"Connexin 26" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gap junction protein encoded by the Gap Junction Beta 2 or GJB2 gene. In the cochlea and epidermis, its hexamers form channels between cells that open to allow cell-to-cell diffusion of small molecules as well as recycling of potassium. Mutations in Connexin 26 are associated with congenital SENSORINEURAL HEARING LOSS.
| Descriptor ID |
D000072259
|
| MeSH Number(s) |
D12.776.543.585.250.100
|
| Concept/Terms |
Connexin 26- Connexin 26
- 26, Connexin
- beta2 Connexin
- Connexin, beta2
- Connexin beta-2
- Connexin beta 2
- beta-2, Connexin
- Connexin Cx26
- Cx26, Connexin
|
Below are MeSH descriptors whose meaning is more general than "Connexin 26".
Below are MeSH descriptors whose meaning is more specific than "Connexin 26".
This graph shows the total number of publications written about "Connexin 26" by people in this website by year, and whether "Connexin 26" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Connexin 26" by people in Profiles.
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Shearer AE, Eppsteiner RW, Booth KT, Ephraim SS, Gurrola J, Simpson A, Black-Ziegelbein EA, Joshi S, Ravi H, Giuffre AC, Happe S, Hildebrand MS, Azaiez H, Bayazit YA, Erdal ME, Lopez-Escamez JA, Gazquez I, Tamayo ML, Gelvez NY, Leal GL, Jalas C, Ekstein J, Yang T, Usami S, Kahrizi K, Bazazzadegan N, Najmabadi H, Scheetz TE, Braun TA, Casavant TL, LeProust EM, Smith RJ. Utilizing ethnic-specific differences in minor allele frequency to recategorize reported pathogenic deafness variants. Am J Hum Genet. 2014 Oct 02; 95(4):445-53.
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Diaz-Horta O, Duman D, Foster J, Sirmaci A, Gonzalez M, Mahdieh N, Fotouhi N, Bonyadi M, Cengiz FB, Menendez I, Ulloa RH, Edwards YJ, Z?chner S, Blanton S, Tekin M. Whole-exome sequencing efficiently detects rare mutations in autosomal recessive nonsyndromic hearing loss. PLoS One. 2012; 7(11):e50628.
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Eppsteiner RW, Smith RJ. Genetic disorders of the vestibular system. Curr Opin Otolaryngol Head Neck Surg. 2011 Oct; 19(5):397-402.
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Paemeleire K, Martin PE, Coleman SL, Fogarty KE, Carrington WA, Leybaert L, Tuft RA, Evans WH, Sanderson MJ. Intercellular calcium waves in HeLa cells expressing GFP-labeled connexin 43, 32, or 26. Mol Biol Cell. 2000 May; 11(5):1815-27.