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Maria Jose Duenas Decamp PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentProgram in Molecular Medicine
Phone508-856-6281
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentProgram in Molecular Medicine


    Collapse Overview 
    Collapse overview
    Our research is focused on HIV infection in hematopoietic stem and progenitor cells (HSPC).


    Collapse Research 
    Collapse research activities and funding
    P30 AI042845-14     (Duenas Decamp, Maria Jose)Nov 1, 2011 - Nov 1, 2012
    University of Massachusetts Center for AIDS Research (CFAR) pilot study
    HIV-1-infected Hematopoietic Stem/Progenitor Cells differentiation and tropism implication for HSPC infection.
    Role: Principal investigator

    R21NS097145     (Duenas-Decamp, Maria)Mar 1, 2016 - Feb 28, 2018
    NIH
    HIV-1 infection of hematopoietic progenitor cells, their differentiation and seeding of virus into brain tissue
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Beauparlant D, Rusert P, Magnus C, Kadelka C, Weber J, Uhr T, Zagordi O, Oberle C, Duenas-Decamp MJ, Clapham PR, Metzner KJ, Günthard HF, Trkola A. Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality. PLoS Pathog. 2017 Mar 06; 13(3):e1006255. PMID: 28264054.
      View in: PubMed
    2. Duenas-Decamp M, Jiang L, Bolon D, Clapham PR. Saturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations. PLoS Pathog. 2016 Nov; 12(11):e1005988. PMID: 27820858.
      View in: PubMed
    3. O'Connell O, Repik A, Reeves JD, Gonzalez-Perez MP, Quitadamo B, Anton ED, Duenas-Decamp M, Peters P, Lin R, Zolla-Pazner S, Corti D, Wallace A, Wang S, Kong XP, Lu S, Clapham PR. Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism. J Virol. 2013 Jan; 87(1):187-98. PMID: 23055568.
      View in: PubMed
    4. Dueñas-Decamp MJ, O'Connell OJ, Corti D, Zolla-Pazner S, Clapham PR. The W100 pocket on HIV-1 gp120 penetrated by b12 is not a target for other CD4bs monoclonal antibodies. Retrovirology. 2012 Jan 27; 9:9. PMID: 22284192.
      View in: PubMed
    5. Vaine M, Duenas-Decamp M, Peters P, Liu Q, Arthos J, Wang S, Clapham P, Lu S. Two closely related Env antigens from the same patient elicited different spectra of neutralizing antibodies against heterologous HIV-1 isolates. J Virol. 2011 May; 85(10):4927-36. PMID: 21411542.
      View in: PubMed
    6. Musich T, Peters PJ, Duenas-Decamp MJ, Gonzalez-Perez MP, Robinson J, Zolla-Pazner S, Ball JK, Luzuriaga K, Clapham PR. A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection. J Virol. 2011 Mar; 85(5):2397-405. PMID: 21159865.
      View in: PubMed
    7. Duenas-Decamp MJ, Clapham PR. HIV-1 gp120 determinants proximal to the CD4 binding site shift protective glycans that are targeted by monoclonal antibody 2G12. J Virol. 2010 Sep; 84(18):9608-12. PMID: 20610714.
      View in: PubMed
    8. Duenas-Decamp MJ, Peters PJ, Repik A, Musich T, Gonzalez-Perez MP, Caron C, Brown R, Ball J, Clapham PR. Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis. Future Virol. 2010 Jul; 5(4):435-451. PMID: 20930940.
      View in: PubMed
    9. Duenas-Decamp MJ, Peters PJ, Burton D, Clapham PR. Determinants flanking the CD4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 R5 envelopes. J Virol. 2009 Mar; 83(6):2575-83. PMID: 19129457.
      View in: PubMed
    10. Duenas-Decamp MJ, Peters P, Burton D, Clapham PR. Natural resistance of human immunodeficiency virus type 1 to the CD4bs antibody b12 conferred by a glycan and an arginine residue close to the CD4 binding loop. J Virol. 2008 Jun; 82(12):5807-14. PMID: 18385254.
      View in: PubMed
    11. Peters PJ, Duenas-Decamp MJ, Sullivan WM, Brown R, Ankghuambom C, Luzuriaga K, Robinson J, Burton DR, Bell J, Simmonds P, Ball J, Clapham PR. Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors. Retrovirology. 2008 Jan 18; 5:5. PMID: 18205925.
      View in: PubMed
    12. Peters PJ, Dueñas-Decamp MJ, Sullivan WM, Clapham PR. Variation of macrophage tropism among HIV-1 R5 envelopes in brain and other tissues. J Neuroimmune Pharmacol. 2007 Mar; 2(1):32-41. PMID: 18040824.
      View in: PubMed
    13. Peters PJ, Sullivan WM, Duenas-Decamp MJ, Bhattacharya J, Ankghuambom C, Brown R, Luzuriaga K, Bell J, Simmonds P, Ball J, Clapham PR. Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesis. J Virol. 2006 Jul; 80(13):6324-32. PMID: 16775320.
      View in: PubMed
    14. Dueñas, M.J. and Estrada P. Immobilization of B-Xylosidase from Trichoderma Reesei QM 9414 on nylon powder. Bio-catalysis and Biotransformatio. 1996;17:139-16.
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