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Shyam Ajay Patel MD, PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentMedicine
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Phone774-442-6553
Email
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentMedicine
    DivisionHematology Oncology


    Collapse Biography 
    Collapse education and training
    Drexel University, Philadelphia, PA, United StatesBSBiological Sciences
    Stanford University, Stanford, CAFellowship2019Hematology
    Rutgers New Jersey Medical School, Newark, NJ, United StatesMD
    Stanford University, Stanford, CAFellowship2019Oncology
    Rutgers University Newark, Newark, NJ, United StatesPHDStem Cell Biology/Cancer Biolo
    Stanford University, Stanford, CAResidency2016Internal Medicine
    Rutgers - New Jersey Medical School, Newark, NJMD2013Medicine
    Rutgers - Graduate School of Biomedical Sciences, Newark, NJPhD2011Stem Cell Biology, Cancer Biology
    Collapse awards and honors
    2021Best Educator Award - Hematology/Oncology Fellowship, Univ. of Massachusetts Medical School
    2019Board Certification - ABIM Medical Oncology, Stanford University
    2019Board Certification - ABIM Hematology, Stanford University
    2018American Society of Hematology (ASH) Trainee Council - Appointed Member, Stanford University
    2018NIH T32 – Ruth L. Kirschstein Nat’l Research Service Award, Stanford University
    2017Nat’l Comprehensive Cancer Network (NCCN) Oncology Fellows Educational Grant, Stanford University
    2016Board Certification - ABIM Internal Medicine, Stanford University
    2013Merck Manual Award for Overall Academic Achievement, Rutgers - New Jersey Medical School
    2012American Society of Hematology (ASH) Trainee Research Award (HONORS Award), Rutgers - New Jersey Medical School
    2011Alpha Omega Alpha (AOA) Medical Honors Society - Junior Induction, Rutgers - New Jersey Medical School
    2010Alpha Omega Alpha (AOA) Medical Student Research Award, Rutgers - New Jersey Medical School
    2010The Dean Morris Schaffer Endowed Scholarship Fund, Rutgers - Graduate School of Biomedical Sciences
    2006The Dr. Wilhelm Frisell Award for Best Performance in Rutgers-NJMS Biochemistry, Rutgers - New Jersey Medical School
    2006Summa Cum Laude, Drexel University
    2006Best Poster Presentation, Eighth Annual Research Day, Drexel University
    2005The Damon M. Fellman, M.D. Scholarship, Hackensack University Medical Center
    2004The Alvin Seligson, M.D. Scholarship, Hackensack University Medical Center

    Collapse Overview 
    Collapse overview

    Dr. Patel attended Rutgers – New Jersey Medical School and Rutgers - Graduate School of Biomedical Sciences from 2006-13, where he completed the physician-scientist training program (PSTP). He trained in the disciplines of stem cell biology and cancer biology. His doctoral thesis focused on the mechanisms of breast cancer resistance to chemotherapy and breast cancer dormancy in the bone marrow. He then completed Internal Medicine residency at Stanford University (2013-16) and Hematology/Oncology fellowship at Stanford University (2016-19), during which time he studied the leukemic stem cell niche in acute myeloid leukemia (AML). He is board-certified in Internal Medicine (2016), Hematology (2019), and Medical Oncology (2019).

    His current research involves clinico-genomic profiling of mutation-specific cohorts of myelodysplastic syndrome and acute myeloid leukemia (Dalela et al., Abstract 1072; ASH 2020) (Narayanan et al., J Clin Oncol. 39 (suppl 15). Abstract e19007, 2021).

    Dr. Patel specializes in acute leukemia, myeloid malignancies, myelodysplastic syndrome, myeloproliferative neoplasms, lymphoma, and bone marrow (stem cell) transplant. He believes strongly in servant leadership and hopes to empower his patients through advocacy. He envisions that his translational research focus in hematologic malignancies will ultimately help provide precision therapies for his patients.




    Collapse Research 
    Collapse research activities and funding
    NIH T32     (Laboratory of Ravindra Majeti, MD, PhD, Stanford University)
    NIH
    Investigating Leukemia Stem Cell Niche Interactions in Acute Myeloid Leukemia

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wang X, Patel SA, Haddadin M, Cerny J. Post-allogeneic hematopoietic stem cell transplantation viral reactivations and viremias: a focused review on human herpesvirus-6, BK virus and adenovirus. Ther Adv Infect Dis. 2021 Jan-Dec; 8:20499361211018027. PMID: 34104434.
      View in: PubMed
    2. Sandiford OA, Donnelly RJ, El-Far M, Burgmeyer LM, Sinha G, Pamarthi SH, Sherman LS, Ferrer AI, DeVore DE, Patel SA, Naaldijk Y, Alonso S, Barak P, Bryan M, Ponzio NM, Narayanan R, Etchegaray JP, Kumar R, Rameshwar P. Mesenchymal stem cell-secreted extracellular vesicles instruct stepwise dedifferentiation of breast cancer cells into dormancy at the bone marrow perivascular region. Cancer Res. 2021 Jan 26. PMID: 33500249.
      View in: PubMed
    3. Dalela D, Bledsoe JR, Patel SA. Clonal IgH gene rearrangements identify Richter's transformation to diffuse large B cell lymphoma. Ann Hematol. 2020 Nov 07. PMID: 33159568.
      View in: PubMed
    4. Patel SA, Bledsoe JR, Gordon J, Cerny J. Extramedullary Acute Myeloid Leukemia of the Renal Pelvis: Insights into a Visceral Niche. Acta Haematol. 2020 Aug 19; 1-5. PMID: 32814320.
      View in: PubMed
    5. Azizi A, Ediriwickrema A, Dutta R, Patel SA, Shomali W, Medeiros B, Iberri D, Gotlib J, Mannis G, Greenberg P, Majeti R, Zhang T. Venetoclax and hypomethylating agent therapy in high risk myelodysplastic syndromes: a retrospective evaluation of a real-world experience. Leuk Lymphoma. 2020 Jun 16; 1-8. PMID: 32543932.
      View in: PubMed
    6. Patel SA, Gerber JM. A User's Guide to Novel Therapies for Acute Myeloid Leukemia. Clin Lymphoma Myeloma Leuk. 2020 Jan 30. PMID: 32113891.
      View in: PubMed
    7. Khan S, Choi J, Patel SA, Spain DA. Altered Mental Status and Hypercalcemia with a Splenic Mass. J Trauma Acute Care Surg. 2019 Oct 31. PMID: 31688787.
      View in: PubMed
    8. Patel SA. Myelodysplastic Syndrome and Acute Myeloid Leukemia Risk Associated With Solid Tumor Chemotherapy. JAMA Oncol. 2018 Dec 20. PMID: 30570644.
      View in: PubMed
    9. Patel SA, Longacre TA, Ladabaum U, Lebensohn A, Lin AY, Haraldsdottir S. Tumor Molecular Testing Guides Anti-PD-1 Therapy and Provides Evidence for Pathogenicity of Mismatch Repair Variants. Oncologist. 2018 Dec; 23(12):1395-1400. PMID: 30072391.
      View in: PubMed
    10. Patel SA. Enasidenib-Induced Differentiation Syndrome in IDH2-Mutant Acute Myeloid Leukemia. JAMA Oncol. 2018 Aug 01; 4(8):1110-1111. PMID: 29346477.
      View in: PubMed
    11. Silverio KA, Patel SA. Harnessing antitumor immunity: Employment of tumor recall antigens to optimize the inflammatory response to cancer. Oncol Lett. 2017 Apr; 13(4):2015-2020. PMID: 28454356.
      View in: PubMed
    12. Patel SA. Acute Myeloid Leukemia Relapse Presenting as Complete Monocular Vision Loss due to Optic Nerve Involvement. Case Rep Hematol. 2016; 2016:3794284. PMID: 27668104.
      View in: PubMed
    13. Silverio KA, Patel SA. Progressive Multifocal Leukoencephalopathy with Negative JC Virus PCR following Treatment of Follicular Lymphoma: Implications for Biologics in the Era of Targeted Cancer Therapy. Case Rep Oncol Med. 2015; 2015:534529. PMID: 26788389.
      View in: PubMed
    14. Patel SA. The inferior vena cava (IVC) syndrome as the initial manifestation of newly diagnosed gastric adenocarcinoma: a case report. J Med Case Rep. 2015 Sep 28; 9:204. PMID: 26411979.
      View in: PubMed
    15. Nahas GR, Murthy RG, Patel SA, Ganta T, Greco SJ, Rameshwar P. The RNA-binding protein Musashi 1 stabilizes the oncotachykinin 1 mRNA in breast cancer cells to promote cell growth. FASEB J. 2016 Jan; 30(1):149-59. PMID: 26373800.
      View in: PubMed
    16. Guiro K, Patel SA, Greco SJ, Rameshwar P, Arinzeh TL. Investigating breast cancer cell behavior using tissue engineering scaffolds. PLoS One. 2015; 10(3):e0118724. PMID: 25837691.
      View in: PubMed
    17. Patel SA, Dave MA, Bliss SA, Giec-Ujda AB, Bryan M, Pliner LF, Rameshwar P. Treg/Th17 polarization by distinct subsets of breast cancer cells is dictated by the interaction with mesenchymal stem cells. J Cancer Stem Cell Res. 2014 May 29; 2014(2). PMID: 25705705.
      View in: PubMed
    18. Desai MB, Gavrilova T, Liu J, Patel SA, Kartan S, Greco SJ, Capitle E, Rameshwar P. Pollen-induced antigen presentation by mesenchymal stem cells and T cells from allergic rhinitis. Clin Transl Immunology. 2013 Oct; 2(10):e7. PMID: 25505949.
      View in: PubMed
    19. Rasouli J, Patel SA, Skovrlj B, Gologorsky Y, Mascitelli J, Petersen B, Caridi J. Primary extranodal marginal zone lymphoma involving the skull. J Clin Neurosci. 2014 Feb; 21(2):351-3. PMID: 24094361.
      View in: PubMed
    20. Helmy KY, Patel SA, Nahas GR, Rameshwar P. Cancer immunotherapy: accomplishments to date and future promise. Ther Deliv. 2013 Oct; 4(10):1307-20. PMID: 24116914.
      View in: PubMed
    21. Park JM, Munoz JL, Won BW, Bliss SA, Greco SJ, Patel SA, Kandouz M, Rameshwar P. Exogenous CXCL12 activates protein kinase C to phosphorylate connexin 43 for gap junctional intercellular communication among confluent breast cancer cells. Cancer Lett. 2013 Apr 30; 331(1):84-91. PMID: 23262036.
      View in: PubMed
    22. Patel SA, Ramkissoon SH, Bryan M, Pliner LF, Dontu G, Patel PS, Amiri S, Pine SR, Rameshwar P. Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy. Sci Rep. 2012; 2:906. PMID: 23205268.
      View in: PubMed
    23. Navarro P, Ramkissoon SH, Shah S, Park JM, Murthy RG, Patel SA, Greco SJ, Rameshwar P. An indirect role for oncomir-519b in the expression of truncated neurokinin-1 in breast cancer cells. Exp Cell Res. 2012 Dec 10; 318(20):2604-15. PMID: 22981979.
      View in: PubMed
    24. Munoz JL, Greco SJ, Patel SA, Sherman LS, Bhatt S, Bhatt RS, Shrensel JA, Guan YZ, Xie G, Ye JH, Rameshwar P, Siegel A. Feline bone marrow-derived mesenchymal stromal cells (MSCs) show similar phenotype and functions with regards to neuronal differentiation as human MSCs. Differentiation. 2012 Sep; 84(2):214-22. PMID: 22824626.
      View in: PubMed
    25. Reddy BY, Lim PK, Silverio K, Patel SA, Won BW, Rameshwar P. The Microenvironmental Effect in the Progression, Metastasis, and Dormancy of Breast Cancer: A Model System within Bone Marrow. Int J Breast Cancer. 2012; 2012:721659. PMID: 22482060.
      View in: PubMed
    26. Greco SJ, Patel SA, Rameshwar P. A reporter assay to detect transfer and targeting of miRNAs in stem cell-breast cancer co-cultures. Methods Mol Biol. 2012; 879:195-201. PMID: 22610562.
      View in: PubMed
    27. Nahas GR, Patel SA, Bliss SA, Rameshwar P. Can breast cancer stem cells evade the immune system? Curr Med Chem. 2012; 19(35):6036-49. PMID: 22963570.
      View in: PubMed
    28. Kapoor S, Patel SA, Kartan S, Axelrod D, Capitle E, Rameshwar P. Tolerance-like mediated suppression by mesenchymal stem cells in patients with dust mite allergy-induced asthma. J Allergy Clin Immunol. 2012 Apr; 129(4):1094-101. PMID: 22196773.
      View in: PubMed
    29. Sherman LS, Munoz J, Patel SA, Dave MA, Paige I, Rameshwar P. Moving from the laboratory bench to patients' bedside: considerations for effective therapy with stem cells. Clin Transl Sci. 2011 Oct; 4(5):380-6. PMID: 22029813.
      View in: PubMed
    30. Patel SA, Rameshwar P. Stem Cell Transplantation for Hematological Malignancies: Prospects for Personalized Medicine and Co-therapy with Mesenchymal Stem Cells. Curr Pharmacogenomics Person Med. 2011 Sep 01; 9(3):229-239. PMID: 21892378.
      View in: PubMed
    31. Gregory LA, Ricart RA, Patel SA, Lim PK, Rameshwar P. microRNAs, Gap Junctional Intercellular Communication and Mesenchymal Stem Cells in Breast Cancer Metastasis. Curr Cancer Ther Rev. 2011 Aug; 7(3):176-183. PMID: 21886602.
      View in: PubMed
    32. Patel N, Klassert TE, Greco SJ, Patel SA, Munoz JL, Reddy BY, Bryan M, Campbell N, Kokorina N, Sabaawy HE, Rameshwar P. Developmental regulation of TAC1 in peptidergic-induced human mesenchymal stem cells: implication for spinal cord injury in zebrafish. Stem Cells Dev. 2012 Jan 20; 21(2):308-20. PMID: 21671725.
      View in: PubMed
    33. Greco SJ, Patel SA, Bryan M, Pliner LF, Banerjee D, Rameshwar P. AMD3100-mediated production of interleukin-1 from mesenchymal stem cells is key to chemosensitivity of breast cancer cells. Am J Cancer Res. 2011; 1(6):701-15. PMID: 22016821.
      View in: PubMed
    34. Patel SA, Dave MA, Murthy RG, Helmy KY, Rameshwar P. Metastatic breast cancer cells in the bone marrow microenvironment: novel insights into oncoprotection. Oncol Rev. 2011 Jun 01; 5(2):93-102. PMID: 21776337.
      View in: PubMed
    35. Lim PK, Bliss SA, Patel SA, Taborga M, Dave MA, Gregory LA, Greco SJ, Bryan M, Patel PS, Rameshwar P. Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells. Cancer Res. 2011 Mar 01; 71(5):1550-60. PMID: 21343399.
      View in: PubMed
    36. Helmy KY, Patel SA, Silverio K, Pliner L, Rameshwar P. Stem cells and regenerative medicine: accomplishments to date and future promise. Ther Deliv. 2010 Nov; 1(5):693-705. PMID: 21113422.
      View in: PubMed
    37. Patel SA, Meyer JR, Greco SJ, Corcoran KE, Bryan M, Rameshwar P. Mesenchymal stem cells protect breast cancer cells through regulatory T cells: role of mesenchymal stem cell-derived TGF-beta. J Immunol. 2010 May 15; 184(10):5885-94. PMID: 20382885.
      View in: PubMed
    38. Klassert TE, Patel SA, Rameshwar P. Tachykinins and Neurokinin Receptors in Bone Marrow Functions: Neural-Hematopoietic Link. J Receptor Ligand Channel Res. 2010 Apr 01; 2010(3):51-61. PMID: 20593004.
      View in: PubMed
    39. Patel SA, Ndabahaliye A, Lim PK, Milton R, Rameshwar P. Challenges in the development of future treatments for breast cancer stem cells. Breast Cancer (Dove Med Press). 2010; 2:1-11. PMID: 25114585.
      View in: PubMed
    40. Patel SA, Heinrich AC, Reddy BY, Rameshwar P. Inflammatory mediators: Parallels between cancer biology and stem cell therapy. J Inflamm Res. 2009 Jan 01; 2:13-19. PMID: 20428325.
      View in: PubMed
    41. Heinrich AC, Patel SA, Reddy BY, Milton R, Rameshwar P. Multi- and inter-disciplinary science in personalized delivery of stem cells for tissue repair. Curr Stem Cell Res Ther. 2009 Jan; 4(1):16-22. PMID: 19149626.
      View in: PubMed
    42. Patel SA, Heinrich AC, Reddy BY, Srinivas B, Heidaran N, Rameshwar P. Breast cancer biology: the multifaceted roles of mesenchymal stem cells. J Oncol. 2008; 2008:425895. PMID: 19277104.
      View in: PubMed
    43. Patel SA, Sherman L, Munoz J, Rameshwar P. Immunological properties of mesenchymal stem cells and clinical implications. Arch Immunol Ther Exp (Warsz). 2008 Jan-Feb; 56(1):1-8. PMID: 18250975.
      View in: PubMed
    44. Zhang C, Khandelwal PJ, Chakraborty R, Cuellar TL, Sarangi S, Patel SA, Cosentino CP, O'Connor M, Lee JC, Tanzi RE, Saunders AJ. An AICD-based functional screen to identify APP metabolism regulators. Mol Neurodegener. 2007 Aug 24; 2:15. PMID: 17718916.
      View in: PubMed
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