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Lawrence M Rhein MD, MPH

TitleChair and Associate Professor
Endowed TitleThe Stoddard Chair of Pediatrics
InstitutionUMass Chan Medical School
DepartmentPediatrics
AddressUMass Memorial
119 Belmont Street
Worcester MA 01605
Phone508-334-6206
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentPediatrics
    DivisionPediatric Neonatalogy

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentClinical Population Health Research

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMasters in Clinical Investigation


    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MA, United StatesBSBiology
    Harvard University School of Public Health, Boston, MA, United StatesMPH
    University of Pennsylvania Pereleman School of Medicine, Philadelphia, PA, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Collaco JM, Tracy MC, Sheils CA, Rice JL, Rhein LM, Nelin LD, Moore PE, Manimtim WM, Levin JC, Lai K, Hayden LP, Fierro JL, Austin ED, Alexiou S, Agarwal A, Villafranco N, Siddaiah R, Popova AP, Cristea IA, Baker CD, Bansal M, McGrath-Morrow SA. Insurance coverage and respiratory morbidities in bronchopulmonary dysplasia. Pediatr Pulmonol. 2022 Apr 18. PMID: 35437911.
      Citations:    Fields:    
    2. Garg A, Wilkie T, LeBlanc A, Lyu R, Scornavacca T, Fowler J, Rhein L, Alper E. Prioritizing Child Health: Promoting Adherence to Well-Child Visits in an Urban, Safety-Net Health System During the COVID-19 Pandemic. Jt Comm J Qual Patient Saf. 2022 Apr; 48(4):189-195. PMID: 35216919.
      Citations:    Fields:    Translation:HumansPHPublic Health
    3. Cristea AI, Ren CL, Amin R, Eldredge LC, Levin JC, Majmudar PP, May AE, Rose RS, Tracy MC, Watters KF, Allen J, Austin ED, Cataletto ME, Collaco JM, Fleck RJ, Gelfand A, Hayes D, Jones MH, Kun SS, Mandell EW, McGrath-Morrow SA, Panitch HB, Popatia R, Rhein LM, Teper A, Woods JC, Iyer N, Baker CD. Outpatient Respiratory Management of Infants, Children, and Adolescents with Post-Prematurity Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2021 12 15; 204(12):e115-e133. PMID: 34908518.
      Citations:    Fields:    Translation:Humans
    4. White H, Sobelman C, Kremer T, Lee A, Rhein LM. Does recorded oximetry utilizing a consensus-based algorithm compare to polysomnography in discontinuing home oxygen therapy in premature infants? Pediatr Pulmonol. 2022 02; 57(2):476-482. PMID: 34811971.
      Citations:    Fields:    Translation:Humans
    5. Philip SS, Davenport SE, Mannan J, White HO, Lee AF, Rhein LM. Impact of a targeted volume-increase nutrition guideline on growth and body mass index in premature infants: A retrospective review. JPEN J Parenter Enteral Nutr. 2022 03; 46(3):561-571. PMID: 34114671.
      Citations: 1     Fields:    Translation:Humans
    6. Daigneault J, White H, Dube A, Shi Q, Gauguet JM, Rhein L. Lack of Progression of Intraventricular Hemorrhage in Premature Infants: Implications for Head Ultrasound Screening. Glob Pediatr Health. 2021; 8:2333794X211010729. PMID: 34046517.
      Citations:    
    7. Levin JC, Sheils CA, Gaffin JM, Hersh CP, Rhein LM, Hayden LP. Lung function trajectories in children with post-prematurity respiratory disease: identifying risk factors for abnormal growth. Respir Res. 2021 May 10; 22(1):143. PMID: 33971884.
      Citations: 1     Fields:    Translation:Humans
    8. Collaco JM, Agarwal A, Austin ED, Hayden LP, Lai K, Levin J, Manimtim WM, Moore PE, Sheils CA, Tracy MC, Alexiou S, Baker CD, Cristea AI, Fierro JL, Rhein LM, Villafranco N, Nelin LD, McGrath-Morrow SA. Characteristics of infants or children presenting to outpatient bronchopulmonary dysplasia clinics in the United States. Pediatr Pulmonol. 2021 06; 56(6):1617-1625. PMID: 33713587.
      Citations: 1     Fields:    Translation:Humans
    9. Singh R, Houghton M, Melvin P, Wachman EM, Diop H, Iverson R, Picarillo A, Rhein L, Gupta M. Predictors of pharmacologic therapy for neonatal opioid withdrawal syndrome: a retrospective analysis of a statewide database. J Perinatol. 2021 06; 41(6):1381-1388. PMID: 33608626.
      Citations:    Fields:    Translation:Humans
    10. Sullivan KP, White HO, Grover LE, Negron JJ, Lee AF, Rhein LM. Transcutaneous carbon dioxide pattern and trend over time in preterm infants. Pediatr Res. 2021 10; 90(4):840-846. PMID: 33469188.
      Citations:    Fields:    Translation:Humans
    11. Chu SS, White HO, Rindone SL, Tripp SA, Rhein LM. An Initiative to Reduce Preterm Infants Pre-discharge Growth Failure Through Time-specific Feeding Volume Increase. Pediatr Qual Saf. 2021 Jan-Feb; 6(1):e366. PMID: 33403313.
      Citations:    
    12. Parker MG, Garg A, Brochier A, Rhein LM, Forbes ES, Klawetter S, Drainoni ML. Approaches to addressing social determinants of health in the NICU: a mixed methods study. J Perinatol. 2021 08; 41(8):1983-1991. PMID: 33128013.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    13. Rhein L, White H, Simoneau T, Traeger N, Lahiri T, Kremer T, Sheils C, Meyer K, Rosenkrantz T, Krishnan S, Hartman T, Feldman HA, Abu Jawdeh EG. Transmitted Home Oximetry and Duration of Home Oxygen in Premature Infants. Pediatrics. 2020 08; 146(2). PMID: 32665372.
      Citations: 1     Fields:    Translation:Humans
    14. Litt JS, Edwards EM, Lainwala S, Mercier C, Montgomery A, O'Reilly D, Rhein L, Woythaler M, Hartman T. Optimizing High-risk Infant Follow-up in Nonresearch-based Paradigms: The New England Follow-up Network. Pediatr Qual Saf. 2020 May-Jun; 5(3):e287. PMID: 32656462.
      Citations:    
    15. White H, Berenson A, Mannan J, Feldman HA, Rhein L. Utilization trends of respiratory medication in premature infants discharged on home oxygen therapy. Pediatr Pulmonol. 2020 06; 55(6):1359-1365. PMID: 32348638.
      Citations:    Fields:    Translation:Humans
    16. Chu S, Procaskey A, Tripp S, Naples M, White H, Rhein L. Quality improvement initiative to decrease time to full feeds and central line utilization among infants born less than or equal to 32 0/7 weeks through compliance with standardized feeding guidelines. J Perinatol. 2019 Aug; 39(8):1140-1148. PMID: 31197237.
      Citations: 2     Fields:    Translation:Humans
    17. Hayes D, Wilson KC, Krivchenia K, Hawkins SMM, Balfour-Lynn IM, Gozal D, Panitch HB, Splaingard ML, Rhein LM, Kurland G, Abman SH, Hoffman TM, Carroll CL, Cataletto ME, Tumin D, Oren E, Martin RJ, Baker J, Porta GR, Kaley D, Gettys A, Deterding RR. Home Oxygen Therapy for Children. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2019 02 01; 199(3):e5-e23. PMID: 30707039.
      Citations: 11     Fields:    Translation:Humans
    18. Procaskey A, White H, Simoneau T, Traeger N, Lahiri T, Abu Jawdeh EG, Kremer T, Sheils C, Meyer K, Rosenkrantz T, Krishnan S, Hartman T, Feldman H, Rhein L. The optimization of home oxygen weaning in premature infants trial: Design, rationale, methods, and lessons learned. Contemp Clin Trials. 2018 12; 75:72-77. PMID: 30107239.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    19. Montenegro B, Freiberger C, Veit L, Amberson M, Mukhopadhyay S, Rhein L. An occurrence of apnea, bradycardia, and desaturation events resulting in a delay of discharge in late preterm and full term infants. Pediatr Neonatol. 2018 12; 59(6):630-631. PMID: 29506951.
      Citations:    Fields:    
    20. Mandell L, Rhein LM, Feldman HA, Bergling E, Porter C, DeGrazia M. Predictors of Persistent Infant Car Seat Challenge Failure. Adv Neonatal Care. 2017 Dec; 17(6):499-508. PMID: 28953055.
      Citations: 1     Fields:    Translation:Humans
    21. ElMallah M, Bailey E, Trivedi M, Kremer T, Rhein LM. Pediatric Obstructive Sleep Apnea in High-Risk Populations: Clinical Implications. Pediatr Ann. 2017 09 01; 46(9):e336-e339. PMID: 28892549.
      Citations: 5     Fields:    Translation:Humans
    22. Trivedi M, ElMallah M, Bailey E, Kremer T, Rhein LM. Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications. Pediatr Ann. 2017 09 01; 46(9):e332-e335. PMID: 28892548.
      Citations: 3     Fields:    Translation:Humans
    23. Shieh HF, Smithers CJ, Hamilton TE, Zurakowski D, Rhein LM, Manfredi MA, Baird CW, Jennings RW. Posterior tracheopexy for severe tracheomalacia. J Pediatr Surg. 2017 Jun; 52(6):951-955. PMID: 28385426.
      Citations: 10     Fields:    Translation:Humans
    24. Montenegro BL, Amberson M, Veit L, Freiberger C, Dukhovny D, Rhein LM. Economics of Home Monitoring for Apnea in Late Preterm Infants. Respir Care. 2017 Jan; 62(1):42-48. PMID: 28003553.
      Citations: 4     Fields:    Translation:Humans
    25. Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE, Truog WE, McGrath-Morrow SA, Moore PE, Rhein LM, Kirpalani H, Zhang H, Gratny LL, Lynch SK, Curtiss J, Stonestreet BS, McKinney RL, Dysart KC, Gien J, Baker CD, Donohue PK, Austin E, Fike C, Nelin LD. Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia. J Pediatr. 2017 02; 181:12-28.e1. PMID: 27908648.
      Citations: 62     Fields:    Translation:Humans
    26. Levin JC, Jang J, Rhein LM. Apnea in the Otherwise Healthy, Term Newborn: National Prevalence and Utilization during the Birth Hospitalization. J Pediatr. 2017 02; 181:67-73.e1. PMID: 27865430.
      Citations: 4     Fields:    Translation:Humans
    27. Smithers CJ, Hamilton TE, Manfredi MA, Rhein L, Ngo P, Gallagher D, Foker JE, Jennings RW. Categorization and repair of recurrent and acquired tracheoesophageal fistulae occurring after esophageal atresia repair. J Pediatr Surg. 2017 Mar; 52(3):424-430. PMID: 27616617.
      Citations: 11     Fields:    Translation:Humans
    28. Dobson NR, Liu X, Rhein LM, Darnall RA, Corwin MJ, McEntire BL, Ward RM, James LP, Sherwin CM, Heeren TC, Hunt CE. Salivary caffeine concentrations are comparable to plasma concentrations in preterm infants receiving extended caffeine therapy. Br J Clin Pharmacol. 2016 09; 82(3):754-61. PMID: 27145974.
      Citations: 11     Fields:    Translation:HumansCTClinical Trials
    29. Veit L, Amberson M, Freiberger C, Montenegro B, Mukhopadhyay S, Rhein LM. Diagnostic Evaluation and Home Monitor Use in Late Preterm to Term Infants With Apnea, Bradycardia, and Desaturations. Clin Pediatr (Phila). 2016 Nov; 55(13):1210-1218. PMID: 26957524.
      Citations: 1     Fields:    Translation:Humans
    30. Belfort MB, Cohen RT, Rhein LM, McCormick MC. Preterm infant growth and asthma at age 8?years. Arch Dis Child Fetal Neonatal Ed. 2016 May; 101(3):F230-4. PMID: 26354369.
      Citations: 6     Fields:    Translation:Humans
    31. Bairdain S, Dodson B, Zurakowski D, Rhein L, Snyder BD, Putman M, Jennings RW. High incidence of fracture events in patients with Long-Gap Esophageal Atresia (LGEA): A retrospective review prompting implementation of standardized protocol. Bone Rep. 2015 Dec; 3:1-4. PMID: 28377960.
      Citations:    
    32. Bairdain S, Smithers CJ, Hamilton TE, Zurakowski D, Rhein L, Foker JE, Baird C, Jennings RW. Direct tracheobronchopexy to correct airway collapse due to severe tracheobronchomalacia: Short-term outcomes in a series of 20 patients. J Pediatr Surg. 2015 Jun; 50(6):972-7. PMID: 25824437.
      Citations: 11     Fields:    Translation:Humans
    33. Rhein LM, Dobson NR, Darnall RA, Corwin MJ, Heeren TC, Poets CF, McEntire BL, Hunt CE. Effects of caffeine on intermittent hypoxia in infants born prematurely: a randomized clinical trial. JAMA Pediatr. 2014 Mar; 168(3):250-7. PMID: 24445955.
      Citations: 39     Fields:    Translation:Humans
    34. Davis NL, Liu A, Rhein L. Feeding immaturity in preterm neonates: risk factors for oropharyngeal aspiration and timing of maturation. J Pediatr Gastroenterol Nutr. 2013 Dec; 57(6):735-40. PMID: 23969537.
      Citations: 13     Fields:    Translation:Humans
    35. Davis NL, Condon F, Rhein LM. Epidemiology and predictors of failure of the infant car seat challenge. Pediatrics. 2013 May; 131(5):951-7. PMID: 23545379.
      Citations: 4     Fields:    Translation:Humans
    36. Davis NL, Zenchenko Y, Lever A, Rhein L. Car seat safety for preterm neonates: implementation and testing parameters of the infant car seat challenge. Acad Pediatr. 2013 May-Jun; 13(3):272-7. PMID: 23680345.
      Citations: 9     Fields:    Translation:Humans
    37. Rhein LM, Konnikova L, McGeachey A, Pruchniewski M, Smith VC. The role of pulmonary follow-up in reducing health care utilization in infants with bronchopulmonary dysplasia. Clin Pediatr (Phila). 2012 Jul; 51(7):645-50. PMID: 22492835.
      Citations: 4     Fields:    Translation:Humans
    38. Rhein L, Simoneau T, Davis J, Correia C, Ferrari D, Monuteaux M, Gregory M. Reference values of nocturnal oxygenation for use in outpatient oxygen weaning protocols in premature infants. Pediatr Pulmonol. 2012 May; 47(5):453-9. PMID: 22102606.
      Citations: 7     Fields:    Translation:Humans
    39. Palm K, Simoneau T, Sawicki G, Rhein L. Assessment of current strategies for weaning premature infants from supplemental oxygen in the outpatient setting. Adv Neonatal Care. 2011 Oct; 11(5):349-56. PMID: 22123406.
      Citations: 9     Fields:    Translation:Humans
    40. Bera MM, Lu B, Martin TR, Cui S, Rhein LM, Gerard C, Gerard NP. Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins. J Immunol. 2011 Oct 15; 187(8):4245-55. PMID: 21918196.
      Citations: 31     Fields:    Translation:AnimalsCells
    41. Berry JG, Graham RJ, Roberson DW, Rhein L, Graham DA, Zhou J, O'Brien J, Putney H, Goldmann DA. Patient characteristics associated with in-hospital mortality in children following tracheotomy. Arch Dis Child. 2010 Sep; 95(9):703-10. PMID: 20522454.
      Citations: 27     Fields:    Translation:Humans
    42. Kulik TJ, Rhein LM, Mullen MP. Pulmonary arterial hypertension in infants with chronic lung disease: will we ever understand it? J Pediatr. 2010 Aug; 157(2):186-90. PMID: 20421106.
      Citations: 1     Fields:    Translation:Humans
    43. Degrazia M, Guo CY, Wilkinson AA, Rhein L. Weight and age as predictors for passing the infant car seat challenge. Pediatrics. 2010 Mar; 125(3):526-31. PMID: 20142291.
      Citations: 3     Fields:    Translation:Humans
    44. Khemani E, McElhinney DB, Rhein L, Andrade O, Lacro RV, Thomas KC, Mullen MP. Pulmonary artery hypertension in formerly premature infants with bronchopulmonary dysplasia: clinical features and outcomes in the surfactant era. Pediatrics. 2007 Dec; 120(6):1260-9. PMID: 18055675.
      Citations: 185     Fields:    Translation:Humans
    45. Rhein LM, Perkins M, Gerard NP, Gerard C. FcgammaRIII is protective against Pseudomonas aeruginosa pneumonia. Am J Respir Cell Mol Biol. 2008 Apr; 38(4):401-6. PMID: 17975174.
      Citations: 10     Fields:    Translation:AnimalsCells
    46. Fox LM, Wingerter S, Ahmed A, Arnold A, Chou J, Rhein L, Levy O. Neonatal babesiosis: case report and review of the literature. Pediatr Infect Dis J. 2006 Feb; 25(2):169-73. PMID: 16462298.
      Citations: 24     Fields:    Translation:HumansAnimals
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