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Guido Musch MD, MBA

InstitutionUMass Chan Medical School
DepartmentAnesthesiology and Perioperative Medicine
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentAnesthesiology and Perioperative Medicine
    DivisionThoracic Anesthesia

    Collapse Biography 
    Collapse education and training
    Simmons College, Boston, MA, United StatesMBA
    University of Milan, Milano, MI, ItalyMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Musch G. Molecular imaging of inflammation with PET in acute and ventilator-induced lung injury. Front Physiol. 2023; 14:1177717. PMID: 37457026.
    2. Musch G, Vidal Melo MF. Intraoperative Protective Mechanical Ventilation: Fact or Fiction? Anesthesiology. 2022 10 01; 137(4):381-383. PMID: 36137258.
      Citations: 1     Fields:    Translation:Humans
    3. Musch G. New Frontiers in Functional and Molecular Imaging of the Acutely Injured Lung: Pathophysiological Insights and Research Applications. Front Physiol. 2021; 12:762688. PMID: 34955883.
    4. Musch G. Ventilating the Dorsocaudal Lung. Anesthesiology. 2020 11 01; 133(5):979-981. PMID: 32946544.
      Citations:    Fields:    
    5. Gerard SE, Herrmann J, Kaczka DW, Musch G, Fernandez-Bustamante A, Reinhardt JM. Multi-resolution convolutional neural networks for fully automated segmentation of acutely injured lungs in multiple species. Med Image Anal. 2020 02; 60:101592. PMID: 31760194.
      Citations: 26     Fields:    Translation:HumansAnimals
    6. Musch G. A Window on the Lung: Molecular Imaging as a Tool to Dissect Pathophysiologic Mechanisms of Acute Lung Disease. Contrast Media Mol Imaging. 2019; 2019:1510507. PMID: 31531003.
      Citations:    Fields:    Translation:HumansAnimals
    7. Szabari MV, Takahashi K, Feng Y, Locascio JJ, Chao W, Carter EA, Vidal Melo MF, Musch G. Relation between Respiratory Mechanics, Inflammation, and Survival in Experimental Mechanical Ventilation. Am J Respir Cell Mol Biol. 2019 02; 60(2):179-188. PMID: 30199644.
      Citations: 12     Fields:    Translation:HumansAnimals
    8. Wellman TJ, de Prost N, Tucci M, Winkler T, Baron RM, Filipczak P, Raby B, Chu JH, Harris RS, Musch G, Dos Reis Falcao LF, Capelozzi V, Venegas JG, Vidal Melo MF. Lung Metabolic Activation as an Early Biomarker of Acute Respiratory Distress Syndrome and Local Gene Expression Heterogeneity. Anesthesiology. 2016 11; 125(5):992-1004. PMID: 27611185.
      Citations: 14     Fields:    Translation:Animals
    9. Pesenti A, Musch G, Lichtenstein D, Mojoli F, Amato MBP, Cinnella G, Gattinoni L, Quintel M. Imaging in acute respiratory distress syndrome. Intensive Care Med. 2016 May; 42(5):686-698. PMID: 27033882.
      Citations: 46     Fields:    Translation:Humans
    10. Winkler T, Melo MF, Degani-Costa LH, Harris RS, Correia JA, Musch G, Venegas JG. Estimation of noise-free variance to measure heterogeneity. PLoS One. 2015; 10(4):e0123417. PMID: 25906374.
      Citations: 5     Fields:    Translation:Humans
    11. Richter T, Bergmann R, Musch G, Pietzsch J, Koch T. Reduced pulmonary blood flow in regions of injury 2 hours after acid aspiration in rats. BMC Anesthesiol. 2015; 15:36. PMID: 25805960.
      Citations: 9     Fields:    Translation:Animals
    12. Agarwala AV, Firth PG, Albrecht MA, Warren L, Musch G. An electronic checklist improves transfer and retention of critical information at intraoperative handoff of care. Anesth Analg. 2015 Jan; 120(1):96-104. PMID: 25625256.
      Citations: 16     Fields:    Translation:Humans
    13. de Prost N, Feng Y, Wellman T, Tucci MR, Costa EL, Musch G, Winkler T, Harris RS, Venegas JG, Chao W, Vidal Melo MF. 18F-FDG kinetics parameters depend on the mechanism of injury in early experimental acute respiratory distress syndrome. J Nucl Med. 2014 Nov; 55(11):1871-7. PMID: 25286924.
      Citations: 31     Fields:    Translation:AnimalsCells
    14. Wellman TJ, Winkler T, Costa EL, Musch G, Harris RS, Zheng H, Venegas JG, Vidal Melo MF. Effect of local tidal lung strain on inflammation in normal and lipopolysaccharide-exposed sheep*. Crit Care Med. 2014 Jul; 42(7):e491-500. PMID: 24758890.
      Citations: 53     Fields:    Translation:Animals
    15. Musch G, Winkler T, Harris RS, Vidal Melo MF, Wellman TJ, de Prost N, Kradin RL, Venegas JG. Lung [(18)F]fluorodeoxyglucose uptake and ventilation-perfusion mismatch in the early stage of experimental acute smoke inhalation. Anesthesiology. 2014 Mar; 120(3):683-93. PMID: 24051392.
      Citations: 8     Fields:    Translation:Animals
    16. de Prost N, Costa EL, Wellman T, Musch G, Tucci MR, Winkler T, Harris R, Venegas JG, Kavanagh BP, Vidal Melo MF. Effects of ventilation strategy on distribution of lung inflammatory cell activity. Crit Care. 2013 Aug 15; 17(4):R175. PMID: 23947920.
      Citations: 27     Fields:    Translation:AnimalsCells
    17. Kelmenson DA, Kelly VJ, Winkler T, Kone MT, Musch G, Melo MF, Venegas JG, Harris RS. The effect of omalizumab on ventilation and perfusion in adults with allergic asthma. Am J Nucl Med Mol Imaging. 2013; 3(4):350-60. PMID: 23901360.
    18. Tucci MR, Costa EL, Wellman TJ, Musch G, Winkler T, Harris RS, Venegas JG, Amato MB, Melo MF. Regional lung derecruitment and inflammation during 16 hours of mechanical ventilation in supine healthy sheep. Anesthesiology. 2013 Jul; 119(1):156-65. PMID: 23535501.
      Citations: 12     Fields:    Translation:AnimalsCells
    19. Harris RS, Fujii-Rios H, Winkler T, Musch G, Vidal Melo MF, Venegas JG. Ventilation defect formation in healthy and asthma subjects is determined by lung inflation. PLoS One. 2012; 7(12):e53216. PMID: 23285270.
      Citations: 14     Fields:    Translation:Humans
    20. Dittrich AS, Winkler T, Wellman T, de Prost N, Musch G, Harris RS, Vidal Melo MF. Modeling 18F-FDG kinetics during acute lung injury: experimental data and estimation errors. PLoS One. 2012; 7(10):e47588. PMID: 23118881.
      Citations: 10     Fields:    Translation:HumansAnimals
    21. Vidal Melo MF, Musch G, Kaczka DW. Pulmonary pathophysiology and lung mechanics in anesthesiology: a case-based overview. Anesthesiol Clin. 2012 Dec; 30(4):759-84. PMID: 23089508.
      Citations: 4     Fields:    Translation:Humans
    22. Wellman TJ, Winkler T, Costa EL, Musch G, Harris RS, Venegas JG, Vidal Melo MF. Effect of regional lung inflation on ventilation heterogeneity at different length scales during mechanical ventilation of normal sheep lungs. J Appl Physiol (1985). 2012 Sep; 113(6):947-57. PMID: 22678958.
      Citations: 24     Fields:    Translation:Animals
    23. Harris RS, Venegas JG, Wongviriyawong C, Winkler T, Kone M, Musch G, Vidal Melo MF, de Prost N, Hamilos DL, Afshar R, Cho J, Luster AD, Medoff BD. 18F-FDG uptake rate is a biomarker of eosinophilic inflammation and airway response in asthma. J Nucl Med. 2011 Nov; 52(11):1713-20. PMID: 21990575.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    24. de Prost N, Costa EL, Wellman T, Musch G, Winkler T, Tucci MR, Harris RS, Venegas JG, Vidal Melo MF. Effects of surfactant depletion on regional pulmonary metabolic activity during mechanical ventilation. J Appl Physiol (1985). 2011 Nov; 111(5):1249-58. PMID: 21799132.
      Citations: 27     Fields:    Translation:Animals
    25. Musch G. Positron emission tomography: a tool for better understanding of ventilator-induced and acute lung injury. Curr Opin Crit Care. 2011 Feb; 17(1):7-12. PMID: 21169828.
      Citations: 5     Fields:    Translation:Humans
    26. Bellani G, Guerra L, Musch G, Zanella A, Patroniti N, Mauri T, Messa C, Pesenti A. Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury. Am J Respir Crit Care Med. 2011 May 01; 183(9):1193-9. PMID: 21257791.
      Citations: 87     Fields:    Translation:Humans
    27. Wellman TJ, Winkler T, Costa EL, Musch G, Harris RS, Venegas JG, Melo MF. Measurement of regional specific lung volume change using respiratory-gated PET of inhaled 13N-nitrogen. J Nucl Med. 2010 Apr; 51(4):646-53. PMID: 20237036.
      Citations: 20     Fields:    Translation:Animals
    28. Costa EL, Musch G, Winkler T, Schroeder T, Harris RS, Jones HA, Venegas JG, Vidal Melo MF. Mild endotoxemia during mechanical ventilation produces spatially heterogeneous pulmonary neutrophilic inflammation in sheep. Anesthesiology. 2010 Mar; 112(3):658-69. PMID: 20179503.
      Citations: 43     Fields:    Translation:AnimalsCells
    29. Musch G, Wiener-Kronish JP. Effect of ventilator-induced lung injury on skeletal muscle oxidative balance. Anesthesiology. 2010 Feb; 112(2):279-81. PMID: 20098126.
      Citations:    Fields:    Translation:Humans
    30. Vidal Melo MF, Winkler T, Harris RS, Musch G, Greene RE, Venegas JG. Spatial heterogeneity of lung perfusion assessed with (13)N PET as a vascular biomarker in chronic obstructive pulmonary disease. J Nucl Med. 2010 Jan; 51(1):57-65. PMID: 20008987.
      Citations: 33     Fields:    Translation:Humans
    31. Bellani G, Messa C, Guerra L, Spagnolli E, Foti G, Patroniti N, Fumagalli R, Musch G, Fazio F, Pesenti A. Lungs of patients with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: a [18F]-fluoro-2-deoxy-D-glucose PET/CT study. Crit Care Med. 2009 Jul; 37(7):2216-22. PMID: 19487931.
      Citations: 70     Fields:    Translation:Humans
    32. Harris RS, Winkler T, Musch G, Vidal Melo MF, Schroeder T, Tgavalekos N, Venegas JG. The prone position results in smaller ventilation defects during bronchoconstriction in asthma. J Appl Physiol (1985). 2009 Jul; 107(1):266-74. PMID: 19443742.
      Citations: 20     Fields:    Translation:Humans
    33. Schroeder T, Vidal Melo MF, Musch G, Harris RS, Venegas JG, Winkler T. Modeling pulmonary kinetics of 2-deoxy-2-[18F]fluoro-D-glucose during acute lung injury. Acad Radiol. 2008 Jun; 15(6):763-75. PMID: 18486012.
      Citations: 35     Fields:    Translation:Animals
    34. Schroeder T, Vidal Melo MF, Musch G, Harris RS, Venegas JG, Winkler T. Image-derived input function for assessment of 18F-FDG uptake by the inflamed lung. J Nucl Med. 2007 Nov; 48(11):1889-96. PMID: 17942803.
      Citations: 26     Fields:    Translation:HumansAnimals
    35. Musch G, Bellani G, Vidal Melo MF, Harris RS, Winkler T, Schroeder T, Venegas JG. Relation between shunt, aeration, and perfusion in experimental acute lung injury. Am J Respir Crit Care Med. 2008 Feb 01; 177(3):292-300. PMID: 17932380.
      Citations: 21     Fields:    Translation:Animals
    36. Musch G, Venegas JG, Bellani G, Winkler T, Schroeder T, Petersen B, Harris RS, Melo MF. Regional gas exchange and cellular metabolic activity in ventilator-induced lung injury. Anesthesiology. 2007 Apr; 106(4):723-35. PMID: 17413910.
      Citations: 55     Fields:    Translation:Animals
    37. Tgavalekos NT, Musch G, Harris RS, Vidal Melo MF, Winkler T, Schroeder T, Callahan R, Lutchen KR, Venegas JG. Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics. Eur Respir J. 2007 Jun; 29(6):1174-81. PMID: 17360726.
      Citations: 29     Fields:    Translation:Humans
    38. Schroeder T, Vidal Melo MF, Musch G, Harris RS, Winkler T, Venegas JG. PET imaging of regional 18F-FDG uptake and lung function after cigarette smoke inhalation. J Nucl Med. 2007 Mar; 48(3):413-9. PMID: 17332619.
      Citations: 19     Fields:    Translation:AnimalsPHPublic Health
    39. Musch G, Venegas JG. Positron emission tomography imaging of regional lung function. Minerva Anestesiol. 2006 Jun; 72(6):363-7. PMID: 16682902.
      Citations: 4     Fields:    Translation:Humans
    40. Harris RS, Winkler T, Tgavalekos N, Musch G, Melo MF, Schroeder T, Chang Y, Venegas JG. Regional pulmonary perfusion, inflation, and ventilation defects in bronchoconstricted patients with asthma. Am J Respir Crit Care Med. 2006 Aug 01; 174(3):245-53. PMID: 16690973.
      Citations: 51     Fields:    Translation:Humans
    41. Tgavalekos NT, Tawhai M, Harris RS, Musch G, Mush G, Vidal-Melo M, Venegas JG, Lutchen KR. Identifying airways responsible for heterogeneous ventilation and mechanical dysfunction in asthma: an image functional modeling approach. J Appl Physiol (1985). 2005 Dec; 99(6):2388-97. PMID: 16081622.
      Citations: 57     Fields:    Translation:HumansCTClinical Trials
    42. Bellani G, Musch G. Repeated lung inflations and deterioration in gas exchange. Intensive Care Med. 2005 Sep; 31(9):1295; author reply 1296. PMID: 15968534.
      Citations:    Fields:    Translation:Animals
    43. Richter T, Bellani G, Scott Harris R, Vidal Melo MF, Winkler T, Venegas JG, Musch G. Effect of prone position on regional shunt, aeration, and perfusion in experimental acute lung injury. Am J Respir Crit Care Med. 2005 Aug 15; 172(4):480-7. PMID: 15901611.
      Citations: 76     Fields:    Translation:Animals
    44. Venegas JG, Winkler T, Musch G, Vidal Melo MF, Layfield D, Tgavalekos N, Fischman AJ, Callahan RJ, Bellani G, Harris RS. Self-organized patchiness in asthma as a prelude to catastrophic shifts. Nature. 2005 Apr 07; 434(7034):777-82. PMID: 15772676.
      Citations: 179     Fields:    Translation:Humans
    45. Wozniak MF, LaMuraglia GM, Musch G. Anesthesia for open abdominal aortic surgery. Int Anesthesiol Clin. 2005; 43(1):61-78. PMID: 15632517.
      Citations: 1     Fields:    Translation:Humans
    46. Musch G, Venegas JG. Positron emission tomography imaging of regional pulmonary perfusion and ventilation. Proc Am Thorac Soc. 2005; 2(6):522-7, 508-9. PMID: 16352758.
      Citations: 12     Fields:    Translation:HumansAnimals
    47. Musch G, Harris RS, Vidal Melo MF, O'Neill KR, Layfield JD, Winkler T, Venegas JG. Mechanism by which a sustained inflation can worsen oxygenation in acute lung injury. Anesthesiology. 2004 Feb; 100(2):323-30. PMID: 14739807.
      Citations: 38     Fields:    Translation:Animals
    48. Muhlsteff J, Such O, Schmidt R, Perkuhn M, Reiter H, Lauter J, Thijs J, Musch G, Harris M. Wearable approach for continuous ECG--and activity patient-monitoring. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:2184-7. PMID: 17272158.
      Citations: 5     Fields:    
    49. Vidal Melo MF, Layfield D, Harris RS, O'Neill K, Musch G, Richter T, Winkler T, Fischman AJ, Venegas JG. Quantification of regional ventilation-perfusion ratios with PET. J Nucl Med. 2003 Dec; 44(12):1982-91. PMID: 14660725.
      Citations: 60     Fields:    Translation:Animals
    50. O'Neill K, Venegas JG, Richter T, Harris RS, Layfield JD, Musch G, Winkler T, Melo MF. Modeling kinetics of infused 13NN-saline in acute lung injury. J Appl Physiol (1985). 2003 Dec; 95(6):2471-84. PMID: 12897030.
      Citations: 18     Fields:    Translation:Animals
    51. Vidal Melo MF, Harris RS, Layfield D, Musch G, Venegas JG. Changes in regional ventilation after autologous blood clot pulmonary embolism. Anesthesiology. 2002 Sep; 97(3):671-81. PMID: 12218535.
      Citations: 25     Fields:    Translation:Animals
    52. Rossi N, Musch G, Sangalli F, Verweij M, Patroniti N, Fumagalli R, Pesenti A. Reverse-thrust ventilation in hypercapnic patients with acute respiratory distress syndrome. Acute physiological effects. Am J Respir Crit Care Med. 2000 Aug; 162(2 Pt 1):363-8. PMID: 10934054.
      Citations: 1     Fields:    Translation:Humans
    53. Musch G, Liposky J. Dysphagia following intrathecal local anesthetic-opioid administration. J Clin Anesth. 1999 Aug; 11(5):413-5. PMID: 10526813.
      Citations: 1     Fields:    Translation:Humans
    54. Jimidar M, Beyns I, Rome R, Peeters R, Musch G. Determination of benzalkonium chloride in drug formulations by capillary electrophoresis (CE). Biomed Chromatogr. 1998 May-Jun; 12(3):128-30. PMID: 9646909.
      Citations:    Fields:    
    55. Cavagna GA, Mantovani M, Willems PA, Musch G. The resonant step frequency in human running. Pflugers Arch. 1997 Nov; 434(6):678-84. PMID: 9305998.
      Citations: 17     Fields:    Translation:Humans
    56. Musch G, Foti G, Cereda M, Pelosi P, Poppi D, Pesenti A. Lung and chest wall mechanics in normal anaesthetized subjects and in patients with COPD at different PEEP levels. Eur Respir J. 1997 Nov; 10(11):2545-52. PMID: 9426093.
      Citations: 4     Fields:    Translation:Humans
    57. Musch G, Verweij M, Bombino M, Banfi G, Fumagalli R, Pesenti A. Small pore size microporous membrane oxygenator reduces plasma leakage during prolonged extracorporeal circulation: a case report. Int J Artif Organs. 1996 Mar; 19(3):177-80. PMID: 8675362.
      Citations:    Fields:    Translation:Humans
    58. Cereda M, Foti G, Musch G, Sparacino ME, Pesenti A. Positive end-expiratory pressure prevents the loss of respiratory compliance during low tidal volume ventilation in acute lung injury patients. Chest. 1996 Feb; 109(2):480-5. PMID: 8620726.
      Citations: 6     Fields:    Translation:Humans
    59. Vercruysse I, Schoors DF, Musch G, Massart DL, Dupont AG. Nicardipine does not influence the pharmacokinetics and pharmacodynamics of atenolol. Br J Clin Pharmacol. 1990 Sep; 30(3):499-500. PMID: 2223431.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    60. Schoors DF, Vercruysse I, Musch G, Massart DL, Dupont AG. Influence of nicardipine on the pharmacokinetics and pharmacodynamics of propranolol in healthy volunteers. Br J Clin Pharmacol. 1990 May; 29(5):497-501. PMID: 2350528.
      Citations: 10     Fields:    Translation:HumansCTClinical Trials
    61. Musch G, Hamoir T, Massart DL. Determination of pentoxifylline and its 5-hydroxy metabolite in human plasma by solid-phase extraction and high-performance liquid chromatography with ultraviolet detection. J Chromatogr. 1989 Oct 27; 495:215-26. PMID: 2613806.
      Citations:    Fields:    Translation:Humans
    62. Musch G, Buelens Y, Massart DL. A strategy for the determination of beta blockers in plasma using solid-phase extraction in combination with high-performance liquid chromatography. J Pharm Biomed Anal. 1989; 7(4):483-97. PMID: 2577451.
      Citations: 1     Fields:    Translation:Humans
    63. Musch G, Massart DL. Isolation of basic drugs from plasma using solid-phase extraction with a cyanopropyl-bonded phase. J Chromatogr. 1988 Nov 18; 432:209-22. PMID: 3220888.
      Citations: 3     Fields:    Translation:HumansCells
    64. Detaevernier MR, Michotte Y, Buydens L, Derde MP, Desmet M, Kaufman L, Musch G, Smeyers-Verbeke J, Thielemans A, Dryon L, Massart DL. Feasibility study concerning the use of expert systems for the development of procedures in pharmaceutical analysis. J Pharm Biomed Anal. 1986; 4(3):297-307. PMID: 16867595.
      Citations:    Fields:    
    65. Musch G, De Smet M, Massart DL. Expert system for pharmaceutical analysis. I. Selection of the detection system in high-performance liquid chromatographic analysis: UV versus amperometric detection. J Chromatogr. 1985 Nov 27; 348(1):97-110. PMID: 2868023.
      Citations:    Fields:    
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