AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
"AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dioxygenase and alkylation repair homolog that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. It can also repair alkylated DNA containing 1-ethenoadenine in vitro. It has highest affinity for double-stranded DNA.
| Descriptor ID |
D000071499
|
| MeSH Number(s) |
D08.811.074.062.750 D08.811.682.690.416.139.750
|
| Concept/Terms |
AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase- AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
- AlkB Homolog 2, Alpha Ketoglutarate Dependent Dioxygenase
- Alkylated DNA Repair Protein AlkB Homolog 2
- Oxy DC1 Protein
- DNA Oxidative Demethylase ALKBH2
- Alpha-ketoglutarate-Dependent Dioxygenase AlkB Homolog 2
- Alpha ketoglutarate Dependent Dioxygenase AlkB Homolog 2
|
Below are MeSH descriptors whose meaning is more general than "AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase".
Below are MeSH descriptors whose meaning is more specific than "AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase".
This graph shows the total number of publications written about "AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase" by people in this website by year, and whether "AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase" by people in Profiles.
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Giri NC, Sun H, Chen H, Costa M, Maroney MJ. X-ray absorption spectroscopy structural investigation of early intermediates in the mechanism of DNA repair by human ABH2. Biochemistry. 2011 Jun 07; 50(22):5067-76.
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Chen H, Giri NC, Zhang R, Yamane K, Zhang Y, Maroney M, Costa M. Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. J Biol Chem. 2010 Mar 05; 285(10):7374-83.