Header Logo

Milka Koupenova PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
vCardDownload vCard
    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionCardiovascular Medicine

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    Collapse Biography 
    Collapse education and training
    University of California, Los Angeles, Los Angeles, CA, United StatesBSBiochemistry
    Boston University School of Medicine, Boston, MA, United StatesPHDBiochemistry

    Collapse Overview 
    Collapse Summary
    Research in Dr. Koupenova's lab focuses on the contribution of platelets to the immune response during viral infection and the consequent implications of that response to cardiovascular disease. For additional information about projects or joining the lab, contact Dr. Koupenova @ milka.koupenova@umassmed.edu

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu H, Caliz AD, Learnard H, Koupenova M, Keaney JF, Kant S, Zhu LJ, Vertii A. Inflammatory stress-mediated chromatin changes underlie dysfunction in endothelial cells. bioRxiv. 2023 Oct 16. PMID: 37905100.
    2. Koupenova M, Chung MK, Bristow MR. COVID-19 and the Cardiovascular System: Requiem for a Medical Minotaur. Circ Res. 2023 05 12; 132(10):1255-1258. PMID: 37167357.
      Citations:    Fields:    Translation:Humans
    3. Sciaudone A, Corkrey H, Humphries F, Koupenova M. Platelets and SARS-CoV-2 During COVID-19: Immunity, Thrombosis, and Beyond. Circ Res. 2023 05 12; 132(10):1272-1289. PMID: 37167360.
      Citations: 10     Fields:    Translation:AnimalsCells
    4. Desai C, Koupenova M, Machlus KR, Sen Gupta A. Beyond the thrombus: Platelet-inspired nanomedicine approaches in inflammation, immune response, and cancer. J Thromb Haemost. 2022 07; 20(7):1523-1534. PMID: 35441793.
      Citations: 4     Fields:    Translation:HumansCells
    5. Koupenova M, Livada AC, Morrell CN. Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity. Circ Res. 2022 01 21; 130(2):288-308. PMID: 35050690.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    6. Bote J, Corkrey HA, Koupenova M. Human Platelets and Influenza Virus: Internalization and Platelet Activation. Platelets. 2022 Feb 17; 33(2):184-191. PMID: 34369285.
      Citations: 3     Fields:    Translation:HumansCells
    7. Koupenova M, Corkrey HA, Vitseva O, Tanriverdi K, Somasundaran M, Liu P, Soofi S, Bhandari R, Godwin M, Parsi KM, Cousineau A, Maehr R, Wang JP, Cameron SJ, Rade J, Finberg RW, Freedman JE. SARS-CoV-2 Initiates Programmed Cell Death in Platelets. Circ Res. 2021 09 03; 129(6):631-646. PMID: 34293929.
      Citations: 89     Fields:    Translation:HumansCells
    8. Sahai A, Bhandari R, Koupenova M, Freedman JE, Godwin M, McIntyre T, Chung MK, Iskandar JP, Kamran H, Hariri E, Aggarwal A, Kalra A, Bartholomew JR, McCrae KR, Elbadawi A, Svensson LG, Kapadia S, Cameron SJ. SARS-CoV-2 Receptors are Expressed on Human Platelets and the Effect of Aspirin on Clinical Outcomes in COVID-19 Patients. Res Sq. 2020 Dec 23. PMID: 33398263.
    9. Koupenova M, Freedman JE. Platelets and COVID-19: Inflammation, Hyperactivation and Additional Questions. Circ Res. 2020 11 06; 127(11):1419-1421. PMID: 33151798.
      Citations: 21     Fields:    Translation:HumansCellsPHPublic Health
    10. Palace SG, Vitseva O, Proulx MK, Freedman JE, Goguen JD, Koupenova M. Yersinia pestis escapes entrapment in thrombi by targeting platelet function. J Thromb Haemost. 2020 12; 18(12):3236-3248. PMID: 33470041.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    11. Fazzalari A, Basadonna G, Kucukural A, Tanriverdi K, Koupenova M, Pozzi N, Kakuturu J, Friedrich AU, Korstanje R, Fowler N, Belant JL, Beyer DE, Brooks MB, Dickson EW, Blackwood M, Mueller C, Palesty JA, Freedman JE, Cahan MA. A Translational Model for Venous Thromboembolism: MicroRNA Expression in Hibernating Black Bears. J Surg Res. 2021 01; 257:203-212. PMID: 32858321.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    12. Koupenova M, Freedman JE. Platelets and Immunity: Going Viral. Arterioscler Thromb Vasc Biol. 2020 07; 40(7):1605-1607. PMID: 32579477.
      Citations: 10     Fields:    Translation:Cells
    13. Koupenova M. Potential role of platelets in COVID-19: Implications for thrombosis. Res Pract Thromb Haemost. 2020 Jul; 4(5):737-740. PMID: 32685881.
    14. Murthy VL, Koupenova M, Shah RV. ACEing COVID-19: A Role for Angiotensin Axis Inhibition in SARS-CoV-2 Infection? Circ Res. 2020 06 05; 126(12):1682-1684. PMID: 32302248.
      Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
    15. Koupenova M, Mick E, Corkrey HA, Singh A, Tanriverdi SE, Vitseva O, Levy D, Keeler AM, Ezzaty Mirhashemi M, ElMallah MK, Gerstein M, Rozowsky J, Tanriverdi K, Freedman JE. Pollen-derived RNAs Are Found in the Human Circulation. iScience. 2019 Sep 27; 19:916-926. PMID: 31518900.
    16. Koupenova M, Corkrey HA, Vitseva O, Manni G, Pang CJ, Clancy L, Yao C, Rade J, Levy D, Wang JP, Finberg RW, Kurt-Jones EA, Freedman JE. The role of platelets in mediating a response to human influenza infection. Nat Commun. 2019 04 16; 10(1):1780. PMID: 30992428.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    17. Koupenova M, Mick E, Corkrey HA, Huan T, Clancy L, Shah R, Benjamin EJ, Levy D, Kurt-Jones EA, Tanriverdi K, Freedman JE. Micro RNAs from DNA Viruses are Found Widely in Plasma in a Large Observational Human Population. Sci Rep. 2018 04 23; 8(1):6397. PMID: 29686252.
      Citations: 3     Fields:    Translation:HumansCells
    18. Koupenova M, Ravid K. Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity. Front Pharmacol. 2018; 9:37. PMID: 29441021.
    19. Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis. Circ Res. 2018 01 19; 122(2):337-351. PMID: 29348254.
      Citations: 325     Fields:    Translation:HumansAnimalsCells
    20. Koupenova M, Kehrel BE, Corkrey HA, Freedman JE. Thrombosis and platelets: an update. Eur Heart J. 2017 Mar 14; 38(11):785-791. PMID: 28039338.
      Citations: 158     Fields:    Translation:HumansCells
    21. Freedman JE, Gerstein M, Mick E, Rozowsky J, Levy D, Kitchen R, Das S, Shah R, Danielson K, Beaulieu L, Navarro FC, Wang Y, Galeev TR, Holman A, Kwong RY, Murthy V, Tanriverdi SE, Koupenova M, Mikhalev E, Tanriverdi K. Corrigendum: Diverse human extracellular RNAs are widely detected in human plasma. Nat Commun. 2016 06 03; 7:11902. PMID: 27255613.
      Citations: 3     Fields:    
    22. Matsuura S, Mi R, Koupenova M, Eliades A, Patterson S, Toselli P, Thon J, Italiano JE, Trackman PC, Papadantonakis N, Ravid K. Lysyl oxidase is associated with increased thrombosis and platelet reactivity. Blood. 2016 Mar 17; 127(11):1493-501. PMID: 26755713.
      Citations: 22     Fields:    Translation:AnimalsCells
    23. Koupenova M, Mick E, Mikhalev E, Benjamin EJ, Tanriverdi K, Freedman JE. Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):1030-7. PMID: 25657311.
      Citations: 58     Fields:    Translation:HumansCells
    24. Koupenova M, Freedman JE. Platelets: the unsung hero of the immune response. J Thromb Haemost. 2015 Feb; 13(2):268-70. PMID: 25471925.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    25. Johnston-Cox H, Eisenstein AS, Koupenova M, Carroll S, Ravid K. The macrophage A2B adenosine receptor regulates tissue insulin sensitivity. PLoS One. 2014; 9(6):e98775. PMID: 24892847.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    26. Koupenova M, Vitseva O, MacKay CR, Beaulieu LM, Benjamin EJ, Mick E, Kurt-Jones EA, Ravid K, Freedman JE. Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis. Blood. 2014 Jul 31; 124(5):791-802. PMID: 24755410.
      Citations: 129     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    27. Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE. Interleukin 1 receptor 1 and interleukin 1? regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):552-64. PMID: 24458711.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    28. Koupenova M, Ravid K. Adenosine, adenosine receptors and their role in glucose homeostasis and lipid metabolism. J Cell Physiol. 2013 Mar 04. PMID: 23460239.
      Citations: 22     Fields:    
    29. Koupenova M, Johnston-Cox H, Ravid K. Regulation of atherosclerosis and associated risk factors by adenosine and adenosine receptors. Curr Atheroscler Rep. 2012 Oct; 14(5):460-8. PMID: 22850979.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    30. Johnston-Cox H, Koupenova M, Yang D, Corkey B, Gokce N, Farb MG, LeBrasseur N, Ravid K. The A2b adenosine receptor modulates glucose homeostasis and obesity. PLoS One. 2012; 7(7):e40584. PMID: 22848385.
      Citations: 59     Fields:    Translation:HumansAnimals
    31. Johnston-Cox HA, Koupenova M, Ravid K. A2 adenosine receptors and vascular pathologies. Arterioscler Thromb Vasc Biol. 2012 Apr; 32(4):870-8. PMID: 22423039.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    32. Koupenova M, Johnston-Cox H, Vezeridis A, Gavras H, Yang D, Zannis V, Ravid K. A2b adenosine receptor regulates hyperlipidemia and atherosclerosis. Circulation. 2012 Jan 17; 125(2):354-63. PMID: 22144568.
      Citations: 43     Fields:    Translation:Animals
    33. Chen H, Koupenova M, Yang D, Sume SS, Trackman PC, Ravid K. Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-a signaling. Exp Hematol. 2011 May; 39(5):525-30. PMID: 21320567.
      Citations: 9     Fields:    Translation:AnimalsCells
    34. Yang D, Chen H, Koupenova M, Carroll SH, Eliades A, Freedman JE, Toselli P, Ravid K. A new role for the A2b adenosine receptor in regulating platelet function. J Thromb Haemost. 2010 Apr; 8(4):817-27. PMID: 20102488.
      Citations: 34     Fields:    Translation:AnimalsCells
    35. St Hilaire C, Koupenova M, Carroll SH, Smith BD, Ravid K. TNF-alpha upregulates the A2B adenosine receptor gene: The role of NAD(P)H oxidase 4. Biochem Biophys Res Commun. 2008 Oct 24; 375(3):292-6. PMID: 18647598.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    36. Yang D, Koupenova M, McCrann DJ, Kopeikina KJ, Kagan HM, Schreiber BM, Ravid K. The A2b adenosine receptor protects against vascular injury. Proc Natl Acad Sci U S A. 2008 Jan 15; 105(2):792-6. PMID: 18184815.
      Citations: 60     Fields:    Translation:AnimalsCells
    37. Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K. The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest. 2006 Jul; 116(7):1913-23. PMID: 16823489.
      Citations: 196     Fields:    Translation:AnimalsCells
    Koupenova's Networks
    Click the
    buttons for more information and interactive visualizations!
    Concepts (185)
    Co-Authors (17)
    Similar People (60)
    Same Department Expand Description
    Physical Neighbors