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Christopher N Otis MD

TitleProfessor Emeritus
InstitutionUMMS - Baystate Regional Campus
DepartmentPathology at UMCMS-Baystate
AddressBaystate Health Medical Center
759 Chestnut Street
Springfield MA 01199
Phone413-794-4500
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    Collapse Biography 
    Collapse education and training
    Bowdoin College, Brunswick, ME, United StatesBABiochemistry
    Yale University School of Medicine, New Haven, CT, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ersoy E, Cao QJ, Otis CN. HER2 Protein Overexpression and Gene Amplification in Tubo-Ovarian High-grade Serous Carcinomas. Int J Gynecol Pathol. 2021 Jul 28. PMID: 34320531.
      View in: PubMed
    2. El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA. Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma. Am J Surg Pathol. 2021 03 01; 45(3):374-383. PMID: 33565764.
      View in: PubMed
    3. Acosta AM, Sholl LM, Dal Cin P, Howitt BE, Otis CN, Nucci MR. Malignant Tumors of the Uterus and Ovaries with Mullerian and Germ Cell or Trophoblastic Components Have a Somatic Origin and are Characterized by Genomic Instability. Histopathology. 2020 Jun 19. PMID: 32558949.
      View in: PubMed
    4. Muse ME, Titus AJ, Salas LA, Wilkins OM, Mullen C, Gregory KJ, Schneider SS, Crisi GM, Jawale RM, Otis CN, Christensen BC, Arcaro KF. Enrichment of CpG island shore region hypermethylation in epigenetic breast field cancerization. Epigenetics. 2020 Apr 07; 1-14. PMID: 32255732.
      View in: PubMed
    5. Staats PN, Parkash V, Otis CN, Sharma P, Ioffe O, Bracamonte ER. The Current State of Communication of Urgent and Significant, Unexpected Diagnoses in Anatomic Pathology: Results of an Association of Directors of Anatomic and Surgical Pathology Survey. Arch Pathol Lab Med. 2020 Feb 05. PMID: 32023089.
      View in: PubMed
    6. Bhele S, Stoddart L, Petersen C, Baum J, Otis CN. Parasitic Microcalcifications of the Breast. Int J Surg Pathol. 2019 Dec 18; 1066896919894687. PMID: 31852339.
      View in: PubMed
    7. Bean GR, Krings G, Otis CN, Solomon DA, García JJ, van Zante A, Camelo-Piragua S, Ziffle JV, Chen YY. CRTC1-MAML2 Fusion in Mucoepidermoid Carcinoma of the Breast. Histopathology. 2018 Oct 31. PMID: 30380176.
      View in: PubMed
    8. Cretara AD, Otis CN. Perspectives and perceptions of urgent and alert values in surgical pathology and cytopathology: A survey of clinical practitioners and pathologists. Cancer Cytopathol. 2018 Oct 06. PMID: 30291817.
      View in: PubMed
    9. Williams KE, Jawale RM, Schneider SS, Otis CN, Pentecost BT, Arcaro KF. DNA methylation in breast cancers: Differences based on estrogen receptor status and recurrence. J Cell Biochem. 2018 Sep 19. PMID: 30230580.
      View in: PubMed
    10. Zimmers SM, Browne EP, Williams KE, Jawale RM, Otis CN, Schneider SS, Arcaro KF. TROP2 methylation and expression in tamoxifen-resistant breast cancer. Cancer Cell Int. 2018; 18:94. PMID: 30002602.
      View in: PubMed
    11. McCluggage WG, Judge MJ, Alvarado-Cabrero I, Duggan MA, Horn LC, Hui P, Ordi J, Otis CN, Park KJ, Plante M, Stewart CJR, Wiredu EK, Rous B, Hirschowitz L. Data Set for the Reporting of Carcinomas of the Cervix: Recommendations From the International Collaboration on Cancer Reporting (ICCR). Int J Gynecol Pathol. 2018 May; 37(3):205-228. PMID: 28700433.
      View in: PubMed
    12. Longacre TA, Broaddus R, Chuang LT, Cohen MB, Jarboe EA, Mutter GL, Otis CN, Zaino RJ. Template for Reporting Results of Biomarker Testing of Specimens From Patients With Carcinoma of the Endometrium. Arch Pathol Lab Med. 2017 Mar 16. PMID: 28301227.
      View in: PubMed
    13. Ordulu Z, Nucci MR, Dal Cin P, Hollowell ML, Otis CN, Hornick JL, Park PJ, Kim TM, Quade BJ, Morton CC. Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors. Mod Pathol. 2016 May; 29(5):500-10. PMID: 26892441.
      View in: PubMed
    14. Fitzgerald LM, Browne EP, Christie KD, Punska EC, Simmons LO, Williams KE, Pentecost BT, M Jawale R, Otis CN, Arcaro KF. ELF5 and DOK7 regulation in anti-estrogen treated cells and tumors. Cancer Cell Int. 2016; 16:8. PMID: 26884724.
      View in: PubMed
    15. Nakhleh RE, Nosé V, Colasacco C, Fatheree LA, Lillemoe TJ, McCrory DC, Meier FA, Otis CN, Owens SR, Raab SS, Turner RR, Ventura CB, Renshaw AA. Interpretive Diagnostic Error Reduction in Surgical Pathology and Cytology: Guideline From the College of American Pathologists Pathology and Laboratory Quality Center and the Association of Directors of Anatomic and Surgical Pathology. Arch Pathol Lab Med. 2016 Jan; 140(1):29-40. PMID: 25965939.
      View in: PubMed
    16. Fagan-Solis KD, Pentecost BT, Gozgit JM, Bentley BA, Marconi SM, Otis CN, Anderton DL, Schneider SS, Arcaro KF. SKP2 overexpression is associated with increased serine 10 phosphorylation of p27 (pSer10p27) in triple-negative breast cancer. J Cell Physiol. 2014 Sep; 229(9):1160-9. PMID: 24443386.
      View in: PubMed
    17. Chander A, Otis CN, Cole LL. Pure glandular endometrioid-like yolk sac tumor of the testis. Int J Surg Pathol. 2015 Feb; 23(1):30-1. PMID: 25145708.
      View in: PubMed
    18. Wang Y, Otis CN, Florence RR. Atypical squamous cells in the urine revealing endometrioid adenocarcinoma of the endometrium with squamous cell differentiation: a case report. Diagn Cytopathol. 2015 Jan; 43(1):49-52. PMID: 24535963.
      View in: PubMed
    19. Fagan-Solis KD, Schneider SS, Pentecost BT, Bentley BA, Otis CN, Gierthy JF, Arcaro KF. The RhoA pathway mediates MMP-2 and MMP-9-independent invasive behavior in a triple-negative breast cancer cell line. J Cell Biochem. 2013 Jun; 114(6):1385-94. PMID: 23255405.
      View in: PubMed
    20. Prieto-Granada C, Setia N, Otis CN. Lymph node extramedullary hematopoiesis in breast cancer patients receiving neoadjuvant therapy: a potential diagnostic pitfall. Int J Surg Pathol. 2013 Jun; 21(3):264-6. PMID: 23493877.
      View in: PubMed
    21. McCluggage WG, Colgan T, Duggan M, Hacker NF, Mulvany N, Otis C, Wilkinson N, Zaino RJ, Hirschowitz L. Data set for reporting of endometrial carcinomas: recommendations from the International Collaboration on Cancer Reporting (ICCR) between United Kingdom, United States, Canada, and Australasia. Int J Gynecol Pathol. 2013 Jan; 32(1):45-65. PMID: 23202790.
      View in: PubMed
    22. Turk CM, Fagan-Solis KD, Williams KE, Gozgit JM, Smith-Schneider S, Marconi SA, Otis CN, Crisi GM, Anderton DL, Kilimann MW, Arcaro KF. Paralemmin-1 is over-expressed in estrogen-receptor positive breast cancers. Cancer Cell Int. 2012; 12(1):17. PMID: 22574838.
      View in: PubMed
    23. Browne EP, Punska EC, Lenington S, Otis CN, Anderton DL, Arcaro KF. Increased promoter methylation in exfoliated breast epithelial cells in women with a previous breast biopsy. Epigenetics. 2011 Dec; 6(12):1425-35. PMID: 22139572.
      View in: PubMed
    24. Kuperman M, Florence RR, Pantanowitz L, Visintainer PF, Cibas ES, Otis CN. Distinguishing benign from malignant mesothelial cells in effusions by Glut-1, EMA, and Desmin expression: an evidence-based approach. Diagn Cytopathol. 2013 Feb; 41(2):131-40. PMID: 23002041.
      View in: PubMed
    25. Chapman CN, Otis CN. From critical values to critical diagnoses: a review with an emphasis on cytopathology. Cancer Cytopathol. 2011 Jun 25; 119(3):148-57. PMID: 21509947.
      View in: PubMed
    26. Setia N, Goulart RA, Leiman G, Otis CN, Modem R, Pantanowtiz L. Cytomorphology of cervicovaginal melanoma: ThinPrep versus conventional Papanicolaou tests. Cytojournal. 2010; 7:25. PMID: 21298024.
      View in: PubMed
    27. Canadian Association of Pathologists-Association canadienne des pathologistes National Standards Committee/Immunohistochemistry: best practice recommendations for standardization of immunohistochemistry tests. Am J Clin Pathol. 2010 Mar; 133(3):354-65. PMID: 20154273.
      View in: PubMed
    28. Yan H, Blackburn AC, McLary SC, Tao L, Roberts AL, Xavier EA, Dickinson ES, Seo JH, Arenas RB, Otis CN, Cao QJ, Lawlor RG, Osborne BA, Kittrell FS, Medina D, Jerry DJ. Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice. Am J Pathol. 2010 Mar; 176(3):1421-32. PMID: 20110418.
      View in: PubMed
    29. Doldan A, Otis CN, Pantanowitz L. Adipose tissue: a normal constituent of the uterine cervical stroma. Int J Gynecol Pathol. 2009 Jul; 28(4):396-400. PMID: 19483621.
      View in: PubMed
    30. Talbert ML, Ashwood ER, Brownlee NA, Clark JR, Horowitz RE, Lepoff RB, Neumann A, Otis CN, Powell SZ, Sodeman TM. Resident preparation for practice: a white paper from the College of American Pathologists and Association of Pathology Chairs. Arch Pathol Lab Med. 2009 Jul; 133(7):1139-47. PMID: 19642741.
      View in: PubMed
    31. Pantanowitz L, Otis CN, Goulart RA. Cytologic findings of psammocarcinoma in peritoneal washings. Acta Cytol. 2009 May-Jun; 53(3):263-7. PMID: 19534264.
      View in: PubMed
    32. Camelo-Piragua SI, Habib C, Kanumuri P, Lago CE, Mason HS, Otis CN. Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a case report with molecular analysis and review of the literature. Hum Pathol. 2009 Jun; 40(6):887-92. PMID: 19200580.
      View in: PubMed
    33. Caponetti GC, Pantanowitz L, Marconi S, Havens JM, Lamps LW, Otis CN. Evaluation of immunohistochemistry in identifying Bartonella henselae in cat-scratch disease. Am J Clin Pathol. 2009 Feb; 131(2):250-6. PMID: 19141385.
      View in: PubMed
    34. Pinco J, Goulart RA, Otis CN, Garb J, Pantanowitz L. Impact of digital image manipulation in cytology. Arch Pathol Lab Med. 2009 Jan; 133(1):57-61. PMID: 19123737.
      View in: PubMed
    35. Piragua SC, Otis CN, Prefontaine M, Pantanowitz L. Cystic struma ovarii (with macrocystic change). Int J Surg Pathol. 2008 Oct; 16(4):433-4. PMID: 18397898.
      View in: PubMed
    36. Pantanowitz L, Henneberry JM, Otis CN, Zakhary M. Adenolipoma of the external female genitalia. Int J Gynecol Pathol. 2008 Apr; 27(2):297-300. PMID: 18317208.
      View in: PubMed
    37. Pantanowitz L, Otis CN. Cystitis glandularis. Diagn Cytopathol. 2008 Mar; 36(3):181-2. PMID: 18232007.
      View in: PubMed
    38. Assaad MW, Pantanowitz L, Otis CN. Diagnostic accuracy of image-guided percutaneous fine needle aspiration biopsy of the mediastinum. Diagn Cytopathol. 2007 Nov; 35(11):705-9. PMID: 17924408.
      View in: PubMed
    39. Hollowell ML, Goulart RA, Gang DL, Otis CN, Prior J, Sachs BF, Pantanowitz L. Cytologic features of müllerian papilloma of the cervix: mimic of malignancy. Diagn Cytopathol. 2007 Sep; 35(9):607-11. PMID: 17703455.
      View in: PubMed
    40. Modem RR, Otis CN, Florence RR, Pantanowitz L. Intestinal type adenocarcinoma in situ of the cervix. Diagn Cytopathol. 2007 Sep; 35(9):584-5. PMID: 17703459.
      View in: PubMed
    41. Blackburn AC, Hill LZ, Roberts AL, Wang J, Aud D, Jung J, Nikolcheva T, Allard J, Peltz G, Otis CN, Cao QJ, Ricketts RS, Naber SP, Mollenhauer J, Poustka A, Malamud D, Jerry DJ. Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk. Am J Pathol. 2007 Jun; 170(6):2030-41. PMID: 17525270.
      View in: PubMed
    42. Pantanowitz L, Otis CN. Myxoid liposarcoma. Diagn Cytopathol. 2007 May; 35(5):283-4. PMID: 17427222.
      View in: PubMed
    43. Gozgit JM, Pentecost BT, Marconi SA, Otis CN, Wu C, Arcaro KF. Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer. Mol Cancer Res. 2006 Dec; 4(12):905-13. PMID: 17189381.
      View in: PubMed
    44. Crisi GM, Pantanowitz L, Otis CN. Images in pathology. Mammotome footprints: histologic artefacts in the era of stereotactic vacuum mammotome biopsy. Int J Surg Pathol. 2006 Jul; 14(3):221-2. PMID: 16959703.
      View in: PubMed
    45. Karim S, Hession C, Marconi S, Gang DL, Otis CN. The identification of ganglion cells in Hirschsprung disease by the immunohistochemical detection of ret oncoprotein. Am J Clin Pathol. 2006 Jul; 126(1):49-54. PMID: 16753599.
      View in: PubMed
    46. Otis CN. Residency training in anatomic pathology: looking forward in the 21st century. Hum Pathol. 2006 Aug; 37(8):929-31. PMID: 16867853.
      View in: PubMed
    47. Pantanowitz L, Otis CN. Malignant mesothelioma. N Engl J Med. 2006 Jan 19; 354(3):305-7; author reply 305-7. PMID: 16421378.
      View in: PubMed
    48. Otis CN, Moral LA. Images in pathology: granule cell loss in AIDS-associated progressive multifocal leukoencephalopathy. Int J Surg Pathol. 2005 Oct; 13(4):360. PMID: 16273193.
      View in: PubMed
    49. Pantanowitz L, Florence RR, Goulart RA, Otis CN. Trichomonas vaginalis P16 Immunoreactivity in cervicovaginal Pap tests: a diagnostic pitfall. Diagn Cytopathol. 2005 Sep; 33(3):210-3. PMID: 16078255.
      View in: PubMed
    50. Galan A, Rauch CA, Otis CN. Fatal BK polyoma viral pneumonia associated with immunosuppression. Hum Pathol. 2005 Sep; 36(9):1031-4. PMID: 16153469.
      View in: PubMed
    51. Varnholt H, Otis CN, Nucci MR, Johari VP. Fallopian tube prolapse mimicking aggressive angiomyxoma. Int J Gynecol Pathol. 2005 Jul; 24(3):292-4. PMID: 15968207.
      View in: PubMed
    52. Pantanowitz L, Cao QJ, Goulart RA, Otis CN. Diagnostic utility of p16 immunocytochemistry for Trichomonas in urine cytology. Cytojournal. 2005 Jun 29; 2(1):11. PMID: 15985185.
      View in: PubMed
    53. Otis CN. Checklists and guidelines in surgical pathology. Am J Clin Pathol. 2004 Nov; 122(5):817-8; discussion 818-9. PMID: 15540389.
      View in: PubMed
    54. Blackburn AC, McLary SC, Naeem R, Luszcz J, Stockton DW, Donehower LA, Mohammed M, Mailhes JB, Soferr T, Naber SP, Otis CN, Jerry DJ. Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain. Cancer Res. 2004 Aug 1; 64(15):5140-7. PMID: 15289317.
      View in: PubMed
    55. Powell JL, Otis CN. Commenting on "Vulvar langerhans cell histocytosis: a case report and review of the literature" by Santillan et al. 91:241-246. Gynecol Oncol. 2004 Jun; 93(3):719; author reply 719. PMID: 15196873.
      View in: PubMed
    56. Arcaro KF, Wang J, Otis CN, Zuckerman BM. Beta-galactosidase and alpha-mannosidase inhibit formation of multicellular nodules in breast cancer cell cultures. Anticancer Res. 2004 Jan-Feb; 24(1):139-44. PMID: 15015588.
      View in: PubMed
    57. Seliem RM, Assaad MW, Gorombey SJ, Moral LA, Kirkwood JR, Otis CN. Fine-needle aspiration biopsy of the central nervous system performed freehand under computed tomography guidance without stereotactic instrumentation. Cancer. 2003 Oct 25; 99(5):277-84. PMID: 14579294.
      View in: PubMed
    58. Blackburn AC, Brown JS, Naber SP, Otis CN, Wood JT, Jerry DJ. BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice. Cancer Res. 2003 May 15; 63(10):2364-8. PMID: 12750252.
      View in: PubMed
    59. Otis CN, Krebs PA, Albuquerque A, Quezado MM, San Juan X, Sobel ME, Merino MJ. Loss of heterozygosity of p53, BRCA1, VHL, and estrogen receptor genes in breast carcinoma: correlation with related protein products and morphologic features. Int J Surg Pathol. 2002 Oct; 10(4):237-45. PMID: 12490973.
      View in: PubMed
    60. Hendsch SA, Glover SD, Otis CN, Donovan JT. Atypical glandular cells of undetermined significance from extramammary Paget's of the bladder. Obstet Gynecol. 2002 May; 99(5 Pt 2):912-4. PMID: 11975956.
      View in: PubMed
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