James B Munro PhD
Title | Associate Professor |
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Institution | University of Massachusetts Medical School |
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Department | Microbiology and Physiological Systems |
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Address | University of Massachusetts Medical School 368 Plantation Street, AS8-1055 Worcester MA 01605
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Phone | 774-455-4754 |
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vCard | Download vCard |
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Institution | UMMS - School of Medicine |
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Department | Biochemistry and Molecular Pharmacology |
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Institution | UMMS - School of Medicine |
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Department | Microbiology and Physiological Systems |
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ORNG Applications Biography Middlebury College, Middlebury, VT, United States | BA | | Physics | Yale University, New Haven, CT | Postdoc | 07/2014 | Virology/biophysics | University of Chicago, Chicago, IL, United States | MS | | Physics | Cornell University, New York, NY | Ph.D. | 05/2010 | Biophysics | Cornell University, Ithaca, NY, United States | PHD | | Biophysics | University of Chicago, Chicago, IL | M.S. | 05/2004 | Physics | Middlebury College, Middlebury, VT | B.A. | 05/2002 | Physics/mathematics |
2015 - 2020 | NIH Director's New Innovator Award, NIAID/NIH | 2016 - 2018 | Gilead Research Scholar in HIV, Gilead Sciences |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Yurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina NV, Shen K, Luban J. Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. Cell. 2020 Sep 15. PMID: 32991842.
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Bulow U, Govindan R, Munro JB. Acidic pH Triggers Lipid Mixing Mediated by Lassa Virus GP. Viruses. 2020 Jul 02; 12(7). PMID: 32630688.
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Joshi VR, Newman RM, Pack ML, Power KA, Munro JB, Okawa K, Madani N, Sodroski JG, Schmidt AG, Allen TM. Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein. PLoS Pathog. 2020 May 11; 16(5):e1008577. PMID: 32392227.
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Das DK, Bulow U, Diehl WE, Durham ND, Senjobe F, Chandran K, Luban J, Munro JB. Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding. PLoS Biol. 2020 Feb 10; 18(2):e3000626. PMID: 32040508.
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Durham ND, Howard AR, Govindan R, Senjobe F, Fels JM, Diehl WE, Luban J, Chandran K, Munro JB. Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics. Viruses. 2020 Jan 15; 12(1). PMID: 31952255.
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Howard AR, Munro JB. Developments in single-molecule and single-particle fluorescence-based approaches for studying viral envelope glycoprotein dynamics and membrane fusion. Adv Virus Res. 2019; 104:123-146. PMID: 31439147.
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Brigham BS, Kitzrow JP, Reyes JC, Musier-Forsyth K, Munro JB. Intrinsic conformational dynamics of the HIV-1 genomic RNA 5'UTR. Proc Natl Acad Sci U S A. 2019 May 21; 116(21):10372-10381. PMID: 31068467.
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Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB. An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity. Cell Host Microbe. 2019 Apr 10; 25(4):578-587.e5. PMID: 30974085.
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Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Nikic-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W. Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET. Nature. 2019 Apr; 568(7752):415-419. PMID: 30971821.
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Das DK, Govindan R, Nikic-Spiegel I, Krammer F, Lemke EA, Munro JB. Direct Visualization of the Conformational Dynamics of Single Influenza Hemagglutinin Trimers. Cell. 2018 08 09; 174(4):926-937.e12. PMID: 29961575.
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Munro JB. HIV Env on Lockdown. Cell Host Microbe. 2018 06 13; 23(6):699-701. PMID: 29902434.
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Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB, Mothes W. HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations. Elife. 2018 03 21; 7. PMID: 29561264.
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Munro JB, Lee KK. Probing Structural Variation and Dynamics in the HIV-1 Env Fusion Glycoprotein. Curr HIV Res. 2018; 16(1):5-12. PMID: 29268688.
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Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J. Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins. MBio. 2016 10 25; 7(5). PMID: 27795397.
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Kwon YD, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Schön A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD. Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. Nat Struct Mol Biol. 2015 Jul; 22(7):522-31. PMID: 26098315.
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Munro JB, Mothes W. Structure and Dynamics of the Native HIV-1 Env Trimer. J Virol. 2015 Jun; 89(11):5752-5. PMID: 25762739.
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Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB, Kwong PD, Blanchard SC, Mothes W. Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions. Science. 2014 Nov 07; 346(6210):759-63. PMID: 25298114.
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Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD. Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 2014 Oct 23; 514(7523):455-61. PMID: 25296255.
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Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro JB, Huang F, Floyd RW, Yang H, Hamilton WL, Bewersdorf J, Xiong Y, Calderwood DA, Mothes W. TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly. J Cell Sci. 2014 Sep 15; 127(Pt 18):3928-42. PMID: 25015296.
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Munro JB, Mothes W. The HIV-1 Env trimer in HD. Structure. 2014 Jul 08; 22(7):935-6. PMID: 25007222.
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Agosto LM, Zhong P, Munro J, Mothes W. Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission. PLoS Pathog. 2014 Feb; 10(2):e1003982. PMID: 24586176.
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Munro JB, Nath A, Färber M, Datta SA, Rein A, Rhoades E, Mothes W. A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles. J Virol. 2014 Mar; 88(6):3577-85. PMID: 24403576.
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Zhong P, Agosto LM, Munro JB, Mothes W. Cell-to-cell transmission of viruses. Curr Opin Virol. 2013 Feb; 3(1):44-50. PMID: 23219376.
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Budkevich T, Giesebrecht J, Altman RB, Munro JB, Mielke T, Nierhaus KH, Blanchard SC, Spahn CM. Structure and dynamics of the mammalian ribosomal pretranslocation complex. Mol Cell. 2011 Oct 21; 44(2):214-24. PMID: 22017870.
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Fu J, Munro JB, Blanchard SC, Frank J. Cryoelectron microscopy structures of the ribosome complex in intermediate states during tRNA translocation. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):4817-21. PMID: 21383139.
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Munro JB, Wasserman MR, Altman RB, Wang L, Blanchard SC. Correlated conformational events in EF-G and the ribosome regulate translocation. Nat Struct Mol Biol. 2010 Dec; 17(12):1470-7. PMID: 21057527.
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Geggier P, Dave R, Feldman MB, Terry DS, Altman RB, Munro JB, Blanchard SC. Conformational sampling of aminoacyl-tRNA during selection on the bacterial ribosome. J Mol Biol. 2010 Jun 18; 399(4):576-95. PMID: 20434456.
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Munro JB, Altman RB, Tung CS, Sanbonmatsu KY, Blanchard SC. A fast dynamic mode of the EF-G-bound ribosome. EMBO J. 2010 Feb 17; 29(4):770-81. PMID: 20033061.
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Munro JB, Altman RB, Tung CS, Cate JH, Sanbonmatsu KY, Blanchard SC. Spontaneous formation of the unlocked state of the ribosome is a multistep process. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):709-14. PMID: 20018653.
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Munro JB, Sanbonmatsu KY, Spahn CM, Blanchard SC. Navigating the ribosome's metastable energy landscape. Trends Biochem Sci. 2009 Aug; 34(8):390-400. PMID: 19647434.
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Dave R, Terry DS, Munro JB, Blanchard SC. Mitigating unwanted photophysical processes for improved single-molecule fluorescence imaging. Biophys J. 2009 Mar 18; 96(6):2371-81. PMID: 19289062.
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Munro JB, Vaiana A, Sanbonmatsu KY, Blanchard SC. A new view of protein synthesis: mapping the free energy landscape of the ribosome using single-molecule FRET. Biopolymers. 2008 Jul; 89(7):565-77. PMID: 18286627.
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Munro JB, Altman RB, O'Connor N, Blanchard SC. Identification of two distinct hybrid state intermediates on the ribosome. Mol Cell. 2007 Feb 23; 25(4):505-17. PMID: 17317624.
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Bleuit JS, Ma Y, Munro J, Morrical SW. Mutations in a conserved motif inhibit single-stranded DNA binding and recombination mediator activities of bacteriophage T4 UvsY protein. J Biol Chem. 2004 Feb 13; 279(7):6077-86. PMID: 14634008.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2003 | 1 | 2007 | 1 | 2008 | 1 | 2009 | 4 | 2010 | 2 | 2011 | 2 | 2012 | 1 | 2014 | 6 | 2015 | 2 | 2016 | 1 | 2018 | 4 | 2019 | 4 | 2020 | 5 |
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