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William M McDougall PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMicrobiology and Physiological Systems
AddressUniversity of Massachusetts Medical School
368 Plantation Street, AS8-1002
Worcester MA 01605
Phone508-856-3351
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMicrobiology and Physiological Systems


    Collapse Biography 
    Collapse education and training
    State University of New York, Buffalo, Buffalo, NY, United StatesBAForensic Chemistry
    University of Rochester, Rochester, NY, United StatesPHDBiochemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yant SR, Mulato A, Hansen D, Tse WC, Niedziela-Majka A, Zhang JR, Stepan GJ, Jin D, Wong MH, Perreira JM, Singer E, Papalia GA, Hu EY, Zheng J, Lu B, Schroeder SD, Chou K, Ahmadyar S, Liclican A, Yu H, Novikov N, Paoli E, Gonik D, Ram RR, Hung M, McDougall WM, Brass AL, Sundquist WI, Cihlar T, Link JO. A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model. Nat Med. 2019 Sep; 25(9):1377-1384. PMID: 31501601.
      View in: PubMed
    2. E X, Meraner P, Lu P, Perreira JM, Aker AM, McDougall WM, Zhuge R, Chan GC, Gerstein RM, Caposio P, Yurochko AD, Brass AL, Kowalik TF. OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism. Proc Natl Acad Sci U S A. 2019 Mar 20. PMID: 30894498.
      View in: PubMed
    3. McDougall WM, Perreira JM, Hung HF, Vertii A, Xiaofei E, Zimmerman W, Kowalik TF, Doxsey S, Brass AL. Viral Infection or IFN-a Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels. iScience. 2019 Jan 21; 12:270-279. PMID: 30716700.
      View in: PubMed
    4. Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration. Cell Host Microbe. 2018 Aug 24. PMID: 30173955.
      View in: PubMed
    5. McDougall WM, Perreira JM, Reynolds EC, Brass AL. CRISPR genetic screens to discover host-virus interactions. Curr Opin Virol. 2018 Apr; 29:87-100. PMID: 29684735.
      View in: PubMed
    6. Savidis G, McDougall WM, Meraner P, Perreira JM, Portmann JM, Trincucci G, John SP, Aker AM, Renzette N, Robbins DR, Guo Z, Green S, Kowalik TF, Brass AL. Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics. Cell Rep. 2016 Jun 28; 16(1):232-46. PMID: 27342126.
      View in: PubMed
    7. Polevoda B, McDougall WM, Bennett RP, Salter JD, Smith HC. Structural and functional assessment of APOBEC3G macromolecular complexes. Methods. 2016 09 01; 107:10-22. PMID: 26988126.
      View in: PubMed
    8. Polevoda B, McDougall WM, Tun BN, Cheung M, Salter JD, Friedman AE, Smith HC. RNA binding to APOBEC3G induces the disassembly of functional deaminase complexes by displacing single-stranded DNA substrates. Nucleic Acids Res. 2015 Oct 30; 43(19):9434-45. PMID: 26424853; PMCID: PMC4627094.
    9. Perreira JM, Aker AM, Savidis G, Chin CR, McDougall WM, Portmann JM, Meraner P, Smith MC, Rahman M, Baker RE, Gauthier A, Franti M, Brass AL. RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus. Cell Rep. 2015 Aug 4; 12(5):850-63. PMID: 26212330.
      View in: PubMed
    10. Smith HC, Bennett RP, Kizilyer A, McDougall WM, Prohaska KM. Functions and regulation of the APOBEC family of proteins. Semin Cell Dev Biol. 2012 May; 23(3):258-68. PMID: 22001110; PMCID: PMC4017262.
    11. McDougall WM, Smith HC. Direct evidence that RNA inhibits APOBEC3G ssDNA cytidine deaminase activity. Biochem Biophys Res Commun. 2011 Sep 09; 412(4):612-7. PMID: 21856286; PMCID: PMC3171569.
    12. McDougall WM, Okany C, Smith HC. Deaminase activity on single-stranded DNA (ssDNA) occurs in vitro when APOBEC3G cytidine deaminase forms homotetramers and higher-order complexes. J Biol Chem. 2011 Sep 02; 286(35):30655-61. PMID: 21737457; PMCID: PMC3162426.
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