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Mary M Lee MD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentPediatrics
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-856-3199
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentPediatrics
    DivisionPediatric Endocrine/Diabetes

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentCell Biology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMasters in Clinical Investigation


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA, United StatesABEast Asian Languages & Civ
    State University of New York at Upstate Medical University, Syracuse, NY, United StatesMDMedicine

    Collapse Overview 
    Collapse overview

    Biography

    M.D.,SUNY-Buffalo School of Medicine 1983
    Resident in Pediatrics, Children's Hospital of Buffalo 1983-1986
    Fellow, Pediatric Endocrinology and Metabolism, Children's Hospital of Philadelphia1986-1989
    Research fellow,Massachusetts General Hospital 1989-1992
    Assistant Professor of Pediatrics,Harvard Medical School, Boston, MA 1993-2000
    Associate Professor of Pediatrics, Duke University Medical Center, Durham, NC 2000-2004

    Prof of Pediatrics and Cell Biology
    Director, Ped Endo and Diabetes, UMass Medical School Current

    Mary Lee, MD

    Testicular Development

    We are interested in understanding the role of Mullerian inhibiting substance in the testis and elucidating the hormonal and cellular interactions that are critical for testicular development. Our research involves both clinical investigations and laboratory studies. Our basic research efforts have focused on clarifying the paracrine and endocrine regulation of Leydig cell differentiation and on identifying the effects of persistent organic pollutants (endocrine disruptors, such as dioxins) on the developing male reproductive system.

    Areas of research interest:

    • Biology and regulation of Mullerian inhibiting substance
    • Sexual differentiation and intersex disorders
    • Testicular differentiation and development (fetal and postnatal) of Leydig cells
    • The effects of environmental toxins on reproductive development
    • Gonadal toxicity of chemotherapy and radiation for childhood malignancies

    schematic MIS actions in Leydig cells

    Figure 1. Mullerian Inhibiting Substance (MIS) is a negative regulator of progenitor Leydig cell proliferation and differentation and an inhibitor of adult Leydig cell androgen biosynthesis.

    TUNEL staining testicular sections

    Figure 2. TUNEL staining of representative light micrographs of 4-µm-thick testicular sections from MIS and control-treated rats on Day 15 after EDS treatment. A) Control rat. B and C) MIS-treated rats. Most of the TUNEL-positive nuclei are located within the seminferous tubules and correspond to germ cells. Arrow: interstitial cell with TUNEL-positive nucleus. Scale bar = (A and B) 100µm and (C) 25µm. (Salva A, et al. Biology of Reproduction 2004;70:600-607)



    Collapse Rotation Projects

    Potential Rotations for Students

    1. Characterize the Leydig cell phenotype of different KO and transgenic models of specific genes relevant to reproductive development to determine the role of these genes in Leydig cell development: i.e. GPR54, androgen receptor, etc.
    2. Examine the mechanisms underlying the inhibitory effects of dioxin on Leydig cell steroidogenesis and investigate the developmental basis of this.
    3. Investigate the role of MIS in the development of Leydig cell tumors.
    4. Examine MIS signaling in Leydig cells.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Williams PL, Bellavia A, Korrick SA, Burns JS, Lee MM, Sergeyev O, Hauser R. Blood lead levels and timing of male sexual maturity: A longitudinal study of Russian boys. Environ Int. 2019 Apr; 125:470-477. PMID: 30769180.
      View in: PubMed
    2. Huang L, Liu J, Zhang XO, Sibley K, Najjar SM, Lee MM, Wu JQ. Inhibition of protein arginine methyltransferase 5 enhances hepatic mitochondrial biogenesis. J Biol Chem. 2018 May 17. PMID: 29773653.
      View in: PubMed
    3. Pilsner JR, Shershebnev A, Medvedeva YA, Suvorov A, Wu H, Goltsov A, Loukianov E, Andreeva T, Gusev F, Manakhov A, Smigulina L, Logacheva M, Shtratnikova V, Kuznetsova I, Speranskiy-Podobed P, Burns JS, Williams PL, Korrick S, Lee MM, Rogaev E, Hauser R, Sergeyev O. Peripubertal serum dioxin concentrations and subsequent sperm methylome profiles of young Russian adults. Reprod Toxicol. 2018 06; 78:40-49. PMID: 29550351.
      View in: PubMed
    4. Greenspan LC, Lee MM. Endocrine disrupters and pubertal timing. Curr Opin Endocrinol Diabetes Obes. 2018 02; 25(1):49-54. PMID: 29135489.
      View in: PubMed
    5. Creo AL, Candela N, Lee MM, Feldman PM. An Unusual Manifestation of Celiac Disease in an Adolescent With Down Syndrome and Graves Disease. J Pediatr Gastroenterol Nutr. 2017 Jul; 65(1):e20-e22. PMID: 28644364.
      View in: PubMed
    6. Burns JS, Williams PL, Lee MM, Revich B, Sergeyev O, Hauser R, Korrick SA. Peripubertal blood lead levels and growth among Russian boys. Environ Int. 2017 09; 106:53-59. PMID: 28599171.
      View in: PubMed
    7. Sergeyev O, Burns JS, Williams PL, Korrick SA, Lee MM, Revich B, Hauser R. The association of peripubertal serum concentrations of organochlorine chemicals and blood lead with growth and pubertal development in a longitudinal cohort of boys: a review of published results from the Russian Children's Study. Rev Environ Health. 2017 Mar 01; 32(1-2):83-92. PMID: 28231067.
      View in: PubMed
    8. Mínguez-Alarcón L, Sergeyev O, Burns JS, Williams PL, Lee MM, Korrick SA, Smigulina L, Revich B, Hauser R. A Longitudinal Study of Peripubertal Serum Organochlorine Concentrations and Semen Parameters in Young Men: The Russian Children's Study. Environ Health Perspect. 2017 03; 125(3):460-466. PMID: 27713107.
      View in: PubMed
    9. Burns JS, Lee MM, Williams PL, Korrick SA, Sergeyev O, Lam T, Revich B, Hauser R. Associations of Peripubertal Serum Dioxin and Polychlorinated Biphenyl Concentrations with Pubertal Timing among Russian Boys. Environ Health Perspect. 2016 Nov; 124(11):1801-1807. PMID: 27187981.
      View in: PubMed
    10. Nwosu BU, Maranda L, Cullen K, Greenman L, Fleshman J, McShea N, Barton BA, Lee MM. A Randomized, Double-Blind, Placebo-Controlled Trial of Adjunctive Metformin Therapy in Overweight/Obese Youth with Type 1 Diabetes. PLoS One. 2015; 10(9):e0137525. PMID: 26367281.
      View in: PubMed
    11. Lam T, Williams PL, Lee MM, Korrick SA, Birnbaum LS, Burns JS, Sergeyev O, Revich B, Altshul LM, Patterson DG, Hauser R. Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys. Environ Health Perspect. 2015 Nov; 123(11):1216-21. PMID: 26009253; PMCID: PMC4629743.
    12. Moore Simas TA, Corvera S, Lee MM, Zhang N, Leung K, Olendzki B, Barton B, Rosal MC. Understanding multifactorial influences on the continuum of maternal weight trajectories in pregnancy and early postpartum: study protocol, and participant baseline characteristics. BMC Pregnancy Childbirth. 2015 Mar 28; 15:71. PMID: 25885002.
      View in: PubMed
    13. Burns JS, Williams PL, Korrick SA, Hauser R, Sergeyev O, Revich B, Lam T, Lee MM. Association between chlorinated pesticides in the serum of prepubertal Russian boys and longitudinal biomarkers of metabolic function. Am J Epidemiol. 2014 Nov 01; 180(9):909-19. PMID: 25255811; PMCID: PMC4207719.
    14. Lam T, Williams PL, Lee MM, Korrick SA, Birnbaum LS, Burns JS, Sergeyev O, Revich B, Altshul LM, Patterson DG, Turner WE, Hauser R. Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys. Environ Int. 2014 Dec; 73:135-42. PMID: 25118086; PMCID: PMC4194160.
    15. Sullivan-Bolyai S, Bova C, Johnson K, Cullen K, Jaffarian C, Quinn D, Aroke EN, Crawford S, Lee MM, Gupta O. Engaging teens and parents in collaborative practice: perspectives on diabetes self-management. Diabetes Educ. 2014 Mar-Apr; 40(2):178-90. PMID: 24470041.
      View in: PubMed
    16. Lam T, Williams PL, Burns JS, Sergeyev O, Korrick SA, Lee MM, Birnbaum LS, Revich B, Altshul LM, Patterson DG, Turner WE, Hauser R. Predictors of serum chlorinated pesticide concentrations among prepubertal Russian boys. Environ Health Perspect. 2013 Nov-Dec; 121(11-12):1372-7. PMID: 23955839; PMCID: PMC3855511.
    17. Zawatski W, Lee MM. Male pubertal development: are endocrine-disrupting compounds shifting the norms? J Endocrinol. 2013; 218(2):R1-12. PMID: 23709001.
      View in: PubMed
    18. Mitchell K, Johnson K, Cullen K, Lee MM, Hardy OT. Parental mastery of continuous subcutaneous insulin infusion skills and glycemic control in youth with type 1 diabetes. Diabetes Technol Ther. 2013 Jul; 15(7):591-5. PMID: 23799273.
      View in: PubMed
    19. Fleisch AF, Burns JS, Williams PL, Lee MM, Sergeyev O, Korrick SA, Hauser R. Blood lead levels and serum insulin-like growth factor 1 concentrations in peripubertal boys. Environ Health Perspect. 2013 Jul; 121(7):854-8. PMID: 23632160; PMCID: PMC3702001.
    20. Nwosu BU, Maranda L, Cullen K, Ciccarelli C, Lee MM. Vitamin D status is associated with early markers of cardiovascular disease in prepubertal children. J Pediatr Endocrinol Metab. 2013; 26(11-12):1067-75. PMID: 23817598.
      View in: PubMed
    21. Humblet O, Korrick SA, Williams PL, Sergeyev O, Emond C, Birnbaum LS, Burns JS, Altshul LM, Patterson DG, Turner WE, Lee MM, Revich B, Hauser R. Genetic modification of the association between peripubertal dioxin exposure and pubertal onset in a cohort of Russian boys. Environ Health Perspect. 2013 Jan; 121(1):111-7. PMID: 23060366.
      View in: PubMed
    22. Wu X, Zhang N, Lee MM. Mullerian inhibiting substance recruits ALK3 to regulate Leydig cell differentiation. Endocrinology. 2012 Oct; 153(10):4929-37. PMID: 22872577.
      View in: PubMed
    23. English RG, Perry M, Lee MM, Hoffman E, Delport S, Dalvie MA. Farm residence and reproductive health among boys in rural South Africa. Environ Int. 2012 Oct 15; 47:73-9. PMID: 22771522.
      View in: PubMed
    24. Sullivan-Bolyai S, Crawford S, Johnson K, Huston B, Lee MM. Educating diabetes camp counselors with a human patient simulator: a pilot study. J Spec Pediatr Nurs. 2012 Apr; 17(2):121-8. PMID: 22463472.
      View in: PubMed
    25. Nwosu BU, Stavre ZG, Maranda L, Cullen K, Lee MM. Hepatic dysfunction is associated with vitamin D deficiency and poor glycemic control in diabetes mellitus. J Pediatr Endocrinol Metab. 2012; 25(1-2):181-6. PMID: 22570973.
      View in: PubMed
    26. Humblet O, Williams PL, Korrick SA, Sergeyev O, Emond C, Birnbaum LS, Burns JS, Altshul L, Patterson DG, Turner WE, Lee MM, Revich B, Hauser R. Dioxin and polychlorinated biphenyl concentrations in mother's serum and the timing of pubertal onset in sons. Epidemiology. 2011 Nov; 22(6):827-35. PMID: 21968773.
      View in: PubMed
    27. Burns JS, Williams PL, Sergeyev O, Korrick SA, Lee MM, Revich B, Altshul L, Del Prato JT, Humblet O, Patterson DG, Turner WE, Starovoytov M, Hauser R. Serum concentrations of organochlorine pesticides and growth among Russian boys. Environ Health Perspect. 2012 Feb; 120(2):303-8. PMID: 21984531; PMCID: PMC3279441.
    28. Humblet O, Sergeyev O, Altshul L, Korrick SA, Williams PL, Emond C, Birnbaum LS, Burns JS, Lee MM, Revich B, Shelepchikov A, Feshin D, Hauser R. Temporal trends in serum concentrations of polychlorinated dioxins, furans, and PCBs among adult women living in Chapaevsk, Russia: a longitudinal study from 2000 to 2009. Environ Health. 2011 Jun 22; 10:62. PMID: 21696632; PMCID: PMC3142486.
    29. Korrick SA, Lee MM, Williams PL, Sergeyev O, Burns JS, Patterson DG, Turner WE, Needham LL, Altshul L, Revich B, Hauser R. Dioxin exposure and age of pubertal onset among Russian boys. Environ Health Perspect. 2011 Sep; 119(9):1339-44. PMID: 21527364.
      View in: PubMed
    30. Nwosu BU, Meltzer B, Maranda L, Ciccarelli C, Reynolds D, Curtis L, King J, Frazier JA, Lee MM. A potential role for adjunctive vitamin D therapy in the management of weight gain and metabolic side effects of second-generation antipsychotics. J Pediatr Endocrinol Metab. 2011; 24(9-10):619-26. PMID: 22145446.
      View in: PubMed
    31. Sullivan-Bolyai S, Lee MM. Parent mentor perspectives on providing social support to empower parents. Diabetes Educ. 2011 Jan-Feb; 37(1):35-43. PMID: 21292621.
      View in: PubMed
    32. Nwosu BU, Soyka LA, Angelescu A, Lee MM. Evidence of insulin-like growth factor binding protein-3 proteolysis during growth hormone stimulation testing. J Pediatr Endocrinol Metab. 2011; 24(3-4):163-7. PMID: 21648284.
      View in: PubMed
    33. Burns JS, Williams PL, Sergeyev O, Korrick S, Lee MM, Revich B, Altshul L, Del Prato JT, Humblet O, Patterson DG, Turner WE, Needham LL, Starovoytov M, Hauser R. Serum dioxins and polychlorinated biphenyls are associated with growth among Russian boys. Pediatrics. 2011 Jan; 127(1):e59-68. PMID: 21187307.
      View in: PubMed
    34. Humblet O, Williams PL, Korrick SA, Sergeyev O, Emond C, Birnbaum LS, Burns JS, Altshul L, Patterson DG, Turner WE, Lee MM, Revich B, Hauser R. Predictors of serum dioxin, furan, and PCB concentrations among women from Chapaevsk, Russia. Environ Sci Technol. 2010 Jul 15; 44(14):5633-40. PMID: 20578718; PMCID: PMC3128795.
    35. Wu X, Arumugam R, Zhang N, Lee MM. Androgen profiles during pubertal Leydig cell development in mice. Reproduction. 2010 Jul; 140(1):113-21. PMID: 20453159.
      View in: PubMed
    36. Williams PL, Sergeyev O, Lee MM, Korrick SA, Burns JS, Humblet O, DelPrato J, Revich B, Hauser R. Blood lead levels and delayed onset of puberty in a longitudinal study of Russian boys. Pediatrics. 2010 May; 125(5):e1088-96. PMID: 20368318; PMCID: PMC3111933.
    37. Nwosu BU, Lee MM. Pseudohypoparathyroidism type 1a and insulin resistance in a child. Nat Rev Endocrinol. 2009 Jun; 5(6):345-50. PMID: 19465898.
      View in: PubMed
    38. Burns JS, Williams PL, Sergeyev O, Korrick S, Lee MM, Revich B, Altshul L, Patterson DG, Turner WE, Needham LL, Saharov I, Hauser R. Predictors of serum dioxins and PCBs among peripubertal Russian boys. Environ Health Perspect. 2009 Oct; 117(10):1593-9. PMID: 20019911.
      View in: PubMed
    39. Jacobson-Dickman E, Lee MM. The influence of endocrine disruptors on pubertal timing. Curr Opin Endocrinol Diabetes Obes. 2009 Feb; 16(1):25-30. PMID: 19115521.
      View in: PubMed
    40. Nwosu BU, Lee MM. Evaluation of short and tall stature in children. Am Fam Physician. 2008 Sep 1; 78(5):597-604. PMID: 18788236.
      View in: PubMed
    41. Wu X, Wan S, Pujar S, Haskins ME, Schlafer DH, Lee MM, Meyers-Wallen VN. A single base pair mutation encoding a premature stop codon in the MIS type II receptor is responsible for canine persistent Müllerian duct syndrome. J Androl. 2009 Jan-Feb; 30(1):46-56. PMID: 18723470.
      View in: PubMed
    42. Hauser R, Sergeyev O, Korrick S, Lee MM, Revich B, Gitin E, Burns JS, Williams PL. Association of blood lead levels with onset of puberty in Russian boys. Environ Health Perspect. 2008 Jul; 116(7):976-80. PMID: 18629324; PMCID: PMC2453170.
    43. Wu X, Wan S, Lee MM. Key factors in the regulation of fetal and postnatal Leydig cell development. J Cell Physiol. 2007 Nov; 213(2):429-33. PMID: 17674364.
      View in: PubMed
    44. Buchold GM, Magyar PL, Arumugam R, Lee MM, O'Brien DA. p19Ink4d and p18Ink4c cyclin-dependent kinase inhibitors in the male reproductive axis. Mol Reprod Dev. 2007 Aug; 74(8):997-1007. PMID: 17342741.
      View in: PubMed
    45. Lee MM. Clinical practice. Idiopathic short stature. N Engl J Med. 2006 Jun 15; 354(24):2576-82. PMID: 16775237.
      View in: PubMed
    46. Hauser R, Williams P, Altshul L, Korrick S, Peeples L, Patterson DG, Turner WE, Lee MM, Revich B, Sergeyev O. Predictors of serum dioxin levels among adolescent boys in Chapaevsk, Russia: a cross-sectional pilot study. Environ Health. 2005 May 26; 4(1):8. PMID: 15918907.
      View in: PubMed
    47. Wu X, Arumugam R, Baker SP, Lee MM. Pubertal and adult Leydig cell function in Mullerian inhibiting substance-deficient mice. Endocrinology. 2005 Feb; 146(2):589-95. PMID: 15514087.
      View in: PubMed
    48. Hardy O, Worley G, Lee MM, Chaing S, Mackey J, Crissman B, Kishnani PS. Hypothyroidism in Down syndrome: screening guidelines and testing methodology. Am J Med Genet A. 2004 Feb 1; 124A(4):436-7. PMID: 14735598.
      View in: PubMed
    49. Lee MM, Misra M, Donahoe PK, MacLaughlin DT. MIS/AMH in the assessment of cryptorchidism and intersex conditions. Mol Cell Endocrinol. 2003 Dec 15; 211(1-2):91-8. PMID: 14656481.
      View in: PubMed
    50. Salva A, Hardy MP, Wu XF, Sottas CM, MacLaughlin DT, Donahoe PK, Lee MM. Müllerian-inhibiting substance inhibits rat Leydig cell regeneration after ethylene dimethanesulphonate ablation. Biol Reprod. 2004 Mar; 70(3):600-7. PMID: 14585814.
      View in: PubMed
    51. Lee MM. Is treatment with a luteinizing hormone-releasing hormone agonist justified in short adolescents? N Engl J Med. 2003 Mar 6; 348(10):942-5. PMID: 12621139.
      View in: PubMed
    52. Misra M, MacLaughlin DT, Donahoe PK, Lee MM. The role of Müllerian inhibiting substance in the evaluation of phenotypic female patients with mild degrees of virilization. J Clin Endocrinol Metab. 2003 Feb; 88(2):787-92. PMID: 12574214.
      View in: PubMed
    53. Lee MM, Sergeyev O, Williams P, Korrick S, Zeilert V, Revich B, Hauser R. Physical growth and sexual maturation of boys in Chapaevsk, Russia. J Pediatr Endocrinol Metab. 2003 Feb; 16(2):169-78. PMID: 12713253.
      View in: PubMed
    54. Litton J, Rice A, Friedman N, Oden J, Lee MM, Freemark M. Insulin pump therapy in toddlers and preschool children with type 1 diabetes mellitus. J Pediatr. 2002 Oct; 141(4):490-5. PMID: 12378187.
      View in: PubMed
    55. Misra M, MacLaughlin DT, Donahoe PK, Lee MM. Measurement of Mullerian inhibiting substance facilitates management of boys with microphallus and cryptorchidism. J Clin Endocrinol Metab. 2002 Aug; 87(8):3598-602. PMID: 12161481.
      View in: PubMed
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