Drug Substitution

"Drug Substitution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The practice of replacing one prescribed drug with another that is expected to have the same clinical or psychological effect.

Descriptor ID	D057915
MeSH Number(s)	E02.319.307.312 N02.421.668.778.500.312
Concept/Terms	Drug Substitution Drug Substitution Drug Substitutions Substitution, Drug Substitutions, Drug Therapeutic Substitution Substitution, Therapeutic Substitutions, Therapeutic Therapeutic Substitutions Drug Switching Drug Switchings Switching, Drug Switchings, Drug Generic Substitution Generic Substitution Generic Substitutions Substitution, Generic Substitutions, Generic

Below are MeSH descriptors whose meaning is more general than "Drug Substitution".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Therapeutics [E02]
Drug Therapy [E02.319]
Drug Prescriptions [E02.319.307]
Drug Substitution [E02.319.307.312]
Health Care [N]
Health Care Facilities, Manpower, and Services [N02]
Health Services [N02.421]
Pharmaceutical Services [N02.421.668]
Prescriptions [N02.421.668.778]
Drug Prescriptions [N02.421.668.778.500]
Drug Substitution [N02.421.668.778.500.312]

Below are MeSH descriptors whose meaning is related to "Drug Substitution".

Below are MeSH descriptors whose meaning is more specific than "Drug Substitution".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Drug Substitution" by people in this website by year, and whether "Drug Substitution" was a major or minor topic of these publications.

Bar chart showing 27 publications over 14 distinct years, with a maximum of 4 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2011	2	0	2
2012	1	2	3
2013	0	2	2
2014	1	2	3
2015	0	1	1
2016	1	2	3
2017	0	1	1
2018	0	1	1
2019	0	1	1
2020	2	2	4
2021	1	0	1
2022	1	0	1
2024	0	3	3
2025	0	1	1

Below are the most recent publications written about "Drug Substitution" by people in Profiles.

Ogdie A, Reddy SM, Gillespie SH, Husni ME, Scher JU, Salomon-Escoto K, Kay J, Luedders BA, Curtis JR, Shields AJS, Chakravarty SD, Gong C, Walsh JA. Guselkumab versus golimumab in patients with active psoriatic arthritis and inadequate response to an initial tumor necrosis factor inhibitor: study protocol for EVOLUTION, a pragmatic, phase 3b, open-label, randomized, controlled effectiveness trial. Trials. 2025 Mar 19; 26(1):96.

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Krugliak Cleveland N, Ghosh S, Chastek B, Bancroft T, Candela N, Fan T, Umashankar K, Rubin DT. Real-World Persistence of Successive Biologics in Patients With Inflammatory Bowel Disease: Findings From ROTARY. Inflamm Bowel Dis. 2024 10 03; 30(10):1776-1787.

View in: PubMed
Rothschild AJ. Question: How Should I Switch From One Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin and Norepinephrine Reuptake Inhibitor (SNRI) to Another SSRI or SNRI in a Patient With Major Depressive Disorder? J Clin Psychopharmacol. 2024 Sep-Oct 01; 44(5):531-532.

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Sukumaran M, Cantrell DR, D'Agostino C, Jahromi BS, Ansari SA, Potts MB. Bivalirudin as a substitute for heparin in neurointervention for patients with heparin-induced thrombocytopenia. J Stroke Cerebrovasc Dis. 2024 Jun; 33(6):107310.

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Walker A, Rupal A, Jani C, Al Omari O, Singh H, Patel D, Perrino C, McCannon J. Longstanding Phenytoin Use as a Cause of Progressive Dyspnea. Chest. 2022 02; 161(2):e91-e96.

View in: PubMed
Llanos-Chea A, Shapiro JM, Winter RW, Jerger L, Menz T, Gibson M, Friedmann AM, Treaba D, Papamichael K, Cheifetz AS, Friedman S, Hamilton MJ, Winter HS. Lymphoma in Pediatric-Onset Inflammatory Bowel Disease Treated with Infliximab Monotherapy: A Case Series. Dig Dis Sci. 2022 01; 67(1):252-258.

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Forester BP, Parikh SV, Weisenbach S, Ajilore O, Vahia I, Rothschild AJ, Thase ME, Dunlop BW, DeBattista C, Conway CR, Shelton RC, Macaluso M, Li J, Traxler P, Logan J, Brown L, Dechairo B, Greden JF. Combinatorial Pharmacogenomic Testing Improves Outcomes for Older Adults With Depression. Am J Geriatr Psychiatry. 2020 09; 28(9):933-945.

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Paredes LG, Arinze NV, Farber A, Garofalo D, Cheng TW, Levin SR, Vilvendhan R, Siracuse JJ. Periprocedural Outcomes in Patients on Chronic Anticoagulation Undergoing Fistulograms. Ann Vasc Surg. 2021 Jan; 70:123-130.

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Parikh KS, Doerfler S, Shelburne N, Kennedy K, Whitson J, Dahhan T, Fortin T, Rajagopal S. Experience in Transitioning From Parenteral Prostacyclins to Selexipag in Pulmonary Arterial Hypertension. J Cardiovasc Pharmacol. 2020 04; 75(4):299-304.

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Gor D, Lee TA, Schumock GT, Walton SM, Gerber BS, Nutescu EA, Touchette DR. Adherence and Persistence with DPP-4 Inhibitors Versus Pioglitazone in Type 2 Diabetes Patients with Chronic Kidney Disease: A Retrospective Claims Database Analysis. J Manag Care Spec Pharm. 2020 Jan; 26(1):67-75.

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