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James B Munro PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUMass Chan Medical School
368 Plantation Street AS8-1055
Worcester MA 01605
Phone774-455-4754
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program


    Collapse Biography 
    Collapse education and training
    Middlebury College, Middlebury, VT, United StatesBAPhysics
    Yale University, New Haven, CTPostdoc07/2014Virology/biophysics
    University of Chicago, Chicago, IL, United StatesMSPhysics
    Cornell University, New York, NYPh.D.05/2010Biophysics
    Cornell University, Ithaca, NY, United StatesPHDBiophysics
    University of Chicago, Chicago, ILM.S.05/2004Physics
    Middlebury College, Middlebury, VTB.A.05/2002Physics/mathematics
    Collapse awards and honors
    2015 - 2020NIH Director's New Innovator Award, NIAID/NIH
    2016 - 2018Gilead Research Scholar in HIV, Gilead Sciences

    Collapse Overview 
    Collapse Summary
    Focus: The Munro laboratory develops and applies quantitative biophysical approaches to visualize virus replication, and probe the functions of the proteins and RNAs involved.
    Collapse webpage

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Díaz-Salinas MA, Li Q, Ejemel M, Yurkovetskiy L, Luban J, Shen K, Wang Y, Munro JB. Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike. Elife. 2022 03 24; 11. PMID: 35323111.
      Citations: 1     Fields:    Translation:HumansCells
    2. Schriml LM, Munro JB, Schor M, Olley D, McCracken C, Felix V, Baron JA, Jackson R, Bello SM, Bearer C, Lichenstein R, Bisordi K, Dialo NC, Giglio M, Greene C. The Human Disease Ontology 2022 update. Nucleic Acids Res. 2022 01 07; 50(D1):D1255-D1261. PMID: 34755882.
      Citations: 5     Fields:    Translation:Humans
    3. Nadendla S, Jackson R, Munro J, Quaglia F, Mészáros B, Olley D, Hobbs ET, Goralski SM, Chibucos M, Mungall CJ, Tosatto SCE, Erill I, Giglio MG. ECO: the Evidence and Conclusion Ontology, an update for 2022. Nucleic Acids Res. 2022 01 07; 50(D1):D1515-D1521. PMID: 34986598.
      Citations:    Fields:    Translation:Humans
    4. Zhou AE, Shah ZV, Bradwell KR, Munro JB, Berry AA, Serre D, Takala-Harrison S, O'Connor TD, Silva JC, Travassos MA. STRIDE: a command-line HMM-based identifier and sub-classifier of Plasmodium falciparum RIFIN and STEVOR variant surface antigen families. BMC Bioinformatics. 2022 Jan 06; 23(1):15. PMID: 34991452.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Díaz-Salinas MA, Li Q, Ejemel M, Yurkovetskiy L, Luban J, Shen K, Wang Y, Munro JB. Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike. bioRxiv. 2021 Nov 09. PMID: 34790979.
      Citations:    
    6. Blakemore RJ, Burnett C, Swanson C, Kharytonchyk S, Telesnitsky A, Munro JB. Stability and conformation of the dimeric HIV-1 genomic RNA 5'UTR. Biophys J. 2021 11 02; 120(21):4874-4890. PMID: 34529947.
      Citations: 3     Fields:    Translation:Cells
    7. Hobbs ET, Goralski SM, Mitchell A, Simpson A, Leka D, Kotey E, Sekira M, Munro JB, Nadendla S, Jackson R, Gonzalez-Aguirre A, Krallinger M, Giglio M, Erill I. ECO-CollecTF: A Corpus of Annotated Evidence-Based Assertions in Biomedical Manuscripts. Front Res Metr Anal. 2021; 6:674205. PMID: 34327299.
      Citations:    
    8. Murray LP, Govindan R, Mora AC, Munro JB, Mace CR. Antibody affinity as a driver of signal generation in a paper-based immunoassay for Ebola virus surveillance. Anal Bioanal Chem. 2021 Jun; 413(14):3695-3706. PMID: 33852053.
      Citations:    Fields:    Translation:HumansCells
    9. Gao R, Yu CJ, Gao L, Piatkevich KD, Neve RL, Munro JB, Upadhyayula S, Boyden ES. A highly homogeneous polymer composed of tetrahedron-like monomers for high-isotropy expansion microscopy. Nat Nanotechnol. 2021 06; 16(6):698-707. PMID: 33782587.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    10. Yurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina NV, Shen K, Luban J. Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. Cell. 2020 10 29; 183(3):739-751.e8. PMID: 32991842.
      Citations: 407     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    11. Bulow U, Govindan R, Munro JB. Acidic pH Triggers Lipid Mixing Mediated by Lassa Virus GP. Viruses. 2020 07 02; 12(7). PMID: 32630688.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    12. Joshi VR, Newman RM, Pack ML, Power KA, Munro JB, Okawa K, Madani N, Sodroski JG, Schmidt AG, Allen TM. Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein. PLoS Pathog. 2020 05; 16(5):e1008577. PMID: 32392227.
      Citations:    Fields:    Translation:HumansCells
    13. Das DK, Bulow U, Diehl WE, Durham ND, Senjobe F, Chandran K, Luban J, Munro JB. Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding. PLoS Biol. 2020 02; 18(2):e3000626. PMID: 32040508.
      Citations: 26     Fields:    Translation:HumansCells
    14. Durham ND, Howard AR, Govindan R, Senjobe F, Fels JM, Diehl WE, Luban J, Chandran K, Munro JB. Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics. Viruses. 2020 01 15; 12(1). PMID: 31952255.
      Citations: 7     Fields:    Translation:HumansCells
    15. Howard AR, Munro JB. Developments in single-molecule and single-particle fluorescence-based approaches for studying viral envelope glycoprotein dynamics and membrane fusion. Adv Virus Res. 2019; 104:123-146. PMID: 31439147.
      Citations: 2     Fields:    Translation:Cells
    16. Brigham BS, Kitzrow JP, Reyes JC, Musier-Forsyth K, Munro JB. Intrinsic conformational dynamics of the HIV-1 genomic RNA 5'UTR. Proc Natl Acad Sci U S A. 2019 05 21; 116(21):10372-10381. PMID: 31068467.
      Citations: 14     Fields:    Translation:Cells
    17. Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB. An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity. Cell Host Microbe. 2019 Apr 10; 25(4):578-587.e5. PMID: 30974085.
      Citations: 52     Fields:    Translation:HumansCells
    18. Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Niki?-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W. Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET. Nature. 2019 04; 568(7752):415-419. PMID: 30971821.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    19. Das DK, Govindan R, Niki?-Spiegel I, Krammer F, Lemke EA, Munro JB. Direct Visualization of the Conformational Dynamics of Single Influenza Hemagglutinin Trimers. Cell. 2018 08 09; 174(4):926-937.e12. PMID: 29961575.
      Citations: 53     Fields:    Translation:HumansCells
    20. Munro JB. HIV Env on Lockdown. Cell Host Microbe. 2018 06 13; 23(6):699-701. PMID: 29902434.
      Citations:    Fields:    Translation:HumansCells
    21. Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB, Mothes W. HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations. Elife. 2018 03 21; 7. PMID: 29561264.
      Citations: 64     Fields:    Translation:HumansCells
    22. Munro JB, Lee KK. Probing Structural Variation and Dynamics in the HIV-1 Env Fusion Glycoprotein. Curr HIV Res. 2018; 16(1):5-12. PMID: 29268688.
      Citations: 6     Fields:    Translation:HumansCells
    23. Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J. Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins. mBio. 2016 10 25; 7(5). PMID: 27795397.
      Citations: 80     Fields:    Translation:HumansCells
    24. Kwon YD, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Schön A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD. Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. Nat Struct Mol Biol. 2015 Jul; 22(7):522-31. PMID: 26098315.
      Citations: 216     Fields:    Translation:HumansCells
    25. Munro JB, Mothes W. Structure and Dynamics of the Native HIV-1 Env Trimer. J Virol. 2015 Jun; 89(11):5752-5. PMID: 25762739.
      Citations: 43     Fields:    Translation:HumansCells
    26. Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB, Kwong PD, Blanchard SC, Mothes W. Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions. Science. 2014 Nov 07; 346(6210):759-63. PMID: 25298114.
      Citations: 277     Fields:    Translation:HumansCells
    27. Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD. Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 2014 Oct 23; 514(7523):455-61. PMID: 25296255.
      Citations: 464     Fields:    Translation:HumansCells
    28. Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro JB, Huang F, Floyd RW, Yang H, Hamilton WL, Bewersdorf J, Xiong Y, Calderwood DA, Mothes W. TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly. J Cell Sci. 2014 Sep 15; 127(Pt 18):3928-42. PMID: 25015296.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    29. Munro JB, Mothes W. The HIV-1 Env trimer in HD. Structure. 2014 Jul 08; 22(7):935-6. PMID: 25007222.
      Citations: 2     Fields:    Translation:HumansCells
    30. Agosto LM, Zhong P, Munro J, Mothes W. Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission. PLoS Pathog. 2014 Feb; 10(2):e1003982. PMID: 24586176.
      Citations: 57     Fields:    Translation:HumansCells
    31. Munro JB, Nath A, Färber M, Datta SA, Rein A, Rhoades E, Mothes W. A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles. J Virol. 2014 Mar; 88(6):3577-85. PMID: 24403576.
      Citations: 32     Fields:    Translation:HumansCells
    32. Zhong P, Agosto LM, Munro JB, Mothes W. Cell-to-cell transmission of viruses. Curr Opin Virol. 2013 Feb; 3(1):44-50. PMID: 23219376.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    33. Budkevich T, Giesebrecht J, Altman RB, Munro JB, Mielke T, Nierhaus KH, Blanchard SC, Spahn CM. Structure and dynamics of the mammalian ribosomal pretranslocation complex. Mol Cell. 2011 Oct 21; 44(2):214-24. PMID: 22017870.
      Citations: 61     Fields:    Translation:AnimalsCells
    34. Fu J, Munro JB, Blanchard SC, Frank J. Cryoelectron microscopy structures of the ribosome complex in intermediate states during tRNA translocation. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):4817-21. PMID: 21383139.
      Citations: 18     Fields:    Translation:Cells
    35. Munro JB, Wasserman MR, Altman RB, Wang L, Blanchard SC. Correlated conformational events in EF-G and the ribosome regulate translocation. Nat Struct Mol Biol. 2010 Dec; 17(12):1470-7. PMID: 21057527.
      Citations: 61     Fields:    Translation:Cells
    36. Geggier P, Dave R, Feldman MB, Terry DS, Altman RB, Munro JB, Blanchard SC. Conformational sampling of aminoacyl-tRNA during selection on the bacterial ribosome. J Mol Biol. 2010 Jun 18; 399(4):576-95. PMID: 20434456.
      Citations: 75     Fields:    Translation:Cells
    37. Munro JB, Altman RB, Tung CS, Sanbonmatsu KY, Blanchard SC. A fast dynamic mode of the EF-G-bound ribosome. EMBO J. 2010 Feb 17; 29(4):770-81. PMID: 20033061.
      Citations: 48     Fields:    Translation:Cells
    38. Munro JB, Altman RB, Tung CS, Cate JH, Sanbonmatsu KY, Blanchard SC. Spontaneous formation of the unlocked state of the ribosome is a multistep process. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):709-14. PMID: 20018653.
      Citations: 71     Fields:    Translation:Cells
    39. Munro JB, Sanbonmatsu KY, Spahn CM, Blanchard SC. Navigating the ribosome's metastable energy landscape. Trends Biochem Sci. 2009 Aug; 34(8):390-400. PMID: 19647434.
      Citations: 71     Fields:    Translation:Cells
    40. Dave R, Terry DS, Munro JB, Blanchard SC. Mitigating unwanted photophysical processes for improved single-molecule fluorescence imaging. Biophys J. 2009 Mar 18; 96(6):2371-81. PMID: 19289062.
      Citations: 96     Fields:    Translation:Cells
    41. Munro JB, Vaiana A, Sanbonmatsu KY, Blanchard SC. A new view of protein synthesis: mapping the free energy landscape of the ribosome using single-molecule FRET. Biopolymers. 2008 Jul; 89(7):565-77. PMID: 18286627.
      Citations: 28     Fields:    Translation:Cells
    42. Munro JB, Altman RB, O'Connor N, Blanchard SC. Identification of two distinct hybrid state intermediates on the ribosome. Mol Cell. 2007 Feb 23; 25(4):505-17. PMID: 17317624.
      Citations: 160     Fields:    Translation:Cells
    43. Bleuit JS, Ma Y, Munro J, Morrical SW. Mutations in a conserved motif inhibit single-stranded DNA binding and recombination mediator activities of bacteriophage T4 UvsY protein. J Biol Chem. 2004 Feb 13; 279(7):6077-86. PMID: 14634008.
      Citations: 11     Fields:    Translation:Cells
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