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Hongwei Yang MD, PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentNeurological Surgery
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone774-455-4584
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentNeurological Surgery

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience


    Collapse Biography 
    Collapse education and training
    Topiwala National Medical College, Mumbai, MH, IndiaMD
    University of Tokyo, Tokyo, JapanPh.D.1999

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yang HW, Lee S, Berry BC, Yang D, Zheng S, Carroll RS, Park PJ, Johnson MD. A role for mutations in AK9 and other genes affecting ependymal cells in idiopathic normal pressure hydrocephalus. Proc Natl Acad Sci U S A. 2023 Dec 19; 120(51):e2300681120. PMID: 38100419.
      Citations:    Fields:    Translation:HumansAnimals
    2. Hou CC, Li D, Berry BC, Zheng S, Carroll RS, Johnson MD, Yang HW. Heterozygous FOXJ1 Mutations Cause Incomplete Ependymal Cell Differentiation and Communicating Hydrocephalus. Cell Mol Neurobiol. 2023 Nov; 43(8):4103-4116. PMID: 37620636.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Mathew EN, Berry BC, Yang HW, Carroll RS, Johnson MD. Delivering Therapeutics to Glioblastoma: Overcoming Biological Constraints. 2022; 3(23):171. View Publication.
    4. Yang D*, Yang H*, Luiselli G, Ogagan C, Dai H, Chiu L, Carroll RS, Johnson MD.(*co-first authors). Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus. Proc Natl Acad Sci U S A. 2021; 333(118):e2010528118. View Publication.
    5. Yang HW, Lee S, Yang D, Dai H, Zhang Y, Han L, Zhao S, Zhang S, Ma Y, Johnson MF, Rattray AK, Johnson TA, Wang G, Zheng S, Carroll RS, Park PJ, Johnson MD. Deletions in CWH43 cause idiopathic normal pressure hydrocephalus. EMBO Mol Med. 2021; 3(13):e13249. View Publication.
    6. Loeian MS, Mehdi Aghaei S, Farhadi F, Rai V, Yang HW, Johnson MD, Aqil F, Mandadi M, Rai SN, Panchapakesan B. Liquid biopsy using the nanotube-CTC-chip: capture of invasive CTCs with high purity using preferential adherence in breast cancer patients. Lab Chip. 2019 06 07; 19(11):1899-1915. PMID: 31049504.
      Citations: 26     Fields:    Translation:HumansCells
    7. Zhao Y, Huang W, Kim TM, Jung Y, Menon LG, Xing H, Li H, Carroll RS, Park PJ, Yang HW, Johnson MD. MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma. J Exp Clin Cancer Res. 2019 Jan 25; 38(1):36. PMID: 30683134.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    8. Luo C, Yang Q, Liu Y, Zhou S, Jiang J, Reiter RJ, Bhattacharya P, Cui Y, Yang H, Ma H, Yao J, Lawler SE, Zhang X, Fu J, Rozental R, Aly H, Johnson MD, Chiocca EA, Wang X. The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. Free Radic Biol Med. 2019 01; 130:215-233. PMID: 30315933.
      Citations: 32     Fields:    Translation:HumansAnimals
    9. Graybill RM, Cardenosa-Rubio MC, Yang H, Johnson MD, Bailey RC. Multiplexed microRNA Expression Profiling by Combined Asymmetric PCR and Label-Free Detection using Silicon Photonic Sensor Arrays. Anal Methods. 2018 Apr 14; 10(14):1618-1623. PMID: 30275912.
      Citations: 4     Fields:    
    10. Liu H, Liu N, Cheng Y, Jin W, Zhang P, Wang X, Yang H, Xu X, Wang Z, Tu Y. Hexokinase 2 (HK2), the tumor promoter in glioma, is downregulated by miR-218/Bmi1 pathway. PLoS One. 2017; 12(12):e0189353. PMID: 29220380.
      Citations: 22     Fields:    Translation:HumansCells
    11. Zhang P, Gao J, Wang X, Wen W, Yang H, Tian Y, Liu N, Wang Z, Liu H, Zhang Y, Tu Y. A novel indication of thioredoxin-interacting protein as a tumor suppressor gene in malignant glioma. Oncol Lett. 2017 Aug; 14(2):2053-2058. PMID: 28781647.
      Citations:    
    12. Hickman TT, Shuman ME, Johnson TA, Yang F, Rice RR, Rice IM, Chung EH, Wiemann R, Tinl M, Iracheta C, Chen G, Flynn P, Mondello MB, Thompson J, Meadows ME, Carroll RS, Yang HW, Xing H, Pilgrim D, Chiocca EA, Dunn IF, Golby AJ, Johnson MD. Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol. J Neurosurg. 2017 Aug; 127(2):240-248. PMID: 27689463.
      Citations: 8     Fields:    Translation:Humans
    13. Wade JH, Alsop AT, Vertin NR, Yang H, Johnson MD, Bailey RC. Rapid, Multiplexed Phosphoprotein Profiling Using Silicon Photonic Sensor Arrays. ACS Cent Sci. 2015 Oct 28; 1(7):374-382. PMID: 26539563.
      Citations:    
    14. Yang HW, Xing H, Johnson MD. A major role for microRNAs in glioblastoma cancer stem-like cells. Arch Pharm Res. 2015 Mar; 38(3):423-34. PMID: 25683176.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    15. Yang HW, Kim TM, Song SS, Menon L, Jiang X, Huang W, Black PM, Park PJ, Carroll RS, Johnson MD. A small subunit processome protein promotes cancer by altering translation. Oncogene. 2015 Aug 20; 34(34):4471-81. PMID: 25435373.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    16. Li H, Jiang X, Yu Y, Huang W, Xing H, Agar NY, Yang HW, Yang B, Carroll RS, Johnson MD. KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway. Oncogene. 2015 Mar 12; 34(11):1432-41. PMID: 24704824.
      Citations: 17     Fields:    Translation:HumansCells
    17. Jiang X, Xing H, Kim TM, Jung Y, Huang W, Yang HW, Song S, Park PJ, Carroll RS, Johnson MD. Numb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and Skp1-Cullin-F-box ubiquitin ligase activity. Stem Cells. 2012 Jul; 30(7):1313-26. PMID: 22553175.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    18. Yang HW, Kim TM, Song SS, Shrinath N, Park R, Kalamarides M, Park PJ, Black PM, Carroll RS, Johnson MD. Alternative splicing of CHEK2 and codeletion with NF2 promote chromosomal instability in meningioma. Neoplasia. 2012 Jan; 14(1):20-8. PMID: 22355270.
      Citations: 22     Fields:    Translation:HumansCells
    19. Menon LG, Pratt J, Yang HW, Black PM, Sorensen GA, Carroll RS. Imaging of human mesenchymal stromal cells: homing to human brain tumors. J Neurooncol. 2012 Apr; 107(2):257-67. PMID: 22081298.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    20. Goutagny S, Yang HW, Zucman-Rossi J, Chan J, Dreyfuss JM, Park PJ, Black PM, Giovannini M, Carroll RS, Kalamarides M. Genomic profiling reveals alternative genetic pathways of meningioma malignant progression dependent on the underlying NF2 status. Clin Cancer Res. 2010 Aug 15; 16(16):4155-64. PMID: 20682713.
      Citations: 56     Fields:    Translation:Humans
    21. Yang HW, Menon LG, Black PM, Carroll RS, Johnson MD. SNAI2/Slug promotes growth and invasion in human gliomas. BMC Cancer. 2010 Jun 17; 10:301. PMID: 20565806.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    22. Agar NY, Malcolm JG, Mohan V, Yang HW, Johnson MD, Tannenbaum A, Agar JN, Black PM. Imaging of meningioma progression by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Anal Chem. 2010 Apr 01; 82(7):2621-5. PMID: 20196536.
      Citations: 15     Fields:    Translation:Humans
    23. Jiang X, Yu Y, Yang HW, Agar NY, Frado L, Johnson MD. The imprinted gene PEG3 inhibits Wnt signaling and regulates glioma growth. J Biol Chem. 2010 Mar 12; 285(11):8472-80. PMID: 20064927.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    24. Menon LG, Kelly K, Yang HW, Kim SK, Black PM, Carroll RS. Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy. Stem Cells. 2009 Sep; 27(9):2320-30. PMID: 19544410.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    25. Agar NY, Yang HW, Carroll RS, Black PM, Agar JN. Matrix solution fixation: histology-compatible tissue preparation for MALDI mass spectrometry imaging. Anal Chem. 2007 Oct 01; 79(19):7416-23. PMID: 17822313.
      Citations: 17     Fields:    Translation:Animals
    26. Zetterberg H, Campbell WA, Yang HW, Xia W. The cytosolic loop of the gamma-secretase component presenilin enhancer 2 protects zebrafish embryos from apoptosis. J Biol Chem. 2006 Apr 28; 281(17):11933-9. PMID: 16507571.
      Citations: 9     Fields:    Translation:AnimalsCells
    27. Campbell WA, Yang H, Zetterberg H, Baulac S, Sears JA, Liu T, Wong ST, Zhong TP, Xia W. Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J Neurochem. 2006 Mar; 96(5):1423-40. PMID: 16464238.
      Citations: 41     Fields:    Translation:AnimalsCells
    28. Yang HW, Kutok JL, Lee NH, Piao HY, Fletcher CD, Kanki JP, Look AT. Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish. Cancer Res. 2004 Oct 15; 64(20):7256-62. PMID: 15492244.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    29. Obana K, Yang HW, Piao HY, Taki T, Hashizume K, Hanada R, Yamamoto K, Tanaka Y, Toyoda Y, Takita J, Tsuchida Y, Hayashi Y. Aberrations of p16INK4A, p14ARF and p15INK4B genes in pediatric solid tumors. Int J Oncol. 2003 Oct; 23(4):1151-7. PMID: 12963998.
      Citations: 11     Fields:    Translation:HumansCells
    30. Chen YY, Takita J, Chen YZ, Yang HW, Hanada R, Yamamoto K, Hayashi Y. Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma. Int J Oncol. 2003 Sep; 23(3):737-44. PMID: 12888911.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    31. Liu TX, Zhou Y, Kanki JP, Deng M, Rhodes J, Yang HW, Sheng XM, Zon LI, Look AT. Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6136-41. PMID: 11983906.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    32. Yang HW, Chen YZ, Takita J, Soeda E, Piao HY, Hayashi Y. Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2. Oncogene. 2001 Aug 16; 20(36):5075-83. PMID: 11526494.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    33. Chen YZ, Soeda E, Yang HW, Takita J, Chai L, Horii A, Inazawa J, Ohki M, Hayashi Y. Homozygous deletion in a neuroblastoma cell line defined by a high-density STS map spanning human chromosome band 1p36. Genes Chromosomes Cancer. 2001 Aug; 31(4):326-32. PMID: 11433523.
      Citations: 8     Fields:    Translation:HumansCells
    34. Takita J, Yang HW, Chen YY, Hanada R, Yamamoto K, Teitz T, Kidd V, Hayashi Y. Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma. Oncogene. 2001 Jul 19; 20(32):4424-32. PMID: 11466626.
      Citations: 18     Fields:    Translation:HumansCells
    35. Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell. 2001 Jun 01; 105(5):587-97. PMID: 11389829.
      Citations: 238     Fields:    Translation:HumansAnimalsCells
    36. Liu M, Taketani T, Li R, Takita J, Taki T, Yang HW, Kawaguchi H, Ida K, Matsuo Y, Hayashi Y. Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation. Leuk Res. 2001 Jun; 25(6):441-7. PMID: 11337015.
      Citations: 10     Fields:    Translation:HumansCells
    37. Yang HW, Chen YZ, Piao HY, Takita J, Soeda E, Hayashi Y. DNA fragmentation factor 45 (DFF45) gene at 1p36.2 is homozygously deleted and encodes variant transcripts in neuroblastoma cell line. Neoplasia. 2001 Mar-Apr; 3(2):165-9. PMID: 11420752.
      Citations: 4     Fields:    Translation:HumansCells
    38. Takita J, Yang HW, Bessho F, Hanada R, Yamamoto K, Kidd V, Teitz T, Wei T, Hayashi Y. Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma. Med Pediatr Oncol. 2000 Dec; 35(6):541-3. PMID: 11107112.
      Citations: 14     Fields:    Translation:HumansCells
    39. Yang HW, Piao HY, Chen YZ, Takita J, Kobayashi M, Taniwaki M, Hashizume K, Hanada R, Yamamoto K, Taki T, Bessho F, Yanagisawa M, Hayashi Y. The p73 gene is less involved in the development but involved in the progression of neuroblastoma. Int J Mol Med. 2000 Apr; 5(4):379-84. PMID: 10719054.
      Citations: 1     Fields:    Translation:HumansCells
    40. Yang HW, Piao HY, Taki T, Chen T, Hashizume K, Ohnishi H, Bessho F, Yanagisawa M, Matsuo Y, Hayashi Y. Pattern of FHIT gene expression in normal and leukaemic cells. Int J Cancer. 1999 Jun 11; 81(6):897-901. PMID: 10362136.
      Citations: 3     Fields:    Translation:HumansCells
    41. Xu F, Taki T, Yang HW, Hanada R, Hongo T, Ohnishi H, Kobayashi M, Bessho F, Yanagisawa M, Hayashi Y. Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children. Br J Haematol. 1999 Apr; 105(1):155-62. PMID: 10233379.
      Citations: 29     Fields:    Translation:HumansCells
    42. Yang HW, Ikeda H, Kato K, Nakagawara A, Choi SH, Hayashi Y, Obana K, Hemmi H, Tsuchida Y. Development of a polyclonal antibody with defined specificity against synthetic peptides from the N-myc oncoprotein using multiple antigen peptide and hemocyanin conjugation methods. J Pediatr Surg. 1999 Mar; 34(3):454-60. PMID: 10211653.
      Citations:    Fields:    Translation:HumansAnimalsCells
    43. Tsuchida Y, Hemmi H, Inoue A, Obana K, Yang HW, Hayashi Y, Kanda N, Shimatake H. Genetic clinical markers of human neuroblastoma with special reference to N-myc oncogene: amplified or not amplified?--An overview. Tumour Biol. 1996; 17(2):65-74. PMID: 8658015.
      Citations: 2     Fields:    Translation:HumansCells
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