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Gary R Ostroff PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentProgram in Molecular Medicine
AddressUniversity of Massachusetts Medical School
373 Plantation Street, Two Biotech, Suite 113
Worcester MA 01605
Phone508-856-1930
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentPediatrics

    InstitutionUMMS - School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionUMMS - School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMasters in Clinical Investigation

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Delaware Valley College of Science and Agriculture, Doylestown, PA, United StatesBSBiology
    University of Delaware, Newark, DE, United StatesPHDMolecular Medicine

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Mirza Z, Soto ER, Dikengil F, Levitz SM, Ostroff GR. Beta-Glucan Particles as Vaccine Adjuvant Carriers. Methods Mol Biol. 2017; 1625:143-157. PMID: 28584989.
      View in: PubMed
    2. Soto ER, O'Connell O, Dikengil F, Peters PJ, Clapham PR, Ostroff GR. Targeted Delivery of Glucan Particle Encapsulated Gallium Nanoparticles Inhibits HIV Growth in Human Macrophages. J Drug Deliv. 2016; 2016:8520629. PMID: 27965897.
      View in: PubMed
    3. Specht CA, Lee CK, Huang H, Tipper DJ, Shen ZT, Lodge JK, Leszyk J, Ostroff GR, Levitz SM. Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles Containing Cryptococcus Alkaline Extracts. MBio. 2015 Dec 22; 6(6):e01905-15. PMID: 26695631.
      View in: PubMed
    4. De Jesus M, Rodriguez AE, Yagita H, Ostroff GR, Mantis NJ. Sampling of Candida albicans and Candida tropicalis by Langerin-positive dendritic cells in mouse Peyer's patches. Immunol Lett. 2015 Nov; 168(1):64-72. PMID: 26386376.
      View in: PubMed
    5. Wüthrich M, Brandhorst TT, Sullivan TD, Filutowicz H, Sterkel A, Stewart D, Li M, Lerksuthirat T, LeBert V, Shen ZT, Ostroff G, Deepe GS, Hung CY, Cole G, Walter JA, Jenkins MK, Klein B. Calnexin induces expansion of antigen-specific CD4(+) T cells that confer immunity to fungal ascomycetes via conserved epitopes. Cell Host Microbe. 2015 Apr 8; 17(4):452-65. PMID: 25800545.
      View in: PubMed
    6. Levitz SM, Huang H, Ostroff GR, Specht CA. Exploiting fungal cell wall components in vaccines. Semin Immunopathol. 2015 Mar; 37(2):199-207. PMID: 25404118.
      View in: PubMed
    7. Bueter CL, Lee CK, Wang JP, Ostroff GR, Specht CA, Levitz SM. Spectrum and mechanisms of inflammasome activation by chitosan. J Immunol. 2014 Jun 15; 192(12):5943-51. PMID: 24829412.
      View in: PubMed
    8. De Jesus M, Ostroff GR, Levitz SM, Bartling TR, Mantis NJ. A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling ß-glucan microparticles. PLoS One. 2014; 9(3):e91002. PMID: 24632738.
      View in: PubMed
    9. Träger U, Andre R, Lahiri N, Magnusson-Lind A, Weiss A, Grueninger S, McKinnon C, Sirinathsinghji E, Kahlon S, Pfister EL, Moser R, Hummerich H, Antoniou M, Bates GP, Luthi-Carter R, Lowdell MW, Björkqvist M, Ostroff GR, Aronin N, Tabrizi SJ. HTT-lowering reverses Huntington's disease immune dysfunction caused by NF?B pathway dysregulation. Brain. 2014 Mar; 137(Pt 3):819-33. PMID: 24459107.
      View in: PubMed
    10. Cole GT, Hung CY, Sanderson SD, Hurtgen BJ, Wüthrich M, Klein BS, Deepe GS, Ostroff GR, Levitz SM. Novel strategies to enhance vaccine immunity against coccidioidomycosis. PLoS Pathog. 2013; 9(12):e1003768. PMID: 24367252.
      View in: PubMed
    11. De Smet R, Demoor T, Verschuere S, Dullaers M, Ostroff GR, Leclercq G, Allais L, Pilette C, Dierendonck M, De Geest BG, Cuvelier CA. ß-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination. J Control Release. 2013 Dec 28; 172(3):671-8. PMID: 24041710.
      View in: PubMed
    12. Huang H, Ostroff GR, Lee CK, Specht CA, Levitz SM. Characterization and optimization of the glucan particle-based vaccine platform. Clin Vaccine Immunol. 2013 Oct; 20(10):1585-91. PMID: 23945157.
      View in: PubMed
    13. Hurtgen BJ, Hung CY, Ostroff GR, Levitz SM, Cole GT. Construction and evaluation of a novel recombinant T cell epitope-based vaccine against Coccidioidomycosis. Infect Immun. 2012 Nov; 80(11):3960-74. PMID: 22949556.
      View in: PubMed
    14. Huang H, Ostroff GR, Lee CK, Agarwal S, Ram S, Rice PA, Specht CA, Levitz SM. Relative contributions of dectin-1 and complement to immune responses to particulate ß-glucans. J Immunol. 2012 Jul 1; 189(1):312-7. PMID: 22649195.
      View in: PubMed
    15. Soto ER, Caras AC, Kut LC, Castle MK, Ostroff GR. Glucan particles for macrophage targeted delivery of nanoparticles. J Drug Deliv. 2012; 2012:143524. PMID: 22013535.
      View in: PubMed
    16. Agarwal S, Specht CA, Haibin H, Ostroff GR, Ram S, Rice PA, Levitz SM. Linkage specificity and role of properdin in activation of the alternative complement pathway by fungal glycans. MBio. 2011; 2(5). PMID: 21878570.
      View in: PubMed
    17. Tesz GJ, Aouadi M, Prot M, Nicoloro SM, Boutet E, Amano SU, Goller A, Wang M, Guo CA, Salomon WE, Virbasius JV, Baum RA, O'Connor MJ, Soto E, Ostroff GR, Czech MP. Glucan particles for selective delivery of siRNA to phagocytic cells in mice. Biochem J. 2011 Jun 1; 436(2):351-62. PMID: 21418037.
      View in: PubMed
    18. Huang H, Ostroff GR, Lee CK, Specht CA, Levitz SM. Robust stimulation of humoral and cellular immune responses following vaccination with antigen-loaded beta-glucan particles. MBio. 2010 Jul 20; 1(3). PMID: 20802824.
      View in: PubMed
    19. Aouadi M, Tesz GJ, Nicoloro SM, Wang M, Chouinard M, Soto E, Ostroff GR, Czech MP. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature. 2009 Apr 30; 458(7242):1180-4. PMID: 19407801.
      View in: PubMed
    20. Huang H, Ostroff GR, Lee CK, Wang JP, Specht CA, Levitz SM. Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists. Infect Immun. 2009 May; 77(5):1774-81. PMID: 19273561.
      View in: PubMed
    21. Soto ER, Ostroff GR. Characterization of multilayered nanoparticles encapsulated in yeast cell wall particles for DNA delivery. Bioconjug Chem. 2008 Apr; 19(4):840-8. PMID: 18376856.
      View in: PubMed
    22. Young SH, Ostroff GR, Zeidler-Erdely PC, Roberts JR, Antonini JM, Castranova V. A comparison of the pulmonary inflammatory potential of different components of yeast cell wall. J Toxicol Environ Health A. 2007 Jul; 70(13):1116-24. PMID: 17558806.
      View in: PubMed
    23. Hong F, Yan J, Baran JT, Allendorf DJ, Hansen RD, Ostroff GR, Xing PX, Cheung NK, Ross GD. Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. J Immunol. 2004 Jul 15; 173(2):797-806. PMID: 15240666.
      View in: PubMed
    24. Hong F, Hansen RD, Yan J, Allendorf DJ, Baran JT, Ostroff GR, Ross GD. Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells. Cancer Res. 2003 Dec 15; 63(24):9023-31. PMID: 14695221.
      View in: PubMed
    25. Donzelli BG, Ostroff G, Harman GE. Enhanced enzymatic hydrolysis of langostino shell chitin with mixtures of enzymes from bacterial and fungal sources. Carbohydr Res. 2003 Sep 1; 338(18):1823-33. PMID: 12932365.
      View in: PubMed
    26. Kournikakis B, Mandeville R, Brousseau P, Ostroff G. Anthrax-protective effects of yeast beta 1,3 glucans. MedGenMed. 2003 Mar 21; 5(1):1. PMID: 12827062.
      View in: PubMed
    27. Niederman R, Kelderman H, Socransky S, Ostroff G, Genco C, Kent R, Stashenko P. Enhanced neutrophil emigration and Porphyromonas gingivalis reduction following PGG-glucan treatment of mice. Arch Oral Biol. 2002 Aug; 47(8):613-8. PMID: 12221019.
      View in: PubMed
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