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James B Munro PhD

TitleAssociate Professor
InstitutionUMass Chan Medical School
DepartmentMicrobiology
AddressUMass Chan Medical School
368 Plantation Street AS8-1055
Worcester MA 01605
Phone774-455-4754
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiophysical Chemical and Computational Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program


    Collapse Biography 
    Collapse education and training
    Middlebury College, Middlebury, VT, United StatesBAPhysics
    Yale University, New Haven, CTPostdoc07/2014Virology/biophysics
    University of Chicago, Chicago, IL, United StatesMSPhysics
    Cornell University, New York, NYPh.D.05/2010Biophysics
    University of Chicago, Chicago, ILM.S.05/2004Physics
    Middlebury College, Middlebury, VTB.A.05/2002Physics/mathematics
    Cornell University, Ithaca, NY, United StatesPHDBiophysics
    Collapse awards and honors
    2015 - 2020NIH Director's New Innovator Award, NIAID/NIH
    2016 - 2018Gilead Research Scholar in HIV, Gilead Sciences

    Collapse Overview 
    Collapse Summary
    Focus: The Munro laboratory develops and applies quantitative biophysical approaches to visualize virus replication, and probe the functions of the proteins and RNAs involved.
    Collapse webpage

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dey S, Pahari P, Mukherjee S, Munro JB, Das DK. Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution. Structure. 2024 Dec 05; 32(12):2449. PMID: 39481372.
      Citations:    
    2. Huang QJ, Kim R, Song K, Grigorieff N, Munro JB, Schiffer CA, Somasundaran M. Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryo-electron tomography. bioRxiv. 2024 Oct 18. PMID: 39463923.
      Citations:    
    3. Dey S, Pahari P, Mukherjee S, Munro JB, Das DK. Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution. Structure. 2024 Nov 07; 32(11):1910-1925.e6. PMID: 39366371.
      Citations:    
    4. Marchitto L, Richard J, Pr?vost J, Tauzin A, Yang D, Chiu T-J, Chen H-C, D?az-Salinas MA, Nayrac M, Benlarbi M, Beaudoin-Bussi?res G, Anand SP, Dionne K, B?langer ?, Chatterjee D, Medjahed H, Bourassa C, Tolbert WD, Hahn BH, Munro JB, Pazgier M, Smith AB, Finzi A. The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity. J Virol. 2024 Oct 22; 98(10):e0101624. PMID: 39248460.
      Citations:    
    5. Richard J, Grunst MW, Niu L, D?az-Salinas MA, Tolbert WD, Marchitto L, Zhou F, Bourassa C, Yang D, Chiu TJ, Chen HC, Benlarbi M, Gottumukkala S, Li W, Dionne K, B?langer ?, Chatterjee D, Medjahed H, Hendrickson WA, Sodroski J, Lang ZC, Morton AJ, Huang RK, Matthies D, Smith AB, Mothes W, Munro JB, Pazgier M, Finzi A. The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC. bioRxiv. 2024 Aug 27. PMID: 39253431.
      Citations:    
    6. D?az-Salinas MA, Chatterjee D, Nayrac M, Medjahed H, Pr?vost J, Pazgier M, Finzi A, Munro JB. Conformational dynamics of the HIV-1 envelope glycoprotein from CRF01_AE is associated with susceptibility to antibody-dependent cellular cytotoxicity. bioRxiv. 2024 Aug 22. PMID: 39229074.
      Citations:    
    7. D?az-Salinas MA, Jain A, Durham ND, Munro JB. Single-molecule imaging reveals allosteric stimulation of SARS-CoV-2 spike receptor binding domain by host sialic acid. Sci Adv. 2024 Jul 19; 10(29):eadk4920. PMID: 39018397.
      Citations:    
    8. Marchitto L, Richard J, Pr?vost J, Tauzin A, Yang D, Chiu T, Chen HC, D?az-Salinas MA, Nayrac M, Benlarbi M, Beaudoin-Bussi?res G, Anand SP, Dionne K, B?langer ?, Chatterjee D, Medjahed H, Bourassa C, Tolbert WD, Hahn BH, Munro JB, Pazgier M, Smith AB, Finzi A. The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity. bioRxiv. 2024 Jun 07. PMID: 38895270.
      Citations:    
    9. Vaknin A, Grossman A, Durham ND, Lupovitz I, Goren S, Golani G, Roichman Y, Munro JB, Sorkin R. Ebola Virus Glycoprotein Strongly Binds to Membranes in the Absence of Receptor Engagement. ACS Infect Dis. 2024 05 10; 10(5):1590-1601. PMID: 38684073.
      Citations:    
    10. Jain A, Govindan R, Berkman AR, Luban J, D?az-Salinas MA, Durham ND, Munro JB. Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome. PLoS Pathog. 2023 Dec; 19(12):e1011848. PMID: 38055723.
      Citations:    Fields:    Translation:HumansCells
    11. Jain A, Govindan R, Berkman A, Luban J, Durham ND, Munro J. Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome. bioRxiv. 2023 Oct 17. PMID: 36711925.
      Citations:    
    12. Chen C, Zhu R, Hodge EA, D?az-Salinas MA, Nguyen A, Munro JB, Lee KK. hACE2-Induced Allosteric Activation in SARS-CoV versus SARS-CoV-2 Spike Assemblies Revealed by Structural Dynamics. ACS Infect Dis. 2023 06 09; 9(6):1180-1189. PMID: 37166130.
      Citations: 4     Fields:    Translation:HumansCells
    13. Egri SB, Wang X, D?az-Salinas MA, Luban J, Dudkina NV, Munro JB, Shen K. Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination. Nat Commun. 2023 05 03; 14(1):2527. PMID: 37137903.
      Citations: 1     Fields:    Translation:HumansCells
    14. Yurkovetskiy L, Egri S, Kurhade C, Diaz-Salinas MA, Jaimes JA, Nyalile T, Xie X, Choudhary MC, Dauphin A, Li JZ, Munro JB, Shi PY, Shen K, Luban J. S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness. bioRxiv. 2023 Apr 24. PMID: 37034621.
      Citations:    
    15. Kumar MS, Stallworth KM, Murthy AC, Lim SM, Li N, Jain A, Munro JB, Fawzi NL, Lagier-Tourenne C, Bosco DA. Interactions between FUS and the C-terminal Domain of Nup62 are Sufficient for their Co-phase Separation into Amorphous Assemblies. J Mol Biol. 2023 03 15; 435(6):167972. PMID: 36690069.
      Citations: 1     Fields:    Translation:HumansCells
    16. Lai KK, Munro JB, Shi G, Majdoul S, Compton AA, Rein A. Restriction of Influenza A Virus by SERINC5. mBio. 2022 12 20; 13(6):e0292322. PMID: 36409124.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    17. D?az-Salinas MA, Li Q, Ejemel M, Yurkovetskiy L, Luban J, Shen K, Wang Y, Munro JB. Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike. Elife. 2022 03 24; 11. PMID: 35323111.
      Citations: 21     Fields:    Translation:HumansCells
    18. Blakemore RJ, Burnett C, Swanson C, Kharytonchyk S, Telesnitsky A, Munro JB. Stability and conformation of the dimeric HIV-1 genomic RNA 5'UTR. Biophys J. 2021 11 02; 120(21):4874-4890. PMID: 34529947.
      Citations: 7     Fields:    Translation:Cells
    19. Murray LP, Govindan R, Mora AC, Munro JB, Mace CR. Antibody affinity as a driver of signal generation in a paper-based immunoassay for Ebola virus surveillance. Anal Bioanal Chem. 2021 Jun; 413(14):3695-3706. PMID: 33852053.
      Citations:    Fields:    Translation:HumansCells
    20. Gao R, Yu CJ, Gao L, Piatkevich KD, Neve RL, Munro JB, Upadhyayula S, Boyden ES. A highly homogeneous polymer composed of tetrahedron-like monomers for high-isotropy expansion microscopy. Nat Nanotechnol. 2021 06; 16(6):698-707. PMID: 33782587.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    21. Yurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina NV, Shen K, Luban J. Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. Cell. 2020 10 29; 183(3):739-751.e8. PMID: 32991842.
      Citations: 567     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    22. Bulow U, Govindan R, Munro JB. Acidic pH Triggers Lipid Mixing Mediated by Lassa Virus GP. Viruses. 2020 07 02; 12(7). PMID: 32630688.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    23. Joshi VR, Newman RM, Pack ML, Power KA, Munro JB, Okawa K, Madani N, Sodroski JG, Schmidt AG, Allen TM. Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein. PLoS Pathog. 2020 05; 16(5):e1008577. PMID: 32392227.
      Citations: 1     Fields:    Translation:HumansCells
    24. Das DK, Bulow U, Diehl WE, Durham ND, Senjobe F, Chandran K, Luban J, Munro JB. Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding. PLoS Biol. 2020 02; 18(2):e3000626. PMID: 32040508.
      Citations: 41     Fields:    Translation:HumansCells
    25. Durham ND, Howard AR, Govindan R, Senjobe F, Fels JM, Diehl WE, Luban J, Chandran K, Munro JB. Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics. Viruses. 2020 01 15; 12(1). PMID: 31952255.
      Citations: 10     Fields:    Translation:HumansCells
    26. Howard AR, Munro JB. Developments in single-molecule and single-particle fluorescence-based approaches for studying viral envelope glycoprotein dynamics and membrane fusion. Adv Virus Res. 2019; 104:123-146. PMID: 31439147.
      Citations: 3     Fields:    Translation:Cells
    27. Brigham BS, Kitzrow JP, Reyes JC, Musier-Forsyth K, Munro JB. Intrinsic conformational dynamics of the HIV-1 genomic RNA 5'UTR. Proc Natl Acad Sci U S A. 2019 05 21; 116(21):10372-10381. PMID: 31068467.
      Citations: 19     Fields:    Translation:Cells
    28. Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Pr?vost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB. An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity. Cell Host Microbe. 2019 Apr 10; 25(4):578-587.e5. PMID: 30974085.
      Citations: 66     Fields:    Translation:HumansCells
    29. Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Nikic-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W. Associating HIV-1 envelope glycoprotein structures with states on the?virus observed by smFRET. Nature. 2019 04; 568(7752):415-419. PMID: 30971821.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    30. Das DK, Govindan R, Nikic-Spiegel I, Krammer F, Lemke EA, Munro JB. Direct Visualization of the Conformational Dynamics of Single Influenza Hemagglutinin Trimers. Cell. 2018 08 09; 174(4):926-937.e12. PMID: 29961575.
      Citations: 73     Fields:    Translation:HumansCells
    31. Munro JB. HIV Env on Lockdown. Cell Host Microbe. 2018 06 13; 23(6):699-701. PMID: 29902434.
      Citations:    Fields:    Translation:HumansCells
    32. Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB, Mothes W. HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations. Elife. 2018 03 21; 7. PMID: 29561264.
      Citations: 81     Fields:    Translation:HumansCells
    33. Munro JB, Lee KK. Probing Structural Variation and Dynamics in the HIV-1 Env Fusion Glycoprotein. Curr HIV Res. 2018; 16(1):5-12. PMID: 29268688.
      Citations: 7     Fields:    Translation:HumansCells
    34. Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J. Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins. mBio. 2016 10 25; 7(5). PMID: 27795397.
      Citations: 92     Fields:    Translation:HumansCells
    35. Kwon YD, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Sch?n A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD. Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. Nat Struct Mol Biol. 2015 Jul; 22(7):522-31. PMID: 26098315.
      Citations: 242     Fields:    Translation:HumansCells
    36. Munro JB, Mothes W. Structure and Dynamics of the Native HIV-1 Env Trimer. J Virol. 2015 Jun; 89(11):5752-5. PMID: 25762739.
      Citations: 47     Fields:    Translation:HumansCells
    37. Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB, Kwong PD, Blanchard SC, Mothes W. Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions. Science. 2014 Nov 07; 346(6210):759-63. PMID: 25298114.
      Citations: 309     Fields:    Translation:HumansCells
    38. Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD. Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 2014 Oct 23; 514(7523):455-61. PMID: 25296255.
      Citations: 497     Fields:    Translation:HumansCells
    39. Uchil PD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro JB, Huang F, Floyd RW, Yang H, Hamilton WL, Bewersdorf J, Xiong Y, Calderwood DA, Mothes W. TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly. J Cell Sci. 2014 Sep 15; 127(Pt 18):3928-42. PMID: 25015296.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    40. Munro JB, Mothes W. The HIV-1 Env trimer in HD. Structure. 2014 Jul 08; 22(7):935-6. PMID: 25007222.
      Citations: 3     Fields:    Translation:HumansCells
    41. Agosto LM, Zhong P, Munro J, Mothes W. Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission. PLoS Pathog. 2014 Feb; 10(2):e1003982. PMID: 24586176.
      Citations: 61     Fields:    Translation:HumansCells
    42. Munro JB, Nath A, F?rber M, Datta SA, Rein A, Rhoades E, Mothes W. A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles. J Virol. 2014 Mar; 88(6):3577-85. PMID: 24403576.
      Citations: 35     Fields:    Translation:HumansCells
    43. Zhong P, Agosto LM, Munro JB, Mothes W. Cell-to-cell transmission of viruses. Curr Opin Virol. 2013 Feb; 3(1):44-50. PMID: 23219376.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    44. Budkevich T, Giesebrecht J, Altman RB, Munro JB, Mielke T, Nierhaus KH, Blanchard SC, Spahn CM. Structure and dynamics of the mammalian ribosomal pretranslocation complex. Mol Cell. 2011 Oct 21; 44(2):214-24. PMID: 22017870.
      Citations: 69     Fields:    Translation:AnimalsCells
    45. Fu J, Munro JB, Blanchard SC, Frank J. Cryoelectron microscopy structures of the ribosome complex in intermediate states during tRNA translocation. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):4817-21. PMID: 21383139.
      Citations: 20     Fields:    Translation:Cells
    46. Munro JB, Wasserman MR, Altman RB, Wang L, Blanchard SC. Correlated conformational events in EF-G and the ribosome regulate translocation. Nat Struct Mol Biol. 2010 Dec; 17(12):1470-7. PMID: 21057527.
      Citations: 65     Fields:    Translation:Cells
    47. Geggier P, Dave R, Feldman MB, Terry DS, Altman RB, Munro JB, Blanchard SC. Conformational sampling of aminoacyl-tRNA during selection on the bacterial ribosome. J Mol Biol. 2010 Jun 18; 399(4):576-95. PMID: 20434456.
      Citations: 81     Fields:    Translation:Cells
    48. Munro JB, Altman RB, Tung CS, Sanbonmatsu KY, Blanchard SC. A fast dynamic mode of the EF-G-bound ribosome. EMBO J. 2010 Feb 17; 29(4):770-81. PMID: 20033061.
      Citations: 53     Fields:    Translation:Cells
    49. Munro JB, Altman RB, Tung CS, Cate JH, Sanbonmatsu KY, Blanchard SC. Spontaneous formation of the unlocked state of the ribosome is a multistep process. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):709-14. PMID: 20018653.
      Citations: 75     Fields:    Translation:Cells
    50. Munro JB, Sanbonmatsu KY, Spahn CM, Blanchard SC. Navigating the ribosome's metastable energy landscape. Trends Biochem Sci. 2009 Aug; 34(8):390-400. PMID: 19647434.
      Citations: 78     Fields:    Translation:Cells
    51. Dave R, Terry DS, Munro JB, Blanchard SC. Mitigating unwanted photophysical processes for improved single-molecule fluorescence imaging. Biophys J. 2009 Mar 18; 96(6):2371-81. PMID: 19289062.
      Citations: 103     Fields:    Translation:Cells
    52. Munro JB, Vaiana A, Sanbonmatsu KY, Blanchard SC. A new view of protein synthesis: mapping the free energy landscape of the ribosome using single-molecule FRET. Biopolymers. 2008 Jul; 89(7):565-77. PMID: 18286627.
      Citations: 28     Fields:    Translation:Cells
    53. Munro JB, Altman RB, O'Connor N, Blanchard SC. Identification of two distinct hybrid state intermediates on the ribosome. Mol Cell. 2007 Feb 23; 25(4):505-17. PMID: 17317624.
      Citations: 168     Fields:    Translation:Cells
    54. Bleuit JS, Ma Y, Munro J, Morrical SW. Mutations in a conserved motif inhibit single-stranded DNA binding and recombination mediator activities of bacteriophage T4 UvsY protein. J Biol Chem. 2004 Feb 13; 279(7):6077-86. PMID: 14634008.
      Citations: 11     Fields:    Translation:Cells
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