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Guido Musch MD, MBA

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentAnesthesiology and Perioperative Medicine
AddressUniversity of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentAnesthesiology and Perioperative Medicine


    Collapse Biography 
    Collapse education and training
    Simmons College, Boston, MA, United StatesMBA
    University of Milan, Milano, MI, ItalyMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Musch G. Ventilating the Dorsocaudal Lung. Anesthesiology. 2020 09 18. PMID: 32946544.
      View in: PubMed
    2. Gerard SE, Herrmann J, Kaczka DW, Musch G, Fernandez-Bustamante A, Reinhardt JM. Multi-resolution convolutional neural networks for fully automated segmentation of acutely injured lungs in multiple species. Med Image Anal. 2020 02; 60:101592. PMID: 31760194.
      View in: PubMed
    3. Musch G. A Window on the Lung: Molecular Imaging as a Tool to Dissect Pathophysiologic Mechanisms of Acute Lung Disease. Contrast Media Mol Imaging. 2019; 2019:1510507. PMID: 31531003.
      View in: PubMed
    4. Szabari MV, Takahashi K, Feng Y, Locascio JJ, Chao W, Carter EA, Vidal Melo MF, Musch G. Relation between Respiratory Mechanics, Inflammation, and Survival in Experimental Mechanical Ventilation. Am J Respir Cell Mol Biol. 2019 02; 60(2):179-188. PMID: 30199644.
      View in: PubMed
    5. Wellman TJ, de Prost N, Tucci M, Winkler T, Baron RM, Filipczak P, Raby B, Chu JH, Harris RS, Musch G, Dos Reis Falcao LF, Capelozzi V, Venegas JG, Vidal Melo MF. Lung Metabolic Activation as an Early Biomarker of Acute Respiratory Distress Syndrome and Local Gene Expression Heterogeneity. Anesthesiology. 2016 11; 125(5):992-1004. PMID: 27611185.
      View in: PubMed
    6. Pesenti A, Musch G, Lichtenstein D, Mojoli F, Amato MBP, Cinnella G, Gattinoni L, Quintel M. Imaging in acute respiratory distress syndrome. Intensive Care Med. 2016 May; 42(5):686-698. PMID: 27033882.
      View in: PubMed
    7. Winkler T, Melo MF, Degani-Costa LH, Harris RS, Correia JA, Musch G, Venegas JG. Estimation of noise-free variance to measure heterogeneity. PLoS One. 2015; 10(4):e0123417. PMID: 25906374.
      View in: PubMed
    8. Richter T, Bergmann R, Musch G, Pietzsch J, Koch T. Reduced pulmonary blood flow in regions of injury 2 hours after acid aspiration in rats. BMC Anesthesiol. 2015; 15:36. PMID: 25805960.
      View in: PubMed
    9. Agarwala AV, Firth PG, Albrecht MA, Warren L, Musch G. An electronic checklist improves transfer and retention of critical information at intraoperative handoff of care. Anesth Analg. 2015 Jan; 120(1):96-104. PMID: 25625256.
      View in: PubMed
    10. de Prost N, Feng Y, Wellman T, Tucci MR, Costa EL, Musch G, Winkler T, Harris RS, Venegas JG, Chao W, Vidal Melo MF. 18F-FDG kinetics parameters depend on the mechanism of injury in early experimental acute respiratory distress syndrome. J Nucl Med. 2014 Nov; 55(11):1871-7. PMID: 25286924.
      View in: PubMed
    11. Wellman TJ, Winkler T, Costa EL, Musch G, Harris RS, Zheng H, Venegas JG, Vidal Melo MF. Effect of local tidal lung strain on inflammation in normal and lipopolysaccharide-exposed sheep*. Crit Care Med. 2014 Jul; 42(7):e491-500. PMID: 24758890.
      View in: PubMed
    12. Musch G, Winkler T, Harris RS, Vidal Melo MF, Wellman TJ, de Prost N, Kradin RL, Venegas JG. Lung [(18)F]fluorodeoxyglucose uptake and ventilation-perfusion mismatch in the early stage of experimental acute smoke inhalation. Anesthesiology. 2014 Mar; 120(3):683-93. PMID: 24051392.
      View in: PubMed
    13. de Prost N, Costa EL, Wellman T, Musch G, Tucci MR, Winkler T, Harris R, Venegas JG, Kavanagh BP, Vidal Melo MF. Effects of ventilation strategy on distribution of lung inflammatory cell activity. Crit Care. 2013 Aug 15; 17(4):R175. PMID: 23947920.
      View in: PubMed
    14. Kelmenson DA, Kelly VJ, Winkler T, Kone MT, Musch G, Melo MF, Venegas JG, Harris RS. The effect of omalizumab on ventilation and perfusion in adults with allergic asthma. Am J Nucl Med Mol Imaging. 2013; 3(4):350-60. PMID: 23901360.
      View in: PubMed
    15. Tucci MR, Costa EL, Wellman TJ, Musch G, Winkler T, Harris RS, Venegas JG, Amato MB, Melo MF. Regional lung derecruitment and inflammation during 16 hours of mechanical ventilation in supine healthy sheep. Anesthesiology. 2013 Jul; 119(1):156-65. PMID: 23535501.
      View in: PubMed
    16. Harris RS, Fujii-Rios H, Winkler T, Musch G, Vidal Melo MF, Venegas JG. Ventilation defect formation in healthy and asthma subjects is determined by lung inflation. PLoS One. 2012; 7(12):e53216. PMID: 23285270.
      View in: PubMed
    17. Dittrich AS, Winkler T, Wellman T, de Prost N, Musch G, Harris RS, Vidal Melo MF. Modeling 18F-FDG kinetics during acute lung injury: experimental data and estimation errors. PLoS One. 2012; 7(10):e47588. PMID: 23118881.
      View in: PubMed
    18. Vidal Melo MF, Musch G, Kaczka DW. Pulmonary pathophysiology and lung mechanics in anesthesiology: a case-based overview. Anesthesiol Clin. 2012 Dec; 30(4):759-84. PMID: 23089508.
      View in: PubMed
    19. Wellman TJ, Winkler T, Costa EL, Musch G, Harris RS, Venegas JG, Vidal Melo MF. Effect of regional lung inflation on ventilation heterogeneity at different length scales during mechanical ventilation of normal sheep lungs. J Appl Physiol (1985). 2012 Sep; 113(6):947-57. PMID: 22678958.
      View in: PubMed
    20. Harris RS, Venegas JG, Wongviriyawong C, Winkler T, Kone M, Musch G, Vidal Melo MF, de Prost N, Hamilos DL, Afshar R, Cho J, Luster AD, Medoff BD. 18F-FDG uptake rate is a biomarker of eosinophilic inflammation and airway response in asthma. J Nucl Med. 2011 Nov; 52(11):1713-20. PMID: 21990575.
      View in: PubMed
    21. de Prost N, Costa EL, Wellman T, Musch G, Winkler T, Tucci MR, Harris RS, Venegas JG, Vidal Melo MF. Effects of surfactant depletion on regional pulmonary metabolic activity during mechanical ventilation. J Appl Physiol (1985). 2011 Nov; 111(5):1249-58. PMID: 21799132.
      View in: PubMed
    22. Musch G. Positron emission tomography: a tool for better understanding of ventilator-induced and acute lung injury. Curr Opin Crit Care. 2011 Feb; 17(1):7-12. PMID: 21169828.
      View in: PubMed
    23. Bellani G, Guerra L, Musch G, Zanella A, Patroniti N, Mauri T, Messa C, Pesenti A. Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury. Am J Respir Crit Care Med. 2011 May 01; 183(9):1193-9. PMID: 21257791.
      View in: PubMed
    24. Wellman TJ, Winkler T, Costa EL, Musch G, Harris RS, Venegas JG, Melo MF. Measurement of regional specific lung volume change using respiratory-gated PET of inhaled 13N-nitrogen. J Nucl Med. 2010 Apr; 51(4):646-53. PMID: 20237036.
      View in: PubMed
    25. Costa EL, Musch G, Winkler T, Schroeder T, Harris RS, Jones HA, Venegas JG, Vidal Melo MF. Mild endotoxemia during mechanical ventilation produces spatially heterogeneous pulmonary neutrophilic inflammation in sheep. Anesthesiology. 2010 Mar; 112(3):658-69. PMID: 20179503.
      View in: PubMed
    26. Musch G, Wiener-Kronish JP. Effect of ventilator-induced lung injury on skeletal muscle oxidative balance. Anesthesiology. 2010 Feb; 112(2):279-81. PMID: 20098126.
      View in: PubMed
    27. Vidal Melo MF, Winkler T, Harris RS, Musch G, Greene RE, Venegas JG. Spatial heterogeneity of lung perfusion assessed with (13)N PET as a vascular biomarker in chronic obstructive pulmonary disease. J Nucl Med. 2010 Jan; 51(1):57-65. PMID: 20008987.
      View in: PubMed
    28. Bellani G, Messa C, Guerra L, Spagnolli E, Foti G, Patroniti N, Fumagalli R, Musch G, Fazio F, Pesenti A. Lungs of patients with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: a [18F]-fluoro-2-deoxy-D-glucose PET/CT study. Crit Care Med. 2009 Jul; 37(7):2216-22. PMID: 19487931.
      View in: PubMed
    29. Harris RS, Winkler T, Musch G, Vidal Melo MF, Schroeder T, Tgavalekos N, Venegas JG. The prone position results in smaller ventilation defects during bronchoconstriction in asthma. J Appl Physiol (1985). 2009 Jul; 107(1):266-74. PMID: 19443742.
      View in: PubMed
    30. Schroeder T, Vidal Melo MF, Musch G, Harris RS, Venegas JG, Winkler T. Modeling pulmonary kinetics of 2-deoxy-2-[18F]fluoro-D-glucose during acute lung injury. Acad Radiol. 2008 Jun; 15(6):763-75. PMID: 18486012.
      View in: PubMed
    31. Schroeder T, Vidal Melo MF, Musch G, Harris RS, Venegas JG, Winkler T. Image-derived input function for assessment of 18F-FDG uptake by the inflamed lung. J Nucl Med. 2007 Nov; 48(11):1889-96. PMID: 17942803.
      View in: PubMed
    32. Musch G, Bellani G, Vidal Melo MF, Harris RS, Winkler T, Schroeder T, Venegas JG. Relation between shunt, aeration, and perfusion in experimental acute lung injury. Am J Respir Crit Care Med. 2008 Feb 01; 177(3):292-300. PMID: 17932380.
      View in: PubMed
    33. Musch G, Venegas JG, Bellani G, Winkler T, Schroeder T, Petersen B, Harris RS, Melo MF. Regional gas exchange and cellular metabolic activity in ventilator-induced lung injury. Anesthesiology. 2007 Apr; 106(4):723-35. PMID: 17413910.
      View in: PubMed
    34. Tgavalekos NT, Musch G, Harris RS, Vidal Melo MF, Winkler T, Schroeder T, Callahan R, Lutchen KR, Venegas JG. Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics. Eur Respir J. 2007 Jun; 29(6):1174-81. PMID: 17360726.
      View in: PubMed
    35. Schroeder T, Vidal Melo MF, Musch G, Harris RS, Winkler T, Venegas JG. PET imaging of regional 18F-FDG uptake and lung function after cigarette smoke inhalation. J Nucl Med. 2007 Mar; 48(3):413-9. PMID: 17332619.
      View in: PubMed
    36. Musch G, Venegas JG. Positron emission tomography imaging of regional lung function. Minerva Anestesiol. 2006 Jun; 72(6):363-7. PMID: 16682902.
      View in: PubMed
    37. Harris RS, Winkler T, Tgavalekos N, Musch G, Melo MF, Schroeder T, Chang Y, Venegas JG. Regional pulmonary perfusion, inflation, and ventilation defects in bronchoconstricted patients with asthma. Am J Respir Crit Care Med. 2006 Aug 01; 174(3):245-53. PMID: 16690973.
      View in: PubMed
    38. Tgavalekos NT, Tawhai M, Harris RS, Musch G, Mush G, Vidal-Melo M, Venegas JG, Lutchen KR. Identifying airways responsible for heterogeneous ventilation and mechanical dysfunction in asthma: an image functional modeling approach. J Appl Physiol (1985). 2005 Dec; 99(6):2388-97. PMID: 16081622.
      View in: PubMed
    39. Bellani G, Musch G. Repeated lung inflations and deterioration in gas exchange. Intensive Care Med. 2005 Sep; 31(9):1295; author reply 1296. PMID: 15968534.
      View in: PubMed
    40. Richter T, Bellani G, Scott Harris R, Vidal Melo MF, Winkler T, Venegas JG, Musch G. Effect of prone position on regional shunt, aeration, and perfusion in experimental acute lung injury. Am J Respir Crit Care Med. 2005 Aug 15; 172(4):480-7. PMID: 15901611.
      View in: PubMed
    41. Venegas JG, Winkler T, Musch G, Vidal Melo MF, Layfield D, Tgavalekos N, Fischman AJ, Callahan RJ, Bellani G, Harris RS. Self-organized patchiness in asthma as a prelude to catastrophic shifts. Nature. 2005 Apr 07; 434(7034):777-82. PMID: 15772676.
      View in: PubMed
    42. Musch G, Venegas JG. Positron emission tomography imaging of regional pulmonary perfusion and ventilation. Proc Am Thorac Soc. 2005; 2(6):522-7, 508-9. PMID: 16352758.
      View in: PubMed
    43. Wozniak MF, LaMuraglia GM, Musch G. Anesthesia for open abdominal aortic surgery. Int Anesthesiol Clin. 2005; 43(1):61-78. PMID: 15632517.
      View in: PubMed
    44. Musch G, Harris RS, Vidal Melo MF, O'Neill KR, Layfield JD, Winkler T, Venegas JG. Mechanism by which a sustained inflation can worsen oxygenation in acute lung injury. Anesthesiology. 2004 Feb; 100(2):323-30. PMID: 14739807.
      View in: PubMed
    45. Muhlsteff J, Such O, Schmidt R, Perkuhn M, Reiter H, Lauter J, Thijs J, Musch G, Harris M. Wearable approach for continuous ECG--and activity patient-monitoring. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:2184-7. PMID: 17272158.
      View in: PubMed
    46. Vidal Melo MF, Layfield D, Harris RS, O'Neill K, Musch G, Richter T, Winkler T, Fischman AJ, Venegas JG. Quantification of regional ventilation-perfusion ratios with PET. J Nucl Med. 2003 Dec; 44(12):1982-91. PMID: 14660725.
      View in: PubMed
    47. O'Neill K, Venegas JG, Richter T, Harris RS, Layfield JD, Musch G, Winkler T, Melo MF. Modeling kinetics of infused 13NN-saline in acute lung injury. J Appl Physiol (1985). 2003 Dec; 95(6):2471-84. PMID: 12897030.
      View in: PubMed
    48. Musch G, Layfield JD, Harris RS, Melo MF, Winkler T, Callahan RJ, Fischman AJ, Venegas JG. Topographical distribution of pulmonary perfusion and ventilation, assessed by PET in supine and prone humans. J Appl Physiol (1985). 2002 Nov; 93(5):1841-51. PMID: 12381773.
      View in: PubMed
    49. Vidal Melo MF, Harris RS, Layfield D, Musch G, Venegas JG. Changes in regional ventilation after autologous blood clot pulmonary embolism. Anesthesiology. 2002 Sep; 97(3):671-81. PMID: 12218535.
      View in: PubMed
    50. Rossi N, Musch G, Sangalli F, Verweij M, Patroniti N, Fumagalli R, Pesenti A. Reverse-thrust ventilation in hypercapnic patients with acute respiratory distress syndrome. Acute physiological effects. Am J Respir Crit Care Med. 2000 Aug; 162(2 Pt 1):363-8. PMID: 10934054.
      View in: PubMed
    51. Musch G, Liposky J. Dysphagia following intrathecal local anesthetic-opioid administration. J Clin Anesth. 1999 Aug; 11(5):413-5. PMID: 10526813.
      View in: PubMed
    52. Jimidar M, Beyns I, Rome R, Peeters R, Musch G. Determination of benzalkonium chloride in drug formulations by capillary electrophoresis (CE). Biomed Chromatogr. 1998 May-Jun; 12(3):128-30. PMID: 9646909.
      View in: PubMed
    53. Cavagna GA, Mantovani M, Willems PA, Musch G. The resonant step frequency in human running. Pflugers Arch. 1997 Nov; 434(6):678-84. PMID: 9305998.
      View in: PubMed
    54. Musch G, Foti G, Cereda M, Pelosi P, Poppi D, Pesenti A. Lung and chest wall mechanics in normal anaesthetized subjects and in patients with COPD at different PEEP levels. Eur Respir J. 1997 Nov; 10(11):2545-52. PMID: 9426093.
      View in: PubMed
    55. Musch G, Verweij M, Bombino M, Banfi G, Fumagalli R, Pesenti A. Small pore size microporous membrane oxygenator reduces plasma leakage during prolonged extracorporeal circulation: a case report. Int J Artif Organs. 1996 Mar; 19(3):177-80. PMID: 8675362.
      View in: PubMed
    56. Cereda M, Foti G, Musch G, Sparacino ME, Pesenti A. Positive end-expiratory pressure prevents the loss of respiratory compliance during low tidal volume ventilation in acute lung injury patients. Chest. 1996 Feb; 109(2):480-5. PMID: 8620726.
      View in: PubMed
    57. Vercruysse I, Schoors DF, Musch G, Massart DL, Dupont AG. Nicardipine does not influence the pharmacokinetics and pharmacodynamics of atenolol. Br J Clin Pharmacol. 1990 Sep; 30(3):499-500. PMID: 2223431.
      View in: PubMed
    58. Schoors DF, Vercruysse I, Musch G, Massart DL, Dupont AG. Influence of nicardipine on the pharmacokinetics and pharmacodynamics of propranolol in healthy volunteers. Br J Clin Pharmacol. 1990 May; 29(5):497-501. PMID: 2350528.
      View in: PubMed
    59. Musch G, Hamoir T, Massart DL. Determination of pentoxifylline and its 5-hydroxy metabolite in human plasma by solid-phase extraction and high-performance liquid chromatography with ultraviolet detection. J Chromatogr. 1989 Oct 27; 495:215-26. PMID: 2613806.
      View in: PubMed
    60. Musch G, Buelens Y, Massart DL. A strategy for the determination of beta blockers in plasma using solid-phase extraction in combination with high-performance liquid chromatography. J Pharm Biomed Anal. 1989; 7(4):483-97. PMID: 2577451.
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    61. Musch G, Massart DL. Isolation of basic drugs from plasma using solid-phase extraction with a cyanopropyl-bonded phase. J Chromatogr. 1988 Nov 18; 432:209-22. PMID: 3220888.
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    62. Detaevernier MR, Michotte Y, Buydens L, Derde MP, Desmet M, Kaufman L, Musch G, Smeyers-Verbeke J, Thielemans A, Dryon L, Massart DL. Feasibility study concerning the use of expert systems for the development of procedures in pharmaceutical analysis. J Pharm Biomed Anal. 1986; 4(3):297-307. PMID: 16867595.
      View in: PubMed
    63. Musch G, De Smet M, Massart DL. Expert system for pharmaceutical analysis. I. Selection of the detection system in high-performance liquid chromatographic analysis: UV versus amperometric detection. J Chromatogr. 1985 Nov 27; 348(1):97-110. PMID: 2868023.
      View in: PubMed
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