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David A Guertin PhD

InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressUMass Chan Medical School
373 Plantation Street Two Biotech Suite 114
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMolecular, Cell and Cancer Biology

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionUMass Chan Programs, Centers and Institutes
    DepartmentDiabetes and Endocrinology Research Center

    Collapse Biography 
    Collapse education and training
    Saint Michael's College, Colchester, VT, United StatesBSScience
    University of Massachusetts Medical School, Worcester, MA, United StatesPHDPhilosophy
    Whitehead Institute for Biomedical Research, Cambridge, MA USAPostdoc2009
    Collapse awards and honors
    2003 - 2005Damon Runyon Cancer Research Foundation Fellowship, Whitehead Institute
    2007 - 2008Leukemia & Lymphoma Society Special Fellow Award, Whitehead Institute
    2008 - 2013NIH/NCI Pathway to Independence Award, Whitehead/UMMS
    2010 - 2012Charles Hood Foundation Child Health Research Award, UMMS
    2010 - 2014PEW Scholar Award, UMMS
    2015 - 2020Leukemia & Lymphoma Society Research Scholar Award, UMMS

    Collapse Overview 
    Collapse overview


    We study the biology of nutrient sensing. Sensing and adapting to changes in nutrient availability are basic survival requirements that occur in individual cells, by organs, and across whole organisms. Altered nutrient sensing is associated with cancer, diabetes, and infectious diseases and one of our long-term goals is to identify nodes of metabolic control that can be targeted therapeutically. We are specifically interested in the interplay between nutrient sensing signaling mechanisms and metabolism focusing on the mTOR pathway, and we have made many significant contributions towards understanding mTOR complex 2 (mTORC2) including its discovery, functions, and roles in health and disease. We also study adipose and liver organ biology including how these tissues utilize nutrients and communicate to maintain energy balance. In this area, we have made important advances in understanding the development and metabolism of brown adipose tissue, which was only recently recognized as a critical regulator of metabolic homeostasis in adult humans.


    For more info, please vist our website at http://www.umassmed.edu/guertinlab/. 



    Collapse Post Docs

    A postdoctoral position is available to study in this laboratory. Contact Dr.Guertin for additional details.

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Haley JA, Jang C, Guertin DA. A new era of understanding in vivo metabolic flux in thermogenic adipocytes. Curr Opin Genet Dev. 2023 Sep 11; 83:102112. PMID: 37703635.
      Citations:    Fields:    
    2. Park G, Haley JA, Le J, Jung SM, Fitzgibbons TP, Korobkina ED, Li H, Fluharty SM, Chen Q, Spinelli JB, Trivedi CM, Jang C, Guertin DA. Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis. Nat Metab. 2023 07; 5(7):1204-1220. PMID: 37337122.
      Citations: 1     Fields:    Translation:Animals
    3. Honeywell ME, Isidor MS, Harper NW, Fontana RE, Gordillo PC, Porto SA, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ. p53 controls choice between apoptotic and non-apoptotic death following DNA damage. bioRxiv. 2023 May 16. PMID: 36712034.
    4. Guertin DA, Wellen KE. Acetyl-CoA metabolism in cancer. Nat Rev Cancer. 2023 03; 23(3):156-172. PMID: 36658431.
      Citations: 8     Fields:    Translation:HumansAnimals
    5. Chen Q, Huang L, Pan D, Hu K, Li R, Friedline RH, Kim JK, Zhu LJ, Guertin DA, Wang YX. A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis. Nat Commun. 2022 Dec 10; 13(1):7633. PMID: 36496438.
      Citations: 2     Fields:    
    6. Luciano AK, Korobkina ED, Lyons SP, Haley JA, Fluharty SM, Jung SM, Kettenbach AN, Guertin DA. Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1. J Biol Chem. 2022 10; 298(10):102379. PMID: 35973513.
      Citations: 3     Fields:    Translation:HumansCells
    7. Calejman CM, Doxsey WG, Fazakerley DJ, Guertin DA. Integrating adipocyte insulin signaling and metabolism in the multi-omics era. Trends Biochem Sci. 2022 06; 47(6):531-546. PMID: 35304047.
      Citations: 7     Fields:    Translation:HumansCells
    8. Jung SM, Le J, Doxsey WG, Haley JA, Park G, Guertin DA, Jang C. Stable Isotope Tracing and Metabolomics to Study In Vivo Brown Adipose Tissue Metabolic Fluxes. Methods Mol Biol. 2022; 2448:119-130. PMID: 35167094.
      Citations: 1     Fields:    
    9. Jung SM, Doxsey WG, Le J, Haley JA, Mazuecos L, Luciano AK, Li H, Jang C, Guertin DA. In?vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate. Cell Rep. 2021 07 27; 36(4):109459. PMID: 34320357.
      Citations: 13     Fields:    Translation:AnimalsCells
    10. Blaustein M, Piegari E, Mart?nez Calejman C, Vila A, Amante A, Manese MV, Zeida A, Abrami L, Veggetti M, Guertin DA, van der Goot FG, Corvi MM, Colman-Lerner A. Akt Is S-Palmitoylated: A New Layer of Regulation for Akt. Front Cell Dev Biol. 2021; 9:626404. PMID: 33659252.
    11. Hsiao WY, Jung SM, Tang Y, Haley JA, Li R, Li H, Calejman CM, Sanchez-Gurmaches J, Hung CM, Luciano AK, DeMambro V, Wellen KE, Rosen CJ, Zhu LJ, Guertin DA. The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development. Cell Rep. 2020 10 06; 33(1):108223. PMID: 33027655.
      Citations: 5     Fields:    Translation:HumansAnimals
    12. Calejman CM, Trefely S, Entwisle SW, Luciano A, Jung SM, Hsiao W, Torres A, Hung CM, Li H, Snyder NW, Vill?n J, Wellen KE, Guertin DA. Author Correction: mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis. Nat Commun. 2020 09 08; 11(1):4585. PMID: 32901020.
      Citations: 2     Fields:    
    13. Entwisle SW, Martinez Calejman C, Valente AS, Lawrence RT, Hung CM, Guertin DA, Vill?n J. Proteome and Phosphoproteome Analysis of Brown Adipocytes Reveals That RICTOR Loss Dampens Global Insulin/AKT Signaling. Mol Cell Proteomics. 2020 07; 19(7):1104-1119. PMID: 32234964.
      Citations: 3     Fields:    Translation:AnimalsCells
    14. Martinez Calejman C, Trefely S, Entwisle SW, Luciano A, Jung SM, Hsiao W, Torres A, Hung CM, Li H, Snyder NW, Vill?n J, Wellen KE, Guertin DA. mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis. Nat Commun. 2020 Jan 29; 11(1):575. PMID: 31996678.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    15. Hsiao WY, Guertin DA. De Novo Lipogenesis as a Source of Second Messengers in Adipocytes. Curr Diab Rep. 2019 11 20; 19(11):138. PMID: 31749022.
      Citations: 4     Fields:    Translation:HumansCells
    16. Jung SM, Hung CM, Hildebrand SR, Sanchez-Gurmaches J, Martinez-Pastor B, Gengatharan JM, Wallace M, Mukhopadhyay D, Martinez Calejman C, Luciano AK, Hsiao WY, Tang Y, Li H, Daniels DL, Mostoslavsky R, Metallo CM, Guertin DA. Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1. Mol Cell. 2019 08 22; 75(4):807-822.e8. PMID: 31442424.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    17. Martinez N, Cheng CY, Ketheesan N, Cullen A, Tang Y, Lum J, West K, Poidinger M, Guertin DA, Singhal A, Kornfeld H. mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis. EBioMedicine. 2019 Jul; 45:314-327. PMID: 31279779.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    18. Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T, Englmaier L, Akkuratova N, Yang Y, H?ring M, Dyachuk V, Bock C, Farlik M, Piacentino ML, Boismoreau F, Hilscher MM, Yokota C, Qian X, Nilsson M, Bronner ME, Croci L, Hsiao WY, Guertin DA, Brunet JF, Consalez GG, Ernfors P, Fried K, Kharchenko PV, Adameyko I. Spatiotemporal structure of cell fate decisions in murine neural crest. Science. 2019 Jun 07; 364(6444). PMID: 31171666.
      Citations: 175     Fields:    Translation:AnimalsCells
    19. Fernandez S, Viola JM, Torres A, Wallace M, Trefely S, Zhao S, Affronti HC, Gengatharan JM, Guertin DA, Snyder NW, Metallo CM, Wellen KE. Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females. Cell Rep. 2019 05 28; 27(9):2772-2784.e6. PMID: 31141698.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    20. Sanchez-Gurmaches J, Martinez Calejman C, Jung SM, Li H, Guertin DA. Brown fat organogenesis and maintenance requires AKT1 and AKT2. Mol Metab. 2019 05; 23:60-74. PMID: 30833219.
      Citations: 20     Fields:    Translation:AnimalsCells
    21. Luciano AK, Guertin DA. Oncogenic AKTivation by methylation. Nat Cell Biol. 2019 02; 21(2):114-115. PMID: 30692624.
      Citations:    Fields:    Translation:HumansCells
    22. Jung SM, Sanchez-Gurmaches J, Guertin DA. Brown Adipose Tissue Development and Metabolism. Handb Exp Pharmacol. 2019; 251:3-36. PMID: 30203328.
      Citations: 31     Fields:    Translation:Humans
    23. Jung SM, Guertin DA. Insulin PACS a Punch in SIRT1 Activity. Mol Cell. 2018 12 20; 72(6):917-919. PMID: 30576653.
      Citations:    Fields:    Translation:Cells
    24. Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nat Chem Biol. 2018 11; 14(11):1021-1031. PMID: 30327559.
      Citations: 65     Fields:    Translation:AnimalsCells
    25. Guertin DA. Unexpected cell population gives fat a brake. Nature. 2018 07; 559(7712):41-42. PMID: 29959410.
      Citations:    Fields:    Translation:AnimalsCells
    26. Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Martinez Calejman C, Gujja S, Li H, Edwards YJK, Wolfrum C, Metallo CM, Nielsen S, Scheele C, Guertin DA. Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis. Cell Metab. 2018 01 09; 27(1):195-209.e6. PMID: 29153407.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    27. Lee PL, Jung SM, Guertin DA. The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond. Trends Endocrinol Metab. 2017 05; 28(5):319-339. PMID: 28237819.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    28. Secco B, Camir? ?, Bri?re MA, Caron A, Billong A, G?linas Y, Lemay AM, Tharp KM, Lee PL, Gobeil S, Guimond JV, Patey N, Guertin DA, Stahl A, Haddad ?, Marsolais D, Boss? Y, Birsoy K, Laplante M. Amplification of Adipogenic Commitment by VSTM2A. Cell Rep. 2017 01 03; 18(1):93-106. PMID: 28052263.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    29. Cederquist CT, Lentucci C, Martinez-Calejman C, Hayashi V, Orofino J, Guertin D, Fried SK, Lee MJ, Cardamone MD, Perissi V. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017 01; 6(1):125-137. PMID: 28123943.
      Citations: 20     Fields:    Translation:AnimalsCells
    30. Tang Y, Wallace M, Sanchez-Gurmaches J, Hsiao WY, Li H, Lee PL, Vernia S, Metallo CM, Guertin DA. Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. Nat Commun. 2016 Apr 21; 7:11365. PMID: 27098609.
      Citations: 81     Fields:    Translation:AnimalsCells
    31. Lee PL, Tang Y, Li H, Guertin DA. Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease. Mol Metab. 2016 Jun; 5(6):422-432. PMID: 27257602.
      Citations: 54     Fields:    
    32. Sanchez-Gurmaches J, Hung CM, Guertin DA. Emerging Complexities in Adipocyte Origins and Identity. Trends Cell Biol. 2016 05; 26(5):313-326. PMID: 26874575.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    33. Hu YJ, Belaghzal H, Hsiao WY, Qi J, Bradner JE, Guertin DA, Sif S, Imbalzano AN. Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6. Nucleic Acids Res. 2015 Sep 18; 43(16):7790-804. PMID: 26117538.
      Citations: 20     Fields:    Translation:AnimalsCells
    34. Sanchez-Gurmaches J, Hsiao WY, Guertin DA. Highly selective in vivo labeling of subcutaneous white adipocyte precursors with Prx1-Cre. Stem Cell Reports. 2015 Apr 14; 4(4):541-50. PMID: 25801508.
      Citations: 53     Fields:    Translation:AnimalsCells
    35. Sanchez-Gurmaches J, Guertin DA. mTORC1 gRABs the Golgi. Cancer Cell. 2014 Nov 10; 26(5):601-3. PMID: 25517745.
      Citations: 10     Fields:    Translation:HumansAnimals
    36. Hung CM, Calejman CM, Sanchez-Gurmaches J, Li H, Clish CB, Hettmer S, Wagers AJ, Guertin DA. Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease. Cell Rep. 2014 Jul 10; 8(1):256-71. PMID: 25001283.
      Citations: 52     Fields:    Translation:AnimalsCells
    37. Sanchez-Gurmaches J, Guertin DA. Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed. Nat Commun. 2014 Jun 19; 5:4099. PMID: 24942009.
      Citations: 159     Fields:    Translation:AnimalsCells
    38. Yang K, Shrestha S, Zeng H, Karmaus PW, Neale G, Vogel P, Guertin DA, Lamb RF, Chi H. T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. Immunity. 2013 Dec 12; 39(6):1043-56. PMID: 24315998.
      Citations: 196     Fields:    Translation:AnimalsCells
    39. Sanchez-Gurmaches J, Guertin DA. Adipocyte lineages: tracing back the origins of fat. Biochim Biophys Acta. 2014 Mar; 1842(3):340-51. PMID: 23747579.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    40. Hung CM, Garcia-Haro L, Sparks CA, Guertin DA. mTOR-dependent cell survival mechanisms. Cold Spring Harb Perspect Biol. 2012 Dec 01; 4(12). PMID: 23124837.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    41. Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA, Armstrong SA. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell. 2012 Sep 07; 11(3):429-39. PMID: 22958934.
      Citations: 111     Fields:    Translation:AnimalsCells
    42. Sanchez-Gurmaches J, Hung CM, Sparks CA, Tang Y, Li H, Guertin DA. PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors. Cell Metab. 2012 Sep 05; 16(3):348-62. PMID: 22940198.
      Citations: 172     Fields:    Translation:AnimalsCells
    43. Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012 Mar 30; 335(6076):1638-43. PMID: 22461615.
      Citations: 604     Fields:    Translation:AnimalsCells
    44. Li H, Cotton JL, Guertin DA. Evaluating the therapeutic potential of mTOR inhibitors using mouse genetics. Methods Mol Biol. 2012; 821:329-47. PMID: 22125076.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    45. Hettmer S, Liu J, Miller CM, Lindsay MC, Sparks CA, Guertin DA, Bronson RT, Langenau DM, Wagers AJ. Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20002-7. PMID: 22135462.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    46. Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metab. 2011 Oct 05; 14(4):516-27. PMID: 21982711.
      Citations: 70     Fields:    Translation:AnimalsCells
    47. Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. 2011 Aug 05; 146(3):408-20. PMID: 21816276.
      Citations: 579     Fields:    Translation:HumansAnimalsCells
    48. Lindquist RA, Ottina KA, Wheeler DB, Hsu PP, Thoreen CC, Guertin DA, Ali SM, Sengupta S, Shaul YD, Lamprecht MR, Madden KL, Papallo AR, Jones TR, Sabatini DM, Carpenter AE. Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. Genome Res. 2011 Mar; 21(3):433-46. PMID: 21239477.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    49. Sparks CA, Guertin DA. Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy. Oncogene. 2010 Jul 01; 29(26):3733-44. PMID: 20418915.
      Citations: 153     Fields:    Translation:HumansAnimals
    50. Guertin DA, Sabatini DM. The pharmacology of mTOR inhibition. Sci Signal. 2009 Apr 21; 2(67):pe24. PMID: 19383975.
      Citations: 282     Fields:    Translation:HumansCells
    51. Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell. 2009 Feb 03; 15(2):148-59. PMID: 19185849.
      Citations: 207     Fields:    Translation:HumansAnimalsCells
    52. Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell. 2007 Jul; 12(1):9-22. PMID: 17613433.
      Citations: 1381     Fields:    Translation:HumansCells
    53. Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell. 2006 Dec; 11(6):859-71. PMID: 17141160.
      Citations: 774     Fields:    Translation:AnimalsCells
    54. Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, Friman O, Guertin DA, Chang JH, Lindquist RA, Moffat J, Golland P, Sabatini DM. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 2006; 7(10):R100. PMID: 17076895.
      Citations: 2246     Fields:    
    55. Guertin DA, Guntur KV, Bell GW, Thoreen CC, Sabatini DM. Functional genomics identifies TOR-regulated genes that control growth and division. Curr Biol. 2006 May 23; 16(10):958-70. PMID: 16713952.
      Citations: 77     Fields:    Translation:AnimalsCells
    56. Guertin DA, Sabatini DM. An expanding role for mTOR in cancer. Trends Mol Med. 2005 Aug; 11(8):353-61. PMID: 16002336.
      Citations: 170     Fields:    Translation:HumansAnimalsCells
    57. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005 Feb 18; 307(5712):1098-101. PMID: 15718470.
      Citations: 3179     Fields:    Translation:HumansAnimalsCells
    58. Wheeler DB, Bailey SN, Guertin DA, Carpenter AE, Higgins CO, Sabatini DM. RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells. Nat Methods. 2004 Nov; 1(2):127-32. PMID: 15782175.
      Citations: 33     Fields:    Translation:AnimalsCells
    59. Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 2004 Jul 27; 14(14):1296-302. PMID: 15268862.
      Citations: 1283     Fields:    Translation:HumansAnimalsCells
    60. Hou MC, Guertin DA, McCollum D. Initiation of cytokinesis is controlled through multiple modes of regulation of the Sid2p-Mob1p kinase complex. Mol Cell Biol. 2004 Apr; 24(8):3262-76. PMID: 15060149.
      Citations: 34     Fields:    Translation:AnimalsCells
    61. Guertin DA, Venkatram S, Gould KL, McCollum D. Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN). Dev Cell. 2002 Dec; 3(6):779-90. PMID: 12479804.
      Citations: 43     Fields:    Translation:AnimalsCells
    62. Guertin DA, Trautmann S, McCollum D. Cytokinesis in eukaryotes. Microbiol Mol Biol Rev. 2002 Jun; 66(2):155-78. PMID: 12040122.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    63. Guertin DA, McCollum D. Interaction between the noncatalytic region of Sid1p kinase and Cdc14p is required for full catalytic activity and localization of Sid1p. J Biol Chem. 2001 Jul 27; 276(30):28185-9. PMID: 11384993.
      Citations: 9     Fields:    Translation:AnimalsCells
    64. Guertin DA, Chang L, Irshad F, Gould KL, McCollum D. The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast. EMBO J. 2000 Apr 17; 19(8):1803-15. PMID: 10775265.
      Citations: 71     Fields:    Translation:AnimalsCells
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