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Lyne Khair PhD

InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
368 Plantation Street
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionVascular Surgery

    Collapse Biography 
    Collapse education and training
    American University of Beirut, Beirut, , LebanonBSBiology
    American University of Beirut, Beirut, , LebanonMSBiology
    University of Illinois, Chicago, Chicago, IL, United StatesPHDBiochemistry & Molecular Genet

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tie G, Yan J, Khair L, Tutto A, Messina LM. Hypercholesterolemia Accelerates the Aging Phenotypes of Hematopoietic Stem Cells by a Tet1-Dependent Pathway. Sci Rep. 2020 02 27; 10(1):3567. PMID: 32107419.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    2. Noguchi C, Singh T, Ziegler MA, Peake JD, Khair L, Aza A, Nakamura TM, Noguchi E. The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning. Epigenetics Chromatin. 2019 04 16; 12(1):24. PMID: 30992049.
      Citations: 5     Fields:    Translation:AnimalsCells
    3. Yan J, Tie G, Wang S, Tutto A, DeMarco N, Khair L, Fazzio TG, Messina LM. Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages. Nat Commun. 2018 01 02; 9(1):33. PMID: 29295997.
      Citations: 67     Fields:    Translation:AnimalsCells
    4. Tie G, Yan J, Khair L, Messina JA, Deng A, Kang J, Fazzio T, Messina LM. Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and ?d T Cells from Hematopoietic Stem Cells. Cancer Res. 2017 05 01; 77(9):2351-2362. PMID: 28249902.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    5. Khair L, Baker RE, Linehan EK, Schrader CE, Stavnezer J. Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells. PLoS Genet. 2015 Aug; 11(8):e1005438. PMID: 26263206.
      Citations: 9     Fields:    Translation:AnimalsCells
    6. Ucher AJ, Ranjit S, Kadungure T, Linehan EK, Khair L, Xie E, Limauro J, Rauch KS, Schrader CE, Stavnezer J. Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching. J Immunol. 2014 Aug 01; 193(3):1440-50. PMID: 24973444.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    7. Khair L, Guikema JE, Linehan EK, Ucher AJ, Leus NG, Ogilvie C, Lou Z, Schrader CE, Stavnezer J. ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination. J Immunol. 2014 May 15; 192(10):4887-96. PMID: 24729610.
      Citations: 13     Fields:    Translation:AnimalsCells
    8. Garabedian MV, Noguchi C, Ziegler MA, Das MM, Singh T, Harper LJ, Leman AR, Khair L, Moser BA, Nakamura TM, Noguchi E. The double-bromodomain proteins Bdf1 and Bdf2 modulate chromatin structure to regulate S-phase stress response in Schizosaccharomyces pombe. Genetics. 2012 Feb; 190(2):487-500. PMID: 22095079.
      Citations: 17     Fields:    Translation:AnimalsCells
    9. Ranjit S, Khair L, Linehan EK, Ucher AJ, Chakrabarti M, Schrader CE, Stavnezer J. AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected]. J Immunol. 2011 Sep 01; 187(5):2464-75. PMID: 21804017.
      Citations: 33     Fields:    Translation:AnimalsCells
    10. Carneiro T, Khair L, Reis CC, Borges V, Moser BA, Nakamura TM, Ferreira MG. Telomeres avoid end detection by severing the checkpoint signal transduction pathway. Nature. 2010 Sep 09; 467(7312):228-32. PMID: 20829797.
      Citations: 38     Fields:    Translation:AnimalsCells
    11. Khair L, Chang YT, Subramanian L, Russell P, Nakamura TM. Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance. Cell Cycle. 2010 Jun 01; 9(11):2237-48. PMID: 20505337.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Khair L, Subramanian L, Moser BA, Nakamura TM. Roles of heterochromatin and telomere proteins in regulation of fission yeast telomere recombination and telomerase recruitment. J Biol Chem. 2010 Feb 19; 285(8):5327-37. PMID: 20040595.
      Citations: 16     Fields:    Translation:AnimalsCells
    13. Moser BA, Subramanian L, Khair L, Chang YT, Nakamura TM. Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment. PLoS Genet. 2009 Aug; 5(8):e1000622. PMID: 19714219.
      Citations: 41     Fields:    Translation:AnimalsCells
    14. Bondar T, Kalinina A, Khair L, Kopanja D, Nag A, Bagchi S, Raychaudhuri P. Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome. Mol Cell Biol. 2006 Apr; 26(7):2531-9. PMID: 16537899.
      Citations: 63     Fields:    Translation:HumansCells
    15. Younis I, Khair L, Dundr M, Lairmore MD, Franchini G, Green PL. Repression of human T-cell leukemia virus type 1 and type 2 replication by a viral mRNA-encoded posttranscriptional regulator. J Virol. 2004 Oct; 78(20):11077-83. PMID: 15452228.
      Citations: 54     Fields:    Translation:HumansCells
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