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Shyam Ajay Patel MD, PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone774-442-6553
Email
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionHematology/Oncology


    Collapse Biography 
    Collapse education and training
    Drexel University, Philadelphia, PA, United StatesBSBiological Sciences
    Stanford University, Stanford, CAResidency2016Internal Medicine
    Stanford University, Stanford, CAFellowship2019Hematology
    Rutgers - New Jersey Medical School, Newark, NJMD2013Medicine
    Stanford University, Stanford, CAFellowship2019Oncology
    Rutgers New Jersey Medical School, Newark, NJ, United StatesMD
    Rutgers University Newark, Newark, NJ, United StatesPHDStem Cell Biology/Cancer Biolo
    Rutgers - Graduate School of Biomedical Sciences, Newark, NJPhD2011Stem Cell Biology, Cancer Biology
    Collapse awards and honors
    202340 Under 40, Drexel University
    2022CCTS Pilot Project Program Award, UMass Chan Medical School
    2021Best Educator Award - Hematology/Oncology Fellowship, UMass Chan Medical School
    2019Board Certification - ABIM Medical Oncology, Stanford University
    2019Board Certification - ABIM Hematology, Stanford University
    2018American Society of Hematology (ASH) Trainee Council - Appointed Member, Stanford University
    2018NIH T32 – Ruth L. Kirschstein Nat’l Research Service Award, Stanford University
    2017Nat’l Comprehensive Cancer Network (NCCN) Oncology Fellows Educational Grant, Stanford University
    2016Board Certification - ABIM Internal Medicine, Stanford University
    2013Merck Manual Award for Overall Academic Achievement, Rutgers - New Jersey Medical School
    2012American Society of Hematology (ASH) Trainee Research Award (HONORS Award), Rutgers - New Jersey Medical School
    2011Alpha Omega Alpha (AOA) Medical Honors Society - Junior Induction, Rutgers - New Jersey Medical School
    2010Alpha Omega Alpha (AOA) Medical Student Research Award, Rutgers - New Jersey Medical School
    2010The Dean Morris Schaffer Endowed Scholarship Fund, Rutgers - Graduate School of Biomedical Sciences
    2006The Dr. Wilhelm Frisell Award for Best Performance in Rutgers-NJMS Biochemistry, Rutgers - New Jersey Medical School
    2006Summa Cum Laude, Drexel University
    2006Best Poster Presentation, Eighth Annual Research Day, Drexel University
    2005The Damon M. Fellman, M.D. Scholarship, Hackensack University Medical Center
    2004The Alvin Seligson, M.D. Scholarship, Hackensack University Medical Center

    Collapse Overview 
    Collapse overview

    Dr. Patel attended Rutgers – New Jersey Medical School and Rutgers - Graduate School of Biomedical Sciences from 2006-13, where he completed the physician-scientist training program (PSTP). He trained in the disciplines of stem cell biology and cancer biology. His prior research focused on breast cancer dormancy in the bone marrow. He then completed Internal Medicine residency at Stanford University (2013-16) and Hematology/Oncology fellowship at Stanford University (2016-19), during which time he studied the leukemic stem cell niche in acute myeloid leukemia (AML). He is board-certified in Internal Medicine (2016), Hematology (2019), and Medical Oncology (2019).

    His current research involves understanding the disease biology and clonal dynamics of TP53-mutant MDS and AML, as well as the genomics of clonal hematopoiesis (Patel SA et al., Br J Haematol 2024).

    The Darkest Side of AML: The TP53 Mutation (umassmed.edu)

    Dr. Patel is part of the hematologic malignancies and stem cell transplant team that treats acute leukemia, myeloid malignancies, myelodysplastic syndrome, myeloproliferative neoplasms, lymphoma, and multiple myeloma.



    Collapse Research 
    Collapse research activities and funding
    NIH T32     Feb 1, 2018 - Jan 31, 2019
    NIH
    Investigating Leukemia Stem Cell Niche Interactions in Acute Myeloid Leukemia
    Role Description: Laboratory of Ravindra Majeti, MD, PhD, Stanford University
    UL1TR001453     Jun 1, 2022 - May 31, 2023
    NIH / National Center for Advancing Translational Sciences (NCATS): UMass CCTS 2022 Pilot Project Program
    Clinical Translation of an Innovative Leukemia Stem Cell Assay for Detection, Prognostication, and Precision Management of Blood Cancer
    Role Description: Laboratory of Dr. Jonathan Gerber, UMass Chan Medical School

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Patel SA. Managing the unmanageable: evidence-driven approaches to real-world patient prototypes of TP53-mutant myelodysplastic neoplasms and acute myeloid leukemia. Leukemia. 2024 Sep 30. PMID: 39349613.
      Citations:    
    2. Xie Y, Kazakova V, Weeks LD, Gerber JM, Tai J, Zhang TY, Lowsky R, Wu X, Yang C, Patel SA. Effects of donor-engrafted clonal hematopoiesis in allogeneic and autologous stem cell transplantation: a systematic review and meta-analysis. Bone Marrow Transplant. 2024 Aug 25. PMID: 39183321.
      Citations:    
    3. Yaniv B, Tanenbaum B, Kazakova V, Patel SA. Translational insights into the genetics and immunobiology of relapsed/refractory follicular lymphoma. Leuk Res. 2024 Jul; 142:107519. PMID: 38761562.
      Citations:    
    4. Ferrer-Diaz AI, Sinha G, Petryna A, Gonzalez-Bermejo R, Kenfack Y, Adetayo O, Patel SA, Hooda-Nehra A, Rameshwar P. Revealing role of epigenetic modifiers and DNA oxidation in cell-autonomous regulation of Cancer stem cells. Cell Commun Signal. 2024 02 12; 22(1):119. PMID: 38347590.
      Citations:    
    5. Patel SA. The heart of VIALE-A: Cardiac complications of hypomethylating agents and venetoclax in acute myeloid leukaemia. Br J Haematol. 2024 Apr; 204(4):1137-1138. PMID: 38339780.
      Citations:    Fields:    
    6. Kennedy A, Patel S, Ramanathan M, Gerber J, Cerny J. Midostaurin for FLT3-mutated AML: a real-world analysis of effectiveness and infection risk at a single center. Ann Hematol. 2024 Mar; 103(3):1031-1033. PMID: 38195923.
      Citations:    Fields:    
    7. Arun Kumar S, Gao J, Patel SA. The shifting therapeutic paradigm for relapsed/refractory mantle cell lymphoma. Leuk Res. 2023 11; 134:107385. PMID: 37672954.
      Citations: 1     Fields:    Translation:Humans
    8. Gao J, Dahiya S, Patel SA. Challenges and solutions to superior chimeric antigen receptor-T design and deployment for B-cell lymphomas. Br J Haematol. 2023 10; 203(2):161-168. PMID: 37488074.
      Citations:    Fields:    Translation:Humans
    9. Patel SA. Precision and strategic targeting of novel mutation-specific vulnerabilities in acute myeloid leukemia: the semi-centennial of 7?+?3. Leuk Lymphoma. 2023 09; 64(9):1503-1513. PMID: 37328939.
      Citations:    Fields:    Translation:Humans
    10. Thomas E, Kennedy A, Walsh W, Carpentier M, Adeyinka H, Patel S, Gerber J, Cerny J, Mittal K. Telehealth through the pandemic at a safety net hospital: observations and next steps for cancer care delivery. Front Public Health. 2023; 11:1186350. PMID: 37333537.
      Citations:    Fields:    Translation:HumansPHPublic Health
    11. Tanenbaum B, Miett T, Patel SA. The emerging therapeutic landscape of relapsed/refractory multiple myeloma. Ann Hematol. 2023 Jan; 102(1):1-11. PMID: 36462062.
      Citations: 4     Fields:    
    12. Patel SA, Cerny J. TP53-mutant myelodysplastic syndrome and acute myeloid leukemia: the black hole of hematology. Blood Adv. 2022 03 22; 6(6):1917-1918. PMID: 35090167.
      Citations: 5     Fields:    Translation:Humans
    13. Patel SA. Functional genomic approaches in acute myeloid leukemia: Insights into disease models and the therapeutic potential of reprogramming. Cancer Lett. 2022 05 01; 533:215579. PMID: 35124146.
      Citations:    Fields:    Translation:HumansCells
    14. Sandiford OA, Donnelly RJ, El-Far MH, Burgmeyer LM, Sinha G, Pamarthi SH, Sherman LS, Ferrer AI, DeVore DE, Patel SA, Naaldijk Y, Alonso S, Barak P, Bryan M, Ponzio NM, Narayanan R, Etchegaray JP, Kumar R, Rameshwar P. Mesenchymal Stem Cell-Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region. Cancer Res. 2021 03 15; 81(6):1567-1582. PMID: 33500249.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    15. Dalela D, Bledsoe JR, Patel SA. Clonal IgH gene rearrangements identify Richter's transformation to diffuse large B cell lymphoma. Ann Hematol. 2021 Dec; 100(12):3075-3077. PMID: 33159568.
      Citations:    Fields:    Translation:Humans
    16. Patel SA, Bledsoe JR, Gordon J, Cerny J. Extramedullary Acute Myeloid Leukemia of the Renal Pelvis: Insights into a Visceral Niche. Acta Haematol. 2021; 144(3):297-301. PMID: 32814320.
      Citations:    Fields:    Translation:Humans
    17. Azizi A, Ediriwickrema A, Dutta R, Patel SA, Shomali W, Medeiros B, Iberri D, Gotlib J, Mannis G, Greenberg P, Majeti R, Zhang T. Venetoclax and hypomethylating agent therapy in high risk myelodysplastic syndromes: a retrospective evaluation of a real-world experience. Leuk Lymphoma. 2020 11; 61(11):2700-2707. PMID: 32543932.
      Citations: 10     Fields:    Translation:Humans
    18. Khan S, Choi J, Patel SA, Spain DA. Altered mental status and hypercalcemia with a splenic mass. J Trauma Acute Care Surg. 2020 03; 88(3):e114-e115. PMID: 31688787.
      Citations:    Fields:    Translation:Humans
    19. Patel SA, Gerber JM. A User's Guide to Novel Therapies for Acute Myeloid Leukemia. Clin Lymphoma Myeloma Leuk. 2020 05; 20(5):277-288. PMID: 32113891.
      Citations: 10     Fields:    Translation:Humans
    20. Patel SA. Myelodysplastic Syndrome and Acute Myeloid Leukemia Risk Associated With Solid Tumor Chemotherapy. JAMA Oncol. 2019 03 01; 5(3):303-304. PMID: 30570644.
      Citations: 4     Fields:    Translation:Humans
    21. Patel SA, Longacre TA, Ladabaum U, Lebensohn A, Lin AY, Haraldsdottir S. Tumor Molecular Testing Guides Anti-PD-1 Therapy and Provides Evidence for Pathogenicity of Mismatch Repair Variants. Oncologist. 2018 12; 23(12):1395-1400. PMID: 30072391.
      Citations: 3     Fields:    Translation:HumansCells
    22. Patel SA. Enasidenib-Induced Differentiation Syndrome in IDH2-Mutant Acute Myeloid Leukemia. JAMA Oncol. 2018 08 01; 4(8):1110-1111. PMID: 29346477.
      Citations: 2     Fields:    Translation:Humans
    23. Silverio KA, Patel SA. Harnessing antitumor immunity: Employment of tumor recall antigens to optimize the inflammatory response to cancer. Oncol Lett. 2017 Apr; 13(4):2015-2020. PMID: 28454356.
      Citations:    
    24. Patel SA. Acute Myeloid Leukemia Relapse Presenting as Complete Monocular Vision Loss due to Optic Nerve Involvement. Case Rep Hematol. 2016; 2016:3794284. PMID: 27668104.
      Citations:    
    25. Silverio KA, Patel SA. Progressive Multifocal Leukoencephalopathy with Negative JC Virus PCR following Treatment of Follicular Lymphoma: Implications for Biologics in the Era of Targeted Cancer Therapy. Case Rep Oncol Med. 2015; 2015:534529. PMID: 26788389.
      Citations:    
    26. Patel SA. The inferior vena cava (IVC) syndrome as the initial manifestation of newly diagnosed gastric adenocarcinoma: a case report. J Med Case Rep. 2015 Sep 28; 9:204. PMID: 26411979.
      Citations: 5     Fields:    Translation:Humans
    27. Nahas GR, Murthy RG, Patel SA, Ganta T, Greco SJ, Rameshwar P. The RNA-binding protein Musashi 1 stabilizes the oncotachykinin 1 mRNA in breast cancer cells to promote cell growth. FASEB J. 2016 Jan; 30(1):149-59. PMID: 26373800.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    28. Guiro K, Patel SA, Greco SJ, Rameshwar P, Arinzeh TL. Investigating breast cancer cell behavior using tissue engineering scaffolds. PLoS One. 2015; 10(3):e0118724. PMID: 25837691.
      Citations: 16     Fields:    Translation:HumansCells
    29. Patel SA, Dave MA, Bliss SA, Giec-Ujda AB, Bryan M, Pliner LF, Rameshwar P. Treg/Th17 polarization by distinct subsets of breast cancer cells is dictated by the interaction with mesenchymal stem cells. J Cancer Stem Cell Res. 2014 May 29; 2014(2). PMID: 25705705.
      Citations:    
    30. Desai MB, Gavrilova T, Liu J, Patel SA, Kartan S, Greco SJ, Capitle E, Rameshwar P. Pollen-induced antigen presentation by mesenchymal stem cells and T cells from allergic rhinitis. Clin Transl Immunology. 2013 Oct; 2(10):e7. PMID: 25505949.
      Citations:    
    31. Rasouli J, Patel SA, Skovrlj B, Gologorsky Y, Mascitelli J, Petersen B, Caridi J. Primary extranodal marginal zone lymphoma involving the skull. J Clin Neurosci. 2014 Feb; 21(2):351-3. PMID: 24094361.
      Citations: 1     Fields:    Translation:Humans
    32. Helmy KY, Patel SA, Nahas GR, Rameshwar P. Cancer immunotherapy: accomplishments to date and future promise. Ther Deliv. 2013 Oct; 4(10):1307-20. PMID: 24116914.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    33. Park JM, Munoz JL, Won BW, Bliss SA, Greco SJ, Patel SA, Kandouz M, Rameshwar P. Exogenous CXCL12 activates protein kinase C to phosphorylate connexin 43 for gap junctional intercellular communication among confluent breast cancer cells. Cancer Lett. 2013 Apr 30; 331(1):84-91. PMID: 23262036.
      Citations: 15     Fields:    Translation:HumansCells
    34. Patel SA, Ramkissoon SH, Bryan M, Pliner LF, Dontu G, Patel PS, Amiri S, Pine SR, Rameshwar P. Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy. Sci Rep. 2012; 2:906. PMID: 23205268.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    35. Navarro P, Ramkissoon SH, Shah S, Park JM, Murthy RG, Patel SA, Greco SJ, Rameshwar P. An indirect role for oncomir-519b in the expression of truncated neurokinin-1 in breast cancer cells. Exp Cell Res. 2012 Dec 10; 318(20):2604-15. PMID: 22981979.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    36. Munoz JL, Greco SJ, Patel SA, Sherman LS, Bhatt S, Bhatt RS, Shrensel JA, Guan YZ, Xie G, Ye JH, Rameshwar P, Siegel A. Feline bone marrow-derived mesenchymal stromal cells (MSCs) show similar phenotype and functions with regards to neuronal differentiation as human MSCs. Differentiation. 2012 Sep; 84(2):214-22. PMID: 22824626.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    37. Reddy BY, Lim PK, Silverio K, Patel SA, Won BW, Rameshwar P. The Microenvironmental Effect in the Progression, Metastasis, and Dormancy of Breast Cancer: A Model System within Bone Marrow. Int J Breast Cancer. 2012; 2012:721659. PMID: 22482060.
      Citations:    
    38. Greco SJ, Patel SA, Rameshwar P. A reporter assay to detect transfer and targeting of miRNAs in stem cell-breast cancer co-cultures. Methods Mol Biol. 2012; 879:195-201. PMID: 22610562.
      Citations: 2     Fields:    Translation:HumansCells
    39. Nahas GR, Patel SA, Bliss SA, Rameshwar P. Can breast cancer stem cells evade the immune system? Curr Med Chem. 2012; 19(35):6036-49. PMID: 22963570.
      Citations: 4     Fields:    Translation:HumansCells
    40. Kapoor S, Patel SA, Kartan S, Axelrod D, Capitle E, Rameshwar P. Tolerance-like mediated suppression by mesenchymal stem cells in patients with dust mite allergy-induced asthma. J Allergy Clin Immunol. 2012 Apr; 129(4):1094-101. PMID: 22196773.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    41. Sherman LS, Munoz J, Patel SA, Dave MA, Paige I, Rameshwar P. Moving from the laboratory bench to patients' bedside: considerations for effective therapy with stem cells. Clin Transl Sci. 2011 Oct; 4(5):380-6. PMID: 22029813.
      Citations: 13     Fields:    Translation:HumansCells
    42. Patel SA, Rameshwar P. Stem Cell Transplantation for Hematological Malignancies: Prospects for Personalized Medicine and Co-therapy with Mesenchymal Stem Cells. Curr Pharmacogenomics Person Med. 2011 Sep 01; 9(3):229-239. PMID: 21892378.
      Citations:    
    43. Gregory LA, Ricart RA, Patel SA, Lim PK, Rameshwar P. microRNAs, Gap Junctional Intercellular Communication and Mesenchymal Stem Cells in Breast Cancer Metastasis. Curr Cancer Ther Rev. 2011 Aug; 7(3):176-183. PMID: 21886602.
      Citations:    
    44. Patel N, Klassert TE, Greco SJ, Patel SA, Munoz JL, Reddy BY, Bryan M, Campbell N, Kokorina N, Sabaawy HE, Rameshwar P. Developmental regulation of TAC1 in peptidergic-induced human mesenchymal stem cells: implication for spinal cord injury in zebrafish. Stem Cells Dev. 2012 Jan 20; 21(2):308-20. PMID: 21671725.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    45. Greco SJ, Patel SA, Bryan M, Pliner LF, Banerjee D, Rameshwar P. AMD3100-mediated production of interleukin-1 from mesenchymal stem cells is key to chemosensitivity of breast cancer cells. Am J Cancer Res. 2011; 1(6):701-15. PMID: 22016821.
      Citations:    
    46. Patel SA, Dave MA, Murthy RG, Helmy KY, Rameshwar P. Metastatic breast cancer cells in the bone marrow microenvironment: novel insights into oncoprotection. Oncol Rev. 2011 Jun 01; 5(2):93-102. PMID: 21776337.
      Citations:    
    47. Lim PK, Bliss SA, Patel SA, Taborga M, Dave MA, Gregory LA, Greco SJ, Bryan M, Patel PS, Rameshwar P. Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells. Cancer Res. 2011 Mar 01; 71(5):1550-60. PMID: 21343399.
      Citations: 223     Fields:    Translation:HumansCells
    48. Helmy KY, Patel SA, Silverio K, Pliner L, Rameshwar P. Stem cells and regenerative medicine: accomplishments to date and future promise. Ther Deliv. 2010 Nov; 1(5):693-705. PMID: 21113422.
      Citations: 15     Fields:    Translation:HumansCells
    49. Patel SA, Meyer JR, Greco SJ, Corcoran KE, Bryan M, Rameshwar P. Mesenchymal stem cells protect breast cancer cells through regulatory T cells: role of mesenchymal stem cell-derived TGF-beta. J Immunol. 2010 May 15; 184(10):5885-94. PMID: 20382885.
      Citations: 166     Fields:    Translation:HumansAnimalsCells
    50. Klassert TE, Patel SA, Rameshwar P. Tachykinins and Neurokinin Receptors in Bone Marrow Functions: Neural-Hematopoietic Link. J Receptor Ligand Channel Res. 2010 Apr 01; 2010(3):51-61. PMID: 20593004.
      Citations:    
    51. Patel SA, Ndabahaliye A, Lim PK, Milton R, Rameshwar P. Challenges in the development of future treatments for breast cancer stem cells. Breast Cancer (Dove Med Press). 2010; 2:1-11. PMID: 25114585.
      Citations:    
    52. Patel SA, Heinrich AC, Reddy BY, Rameshwar P. Inflammatory mediators: Parallels between cancer biology and stem cell therapy. J Inflamm Res. 2009 01 01; 2:13-19. PMID: 20428325.
      Citations:    
    53. Heinrich AC, Patel SA, Reddy BY, Milton R, Rameshwar P. Multi- and inter-disciplinary science in personalized delivery of stem cells for tissue repair. Curr Stem Cell Res Ther. 2009 Jan; 4(1):16-22. PMID: 19149626.
      Citations: 4     Fields:    Translation:HumansCells
    54. Patel SA, Heinrich AC, Reddy BY, Srinivas B, Heidaran N, Rameshwar P. Breast cancer biology: the multifaceted roles of mesenchymal stem cells. J Oncol. 2008; 2008:425895. PMID: 19277104.
      Citations:    
    55. Patel SA, Sherman L, Munoz J, Rameshwar P. Immunological properties of mesenchymal stem cells and clinical implications. Arch Immunol Ther Exp (Warsz). 2008 Jan-Feb; 56(1):1-8. PMID: 18250975.
      Citations: 56     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    56. Zhang C, Khandelwal PJ, Chakraborty R, Cuellar TL, Sarangi S, Patel SA, Cosentino CP, O'Connor M, Lee JC, Tanzi RE, Saunders AJ. An AICD-based functional screen to identify APP metabolism regulators. Mol Neurodegener. 2007 Aug 24; 2:15. PMID: 17718916.
      Citations: 26     Fields:    
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