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Tianle Zou MD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentPathology
AddressUMass Chan Medical School
One Innovation Drive
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentPathology
    DivisionAnatomic Pathology


    Collapse Biography 
    Collapse education and training
    State University of New York, Buffalo, Buffalo, NY, United StatesMS
    Wenzhou Medical College, China, , ChinaMD

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rawan Tahboub,Javier Sanchez-Ortiz,Mia Lai,Jennifer L. Clark, Tianle Zou. Something old, something new: Cervical cytopathology in the new era. Papanicolaou (Pap) smear on cervical cells heralded the revolution of modern cytopathology in the middle of the 19th century, and cervical screening is now considered one of medicine’s greatest success stories. While routine cervical cytology has significantly reduced the incidence of cervical cancer worldwide, it is not without limitations. Although the specificity of Pap smear to detect high-grade intraepithelial lesion (HSIL)/cervical intraepithelial neoplasia (CIN) 2–3 is consistently high, the sensitivity ranges broadly from 34 % to 94 % [1]. Given the rapid evolution in understanding the etiologic role of high-risk human papillomavirus (hrHPV) in cervical cancer development, the clinical guidelines have transitioned from “evidence-based” to “risk-stratified” algorithms. Primary hrHPV testing as a more sensitive test for high-risk cervical lesion (CIN2+) detection is considered the preferred screening test in some guidelines, but due to its low specificity, a follow-up triage test is needed to reduce unnecessary colposcopy referrals. Candidates for the triage test include cytology, biomarkers such as P16/Ki67 dual stain (DS), and hrHPV genotyping. This review discusses the advantages and potential issues with primary hrHPV testing and dual stain, the current American Society of Colposcopy and Cervical Pathology (ASCCP) guideline with a focus on new endocervical curettage (ECC) guidelines, as well as the new World Health Organization (WHO) classification of endocervical adenocarcinoma and the impact on cervical cytopathology. 2025; 37. View Publication.
    2. Massad LS, Perkins RB, Naresh A, Nelson EL, Spiryda L, Gecsi KS, Mulhem E, Kostas-Polston E, Zou T, Giles TL, Wentzensen N. Colposcopy Standards: Guidelines for Endocervical Curettage at Colposcopy. J Low Genit Tract Dis. 2023 01 01; 27(1):97-101. PMID: 36222824.
      Citations:    Fields:    Translation:Humans
    3. Zou T, Dave S, Adler RN, Manning MJ, Scott MP, Strock C, Kandil D, Cosar E, Fischer AH. Colposcopic endocervical brushing cytology appears to be more sensitive than histologic endocervical curettage for detecting endocervical adenocarcinoma. J Am Soc Cytopathol. 2021 Mar-Apr; 10(2):135-140. PMID: 33097463.
      Citations: 2     Fields:    Translation:Humans
    4. Capkova L, Koubkova L, Kodet R. Expression of carbonic anhydrase IX (CAIX) in malignant mesothelioma. An immunohistochemical and immunocytochemical study. Neoplasma. 2014; 61(2):161-9. PMID: 24471939.
      Citations:    
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