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Last Name
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Gary R Ostroff PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentProgram in Molecular Medicine
AddressUniversity of Massachusetts Medical School
373 Plantation Street, Two Biotech, Suite 113
Worcester MA 01605
Phone508-856-1930
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionUMMS - School of Medicine
    DepartmentPediatrics

    InstitutionUMMS - School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionUMMS - School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMasters in Clinical Investigation

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Delaware Valley College of Science and Agriculture, Doylestown, PA, United StatesBSBiology
    University of Delaware, Newark, DE, United StatesPHDMolecular Medicine

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Whelan AO, Flick-Smith HC, Homan J, Shen ZT, Carpenter Z, Khoshkenar P, Abraham A, Walker NJ, Levitz SM, Ostroff GR, Oyston PCF. Protection induced by a Francisella tularensis subunit vaccine delivered by glucan particles. PLoS One. 2018; 13(10):e0200213. PMID: 30296254.
      View in: PubMed
    2. Alexander MP, Fiering SN, Ostroff GR, Cramer RA, Mullins DW. Beta-glucan-induced inflammatory monocytes mediate antitumor efficacy in the murine lung. Cancer Immunol Immunother. 2018 Aug 23. PMID: 30167860.
      View in: PubMed
    3. Hung CY, Zhang H, Castro-Lopez N, Ostroff GR, Khoshlenar P, Abraham A, Cole GT, Negron A, Forsthuber T, Peng T, Galgiani JN, Ampel NM, Yu JJ. Glucan-chitin particles enhance Th17 response and improve protective efficacy of a multivalent antigen (rCpa1) against pulmonary Coccidioides posadasii infection. Infect Immun. 2018 Aug 13. PMID: 30104216.
      View in: PubMed
    4. Hamza Z, El-Hashash M, Aly S, Hathout A, Soto E, Sabry B, Ostroff G. Preparation and characterization of yeast cell wall beta-glucan encapsulated humic acid nanoparticles as an enhanced aflatoxin B1 binder. Carbohydr Polym. 2019 Jan 01; 203:185-192. PMID: 30318202.
      View in: PubMed
    5. Li Q, Nirala NK, Nie Y, Chen HJ, Ostroff G, Mao J, Wang Q, Xu L, Ip YT. Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth. Dev Cell. 2018 05 21; 45(4):433-449.e6. PMID: 29754801.
      View in: PubMed
    6. Hu Y, Nguyen TT, Lee ACY, Urban JF, Miller MM, Zhan B, Koch DJ, Noon JB, Abraham A, Fujiwara RT, Bowman DD, Ostroff GR, Aroian RV. Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure. Int J Parasitol Drugs Drug Resist. 2018 May 04; 8(2):287-294. PMID: 29772478.
      View in: PubMed
    7. Deepe GS, Buesing WR, Ostroff GR, Abraham A, Specht CA, Huang H, Levitz SM. Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice. Vaccine. 2018 05 31; 36(23):3359-3367. PMID: 29729993.
      View in: PubMed
    8. Rockenstein E, Ostroff G, Dikengil F, Rus F, Mante M, Florio J, Adame A, Trinh I, Kim C, Overk C, Masliah E, Rissman RA. Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies. J Neurosci. 2018 Jan 24; 38(4):1000-1014. PMID: 29246926.
      View in: PubMed
    9. Specht CA, Lee CK, Huang H, Hester MM, Liu J, Luckie BA, Torres Santana MA, Mirza Z, Khoshkenar P, Abraham A, Shen ZT, Lodge JK, Akalin A, Homan J, Ostroff GR, Levitz SM. Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species. MBio. 2017 Nov 28; 8(6). PMID: 29184017.
      View in: PubMed
    10. Miller JRC, Pfister EL, Liu W, Andre R, Träger U, Kennington LA, Lo K, Dijkstra S, Macdonald D, Ostroff G, Aronin N, Tabrizi SJ. Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells. Sci Rep. 2017 Apr 24; 7:46740. PMID: 28436437.
      View in: PubMed
    11. Mirza Z, Soto ER, Dikengil F, Levitz SM, Ostroff GR. Beta-Glucan Particles as Vaccine Adjuvant Carriers. Methods Mol Biol. 2017; 1625:143-157. PMID: 28584989.
      View in: PubMed
    12. Soto ER, O'Connell O, Dikengil F, Peters PJ, Clapham PR, Ostroff GR. Targeted Delivery of Glucan Particle Encapsulated Gallium Nanoparticles Inhibits HIV Growth in Human Macrophages. J Drug Deliv. 2016; 2016:8520629. PMID: 27965897.
      View in: PubMed
    13. Specht CA, Lee CK, Huang H, Tipper DJ, Shen ZT, Lodge JK, Leszyk J, Ostroff GR, Levitz SM. Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles Containing Cryptococcus Alkaline Extracts. MBio. 2015 Dec 22; 6(6):e01905-15. PMID: 26695631.
      View in: PubMed
    14. De Jesus M, Rodriguez AE, Yagita H, Ostroff GR, Mantis NJ. Sampling of Candida albicans and Candida tropicalis by Langerin-positive dendritic cells in mouse Peyer's patches. Immunol Lett. 2015 Nov; 168(1):64-72. PMID: 26386376.
      View in: PubMed
    15. Wüthrich M, Brandhorst TT, Sullivan TD, Filutowicz H, Sterkel A, Stewart D, Li M, Lerksuthirat T, LeBert V, Shen ZT, Ostroff G, Deepe GS, Hung CY, Cole G, Walter JA, Jenkins MK, Klein B. Calnexin induces expansion of antigen-specific CD4(+) T cells that confer immunity to fungal ascomycetes via conserved epitopes. Cell Host Microbe. 2015 Apr 8; 17(4):452-65. PMID: 25800545.
      View in: PubMed
    16. Levitz SM, Huang H, Ostroff GR, Specht CA. Exploiting fungal cell wall components in vaccines. Semin Immunopathol. 2015 Mar; 37(2):199-207. PMID: 25404118.
      View in: PubMed
    17. Bueter CL, Lee CK, Wang JP, Ostroff GR, Specht CA, Levitz SM. Spectrum and mechanisms of inflammasome activation by chitosan. J Immunol. 2014 Jun 15; 192(12):5943-51. PMID: 24829412.
      View in: PubMed
    18. De Jesus M, Ostroff GR, Levitz SM, Bartling TR, Mantis NJ. A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling ß-glucan microparticles. PLoS One. 2014; 9(3):e91002. PMID: 24632738.
      View in: PubMed
    19. Träger U, Andre R, Lahiri N, Magnusson-Lind A, Weiss A, Grueninger S, McKinnon C, Sirinathsinghji E, Kahlon S, Pfister EL, Moser R, Hummerich H, Antoniou M, Bates GP, Luthi-Carter R, Lowdell MW, Björkqvist M, Ostroff GR, Aronin N, Tabrizi SJ. HTT-lowering reverses Huntington's disease immune dysfunction caused by NF?B pathway dysregulation. Brain. 2014 Mar; 137(Pt 3):819-33. PMID: 24459107.
      View in: PubMed
    20. Cole GT, Hung CY, Sanderson SD, Hurtgen BJ, Wüthrich M, Klein BS, Deepe GS, Ostroff GR, Levitz SM. Novel strategies to enhance vaccine immunity against coccidioidomycosis. PLoS Pathog. 2013; 9(12):e1003768. PMID: 24367252.
      View in: PubMed
    21. De Smet R, Demoor T, Verschuere S, Dullaers M, Ostroff GR, Leclercq G, Allais L, Pilette C, Dierendonck M, De Geest BG, Cuvelier CA. ß-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination. J Control Release. 2013 Dec 28; 172(3):671-8. PMID: 24041710.
      View in: PubMed
    22. Huang H, Ostroff GR, Lee CK, Specht CA, Levitz SM. Characterization and optimization of the glucan particle-based vaccine platform. Clin Vaccine Immunol. 2013 Oct; 20(10):1585-91. PMID: 23945157.
      View in: PubMed
    23. Hurtgen BJ, Hung CY, Ostroff GR, Levitz SM, Cole GT. Construction and evaluation of a novel recombinant T cell epitope-based vaccine against Coccidioidomycosis. Infect Immun. 2012 Nov; 80(11):3960-74. PMID: 22949556.
      View in: PubMed
    24. Huang H, Ostroff GR, Lee CK, Agarwal S, Ram S, Rice PA, Specht CA, Levitz SM. Relative contributions of dectin-1 and complement to immune responses to particulate ß-glucans. J Immunol. 2012 Jul 1; 189(1):312-7. PMID: 22649195.
      View in: PubMed
    25. Soto ER, Caras AC, Kut LC, Castle MK, Ostroff GR. Glucan particles for macrophage targeted delivery of nanoparticles. J Drug Deliv. 2012; 2012:143524. PMID: 22013535.
      View in: PubMed
    26. Agarwal S, Specht CA, Haibin H, Ostroff GR, Ram S, Rice PA, Levitz SM. Linkage specificity and role of properdin in activation of the alternative complement pathway by fungal glycans. MBio. 2011; 2(5). PMID: 21878570.
      View in: PubMed
    27. Tesz GJ, Aouadi M, Prot M, Nicoloro SM, Boutet E, Amano SU, Goller A, Wang M, Guo CA, Salomon WE, Virbasius JV, Baum RA, O'Connor MJ, Soto E, Ostroff GR, Czech MP. Glucan particles for selective delivery of siRNA to phagocytic cells in mice. Biochem J. 2011 Jun 1; 436(2):351-62. PMID: 21418037.
      View in: PubMed
    28. Huang H, Ostroff GR, Lee CK, Specht CA, Levitz SM. Robust stimulation of humoral and cellular immune responses following vaccination with antigen-loaded beta-glucan particles. MBio. 2010 Jul 20; 1(3). PMID: 20802824.
      View in: PubMed
    29. Aouadi M, Tesz GJ, Nicoloro SM, Wang M, Chouinard M, Soto E, Ostroff GR, Czech MP. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature. 2009 Apr 30; 458(7242):1180-4. PMID: 19407801.
      View in: PubMed
    30. Huang H, Ostroff GR, Lee CK, Wang JP, Specht CA, Levitz SM. Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists. Infect Immun. 2009 May; 77(5):1774-81. PMID: 19273561.
      View in: PubMed
    31. Soto ER, Ostroff GR. Characterization of multilayered nanoparticles encapsulated in yeast cell wall particles for DNA delivery. Bioconjug Chem. 2008 Apr; 19(4):840-8. PMID: 18376856.
      View in: PubMed
    32. Young SH, Ostroff GR, Zeidler-Erdely PC, Roberts JR, Antonini JM, Castranova V. A comparison of the pulmonary inflammatory potential of different components of yeast cell wall. J Toxicol Environ Health A. 2007 Jul; 70(13):1116-24. PMID: 17558806.
      View in: PubMed
    33. Hong F, Yan J, Baran JT, Allendorf DJ, Hansen RD, Ostroff GR, Xing PX, Cheung NK, Ross GD. Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. J Immunol. 2004 Jul 15; 173(2):797-806. PMID: 15240666.
      View in: PubMed
    34. Hong F, Hansen RD, Yan J, Allendorf DJ, Baran JT, Ostroff GR, Ross GD. Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells. Cancer Res. 2003 Dec 15; 63(24):9023-31. PMID: 14695221.
      View in: PubMed
    35. Donzelli BG, Ostroff G, Harman GE. Enhanced enzymatic hydrolysis of langostino shell chitin with mixtures of enzymes from bacterial and fungal sources. Carbohydr Res. 2003 Sep 1; 338(18):1823-33. PMID: 12932365.
      View in: PubMed
    36. Kournikakis B, Mandeville R, Brousseau P, Ostroff G. Anthrax-protective effects of yeast beta 1,3 glucans. MedGenMed. 2003 Mar 21; 5(1):1. PMID: 12827062.
      View in: PubMed
    37. Niederman R, Kelderman H, Socransky S, Ostroff G, Genco C, Kent R, Stashenko P. Enhanced neutrophil emigration and Porphyromonas gingivalis reduction following PGG-glucan treatment of mice. Arch Oral Biol. 2002 Aug; 47(8):613-8. PMID: 12221019.
      View in: PubMed
    38. Bell S, Goldman VM, Bistrian BR, Arnold AH, Ostroff G, Forse RA. Effect of beta-glucan from oats and yeast on serum lipids. Crit Rev Food Sci Nutr. 1999 Mar; 39(2):189-202. PMID: 10198754.
      View in: PubMed
    39. Stashenko P, Wang CY, Riley E, Wu Y, Ostroff G, Niederman R. Reduction of infection-stimulated periapical bone resorption by the biological response modifier PGG glucan. J Dent Res. 1995 Jan; 74(1):323-30. PMID: 7876425.
      View in: PubMed
    40. Onderdonk AB, Cisneros RL, Hinkson P, Ostroff G. Anti-infective effect of poly-beta 1-6-glucotriosyl-beta 1-3-glucopyranose glucan in vivo. Infect Immun. 1992 Apr; 60(4):1642-7. PMID: 1548086.
      View in: PubMed
    41. Simon ES, Toone EJ, Ostroff G, Bednarski MD, Whitesides GM. Preparation of cytidine 5'-monophospho-N-acetylneuraminic acid and uridine 5'-diphosphoglucuronic acid; syntheses of alpha-2, 6-sialyllactosamine, alpha-2, 6-sialyllactose, and hyaluronic acid. Methods Enzymol. 1989; 179:275-87. PMID: 2560122.
      View in: PubMed
    42. Ostroff GR, Pène JJ. Molecular cloning with bifunctional plasmid vectors in Bacillus subtilis. I. Construction and analysis of B. subtilis clone banks in Escherichia coli. Mol Gen Genet. 1984; 193(2):299-305. PMID: 6319967.
      View in: PubMed
    43. Ostroff GR, Pène JJ. Molecular cloning with bifunctional plasmid vectors in Bacillus subtilis. II. Transfer of sequences propagated in Escherichia coli to B. subtilis. Mol Gen Genet. 1984; 193(2):306-11. PMID: 6319968.
      View in: PubMed
    44. Ostroff GR, Pène JJ. Molecular cloning with bifunctional plasmid vectors in Bacillus subtilis: isolation of a spontaneous mutant of Bacillus subtilis with enhanced transformability for Escherichia coli-propagated chimeric plasmid DNA. J Bacteriol. 1983 Nov; 156(2):934-6. PMID: 6313628.
      View in: PubMed
    45. Lynfield YL, Ostroff G. Psoriatic flora. Arch Dermatol. 1973 Sep; 108(3):424-5. PMID: 4729769.
      View in: PubMed
    46. Lynfield YL, Ostroff G, Abraham J. Bacteria, skin sterilization, and wound healing in psoriasis. N Y State J Med. 1972 Jun 1; 72(11):1247-50. PMID: 4503897.
      View in: PubMed
    47. ALLEN EG, OSTROFF G, BOVARNICK MR. Inhibition of the cytochrome reductase activity associated with menigopneumonitis virus by fatty acids derived from infected allantoic fluids. Virology. 1960 Aug; 11:737-52. PMID: 13792724.
      View in: PubMed
    48. LEVEEN HH, FALK G, OSTROFF G, CALEM WS. The production of ulcerative colitis by anticolon sera. Surg Forum. 1960; 11:3-5. PMID: 13761325.
      View in: PubMed
    49. OSTROFF G, AXELROD DR, BOVARNICK M. Antigenicity of polymers of glutamyl peptide on humans. Proc Soc Exp Biol Med. 1958 Nov; 99(2):345-7. PMID: 13601865.
      View in: PubMed
    50. SCHIER WW, ROTH A, OSTROFF G, SCHRIFT MH. Hodgkin's disease and immunity. Am J Med. 1956 Jan; 20(1):94-9. PMID: 13282926.
      View in: PubMed
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