. Nature. 2007 Dec 13; 450(7172):1082-5. PMID: 18046332.
      Citations: 42     Fields:    Translation:Animals
    71. Villefranc JA, Amigo J, Lawson ND. Gateway compatible vectors for analysis of gene function in the zebrafish. Dev Dyn. 2007 Nov; 236(11):3077-87. PMID: 17948311.
      Citations: 188     Fields:    Translation:Animals
    72. Buchner DA, Su F, Yamaoka JS, Kamei M, Shavit JA, Barthel LK, McGee B, Amigo JD, Kim S, Hanosh AW, Jagadeeswaran P, Goldman D, Lawson ND, Raymond PA, Weinstein BM, Ginsburg D, Lyons SE. pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):13996-4001. PMID: 17715297.
      Citations: 43     Fields:    Translation:AnimalsCells
    73. Siekmann AF, Lawson ND. Notch signalling and the regulation of angiogenesis. Cell Adh Migr. 2007 Apr-Jun; 1(2):104-6. PMID: 19329884.
      Citations: 30     Fields:    Translation:AnimalsCells
    74. Siekmann AF, Lawson ND. Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries. Nature. 2007 Feb 15; 445(7129):781-4. PMID: 17259972.
      Citations: 306     Fields:    Translation:AnimalsCells
    75. Pham VN, Lawson ND, Mugford JW, Dye L, Castranova D, Lo B, Weinstein BM. Combinatorial function of ETS transcription factors in the developing vasculature. Dev Biol. 2007 Mar 15; 303(2):772-83. PMID: 17125762.
      Citations: 109     Fields:    Translation:AnimalsCells
    76. Alt B, Elsalini OA, Schrumpf P, Haufs N, Lawson ND, Schwabe GC, Mundlos S, Gr?ters A, Krude H, Rohr KB. Arteries define the position of the thyroid gland during its developmental relocalisation. Development. 2006 Oct; 133(19):3797-804. PMID: 16968815.
      Citations: 22     Fields:    Translation:Animals
    77. Covassin L, Amigo JD, Suzuki K, Teplyuk V, Straubhaar J, Lawson ND. Global analysis of hematopoietic and vascular endothelial gene expression by tissue specific microarray profiling in zebrafish. Dev Biol. 2006 Nov 15; 299(2):551-62. PMID: 16999953.
      Citations: 54     Fields:    Translation:Animals
    78. Covassin LD, Villefranc JA, Kacergis MC, Weinstein BM, Lawson ND. Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6554-9. PMID: 16617120.
      Citations: 131     Fields:    Translation:AnimalsCells
    79. Hong SK, Haldin CE, Lawson ND, Weinstein BM, Dawid IB, Hukriede NA. The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18473-8. PMID: 16344459.
      Citations: 38     Fields:    Translation:AnimalsCells
    80. Crump JG, Maves L, Lawson ND, Weinstein BM, Kimmel CB. An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterning. Development. 2004 Nov; 131(22):5703-16. PMID: 15509770.
      Citations: 95     Fields:    Translation:AnimalsCells
    81. Huang CC, Lawson ND, Weinstein BM, Johnson SL. reg6 is required for branching morphogenesis during blood vessel regeneration in zebrafish caudal fins. Dev Biol. 2003 Dec 01; 264(1):263-74. PMID: 14623247.
      Citations: 35     Fields:    Translation:Animals
    82. Isogai S, Lawson ND, Torrealday S, Horiguchi M, Weinstein BM. Angiogenic network formation in the developing vertebrate trunk. Development. 2003 Nov; 130(21):5281-90. PMID: 12954720.
      Citations: 206     Fields:    Translation:Animals
    83. Lawson ND, Mugford JW, Diamond BA, Weinstein BM. phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development. Genes Dev. 2003 Jun 01; 17(11):1346-51. PMID: 12782653.
      Citations: 104     Fields:    Translation:AnimalsCells
    84. Lawson ND, Weinstein BM. Arteries and veins: making a difference with zebrafish. Nat Rev Genet. 2002 Sep; 3(9):674-82. PMID: 12209142.
      Citations: 92     Fields:    Translation:Animals
    85. Lawson ND, Weinstein BM. In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev Biol. 2002 Aug 15; 248(2):307-18. PMID: 12167406.
      Citations: 940     Fields:    Translation:AnimalsCells
    86. Lawson ND, Vogel AM, Weinstein BM. sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell. 2002 Jul; 3(1):127-36. PMID: 12110173.
      Citations: 332     Fields:    Translation:AnimalsCells
    87. Roman BL, Pham VN, Lawson ND, Kulik M, Childs S, Lekven AC, Garrity DM, Moon RT, Fishman MC, Lechleider RJ, Weinstein BM. Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels. Development. 2002 Jun; 129(12):3009-19. PMID: 12050147.
      Citations: 163     Fields:    Translation:HumansAnimalsCells
    88. Lyons SE, Lawson ND, Lei L, Bennett PE, Weinstein BM, Liu PP. A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5454-9. PMID: 11960002.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    89. Weinstein BM, Lawson ND. Arteries, veins, Notch, and VEGF. Cold Spring Harb Symp Quant Biol. 2002; 67:155-62. PMID: 12858536.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    90. Lawson ND, Scheer N, Pham VN, Kim CH, Chitnis AB, Campos-Ortega JA, Weinstein BM. Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development. 2001 Oct; 128(19):3675-83. PMID: 11585794.
      Citations: 348     Fields:    Translation:AnimalsCells
    91. Lawson ND, Berliner N. Representational difference analysis of a committed myeloid progenitor cell line reveals evidence for bilineage potential. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10129-33. PMID: 9707612.
      Citations: 3     Fields:    Translation:AnimalsCells
    92. Lawson ND, Khanna-Gupta A, Berliner N. Isolation and characterization of the cDNA for mouse neutrophil collagenase: demonstration of shared negative regulatory pathways for neutrophil secondary granule protein gene expression. Blood. 1998 Apr 01; 91(7):2517-24. PMID: 9516153.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    93. Lawson ND, Stillman EA, Whitt MA, Rose JK. Recombinant vesicular stomatitis viruses from DNA. Proc Natl Acad Sci U S A. 1995 May 09; 92(10):4477-81. PMID: 7753828.
      Citations: 340     Fields:    Translation:AnimalsCells
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