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Hongwei Yang MD, PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentNeurological Surgery
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone774-455-4584
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentNeurological Surgery

    InstitutionUMMS - Graduate School of Biomedical Sciences
    DepartmentNeuroscience


    Collapse Biography 
    Collapse education and training
    Topiwala National Medical College, Mumbai, MH, IndiaMD
    University of Tokyo, Tokyo, JapanPh.D.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Loeian MS, Mehdi Aghaei S, Farhadi F, Rai V, Yang HW, Johnson MD, Aqil F, Mandadi M, Rai SN, Panchapakesan B. Liquid biopsy using the nanotube-CTC-chip: capture of invasive CTCs with high purity using preferential adherence in breast cancer patients. Lab Chip. 2019 May 03. PMID: 31049504.
      View in: PubMed
    2. Zhao Y, Huang W, Kim TM, Jung Y, Menon LG, Xing H, Li H, Carroll RS, Park PJ, Yang HW, Johnson MD. MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma. J Exp Clin Cancer Res. 2019 Jan 25; 38(1):36. PMID: 30683134.
      View in: PubMed
    3. Luo C, Yang Q, Liu Y, Zhou S, Jiang J, Reiter RJ, Bhattacharya P, Cui Y, Yang H, Ma H, Yao J, Lawler SE, Zhang X, Fu J, Rozental R, Aly H, Johnson MD, Chiocca EA, Wang X. The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin, in targeting brain injury and liver damage and in maintaining bone health. Free Radic Biol Med. 2018 Oct 10. PMID: 30315933.
      View in: PubMed
    4. Graybill RM, Cardenosa-Rubio MC, Yang H, Johnson MD, Bailey RC. Multiplexed microRNA Expression Profiling by Combined Asymmetric PCR and Label-Free Detection using Silicon Photonic Sensor Arrays. Anal Methods. 2018 Apr 14; 10(14):1618-1623. PMID: 30275912.
      View in: PubMed
    5. Liu H, Liu N, Cheng Y, Jin W, Zhang P, Wang X, Yang H, Xu X, Wang Z, Tu Y. Hexokinase 2 (HK2), the tumor promoter in glioma, is downregulated by miR-218/Bmi1 pathway. PLoS One. 2017; 12(12):e0189353. PMID: 29220380.
      View in: PubMed
    6. Zhang P, Gao J, Wang X, Wen W, Yang H, Tian Y, Liu N, Wang Z, Liu H, Zhang Y, Tu Y. A novel indication of thioredoxin-interacting protein as a tumor suppressor gene in malignant glioma. Oncol Lett. 2017 Aug; 14(2):2053-2058. PMID: 28781647.
      View in: PubMed
    7. Hickman TT, Shuman ME, Johnson TA, Yang F, Rice RR, Rice IM, Chung EH, Wiemann R, Tinl M, Iracheta C, Chen G, Flynn P, Mondello MB, Thompson J, Meadows ME, Carroll RS, Yang HW, Xing H, Pilgrim D, Chiocca EA, Dunn IF, Golby AJ, Johnson MD. Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol. J Neurosurg. 2016 Sep 30; 1-9. PMID: 27689463.
      View in: PubMed
    8. Wade JH, Alsop AT, Vertin NR, Yang H, Johnson MD, Bailey RC. Rapid, Multiplexed Phosphoprotein Profiling Using Silicon Photonic Sensor Arrays. ACS Cent Sci. 2015 Oct 28; 1(7):374-382. PMID: 26539563.
      View in: PubMed
    9. Yang HW, Xing H, Johnson MD. A major role for microRNAs in glioblastoma cancer stem-like cells. Arch Pharm Res. 2015 Mar; 38(3):423-34. PMID: 25683176.
      View in: PubMed
    10. Yang HW, Kim TM, Song SS, Menon L, Jiang X, Huang W, Black PM, Park PJ, Carroll RS, Johnson MD. A small subunit processome protein promotes cancer by altering translation. Oncogene. 2015 Aug 20; 34(34):4471-81. PMID: 25435373.
      View in: PubMed
    11. Li H, Jiang X, Yu Y, Huang W, Xing H, Agar NY, Yang HW, Yang B, Carroll RS, Johnson MD. KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway. Oncogene. 2015 Mar 12; 34(11):1432-41. PMID: 24704824.
      View in: PubMed
    12. Jiang X, Xing H, Kim TM, Jung Y, Huang W, Yang HW, Song S, Park PJ, Carroll RS, Johnson MD. Numb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and Skp1-Cullin-F-box ubiquitin ligase activity. Stem Cells. 2012 Jul; 30(7):1313-26. PMID: 22553175.
      View in: PubMed
    13. Yang HW, Kim TM, Song SS, Shrinath N, Park R, Kalamarides M, Park PJ, Black PM, Carroll RS, Johnson MD. Alternative splicing of CHEK2 and codeletion with NF2 promote chromosomal instability in meningioma. Neoplasia. 2012 Jan; 14(1):20-8. PMID: 22355270.
      View in: PubMed
    14. Menon LG, Pratt J, Yang HW, Black PM, Sorensen GA, Carroll RS. Imaging of human mesenchymal stromal cells: homing to human brain tumors. J Neurooncol. 2012 Apr; 107(2):257-67. PMID: 22081298.
      View in: PubMed
    15. Goutagny S, Yang HW, Zucman-Rossi J, Chan J, Dreyfuss JM, Park PJ, Black PM, Giovannini M, Carroll RS, Kalamarides M. Genomic profiling reveals alternative genetic pathways of meningioma malignant progression dependent on the underlying NF2 status. Clin Cancer Res. 2010 Aug 15; 16(16):4155-64. PMID: 20682713.
      View in: PubMed
    16. Yang HW, Menon LG, Black PM, Carroll RS, Johnson MD. SNAI2/Slug promotes growth and invasion in human gliomas. BMC Cancer. 2010 Jun 17; 10:301. PMID: 20565806.
      View in: PubMed
    17. Agar NY, Malcolm JG, Mohan V, Yang HW, Johnson MD, Tannenbaum A, Agar JN, Black PM. Imaging of meningioma progression by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Anal Chem. 2010 Apr 01; 82(7):2621-5. PMID: 20196536; PMCID: PMC2852177.
    18. Jiang X, Yu Y, Yang HW, Agar NY, Frado L, Johnson MD. The imprinted gene PEG3 inhibits Wnt signaling and regulates glioma growth. J Biol Chem. 2010 Mar 12; 285(11):8472-80. PMID: 20064927; PMCID: PMC2832996.
    19. Menon LG, Kelly K, Yang HW, Kim SK, Black PM, Carroll RS. Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy. Stem Cells. 2009 Sep; 27(9):2320-30. PMID: 19544410.
      View in: PubMed
    20. Agar NY, Yang HW, Carroll RS, Black PM, Agar JN. Matrix solution fixation: histology-compatible tissue preparation for MALDI mass spectrometry imaging. Anal Chem. 2007 Oct 1; 79(19):7416-23. PMID: 17822313.
      View in: PubMed
    21. Zetterberg H, Campbell WA, Yang HW, Xia W. The cytosolic loop of the gamma-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis. J Biol Chem. 2006 Apr 28; 281(17):11933-9. PMID: 16507571.
      View in: PubMed
    22. Campbell WA, Yang H, Zetterberg H, Baulac S, Sears JA, Liu T, Wong ST, Zhong TP, Xia W. Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J Neurochem. 2006 Mar; 96(5):1423-40. PMID: 16464238.
      View in: PubMed
    23. Yang HW, Kutok JL, Lee NH, Piao HY, Fletcher CD, Kanki JP, Look AT. Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish. Cancer Res. 2004 Oct 15; 64(20):7256-62. PMID: 15492244.
      View in: PubMed
    24. Obana K, Yang HW, Piao HY, Taki T, Hashizume K, Hanada R, Yamamoto K, Tanaka Y, Toyoda Y, Takita J, Tsuchida Y, Hayashi Y. Aberrations of p16INK4A, p14ARF and p15INK4B genes in pediatric solid tumors. Int J Oncol. 2003 Oct; 23(4):1151-7. PMID: 12963998.
      View in: PubMed
    25. Chen YY, Takita J, Chen YZ, Yang HW, Hanada R, Yamamoto K, Hayashi Y. Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma. Int J Oncol. 2003 Sep; 23(3):737-44. PMID: 12888911.
      View in: PubMed
    26. Liu TX, Zhou Y, Kanki JP, Deng M, Rhodes J, Yang HW, Sheng XM, Zon LI, Look AT. Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6136-41. PMID: 11983906; PMCID: PMC122915.
    27. Yang HW, Chen YZ, Takita J, Soeda E, Piao HY, Hayashi Y. Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2. Oncogene. 2001 Aug 16; 20(36):5075-83. PMID: 11526494.
      View in: PubMed
    28. Chen YZ, Soeda E, Yang HW, Takita J, Chai L, Horii A, Inazawa J, Ohki M, Hayashi Y. Homozygous deletion in a neuroblastoma cell line defined by a high-density STS map spanning human chromosome band 1p36. Genes Chromosomes Cancer. 2001 Aug; 31(4):326-32. PMID: 11433523.
      View in: PubMed
    29. Takita J, Yang HW, Chen YY, Hanada R, Yamamoto K, Teitz T, Kidd V, Hayashi Y. Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma. Oncogene. 2001 Jul 19; 20(32):4424-32. PMID: 11466626.
      View in: PubMed
    30. Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell. 2001 Jun 01; 105(5):587-97. PMID: 11389829.
      View in: PubMed
    31. Liu M, Taketani T, Li R, Takita J, Taki T, Yang HW, Kawaguchi H, Ida K, Matsuo Y, Hayashi Y. Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation. Leuk Res. 2001 Jun; 25(6):441-7. PMID: 11337015.
      View in: PubMed
    32. Yang HW, Chen YZ, Piao HY, Takita J, Soeda E, Hayashi Y. DNA fragmentation factor 45 (DFF45) gene at 1p36.2 is homozygously deleted and encodes variant transcripts in neuroblastoma cell line. Neoplasia. 2001 Mar-Apr; 3(2):165-9. PMID: 11420752; PMCID: PMC1505420.
    33. Takita J, Yang HW, Bessho F, Hanada R, Yamamoto K, Kidd V, Teitz T, Wei T, Hayashi Y. Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma. Med Pediatr Oncol. 2000 Dec; 35(6):541-3. PMID: 11107112.
      View in: PubMed
    34. Yang HW, Piao HY, Chen YZ, Takita J, Kobayashi M, Taniwaki M, Hashizume K, Hanada R, Yamamoto K, Taki T, Bessho F, Yanagisawa M, Hayashi Y. The p73 gene is less involved in the development but involved in the progression of neuroblastoma. Int J Mol Med. 2000 Apr; 5(4):379-84. PMID: 10719054.
      View in: PubMed
    35. Yang HW, Piao HY, Taki T, Chen T, Hashizume K, Ohnishi H, Bessho F, Yanagisawa M, Matsuo Y, Hayashi Y. Pattern of FHIT gene expression in normal and leukaemic cells. Int J Cancer. 1999 Jun 11; 81(6):897-901. PMID: 10362136.
      View in: PubMed
    36. Xu F, Taki T, Yang HW, Hanada R, Hongo T, Ohnishi H, Kobayashi M, Bessho F, Yanagisawa M, Hayashi Y. Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children. Br J Haematol. 1999 Apr; 105(1):155-62. PMID: 10233379.
      View in: PubMed
    37. Yang HW, Ikeda H, Kato K, Nakagawara A, Choi SH, Hayashi Y, Obana K, Hemmi H, Tsuchida Y. Development of a polyclonal antibody with defined specificity against synthetic peptides from the N-myc oncoprotein using multiple antigen peptide and hemocyanin conjugation methods. J Pediatr Surg. 1999 Mar; 34(3):454-60. PMID: 10211653.
      View in: PubMed
    38. Tsuchida Y, Hemmi H, Inoue A, Obana K, Yang HW, Hayashi Y, Kanda N, Shimatake H. Genetic clinical markers of human neuroblastoma with special reference to N-myc oncogene: amplified or not amplified?--An overview. Tumour Biol. 1996; 17(2):65-74. PMID: 8658015.
      View in: PubMed
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