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Christopher N Otis MD

TitleProfessor Emeritus
InstitutionUMass Chan – Baystate Regional Campus
DepartmentPathology at UMass Chan - Baystate
AddressBaystate Health Medical Center
759 Chestnut Street
Springfield MA 01199
Phone413-794-4500
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    Collapse Biography 
    Collapse education and training
    Bowdoin College, Brunswick, ME, United StatesBABiochemistry
    Yale University School of Medicine, New Haven, CT, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Siegmund S, Sholl LM, Cornejo KM, Sangoi AR, Otis CN, Mehra R, Hirsch MS, Acosta AM. Molecular assessment of testicular adult granulosa cell tumor demonstrates significant differences when compared to ovarian counterparts. Mod Pathol. 2022 05; 35(5):697-704. PMID: 34845303.
      Citations:    Fields:    Translation:Humans
    2. Ersoy E, Cao QJ, Otis CN. HER2 Protein Overexpression and Gene Amplification in Tubo-Ovarian High-grade Serous Carcinomas. Int J Gynecol Pathol. 2022 07 01; 41(4):313-319. PMID: 34320531.
      Citations:    Fields:    Translation:Humans
    3. El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA. Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma. Am J Surg Pathol. 2021 03 01; 45(3):374-383. PMID: 33565764.
      Citations: 4     Fields:    Translation:Humans
    4. Acosta AM, Sholl LM, Cin PD, Howitt BE, Otis CN, Nucci MR. Malignant tumours of the uterus and ovaries with Mullerian and germ cell or trophoblastic components have a somatic origin and are characterised by genomic instability. Histopathology. 2020 Nov; 77(5):788-797. PMID: 32558949.
      Citations: 1     Fields:    Translation:Humans
    5. Staats PN, Parkash V, Otis CN, Sharma P, Ioffe O, Bracamonte ER. The Current State of Communication of Urgent and Significant, Unexpected Diagnoses in Anatomic Pathology. Arch Pathol Lab Med. 2020 09 01; 144(9):1067-1074. PMID: 32023089.
      Citations:    Fields:    Translation:Humans
    6. Muse ME, Titus AJ, Salas LA, Wilkins OM, Mullen C, Gregory KJ, Schneider SS, Crisi GM, Jawale RM, Otis CN, Christensen BC, Arcaro KF. Enrichment of CpG island shore region hypermethylation in epigenetic breast field cancerization. Epigenetics. 2020 10; 15(10):1093-1106. PMID: 32255732.
      Citations: 4     Fields:    Translation:HumansCells
    7. Bhele S, Stoddart L, Petersen C, Baum J, Otis CN. Parasitic Microcalcifications of the Breast. Int J Surg Pathol. 2020 Sep; 28(6):645-646. PMID: 31852339.
      Citations:    Fields:    Translation:HumansAnimals
    8. Bean GR, Krings G, Otis CN, Solomon DA, García JJ, van Zante A, Camelo-Piragua S, van Ziffle J, Chen YY. CRTC1-MAML2 fusion in mucoepidermoid carcinoma of the breast. Histopathology. 2019 Feb; 74(3):463-473. PMID: 30380176.
      Citations: 9     Fields:    Translation:Humans
    9. Cretara AD, Otis CN. Perspectives and perceptions of urgent and alert values in surgical pathology and cytopathology: A survey of clinical practitioners and pathologists. Cancer Cytopathol. 2018 12; 126(12):970-979. PMID: 30291817.
      Citations: 3     Fields:    Translation:Humans
    10. Williams KE, Jawale RM, Schneider SS, Otis CN, Pentecost BT, Arcaro KF. DNA methylation in breast cancers: Differences based on estrogen receptor status and recurrence. J Cell Biochem. 2019 01; 120(1):738-755. PMID: 30230580.
      Citations: 4     Fields:    Translation:HumansCells
    11. Zimmers SM, Browne EP, Williams KE, Jawale RM, Otis CN, Schneider SS, Arcaro KF. TROP2 methylation and expression in tamoxifen-resistant breast cancer. Cancer Cell Int. 2018; 18:94. PMID: 30002602.
      Citations:    
    12. McCluggage WG, Judge MJ, Alvarado-Cabrero I, Duggan MA, Horn LC, Hui P, Ordi J, Otis CN, Park KJ, Plante M, Stewart CJR, Wiredu EK, Rous B, Hirschowitz L. Data Set for the Reporting of Carcinomas of the Cervix: Recommendations From the International Collaboration on Cancer Reporting (ICCR). Int J Gynecol Pathol. 2018 May; 37(3):205-228. PMID: 28700433.
      Citations: 10     Fields:    Translation:Humans
    13. Longacre TA, Broaddus R, Chuang LT, Cohen MB, Jarboe EA, Mutter GL, Otis CN, Zaino RJ. Template for Reporting Results of Biomarker Testing of Specimens From Patients With Carcinoma of the Endometrium. Arch Pathol Lab Med. 2017 11; 141(11):1508-1512. PMID: 28301227.
      Citations: 6     Fields:    Translation:Humans
    14. Ordulu Z, Nucci MR, Dal Cin P, Hollowell ML, Otis CN, Hornick JL, Park PJ, Kim TM, Quade BJ, Morton CC. Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors. Mod Pathol. 2016 05; 29(5):500-10. PMID: 26892441.
      Citations: 21     Fields:    Translation:HumansCells
    15. Fitzgerald LM, Browne EP, Christie KD, Punska EC, Simmons LO, Williams KE, Pentecost BT, M Jawale R, Otis CN, Arcaro KF. ELF5 and DOK7 regulation in anti-estrogen treated cells and tumors. Cancer Cell Int. 2016; 16:8. PMID: 26884724.
      Citations:    
    16. Nakhleh RE, Nosé V, Colasacco C, Fatheree LA, Lillemoe TJ, McCrory DC, Meier FA, Otis CN, Owens SR, Raab SS, Turner RR, Ventura CB, Renshaw AA. Interpretive Diagnostic Error Reduction in Surgical Pathology and Cytology: Guideline From the College of American Pathologists Pathology and Laboratory Quality Center and the Association of Directors of Anatomic and Surgical Pathology. Arch Pathol Lab Med. 2016 Jan; 140(1):29-40. PMID: 25965939.
      Citations: 10     Fields:    Translation:Humans
    17. Fagan-Solis KD, Pentecost BT, Gozgit JM, Bentley BA, Marconi SM, Otis CN, Anderton DL, Schneider SS, Arcaro KF. SKP2 overexpression is associated with increased serine 10 phosphorylation of p27 (pSer10p27) in triple-negative breast cancer. J Cell Physiol. 2014 Sep; 229(9):1160-9. PMID: 24443386.
      Citations: 6     Fields:    Translation:HumansCells
    18. Chander A, Otis CN, Cole LL. Pure glandular endometrioid-like yolk sac tumor of the testis. Int J Surg Pathol. 2015 Feb; 23(1):30-1. PMID: 25145708.
      Citations: 1     Fields:    Translation:Humans
    19. Wang Y, Otis CN, Florence RR. Atypical squamous cells in the urine revealing endometrioid adenocarcinoma of the endometrium with squamous cell differentiation: a case report. Diagn Cytopathol. 2015 Jan; 43(1):49-52. PMID: 24535963.
      Citations: 3     Fields:    Translation:Humans
    20. Fagan-Solis KD, Schneider SS, Pentecost BT, Bentley BA, Otis CN, Gierthy JF, Arcaro KF. The RhoA pathway mediates MMP-2 and MMP-9-independent invasive behavior in a triple-negative breast cancer cell line. J Cell Biochem. 2013 Jun; 114(6):1385-94. PMID: 23255405.
      Citations: 29     Fields:    Translation:HumansCells
    21. Prieto-Granada C, Setia N, Otis CN. Lymph node extramedullary hematopoiesis in breast cancer patients receiving neoadjuvant therapy: a potential diagnostic pitfall. Int J Surg Pathol. 2013 Jun; 21(3):264-6. PMID: 23493877.
      Citations: 4     Fields:    Translation:Humans
    22. McCluggage WG, Colgan T, Duggan M, Hacker NF, Mulvany N, Otis C, Wilkinson N, Zaino RJ, Hirschowitz L. Data set for reporting of endometrial carcinomas: recommendations from the International Collaboration on Cancer Reporting (ICCR) between United Kingdom, United States, Canada, and Australasia. Int J Gynecol Pathol. 2013 Jan; 32(1):45-65. PMID: 23202790.
      Citations: 17     Fields:    Translation:Humans
    23. Turk CM, Fagan-Solis KD, Williams KE, Gozgit JM, Smith-Schneider S, Marconi SA, Otis CN, Crisi GM, Anderton DL, Kilimann MW, Arcaro KF. Paralemmin-1 is over-expressed in estrogen-receptor positive breast cancers. Cancer Cell Int. 2012 May 10; 12(1):17. PMID: 22574838.
      Citations:    
    24. Browne EP, Punska EC, Lenington S, Otis CN, Anderton DL, Arcaro KF. Increased promoter methylation in exfoliated breast epithelial cells in women with a previous breast biopsy. Epigenetics. 2011 Dec; 6(12):1425-35. PMID: 22139572.
      Citations: 18     Fields:    Translation:HumansCells
    25. Kuperman M, Florence RR, Pantanowitz L, Visintainer PF, Cibas ES, Otis CN. Distinguishing benign from malignant mesothelial cells in effusions by Glut-1, EMA, and Desmin expression: an evidence-based approach. Diagn Cytopathol. 2013 Feb; 41(2):131-40. PMID: 23002041.
      Citations: 1     Fields:    Translation:Humans
    26. Chapman CN, Otis CN. From critical values to critical diagnoses: a review with an emphasis on cytopathology. Cancer Cytopathol. 2011 Jun 25; 119(3):148-57. PMID: 21509947.
      Citations: 3     Fields:    Translation:Humans
    27. Setia N, Goulart RA, Leiman G, Otis CN, Modem R, Pantanowtiz L. Cytomorphology of cervicovaginal melanoma: ThinPrep versus conventional Papanicolaou tests. Cytojournal. 2010 Dec 31; 7:25. PMID: 21298024.
      Citations:    
    28. Torlakovic EE, Riddell R, Banerjee D, El-Zimaity H, Pilavdzic D, Dawe P, Magliocco A, Barnes P, Berendt R, Cook D, Gilks B, Williams G, Perez-Ordonez B, Wehrli B, Swanson PE, Otis CN, Nielsen S, Vyberg M, Butany J. Canadian Association of Pathologists-Association canadienne des pathologistes National Standards Committee/Immunohistochemistry: best practice recommendations for standardization of immunohistochemistry tests. Am J Clin Pathol. 2010 Mar; 133(3):354-65. PMID: 20154273.
      Citations: 18     Fields:    Translation:Humans
    29. Yan H, Blackburn AC, McLary SC, Tao L, Roberts AL, Xavier EA, Dickinson ES, Seo JH, Arenas RB, Otis CN, Cao QJ, Lawlor RG, Osborne BA, Kittrell FS, Medina D, Jerry DJ. Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice. Am J Pathol. 2010 Mar; 176(3):1421-32. PMID: 20110418.
      Citations: 8     Fields:    Translation:AnimalsCells
    30. Talbert ML, Ashwood ER, Brownlee NA, Clark JR, Horowitz RE, Lepoff RB, Neumann A, Otis CN, Powell SZ, Sodeman TM. Resident preparation for practice: a white paper from the College of American Pathologists and Association of Pathology Chairs. Arch Pathol Lab Med. 2009 Jul; 133(7):1139-47. PMID: 19642741.
      Citations: 11     Fields:    Translation:Humans
    31. Doldan A, Otis CN, Pantanowitz L. Adipose tissue: a normal constituent of the uterine cervical stroma. Int J Gynecol Pathol. 2009 Jul; 28(4):396-400. PMID: 19483621.
      Citations: 7     Fields:    Translation:Humans
    32. Pantanowitz L, Otis CN, Goulart RA. Cytologic findings of psammocarcinoma in peritoneal washings. Acta Cytol. 2009 May-Jun; 53(3):263-7. PMID: 19534264.
      Citations: 4     Fields:    Translation:HumansCells
    33. Camelo-Piragua SI, Habib C, Kanumuri P, Lago CE, Mason HS, Otis CN. Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a case report with molecular analysis and review of the literature. Hum Pathol. 2009 Jun; 40(6):887-92. PMID: 19200580.
      Citations: 10     Fields:    Translation:Humans
    34. Caponetti GC, Pantanowitz L, Marconi S, Havens JM, Lamps LW, Otis CN. Evaluation of immunohistochemistry in identifying Bartonella henselae in cat-scratch disease. Am J Clin Pathol. 2009 Feb; 131(2):250-6. PMID: 19141385.
      Citations: 10     Fields:    Translation:HumansCells
    35. Pinco J, Goulart RA, Otis CN, Garb J, Pantanowitz L. Impact of digital image manipulation in cytology. Arch Pathol Lab Med. 2009 Jan; 133(1):57-61. PMID: 19123737.
      Citations: 10     Fields:    Translation:Humans
    36. Piragua SC, Otis CN, Prefontaine M, Pantanowitz L. Cystic struma ovarii (with macrocystic change). Int J Surg Pathol. 2008 Oct; 16(4):433-4. PMID: 18397898.
      Citations:    Fields:    Translation:Humans
    37. Pantanowitz L, Henneberry JM, Otis CN, Zakhary M. Adenolipoma of the external female genitalia. Int J Gynecol Pathol. 2008 Apr; 27(2):297-300. PMID: 18317208.
      Citations: 2     Fields:    Translation:Humans
    38. Pantanowitz L, Otis CN. Cystitis glandularis. Diagn Cytopathol. 2008 Mar; 36(3):181-2. PMID: 18232007.
      Citations: 5     Fields:    Translation:Humans
    39. Assaad MW, Pantanowitz L, Otis CN. Diagnostic accuracy of image-guided percutaneous fine needle aspiration biopsy of the mediastinum. Diagn Cytopathol. 2007 Nov; 35(11):705-9. PMID: 17924408.
      Citations: 13     Fields:    Translation:Humans
    40. Hollowell ML, Goulart RA, Gang DL, Otis CN, Prior J, Sachs BF, Pantanowitz L. Cytologic features of müllerian papilloma of the cervix: mimic of malignancy. Diagn Cytopathol. 2007 Sep; 35(9):607-11. PMID: 17703455.
      Citations: 2     Fields:    Translation:Humans
    41. Modem RR, Otis CN, Florence RR, Pantanowitz L. Intestinal type adenocarcinoma in situ of the cervix. Diagn Cytopathol. 2007 Sep; 35(9):584-5. PMID: 17703459.
      Citations: 1     Fields:    Translation:Humans
    42. Blackburn AC, Hill LZ, Roberts AL, Wang J, Aud D, Jung J, Nikolcheva T, Allard J, Peltz G, Otis CN, Cao QJ, Ricketts RS, Naber SP, Mollenhauer J, Poustka A, Malamud D, Jerry DJ. Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk. Am J Pathol. 2007 Jun; 170(6):2030-41. PMID: 17525270.
      Citations: 27     Fields:    Translation:HumansAnimals
    43. Pantanowitz L, Otis CN. Myxoid liposarcoma. Diagn Cytopathol. 2007 May; 35(5):283-4. PMID: 17427222.
      Citations: 2     Fields:    Translation:Humans
    44. Gozgit JM, Pentecost BT, Marconi SA, Otis CN, Wu C, Arcaro KF. Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer. Mol Cancer Res. 2006 Dec; 4(12):905-13. PMID: 17189381.
      Citations: 26     Fields:    Translation:HumansCells
    45. Karim S, Hession C, Marconi S, Gang DL, Otis CN. The identification of ganglion cells in Hirschsprung disease by the immunohistochemical detection of ret oncoprotein. Am J Clin Pathol. 2006 Jul; 126(1):49-54. PMID: 16753599.
      Citations: 7     Fields:    Translation:Humans
    46. Crisi GM, Pantanowitz L, Otis CN. Images in pathology. Mammotome footprints: histologic artefacts in the era of stereotactic vacuum mammotome biopsy. Int J Surg Pathol. 2006 Jul; 14(3):221-2. PMID: 16959703.
      Citations: 1     Fields:    Translation:Humans
    47. Otis CN. Residency training in anatomic pathology: looking forward in the 21st century. Hum Pathol. 2006 Aug; 37(8):929-31. PMID: 16867853.
      Citations: 1     Fields:    Translation:Humans
    48. Pantanowitz L, Otis CN. Malignant mesothelioma. N Engl J Med. 2006 Jan 19; 354(3):305-7; author reply 305-7. PMID: 16421378.
      Citations:    Fields:    Translation:Humans
    49. Otis CN, Moral LA. Images in pathology: granule cell loss in AIDS-associated progressive multifocal leukoencephalopathy. Int J Surg Pathol. 2005 Oct; 13(4):360. PMID: 16273193.
      Citations: 7     Fields:    Translation:HumansCells
    50. Galan A, Rauch CA, Otis CN. Fatal BK polyoma viral pneumonia associated with immunosuppression. Hum Pathol. 2005 Sep; 36(9):1031-4. PMID: 16153469.
      Citations: 7     Fields:    Translation:HumansCells
    51. Pantanowitz L, Florence RR, Goulart RA, Otis CN. Trichomonas vaginalis P16 Immunoreactivity in cervicovaginal Pap tests: a diagnostic pitfall. Diagn Cytopathol. 2005 Sep; 33(3):210-3. PMID: 16078255.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    52. Varnholt H, Otis CN, Nucci MR, Johari VP. Fallopian tube prolapse mimicking aggressive angiomyxoma. Int J Gynecol Pathol. 2005 Jul; 24(3):292-4. PMID: 15968207.
      Citations: 1     Fields:    Translation:Humans
    53. Pantanowitz L, Cao QJ, Goulart RA, Otis CN. Diagnostic utility of p16 immunocytochemistry for Trichomonas in urine cytology. Cytojournal. 2005 Jun 29; 2(1):11. PMID: 15985185.
      Citations:    
    54. Otis CN. Checklists and guidelines in surgical pathology. Am J Clin Pathol. 2004 Nov; 122(5):817-8; discussion 818-9. PMID: 15540389.
      Citations:    Fields:    Translation:Humans
    55. Blackburn AC, McLary SC, Naeem R, Luszcz J, Stockton DW, Donehower LA, Mohammed M, Mailhes JB, Soferr T, Naber SP, Otis CN, Jerry DJ. Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain. Cancer Res. 2004 Aug 01; 64(15):5140-7. PMID: 15289317.
      Citations: 20     Fields:    Translation:AnimalsCells
    56. Powell JL, Otis CN. Commenting on "Vulvar langerhans cell histocytosis: a case report and review of the literature" by Santillan et al. 91:241-246. Gynecol Oncol. 2004 Jun; 93(3):719; author reply 719. PMID: 15196873.
      Citations:    Fields:    Translation:Humans
    57. Arcaro KF, Wang J, Otis CN, Zuckerman BM. Beta-galactosidase and alpha-mannosidase inhibit formation of multicellular nodules in breast cancer cell cultures. Anticancer Res. 2004 Jan-Feb; 24(1):139-44. PMID: 15015588.
      Citations: 1     Fields:    Translation:HumansCells
    58. Seliem RM, Assaad MW, Gorombey SJ, Moral LA, Kirkwood JR, Otis CN. Fine-needle aspiration biopsy of the central nervous system performed freehand under computed tomography guidance without stereotactic instrumentation. Cancer. 2003 Oct 25; 99(5):277-84. PMID: 14579294.
      Citations: 4     Fields:    Translation:Humans
    59. Blackburn AC, Brown JS, Naber SP, Otis CN, Wood JT, Jerry DJ. BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice. Cancer Res. 2003 May 15; 63(10):2364-8. PMID: 12750252.
      Citations: 13     Fields:    Translation:Animals
    60. Otis CN, Krebs PA, Albuquerque A, Quezado MM, San Juan X, Sobel ME, Merino MJ. Loss of heterozygosity of p53, BRCA1, VHL, and estrogen receptor genes in breast carcinoma: correlation with related protein products and morphologic features. Int J Surg Pathol. 2002 Oct; 10(4):237-45. PMID: 12490973.
      Citations: 2     Fields:    Translation:HumansCells
    61. Hendsch SA, Glover SD, Otis CN, Donovan JT. Atypical glandular cells of undetermined significance from extramammary Paget's of the bladder. Obstet Gynecol. 2002 May; 99(5 Pt 2):912-4. PMID: 11975956.
      Citations: 1     Fields:    Translation:Humans
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