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Lawrence M Rhein MD, MPH

TitleChair and Associate Professor
Endowed TitleThe Stoddard Chair of Pediatrics
InstitutionUniversity of Massachusetts Medical School
DepartmentPediatrics
AddressUMass Memorial
119 Belmont Street
Worcester MA 01605
Phone508-334-6206
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentPediatrics
    DivisionPediatric Neonatalogy

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentClinical Population Health Research

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentMasters in Clinical Investigation


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA, United StatesBSBiology
    Harvard University School of Public Health, Boston, MA, United StatesMPH
    University of Pennsylvania Pereleman School of Medicine, Philadelphia, PA, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Philip SS, Davenport SE, Mannan J, White HO, Lee AF, Rhein LM. Impact of a targeted volume increase nutrition guideline on growth and body mass index (BMI) in premature infants: A retrospective review. JPEN J Parenter Enteral Nutr. 2021 Jun 11. PMID: 34114671.
      View in: PubMed
    2. Daigneault J, White H, Dube A, Shi Q, Gauguet JM, Rhein L. Lack of Progression of Intraventricular Hemorrhage in Premature Infants: Implications for Head Ultrasound Screening. Glob Pediatr Health. 2021; 8:2333794X211010729. PMID: 34046517.
      View in: PubMed
    3. Levin JC, Sheils CA, Gaffin JM, Hersh CP, Rhein LM, Hayden LP. Lung function trajectories in children with post-prematurity respiratory disease: identifying risk factors for abnormal growth. Respir Res. 2021 May 10; 22(1):143. PMID: 33971884.
      View in: PubMed
    4. Collaco JM, Agarwal A, Austin ED, Hayden LP, Lai K, Levin J, Manimtim WM, Moore PE, Sheils CA, Tracy MC, Alexiou S, Baker CD, Cristea AI, Fierro JL, Rhein LM, Villafranco N, Nelin LD, McGrath-Morrow SA. Characteristics of infants or children presenting to outpatient bronchopulmonary dysplasia clinics in the United States. Pediatr Pulmonol. 2021 Mar 13. PMID: 33713587.
      View in: PubMed
    5. Singh R, Houghton M, Melvin P, Wachman EM, Diop H, Iverson R, Picarillo A, Rhein L, Gupta M. Predictors of pharmacologic therapy for neonatal opioid withdrawal syndrome: a retrospective analysis of a statewide database. J Perinatol. 2021 Feb 19. PMID: 33608626.
      View in: PubMed
    6. Sullivan KP, White HO, Grover LE, Negron JJ, Lee AF, Rhein LM. Transcutaneous carbon dioxide pattern and trend over time in preterm infants. Pediatr Res. 2021 Jan 19. PMID: 33469188.
      View in: PubMed
    7. Chu SS, White HO, Rindone SL, Tripp SA, Rhein LM. An Initiative to Reduce Preterm Infants Pre-discharge Growth Failure Through Time-specific Feeding Volume Increase. Pediatr Qual Saf. 2021 Jan-Feb; 6(1):e366. PMID: 33403313.
      View in: PubMed
    8. Parker MG, Garg A, Brochier A, Rhein LM, Forbes ES, Klawetter S, Drainoni ML. Approaches to addressing social determinants of health in the NICU: a mixed methods study. J Perinatol. 2020 Oct 30. PMID: 33128013.
      View in: PubMed
    9. Rhein L, White H, Simoneau T, Traeger N, Lahiri T, Kremer T, Sheils C, Meyer K, Rosenkrantz T, Krishnan S, Hartman T, Feldman HA, Abu Jawdeh EG. Transmitted Home Oximetry and Duration of Home Oxygen in Premature Infants. Pediatrics. 2020 Jul 14. PMID: 32665372.
      View in: PubMed
    10. Litt JS, Edwards EM, Lainwala S, Mercier C, Montgomery A, O'Reilly D, Rhein L, Woythaler M, Hartman T. Optimizing High-risk Infant Follow-up in Nonresearch-based Paradigms: The New England Follow-up Network. Pediatr Qual Saf. 2020 May-Jun; 5(3):e287. PMID: 32656462.
      View in: PubMed
    11. White H, Berenson A, Mannan J, Feldman HA, Rhein L. Utilization trends of respiratory medication in premature infants discharged on home oxygen therapy. Pediatr Pulmonol. 2020 Apr 29. PMID: 32348638.
      View in: PubMed
    12. Chu S, Procaskey A, Tripp S, Naples M, White H, Rhein L. Quality improvement initiative to decrease time to full feeds and central line utilization among infants born less than or equal to 32 0/7 weeks through compliance with standardized feeding guidelines. J Perinatol. 2019 Jun 13. PMID: 31197237.
      View in: PubMed
    13. Hayes D, Wilson KC, Krivchenia K, Hawkins SMM, Balfour-Lynn IM, Gozal D, Panitch HB, Splaingard ML, Rhein LM, Kurland G, Abman SH, Hoffman TM, Carroll CL, Cataletto ME, Tumin D, Oren E, Martin RJ, Baker J, Porta GR, Kaley D, Gettys A, Deterding RR. Home Oxygen Therapy for Children. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2019 Feb 01; 199(3):e5-e23. PMID: 30707039.
      View in: PubMed
    14. Procaskey A, White H, Simoneau T, Traeger N, Lahiri T, Jawdeh EA, Kremer T, Sheils C, Meyer K, Rosenkrantz T, Sankaran K, Hartman T, Feldman H, Rhein L. The optimization of home oxygen weaning in premature infants trial: Design, rationale, methods, and lessons learned. Contemp Clin Trials. 2018 Aug 11. PMID: 30107239.
      View in: PubMed
    15. Montenegro B, Freiberger C, Veit L, Amberson M, Mukhopadhyay S, Rhein L. An occurrence of apnea, bradycardia, and desaturation events resulting in a delay of discharge in late preterm and full term infants. Pediatr Neonatol. 2017 Dec 27. PMID: 29506951.
      View in: PubMed
    16. Mandell L, Rhein LM, Feldman HA, Bergling E, Porter C, DeGrazia M. Predictors of Persistent Infant Car Seat Challenge Failure. Adv Neonatal Care. 2017 Dec; 17(6):499-508. PMID: 28953055.
      View in: PubMed
    17. ElMallah M, Bailey E, Trivedi M, Kremer T, Rhein LM. Pediatric Obstructive Sleep Apnea in High-Risk Populations: Clinical Implications. Pediatr Ann. 2017 09 01; 46(9):e336-e339. PMID: 28892549.
      View in: PubMed
    18. Trivedi M, ElMallah M, Bailey E, Kremer T, Rhein LM. Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications. Pediatr Ann. 2017 09 01; 46(9):e332-e335. PMID: 28892548.
      View in: PubMed
    19. Shieh HF, Smithers CJ, Hamilton TE, Zurakowski D, Rhein LM, Manfredi MA, Baird CW, Jennings RW. Posterior tracheopexy for severe tracheomalacia. J Pediatr Surg. 2017 Mar 18. PMID: 28385426.
      View in: PubMed
    20. Montenegro BL, Amberson M, Veit L, Freiberger C, Dukhovny D, Rhein LM. Economics of Home Monitoring for Apnea in Late Preterm Infants. Respir Care. 2017 Jan; 62(1):42-48. PMID: 28003553.
      View in: PubMed
    21. Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE, Truog WE, McGrath-Morrow SA, Moore PE, Rhein LM, Kirpalani H, Zhang H, Gratny LL, Lynch SK, Curtiss J, Stonestreet BS, McKinney RL, Dysart KC, Gien J, Baker CD, Donohue PK, Austin E, Fike C, Nelin LD. Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia. J Pediatr. 2017 Feb; 181:12-28.e1. PMID: 27908648.
      View in: PubMed
    22. Levin JC, Jang J, Rhein LM. Apnea in the Otherwise Healthy, Term Newborn: National Prevalence and Utilization during the Birth Hospitalization. J Pediatr. 2016 Nov 17. PMID: 27865430.
      View in: PubMed
    23. Smithers CJ, Hamilton TE, Manfredi MA, Rhein L, Ngo P, Gallagher D, Foker JE, Jennings RW. Categorization and repair of recurrent and acquired tracheoesophageal fistulae occurring after esophageal atresia repair. J Pediatr Surg. 2016 Aug 31. PMID: 27616617.
      View in: PubMed
    24. Dobson NR, Liu X, Rhein LM, Darnall RA, Corwin MJ, McEntire BL, Ward RM, James LP, Sherwin CM, Heeren TC, Hunt CE. Salivary caffeine concentrations are comparable to plasma concentrations in preterm infants receiving extended caffeine therapy. Br J Clin Pharmacol. 2016 Sep; 82(3):754-61. PMID: 27145974.
      View in: PubMed
    25. Veit L, Amberson M, Freiberger C, Montenegro B, Mukhopadhyay S, Rhein LM. Diagnostic Evaluation and Home Monitor Use in Late Preterm to Term Infants With Apnea, Bradycardia, and Desaturations. Clin Pediatr (Phila). 2016 Nov; 55(13):1210-1218. PMID: 26957524.
      View in: PubMed
    26. Belfort MB, Cohen RT, Rhein LM, McCormick MC. Preterm infant growth and asthma at age 8 years. Arch Dis Child Fetal Neonatal Ed. 2016 May; 101(3):F230-4. PMID: 26354369.
      View in: PubMed
    27. Bairdain S, Dodson B, Zurakowski D, Rhein L, Snyder BD, Putman M, Jennings RW. High incidence of fracture events in patients with Long-Gap Esophageal Atresia (LGEA): A retrospective review prompting implementation of standardized protocol. Bone Rep. 2015 Dec; 3:1-4. PMID: 28377960.
      View in: PubMed
    28. Bairdain S, Smithers CJ, Hamilton TE, Zurakowski D, Rhein L, Foker JE, Baird C, Jennings RW. Direct tracheobronchopexy to correct airway collapse due to severe tracheobronchomalacia: Short-term outcomes in a series of 20 patients. J Pediatr Surg. 2015 Jun; 50(6):972-7. PMID: 25824437.
      View in: PubMed
    29. Rhein LM, Dobson NR, Darnall RA, Corwin MJ, Heeren TC, Poets CF, McEntire BL, Hunt CE. Effects of caffeine on intermittent hypoxia in infants born prematurely: a randomized clinical trial. JAMA Pediatr. 2014 Mar; 168(3):250-7. PMID: 24445955.
      View in: PubMed
    30. Davis NL, Liu A, Rhein L. Feeding immaturity in preterm neonates: risk factors for oropharyngeal aspiration and timing of maturation. J Pediatr Gastroenterol Nutr. 2013 Dec; 57(6):735-40. PMID: 23969537.
      View in: PubMed
    31. Davis NL, Condon F, Rhein LM. Epidemiology and predictors of failure of the infant car seat challenge. Pediatrics. 2013 May; 131(5):951-7. PMID: 23545379.
      View in: PubMed
    32. Davis NL, Zenchenko Y, Lever A, Rhein L. Car seat safety for preterm neonates: implementation and testing parameters of the infant car seat challenge. Acad Pediatr. 2013 May-Jun; 13(3):272-7. PMID: 23680345.
      View in: PubMed
    33. Rhein LM, Konnikova L, McGeachey A, Pruchniewski M, Smith VC. The role of pulmonary follow-up in reducing health care utilization in infants with bronchopulmonary dysplasia. Clin Pediatr (Phila). 2012 Jul; 51(7):645-50. PMID: 22492835.
      View in: PubMed
    34. Rhein L, Simoneau T, Davis J, Correia C, Ferrari D, Monuteaux M, Gregory M. Reference values of nocturnal oxygenation for use in outpatient oxygen weaning protocols in premature infants. Pediatr Pulmonol. 2012 May; 47(5):453-9. PMID: 22102606.
      View in: PubMed
    35. Palm K, Simoneau T, Sawicki G, Rhein L. Assessment of current strategies for weaning premature infants from supplemental oxygen in the outpatient setting. Adv Neonatal Care. 2011 Oct; 11(5):349-56. PMID: 22123406.
      View in: PubMed
    36. Bera MM, Lu B, Martin TR, Cui S, Rhein LM, Gerard C, Gerard NP. Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins. J Immunol. 2011 Oct 15; 187(8):4245-55. PMID: 21918196.
      View in: PubMed
    37. Berry JG, Graham RJ, Roberson DW, Rhein L, Graham DA, Zhou J, O'Brien J, Putney H, Goldmann DA. Patient characteristics associated with in-hospital mortality in children following tracheotomy. Arch Dis Child. 2010 Sep; 95(9):703-10. PMID: 20522454.
      View in: PubMed
    38. Kulik TJ, Rhein LM, Mullen MP. Pulmonary arterial hypertension in infants with chronic lung disease: will we ever understand it? J Pediatr. 2010 Aug; 157(2):186-90. PMID: 20421106.
      View in: PubMed
    39. Degrazia M, Guo CY, Wilkinson AA, Rhein L. Weight and age as predictors for passing the infant car seat challenge. Pediatrics. 2010 Mar; 125(3):526-31. PMID: 20142291.
      View in: PubMed
    40. Khemani E, McElhinney DB, Rhein L, Andrade O, Lacro RV, Thomas KC, Mullen MP. Pulmonary artery hypertension in formerly premature infants with bronchopulmonary dysplasia: clinical features and outcomes in the surfactant era. Pediatrics. 2007 Dec; 120(6):1260-9. PMID: 18055675.
      View in: PubMed
    41. Rhein LM, Perkins M, Gerard NP, Gerard C. FcgammaRIII is protective against Pseudomonas aeruginosa pneumonia. Am J Respir Cell Mol Biol. 2008 Apr; 38(4):401-6. PMID: 17975174.
      View in: PubMed
    42. Fox LM, Wingerter S, Ahmed A, Arnold A, Chou J, Rhein L, Levy O. Neonatal babesiosis: case report and review of the literature. Pediatr Infect Dis J. 2006 Feb; 25(2):169-73. PMID: 16462298.
      View in: PubMed
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