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Andrea Reboldi PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentPathology
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentPathology

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program


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    Collapse Biography 
    Collapse education and training
    University of Padova, Padova, , ItalyBSBiotechnology
    University of Padova, Padova, , ItalyMSImmunological Biotechnology
    Institute for Research in Biomedicine, Bellinzona, , SwitzerlandPHDMolecular Medicine

    Collapse Overview 
    Collapse overview

    B cell response at the mucosal interface

    The focus of our lab is to understand how the immune system develops and functions at the mucosal interface.

    Background

    In the human body the gastrointestinal tract hosts a large number of bacteria that play a critical role in providing essential nutrients and metabolites. The mucosal immune system must selectively remain tolerant to the symbiotic members of the intestinal bacteria (commensals), while simultaneously poised to respond to pathogenic species. Immunoglobulin A (IgA) represents the main antibody class secreted by B lymphocytes at the mucosal surfaces, and is critical in maintaining intestinal homeostasis: patients with specific inability to produce IgA suffer from an increased incidence of gastrointestinal diseases. The mechanisms by which IgAs maintain intestinal homeostasis remain unclear.

    Major Goals:

    (i)   Define the selection mechanisms for IgA maturation to assure intestinal homeostasis.

    (ii)  Decipher the metabolic requirements for mounting a mucosal immune response to commensals.

    (iii) Characterize the cell-intrinsic and environmental cues required for the generation and maintenance of memory B cells at mucosal barriers.




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Albright AR, Kabat J, Li M, Raso F, Reboldi A, Muppidi JR. TGFß signaling in germinal center B cells promotes the transition from light zone to dark zone. J Exp Med. 2019 Sep 10. PMID: 31506281.
      View in: PubMed
    2. Cho HS, Reboldi A, Hall JA, Berg LJ. The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine. Nat Commun. 2019 Feb 15; 10(1):784. PMID: 30770814.
      View in: PubMed
    3. Leng Y, Romero R, Xu Y, Galaz J, Slutsky R, Arenas-Hernandez M, Garcia-Flores V, Motomura K, Hassan SS, Reboldi A, Gomez-Lopez N. Are B Cells Altered in the Decidua of Women with Preterm or Term Labor? Am J Reprod Immunol. 2019 Feb 15; e13102. PMID: 30768818.
      View in: PubMed
    4. Reboldi A, Dang E. Cholesterol metabolism in innate and adaptive response. F1000Res. 2018; 7. PMID: 30364153.
      View in: PubMed
    5. Reboldi A. In Vivo Imaging of Immune Cells in Peyer's Patches. Methods Mol Biol. 2018; 1763:109-118. PMID: 29476492.
      View in: PubMed
    6. Wu S, Majeed SR, Evans TM, Camus MD, Wong NM, Schollmeier Y, Park M, Muppidi JR, Reboldi A, Parham P, Cyster JG, Brodsky FM. Clathrin light chains' role in selective endocytosis influences antibody isotype switching. Proc Natl Acad Sci U S A. 2016 Aug 30; 113(35):9816-21. PMID: 27540116.
      View in: PubMed
    7. Ronchi F, Basso C, Preite S, Reboldi A, Baumjohann D, Perlini L, Lanzavecchia A, Sallusto F. Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1ß production by myeloid cells. Nat Commun. 2016; 7:11541. PMID: 27189410.
      View in: PubMed
    8. Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13; 352(6287):aaf4822. PMID: 27174992.
      View in: PubMed
    9. Reboldi A, Cyster JG. Peyer's patches: organizing B-cell responses at the intestinal frontier. Immunol Rev. 2016 May; 271(1):230-45. PMID: 27088918.
      View in: PubMed
    10. Li Z, Hodgkinson T, Gothard EJ, Boroumand S, Lamb R, Cummins I, Narang P, Sawtell A, Coles J, Leonov G, Reboldi A, Buckley CD, Cupedo T, Siebel C, Bayat A, Coles MC, Ambler CA. Epidermal Notch1 recruits ROR?(+) group 3 innate lymphoid cells to orchestrate normal skin repair. Nat Commun. 2016 Apr 21; 7:11394. PMID: 27099134.
      View in: PubMed
    11. Cyster JG, Dang EV, Reboldi A, Yi T. 25-Hydroxycholesterols in innate and adaptive immunity. Nat Rev Immunol. 2014 Nov; 14(11):731-43. PMID: 25324126.
      View in: PubMed
    12. Reboldi A, Dang EV, McDonald JG, Liang G, Russell DW, Cyster JG. Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science. 2014 Aug 08; 345(6197):679-84. PMID: 25104388.
      View in: PubMed
    13. Baumjohann D, Preite S, Reboldi A, Ronchi F, Ansel KM, Lanzavecchia A, Sallusto F. Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity. 2013 Mar 21; 38(3):596-605. PMID: 23499493.
      View in: PubMed
    14. Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, Uccelli A, Lanzavecchia A, Engelhardt B, Sallusto F. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol. 2009 May; 10(5):514-23. PMID: 19305396.
      View in: PubMed
    15. Indraccolo S, Minuzzo S, Masiero M, Pusceddu I, Persano L, Moserle L, Reboldi A, Favaro E, Mecarozzi M, Di Mario G, Screpanti I, Ponzoni M, Doglioni C, Amadori A. Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy. Cancer Res. 2009 Feb 15; 69(4):1314-23. PMID: 19208840.
      View in: PubMed
    16. Martín-Fontecha A, Baumjohann D, Guarda G, Reboldi A, Hons M, Lanzavecchia A, Sallusto F. CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming. J Exp Med. 2008 Oct 27; 205(11):2561-74. PMID: 18838544.
      View in: PubMed
    17. Grégoire C, Cognet C, Chasson L, Coupet CA, Dalod M, Reboldi A, Marvel J, Sallusto F, Vivier E, Walzer T. Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammation. Eur J Immunol. 2008 Aug; 38(8):2076-84. PMID: 18624307.
      View in: PubMed
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