Howard Smithline MD, MS
Title | Associate Professor |
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Institution | UMMS - Baystate Regional Campus |
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Department | Emergency Medicine at UMMS-Baystate |
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Address | Baystate Health Regional Campus 759 Chestnut Street Springfield MA 01199
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Phone | 413-794-3343 |
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vCard | Download vCard |
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Biography Northwestern University Feinberg School of Medicine, Chicago, IL, United States | BS | | Medicine | University of Michigan, Ann Arbor, Ann Arbor, MI, United States | MS | | Stats Analysis/Clinical Design | Northwestern University Feinberg School of Medicine, Chicago, IL, United States | MD | | |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE, Hayden DL, Hough CL, Johnson NJ, Khan A, Lindsell CJ, Matthay MA, Moss M, Park PK, Rice TW, Robinson BRH, Schoenfeld DA, Shapiro NI, Steingrub JS, Ulysse CA, Weissman A, Yealy DM, Thompson BT, Brown SM. Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2020 11 09. PMID: 33165621.
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Tenforde MW, Kim SS, Lindsell CJ, Billig Rose E, Shapiro NI, Files DC, Gibbs KW, Erickson HL, Steingrub JS, Smithline HA, Gong MN, Aboodi MS, Exline MC, Henning DJ, Wilson JG, Khan A, Qadir N, Brown SM, Peltan ID, Rice TW, Hager DN, Ginde AA, Stubblefield WB, Patel MM, Self WH, Feldstein LR. Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network - United States, March-June 2020. MMWR Morb Mortal Wkly Rep. 2020 Jul 31; 69(30):993-998. PMID: 32730238.
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Tenforde MW, Billig Rose E, Lindsell CJ, Shapiro NI, Files DC, Gibbs KW, Prekker ME, Steingrub JS, Smithline HA, Gong MN, Aboodi MS, Exline MC, Henning DJ, Wilson JG, Khan A, Qadir N, Stubblefield WB, Patel MM, Self WH, Feldstein LR. Characteristics of Adult Outpatients and Inpatients with COVID-19 - 11 Academic Medical Centers, United States, March-May 2020. MMWR Morb Mortal Wkly Rep. 2020 Jul 03; 69(26):841-846. PMID: 32614810.
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Smithline HA, Donnino M, Blank FSJ, Barus R, Coute RA, Knee AB, Visintainer P. Supplemental thiamine for the treatment of acute heart failure syndrome: a randomized controlled trial. BMC Complement Altern Med. 2019 May 06; 19(1):96. PMID: 31060559.
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Selker HP, Kwong M, Ruthazer R, Gorman S, Green G, Patchen E, Udelson JE, Smithline HA, Baumann MR, Harris PA, Shah RU, Nelson SJ, Cohen T, Jones EB, Barnewolt BA, Williams AE. An example of medical device-based projection of clinical trial enrollment: Use of electrocardiographic data to identify candidates for a trial in acute coronary syndromes. J Clin Transl Sci. 2018 Dec; 2(6):377-383. PMID: 31404280.
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Donnino MW, Andersen LW, Berg KM, Chase M, Sherwin R, Smithline H, Carney E, Ngo L, Patel PV, Liu X, Cutlip D, Zimetbaum P, Cocchi MN. Corticosteroid therapy in refractory shock following cardiac arrest: a randomized, double-blind, placebo-controlled, trial. Crit Care. 2016 Apr 03; 20:82. PMID: 27038920; PMCID: PMC4818959.
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Donnino MW, Andersen LW, Chase M, Berg KM, Tidswell M, Giberson T, Wolfe R, Moskowitz A, Smithline H, Ngo L, Cocchi MN. Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study. Crit Care Med. 2016 Feb; 44(2):360-7. PMID: 26771781; PMCID: PMC4754670 [Available on 02/01/17].
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Rathlev N, Almomen R, Deutsch A, Smithline H, Li H, Visintainer P. Randomized Controlled Trial of Electronic Care Plan Alerts and Resource Utilization by High Frequency Emergency Department Users with Opioid Use Disorder. West J Emerg Med. 2016 Jan; 17(1):28-34. PMID: 26823927.
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Trotter Z, Spirko B, Smithline H, Garb J. Prevalence of Inconsistencies in the Recorded Outcomes of Clinical Evaluations. Pediatr Emerg Care. 2015 Jun 27. PMID: 26125531.
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Russell FM, Moore CL, Courtney DM, Kabrhel C, Smithline HA, Nordenholz KE, Richman PB, O'Neil BJ, Plewa MC, Beam DM, Mastouri R, Kline JA. Independent evaluation of a simple clinical prediction rule to identify right ventricular dysfunction in patients with shortness of breath. Am J Emerg Med. 2015 Apr; 33(4):542-7. PMID: 25769797.
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Wilcox SR, Seigel TA, Strout TD, Schneider JI, Mitchell PM, Marcolini EG, Cocchi MN, Smithline HA, Lutfy-Clayton L, Mullen M, Ilgen JS, Richards JB. Emergency medicine residents' knowledge of mechanical ventilation. J Emerg Med. 2015 Apr; 48(4):481-91. PMID: 25497896.
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Hasegawa K, Tsugawa Y, Lopez BL, Smithline HA, Sullivan AF, Camargo CA. Body mass index and risk of hospitalization among adults presenting with asthma exacerbation to the emergency department. Ann Am Thorac Soc. 2014 Nov; 11(9):1439-44. PMID: 25314160.
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Nowak RM, Parker JM, Silverman RA, Rowe BH, Smithline H, Khan F, Fiening JP, Kim K, Molfino NA. A randomized trial of benralizumab, an antiinterleukin 5 receptor a monoclonal antibody, after acute asthma. Am J Emerg Med. 2015 Jan; 33(1):14-20. PMID: 25445859.
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Tutay GJ, Capraro G, Spirko B, Garb J, Smithline H. Electrolyte profile of pediatric patients with hypertrophic pyloric stenosis. Pediatr Emerg Care. 2013 Apr; 29(4):465-8. PMID: 23528507.
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Venkatesh AK, Kline JA, Courtney DM, Camargo CA, Plewa MC, Nordenholz KE, Moore CL, Richman PB, Smithline HA, Beam DM, Kabrhel C. Evaluation of pulmonary embolism in the emergency department and consistency with a national quality measure: quantifying the opportunity for improvement. Arch Intern Med. 2012 Jul 09; 172(13):1028-32. PMID: 22664742; PMCID: PMC3775003.
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Kline JA, Hogg MM, Courtney DM, Miller CD, Jones AE, Smithline HA. D-dimer threshold increase with pretest probability unlikely for pulmonary embolism to decrease unnecessary computerized tomographic pulmonary angiography. J Thromb Haemost. 2012 Apr; 10(4):572-81. PMID: 22284935; PMCID: PMC3319270.
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Smithline HA, Donnino M, Greenblatt DJ. Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects. BMC Clin Pharmacol. 2012 Feb 04; 12:4. PMID: 22305197; PMCID: PMC3293077.
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Greenman RL, Wang X, Smithline HA. Simultaneous acquisition of phosphocreatine and inorganic phosphate images for Pi:PCr ratio mapping using a RARE sequence with chemically selective interleaving. Magn Reson Imaging. 2011 Oct; 29(8):1138-44. PMID: 21641744; PMCID: PMC3172363.
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Greenman RL, Smithline HA. The feasibility of measuring phosphocreatine recovery kinetics in muscle using a single-shot (31)P RARE MRI sequence. Acad Radiol. 2011 Jul; 18(7):917-23. PMID: 21536463; PMCID: PMC3115448.
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Wu JS, Buettner C, Smithline H, Ngo LH, Greenman RL. Evaluation of skeletal muscle during calf exercise by 31-phosphorus magnetic resonance spectroscopy in patients on statin medications. Muscle Nerve. 2011 Jan; 43(1):76-81. PMID: 21171098; PMCID: PMC3332539.
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Smithline HA, Caglar S, Blank FS. Assessing validity by comparing transition and static measures of dyspnea in patients with acute decompensated heart failure. Congest Heart Fail. 2010 Sep-Oct; 16(5):202-7. PMID: 20887616.
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Kabrhel C, Mark Courtney D, Camargo CA, Plewa MC, Nordenholz KE, Moore CL, Richman PB, Smithline HA, Beam DM, Kline JA. Factors associated with positive D-dimer results in patients evaluated for pulmonary embolism. Acad Emerg Med. 2010 Jun; 17(6):589-97. PMID: 20624138; PMCID: PMC3538031.
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Kline JA, Hogg MM, Courtney DM, Miller CD, Jones AE, Smithline HA, Klekowski N, Lanier R. D-dimer and exhaled CO2/O2 to detect segmental pulmonary embolism in moderate-risk patients. Am J Respir Crit Care Med. 2010 Sep 01; 182(5):669-75. PMID: 20448094; PMCID: PMC2937237.
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Smithline HA, Caglar S, Blank FS. Physician vs patient assessment of dyspnea during acute decompensated heart failure. Congest Heart Fail. 2010 Mar-Apr; 16(2):60-4. PMID: 20412470.
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Camargo CA, Gurner DM, Smithline HA, Chapela R, Fabbri LM, Green SA, Malice MP, Legrand C, Dass SB, Knorr BA, Reiss TF. A randomized placebo-controlled study of intravenous montelukast for the treatment of acute asthma. J Allergy Clin Immunol. 2010 Feb; 125(2):374-80. PMID: 20159247.
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Kline JA, Courtney DM, Than MP, Hogg K, Miller CD, Johnson CL, Smithline HA. Accuracy of very low pretest probability estimates for pulmonary embolism using the method of attribute matching compared with the Wells score. Acad Emerg Med. 2010 Feb; 17(2):133-41. PMID: 20370742.
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Courtney DM, Kline JA, Kabrhel C, Moore CL, Smithline HA, Nordenholz KE, Richman PB, Plewa MC. Clinical features from the history and physical examination that predict the presence or absence of pulmonary embolism in symptomatic emergency department patients: results of a prospective, multicenter study. Ann Emerg Med. 2010 Apr; 55(4):307-315.e1. PMID: 20045580; PMCID: PMC2847003.
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Donnino MW, Cocchi MN, Smithline H, Carney E, Chou PP, Salciccioli J, Salciccoli J. Coronary artery bypass graft surgery depletes plasma thiamine levels. Nutrition. 2010 Jan; 26(1):133-6. PMID: 20005469; PMCID: PMC2874825.
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Henneman PL, Garb JL, Capraro GA, Li H, Smithline HA, Wait RB. Geography and travel distance impact emergency department visits. J Emerg Med. 2011 Mar; 40(3):333-9. PMID: 20005663.
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Marchick MR, Courtney DM, Kabrhel C, Nordenholz KE, Plewa MC, Richman PB, Smithline HA, Kline JA. 12-lead ECG findings of pulmonary hypertension occur more frequently in emergency department patients with pulmonary embolism than in patients without pulmonary embolism. Ann Emerg Med. 2010 Apr; 55(4):331-5. PMID: 19766353.
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Smithline HA, Rudnitzky N, Macomber S, Blank FS. Pulse oximetry using a disposable finger sensor placed on the forehead in hypoxic patients. J Emerg Med. 2010 Jul; 39(1):121-5. PMID: 19406607.
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Kabrhel C, Mark Courtney D, Camargo CA, Moore CL, Richman PB, Plewa MC, Nordenholtz KE, Smithline HA, Beam DM, Brown MD, Kline JA. Potential impact of adjusting the threshold of the quantitative D-dimer based on pretest probability of acute pulmonary embolism. Acad Emerg Med. 2009 Apr; 16(4):325-32. PMID: 19298619.
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Henneman PL, Nathanson BH, Li H, Smithline HA, Blank FS, Santoro JP, Maynard AM, Provost DA, Henneman EA. Emergency department patients who stay more than 6 hours contribute to crowding. J Emerg Med. 2010 Jul; 39(1):105-12. PMID: 19157757.
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Capraro GA, Coughlin BF, Mader TJ, Smithline HA. Testicular cooling associated with testicular torsion and its detection by infrared thermography: an experimental study in sheep. J Urol. 2008 Dec; 180(6):2688-93. PMID: 18951560.
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Caglar S, Henneman PL, Blank FS, Smithline HA, Henneman EA. Emergency department medication lists are not accurate. J Emerg Med. 2011 Jun; 40(6):613-6. PMID: 18829201.
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Henneman PL, Lemanski M, Smithline HA, Tomaszewski A, Mayforth JA. Emergency department admissions are more profitable than non-emergency department admissions. Ann Emerg Med. 2009 Feb; 53(2):249-255. PMID: 18786746.
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Blank FS, Miller M, Nichols J, Smithline H, Crabb G, Pekow P. Blood glucose measurement in patients with suspected diabetic ketoacidosis: a comparison of Abbott MediSense PCx point-of-care meter values to reference laboratory values. J Emerg Nurs. 2009 Apr; 35(2):93-6. PMID: 19285169.
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Kline JA, Courtney DM, Kabrhel C, Moore CL, Smithline HA, Plewa MC, Richman PB, O'Neil BJ, Nordenholz K. Prospective multicenter evaluation of the pulmonary embolism rule-out criteria. J Thromb Haemost. 2008 May; 6(5):772-80. PMID: 18318689.
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Baevsky RH, Haber MD, Blank FS, Smithline H. Supine vs semirecumbent and upright 12-lead electrocardiogram: does change in body position alter the electrocardiographic interpretation for ischemia? Am J Emerg Med. 2007 Sep; 25(7):753-6. PMID: 17870476.
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Smithline HA. Acute decompensated heart failure. CMAJ. 2007 Jul 17; 177(2):175; author reply 175-6. PMID: 17638957; PMCID: PMC1913128.
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Smithline HA. Thiamine for the treatment of acute decompensated heart failure. Am J Emerg Med. 2007 Jan; 25(1):124-6. PMID: 17157711.
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Capraro GA, Mader TJ, Coughlin BF, Lovewell C, St Louis MR, Tirabassi M, Wadie G, Smithline HA. Feasibility of using near-infrared spectroscopy to diagnose testicular torsion: an experimental study in sheep. Ann Emerg Med. 2007 Apr; 49(4):520-5. PMID: 16997426.
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Lee SY, Coughlin B, Wolfe JM, Polino J, Blank FS, Smithline HA. Prospective comparison of helical CT of the abdomen and pelvis without and with oral contrast in assessing acute abdominal pain in adult Emergency Department patients. Emerg Radiol. 2006 May; 12(4):150-7. PMID: 16738930.
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Wolfe JM, Smithline H, Lee S, Coughlin B, Polino J, Blank F. The impact of body mass index on concordance in the interpretation of matched noncontrast and contrast abdominal pelvic computed tomographic scans in ED patients with nontraumatic abdominal pain. Am J Emerg Med. 2006 Mar; 24(2):144-8. PMID: 16490641.
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Lemanski M, Smithline H, Blank FS, Henneman PL. Accuracy of laceration length estimation. Am J Emerg Med. 2005 Nov; 23(7):920-1. PMID: 16291461.
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Smithline HA, Rowe BH, Radeos MS, Cydulka RK, Camargo CA. Research opportunities in the management of acute exacerbations of chronic obstructive pulmonary disease. Acad Emerg Med. 2005 Aug; 12(8):742-50. PMID: 16079428.
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Blank FS, Li H, Henneman PL, Smithline HA, Santoro JS, Provost D, Maynard AM. A descriptive study of heavy emergency department users at an academic emergency department reveals heavy ED users have better access to care than average users. J Emerg Nurs. 2005 Apr; 31(2):139-44. PMID: 15834378.
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Griffin JA, Playe SJ, Osborne B, Smithline HA. A report of dangerously high carbon monoxide levels within the passenger compartment of a snow-obstructed vehicle. BMC Emerg Med. 2004 Oct 10; 4(1):4. PMID: 15473913.
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Baevsky RH, Kapur RK, Smithline HA. Beckman Access versus the Bayer ACS:180 and the Abbott AxSYM cardiac Troponin-I real-time immunoassays: an observational prospective study. BMC Emerg Med. 2004 Jul 13; 4(1):2. PMID: 15248900.
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Baevsky RH, Lu MY, Smithline HA. The effectiveness of wireless telephone communication technology on ambient noise level reduction within the ED. Am J Emerg Med. 2004 Jul; 22(4):317-8. PMID: 15258879.
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Wolfe JM, Smithline HA, Phipen S, Montano G, Garb JL, Fiallo V. Does morphine change the physical examination in patients with acute appendicitis? Am J Emerg Med. 2004 Jul; 22(4):280-5. PMID: 15258869.
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Huynh LN, Coughlin BF, Wolfe J, Blank F, Lee SY, Smithline HA. Patient encounter time intervals in the evaluation of emergency department patients requiring abdominopelvic CT: oral contrast versus no contrast. Emerg Radiol. 2004 Jul; 10(6):310-3. PMID: 15278712.
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Baevsky RH, Nyquist SN, Roy MN, Smithline HA. Antipyretic effectiveness of intravenous ketorolac tromethamine. J Emerg Med. 2004 May; 26(4):407-10. PMID: 15093845.
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Arnold JL, Halpern P, Tsai MC, Smithline H. Mass casualty terrorist bombings: a comparison of outcomes by bombing type. Ann Emerg Med. 2004 Feb; 43(2):263-73. PMID: 14747818.
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Smithline H. Use of natriuretic peptides in guiding treatment decisions for acute pulmonary embolism. Circulation. 2003 Sep 30; 108(13):e93; author reply e93. PMID: 14517155.
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Fordyce J, Blank FS, Pekow P, Smithline HA, Ritter G, Gehlbach S, Benjamin E, Henneman PL. Errors in a busy emergency department. Ann Emerg Med. 2003 Sep; 42(3):324-33. PMID: 12944883.
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Mader TJ, Blank FS, Smithline HA, Wolfe JM. How reliable are pain scores? A pilot study of 20 healthy volunteers. J Emerg Nurs. 2003 Aug; 29(4):322-5. PMID: 12874553.
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Arnold JL, Tsai MC, Halpern P, Smithline H, Stok E, Ersoy G. Mass-casualty, terrorist bombings: epidemiological outcomes, resource utilization, and time course of emergency needs (Part I). Prehosp Disaster Med. 2003 Jul-Sep; 18(3):220-34. PMID: 15141862.
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Smithline HA, Thompson M, Moran C, Mader TJ. Can CK-MB and cTn-I be detected in the peripheral circulation within the first 10 min of acute coronary ischemia? Med Hypotheses. 2003 Apr; 60(4):598-602. PMID: 12615531.
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Mader TJ, Smithline HA, Durkin L, Scriver G. A randomized controlled trial of intravenous aminophylline for atropine-resistant out-of-hospital asystolic cardiac arrest. Acad Emerg Med. 2003 Mar; 10(3):192-7. PMID: 12615581.
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Smithline HA, Mader TJ, Ali FM, Cocchi MN. Determining pretest probability of DVT: clinical intuition vs. validated scoring systems. Am J Emerg Med. 2003 Mar; 21(2):161-2. PMID: 12671824.
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Smithline HA, Ward KR, Chiulli DA, Blake HC, Rivers EP. Whole body oxygen consumption and critical oxygen delivery in response to prolonged and severe carbon monoxide poisoning. Resuscitation. 2003 Jan; 56(1):97-104. PMID: 12505745.
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Camargo CA, Smithline HA, Malice MP, Green SA, Reiss TF. A randomized controlled trial of intravenous montelukast in acute asthma. Am J Respir Crit Care Med. 2003 Feb 15; 167(4):528-33. PMID: 12456380.
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Blank FS, Smithline HA. Evaluation of an educational video for cardiac patients. Clin Nurs Res. 2002 Nov; 11(4):403-16. PMID: 12413113.
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Smith DC, Mader TJ, Smithline HA. Low dose intravenous ketamine as an analgesic: a pilot study using an experimental model of acute pain. Am J Emerg Med. 2001 Oct; 19(6):531-2. PMID: 11593484.
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Mader TJ, Smithline HA, Nyquist S, Letourneau P. Social services referral of adolescent trauma patients admitted following alcohol-related injury. J Subst Abuse Treat. 2001 Oct; 21(3):167-72. PMID: 11728791.
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Arnopolin SL, Smithline HA. Patient care by physician assistants and by physicians in an emergency department. JAAPA. 2000 Dec; 13(12):39-40, 49-50, 53-4 passim. PMID: 11523490.
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Wolfe JM, Lein DY, Lenkoski K, Smithline HA. Analgesic administration to patients with an acute abdomen: a survey of emergency medicine physicians. Am J Emerg Med. 2000 May; 18(3):250-3. PMID: 10830676.
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Smithline HA, Mader TJ, Crenshaw BJ. Do patients with acute medical conditions have the capacity to give informed consent for emergency medicine research? Acad Emerg Med. 1999 Aug; 6(8):776-80. PMID: 10463547.
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Rivers EP, Blake HC, Dereczyk B, Ressler JA, Talos EL, Patel R, Smithline HA, Rady MY, Wortsman J. Adrenal dysfunction in hemodynamically unstable patients in the emergency department. Acad Emerg Med. 1999 Jun; 6(6):626-30. PMID: 10386680.
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Mader TJ, Smithline HA, Gibson P. Aminophylline in undifferentiated out-of-hospital asystolic cardiac arrest. Resuscitation. 1999 Jun; 41(1):39-45. PMID: 10459591.
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Baevsky RH, Fisher AL, Smithline HA, Salzberg MR. The influence of physician attire on patient satisfaction. Acad Emerg Med. 1998 Jan; 5(1):82-4. PMID: 9444349.
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Smithline HA, Gerstle ML. Waiver of informed consent: a survey of emergency medicine patients. Am J Emerg Med. 1998 Jan; 16(1):90-1. PMID: 9451323.
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Witting MD, Smithline HA. Orthostatic change in shock index: comparison with traditional tilt test definitions. Acad Emerg Med. 1996 Oct; 3(10):926-31. PMID: 8891038.
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Rady MY, Smithline HA, Blake H, Nowak R, Rivers E. A comparison of the shock index and conventional vital signs to identify acute, critical illness in the emergency department. Ann Emerg Med. 1994 Oct; 24(4):685-90. PMID: 8092595.
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Adams CP, Martin GB, Rivers EP, Ward KR, Smithline HA, Rady MY. Hemodynamics of interposed abdominal compression during human cardiopulmonary resuscitation. Acad Emerg Med. 1994 Sep-Oct; 1(5):498-502. PMID: 7614309.
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Smithline HA, Rivers EP, Rady MY, Blake HC, Nowak RM. Biphasic extrathoracic pressure CPR. A human pilot study. Chest. 1994 Mar; 105(3):842-6. PMID: 8131549.
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Schultz CH, Rivers EP, Feldkamp CS, Goad EG, Smithline HA, Martin GB, Fath JJ, Wortsman J, Nowak RM. A characterization of hypothalamic-pituitary-adrenal axis function during and after human cardiac arrest. Crit Care Med. 1993 Sep; 21(9):1339-47. PMID: 8396524.
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Rivers EP, Rady MY, Martin GB, Fenn NM, Smithline HA, Alexander ME, Nowak RM. Venous hyperoxia after cardiac arrest. Characterization of a defect in systemic oxygen utilization. Chest. 1992 Dec; 102(6):1787-93. PMID: 1446489.
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Rivers EP, Paradis NA, Martin GB, Goetting ME, Rosenberg JA, Smithline HA, Appleton TJ, Nowak RM. Cerebral lactate uptake during cardiopulmonary resuscitation in humans. J Cereb Blood Flow Metab. 1991 May; 11(3):479-84. PMID: 2016356.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1991 | 1 | 1992 | 1 | 1993 | 1 | 1994 | 3 | 1996 | 1 | 1998 | 2 | 1999 | 3 | 2000 | 2 | 2001 | 2 | 2002 | 2 | 2003 | 8 | 2004 | 7 | 2005 | 3 | 2006 | 3 | 2007 | 3 | 2008 | 5 | 2009 | 5 | 2010 | 8 | 2011 | 3 | 2012 | 3 | 2013 | 1 | 2014 | 3 | 2015 | 2 | 2016 | 3 | 2018 | 1 | 2019 | 1 | 2020 | 3 |
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