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Tadatoshi Sato PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressUMass Chan Medical School
364 Plantation Street, LRB Suite 280G
Worcester MA 01605
Phone508-334-1000
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentGene Therapy Center

    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionRheumatology


    Collapse Biography 
    Collapse education and training
    University of Tokushima, Tokushima, , JapanBS
    University of Tokushima, Tokushima, , JapanMS
    University of Tokushima, Tokushima, , JapanPHD
    Harvard School of Dental Medicine, Boston, MAOral Medicine, Infection and Immunity
    Harvard School of Medicine / Massachusetts General Hospital, Boston, MAEndocrine unit

    Collapse Overview 
    Collapse Post Docs
    Post Doc - Open Rank

    Job Number: 2025-48103
    Category: Research
    Location: Worcester, MA
    Shift: Day
    Exempt/Non-Exempt: Exempt
    Business Unit: UMass Chan Medical School
    Department: School - Rheumatology - W710085
    Job Type: Full-Time
    Salary Grade: 86
    Union Code: Non Union Position-W63-Residents/Post Docs
    Num. Openings: 1
    Post Date: May 26, 2025

    https://www.ummsjobs.com/job/11019/

    The Sato Lab at UMass Med is seeking an enthusiastic postdoctoral fellow to join our team at the forefront of gene editing and cell therapy research. Our research group is focusing on elucidating the molecular mechanisms underlying rare diseases and autoimmune disorders. Through innovative approaches such as gene editing and cell therapy, we aim to develop novel therapeutic strategies to combat these conditions and improve patient outcomes.

    Project Highlights:

    • Utilize CRISPR gene editing techniques
    • Engineer and explore gene/cell therapies for disease treatment
    • Investigate the genetic basis of rare skeletal and connective tissue diseases
    • Unravel mechanisms underlying autoimmune disorders

     

    Interested candidates should submit a CV or resume, a cover letter with a short description outlining research interests and relevant experience, and contact information for three references to tadatoshi.sato@umassmed.edu. Please indicate the position you are applying for in the subject line.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sato T, Chaugule S, Greenblatt MB, Gao G, Shim JH. Advances in Bone-Targeting Drug Delivery: Emerging Strategies Using Adeno-Associated Virus. Hum Gene Ther. 2024 05; 35(9-10):329-341. PMID: 38661537.
      Citations:    
    2. Yang YS, Sato T, Chaugule S, Ma H, Xie J, Gao G, Shim JH. AAV-based gene editing of type 1 collagen mutation to treat osteogenesis imperfecta. Mol Ther Nucleic Acids. 2024 Mar 12; 35(1):102111. PMID: 38261950.
      Citations:    
    3. Park Y, Sato T, Lee J. Functional and analytical recapitulation of osteoclast biology on demineralized bone paper. Nat Commun. 2023 12 07; 14(1):8092. PMID: 38062034.
      Citations:    Fields:    Translation:AnimalsCells
    4. Stavre Z, Kim JM, Yang YS, N?ndel K, Chaugule S, Sato T, Park KH, Gao G, Gravallese EM, Shim JH. Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2218019120. PMID: 37141171.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    5. Yoon SH, Meyer MB, Arevalo C, Tekguc M, Zhang C, Wang JS, Castro Andrade CD, Strauss K, Sato T, Benkusky NA, Lee SM, Berdeaux R, Foretz M, Sundberg TB, Xavier RJ, Adelmann CH, Brooks DJ, Anselmo A, Sadreyev RI, Rosales IA, Fisher DE, Gupta N, Morizane R, Greka A, Pike JW, Mannstadt M, Wein MN. A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis. J Clin Invest. 2023 05 01; 133(9). PMID: 36862513.
      Citations: 3     Fields:    Translation:HumansAnimals
    6. Sato T, Andrade CDC, Yoon SH, Zhao Y, Greenlee WJ, Weber PC, Viswanathan U, Kulp J, Brooks DJ, Demay MB, Bouxsein ML, Mitlak B, Lanske B, Wein MN. Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice. Proc Natl Acad Sci U S A. 2022 12 13; 119(50):e2214396119. PMID: 36472957.
      Citations: 7     Fields:    Translation:HumansAnimals
    7. Mazur CM, Castro Andrade CD, Tokavanich N, Sato T, Bruce M, Brooks DJ, Bouxsein ML, Wang JS, Wein MN. Partial prevention of glucocorticoid-induced osteocyte deterioration in young male mice with osteocrin gene therapy. iScience. 2022 Sep 16; 25(9):105019. PMID: 36105586.
      Citations:    
    8. Fan Y, Cui C, Rosen CJ, Sato T, Xu R, Li P, Wei X, Bi R, Yuan Q, Zhou C. Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair. Signal Transduct Target Ther. 2022 05 11; 7(1):155. PMID: 35538062.
      Citations: 6     Fields:    Translation:HumansCells
    9. Tang CC, Castro Andrade CD, O'Meara MJ, Yoon SH, Sato T, Brooks DJ, Bouxsein ML, Martins JDS, Wang J, Gray NS, Misof B, Roschger P, Blouin S, Klaushofer K, Velduis-Vlug A, Vegting Y, Rosen CJ, O'Connell D, Sundberg TB, Xavier RJ, Ung P, Schlessinger A, Kronenberg HM, Berdeaux R, Foretz M, Wein MN. Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption. Elife. 2021 06 23; 10. PMID: 34160349.
      Citations: 5     Fields:    Translation:Animals
    10. Sato T, Verma S, Khatri A, Dean T, Goransson O, Gardella TJ, Wein MN. Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long-Acting PTH. JBMR Plus. 2021 May; 5(5):e10441. PMID: 33977197.
      Citations:    
    11. Sato T, Verma S, Andrade CDC, Omeara M, Campbell N, Wang JS, Cetinbas M, Lang A, Ausk BJ, Brooks DJ, Sadreyev RI, Kronenberg HM, Lagares D, Uda Y, Pajevic PD, Bouxsein ML, Gross TS, Wein MN. A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction. Nat Commun. 2020 07 01; 11(1):3282. PMID: 32612176.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    12. Fan Y, Liu W, Bi R, Densmore MJ, Sato T, Mannstadt M, Yuan Q, Zhou X, Olauson H, Larsson TE, Toka HR, Pollak MR, Brown EM, Lanske B. Interrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasia. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3749-E3758. PMID: 29618612.
      Citations: 21     Fields:    Translation:Animals
    13. Komaba H, Kaludjerovic J, Hu DZ, Nagano K, Amano K, Ide N, Sato T, Densmore MJ, Hanai JI, Olauson H, Bellido T, Larsson TE, Baron R, Lanske B. Klotho expression in osteocytes regulates bone metabolism and controls bone formation. Kidney Int. 2017 09; 92(3):599-611. PMID: 28396120.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    14. Sato T, Courbebaisse M, Ide N, Fan Y, Hanai JI, Kaludjerovic J, Densmore MJ, Yuan Q, Toka HR, Pollak MR, Hou J, Lanske B. Parathyroid hormone controls paracellular Ca2+ transport in the thick ascending limb by regulating the tight-junction protein Claudin14. Proc Natl Acad Sci U S A. 2017 04 18; 114(16):E3344-E3353. PMID: 28373577.
      Citations: 24     Fields:    Translation:AnimalsCells
    15. Kaludjerovic J, Komaba H, Sato T, Erben RG, Baron R, Olauson H, Larsson TE, Lanske B. Klotho expression in long bones regulates FGF23 production during renal failure. FASEB J. 2017 05; 31(5):2050-2064. PMID: 28183805.
      Citations: 17     Fields:    Translation:AnimalsCells
    16. Ide N, Olauson H, Sato T, Densmore MJ, Wang H, Hanai JI, Larsson TE, Lanske B. In?vivo evidence for a limited role of proximal tubular Klotho in renal phosphate handling. Kidney Int. 2016 08; 90(2):348-362. PMID: 27292223.
      Citations: 33     Fields:    Translation:HumansAnimals
    17. Fan Y, Bi R, Densmore MJ, Sato T, Kobayashi T, Yuan Q, Zhou X, Erben RG, Lanske B. Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis. FASEB J. 2016 Jan; 30(1):428-40. PMID: 26428657.
      Citations: 29     Fields:    Translation:Animals
    18. Yuan Q, Jiang Y, Zhao X, Sato T, Densmore M, Sch?ler C, Erben RG, McKee MD, Lanske B. Increased osteopontin contributes to inhibition of bone mineralization in FGF23-deficient mice. J Bone Miner Res. 2014 Mar; 29(3):693-704. PMID: 24038141.
      Citations: 45     Fields:    Translation:Animals
    19. Olauson H, Lindberg K, Amin R, Sato T, Jia T, Goetz R, Mohammadi M, Andersson G, Lanske B, Larsson TE. Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion. PLoS Genet. 2013; 9(12):e1003975. PMID: 24348262.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    20. Kawakami Y, Yamanaka-Okumura H, Sakuma M, Mori Y, Adachi C, Matsumoto Y, Sato T, Yamamoto H, Taketani Y, Katayama T, Takeda E. Gene expression profiling in peripheral white blood cells in response to the intake of food with different glycemic index using a DNA microarray. J Nutrigenet Nutrigenomics. 2013; 6(3):154-68. PMID: 24008923.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    21. Zou H, Zhao X, Sun N, Zhang S, Sato T, Yu H, Chen Q, Weber HP, Dard M, Yuan Q, Lanske B. Effect of chronic kidney disease on the healing of titanium implants. Bone. 2013 Oct; 56(2):410-5. PMID: 23876979.
      Citations: 12     Fields:    Translation:Animals
    22. Yuan Q, Sato T, Densmore M, Saito H, Sch?ler C, Erben RG, Lanske B. Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice. PLoS Genet. 2012; 8(5):e1002726. PMID: 22615584.
      Citations: 21     Fields:    Translation:AnimalsCells
    23. Takei Y, Yamamoto H, Sato T, Otani A, Kozai M, Masuda M, Taketani Y, Muto-Sato K, Lanske B, Takeda E. Stanniocalcin 2 is associated with ectopic calcification in a-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells. Bone. 2012 Apr; 50(4):998-1005. PMID: 22285620.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    24. Yuan Q, Sitara D, Sato T, Densmore M, Saito H, Sch?ler C, Erben RG, Lanske B. PTH ablation ameliorates the anomalies of Fgf23-deficient mice by suppressing the elevated vitamin D and calcium levels. Endocrinology. 2011 Nov; 152(11):4053-61. PMID: 21896668.
      Citations: 11     Fields:    Translation:Animals
    25. Yuan Q, Sato T, Densmore M, Saito H, Sch?ler C, Erben RG, Lanske B. FGF-23/Klotho signaling is not essential for the phosphaturic and anabolic functions of PTH. J Bone Miner Res. 2011 Sep; 26(9):2026-35. PMID: 21590742.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    26. Seriwatanachai D, Densmore MJ, Sato T, Correa D, Neff L, Baron R, Lanske B. Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen metaphyseal chondrodysplasia. FASEB J. 2011 Sep; 25(9):3057-67. PMID: 21642473.
      Citations: 12     Fields:    Translation:AnimalsCells
    27. Ishiguro M, Yamamoto H, Masuda M, Kozai M, Takei Y, Tanaka S, Sato T, Segawa H, Taketani Y, Arai H, Miyamoto K, Takeda E. Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene. Biochem J. 2010 Mar 15; 427(1):161-9. PMID: 20088828.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    28. Tsuji M, Yamamoto H, Sato T, Mizuha Y, Kawai Y, Taketani Y, Kato S, Terao J, Inakuma T, Takeda E. Dietary quercetin inhibits bone loss without effect on the uterus in ovariectomized mice. J Bone Miner Metab. 2009; 27(6):673-81. PMID: 19495926.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    29. Uebanso T, Taketani Y, Fukaya M, Sato K, Takei Y, Sato T, Sawada N, Amo K, Harada N, Arai H, Yamamoto H, Takeda E. Hypocaloric high-protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways. Am J Physiol Endocrinol Metab. 2009 Jul; 297(1):E76-84. PMID: 19435858.
      Citations: 22     Fields:    Translation:AnimalsCells
    30. Takei Y, Yamamoto H, Masuda M, Sato T, Taketani Y, Takeda E. Stanniocalcin 2 is positively and negatively controlled by 1,25(OH)(2)D(3) and PTH in renal proximal tubular cells. J Mol Endocrinol. 2009 Mar; 42(3):261-8. PMID: 19131501.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    31. Sato K, Arai H, Miyazawa Y, Fukaya M, Uebanso T, Koganei M, Sasaki H, Sato T, Yamamoto H, Taketani Y, Takeda E. Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats. J Med Invest. 2008 Aug; 55(3-4):183-95. PMID: 18797130.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    32. Sato K, Arai H, Mizuno A, Fukaya M, Sato T, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Doi T, Takeda E. Dietary palatinose and oleic acid ameliorate disorders of glucose and lipid metabolism in Zucker fatty rats. J Nutr. 2007 Aug; 137(8):1908-15. PMID: 17634263.
      Citations: 19     Fields:    Translation:Animals
    33. Matsuo K, Arai H, Muto K, Fukaya M, Sato T, Mizuno A, Sakuma M, Yamanaka-Okumura H, Sasaki H, Yamamoto H, Taketani Y, Doi T, Takeda E. The Anti-Obesity Effect of the Palatinose-Based Formula Inslow is Likely due to an Increase in the Hepatic PPAR-alpha and Adipocyte PPAR-gamma Gene Expressions. J Clin Biochem Nutr. 2007 May; 40(3):234-41. PMID: 18398502.
      Citations:    
    34. Tani Y, Sato T, Yamanaka-Okumura H, Yamamoto H, Arai H, Sawada N, Genjida K, Taketani Y, Takeda E. Effects of prolonged high phosphorus diet on phosphorus and calcium balance in rats. J Clin Biochem Nutr. 2007 May; 40(3):221-8. PMID: 18398500.
      Citations:    
    35. Sawada N, Taketani Y, Amizuka N, Ichikawa M, Ogawa C, Nomoto K, Nashiki K, Sato T, Arai H, Isshiki M, Segawa H, Yamamoto H, Miyamoto K, Takeda E. Caveolin-1 in extracellular matrix vesicles secreted from osteoblasts. Bone. 2007 Jul; 41(1):52-8. PMID: 17448744.
      Citations: 10     Fields:    Translation:AnimalsCells
    36. Takeda E, Yamamoto H, Nishida Y, Sato T, Sawada N, Taketani Y. Phosphate restriction in diet therapy. Contrib Nephrol. 2007; 155:113-124. PMID: 17369719.
      Citations: 4     Fields:    Translation:Humans
    37. Mizuha Y, Yamamoto H, Sato T, Tsuji M, Masuda M, Uchida M, Sakai K, Taketani Y, Yasutomo K, Sasaki H, Takeda E. Water extract of Cordyceps sinensis (WECS) inhibits the RANKL-induced osteoclast differentiation. Biofactors. 2007; 30(2):105-16. PMID: 18356582.
      Citations: 4     Fields:    Translation:AnimalsCells
    38. Nishida Y, Taketani Y, Yamanaka-Okumura H, Imamura F, Taniguchi A, Sato T, Shuto E, Nashiki K, Arai H, Yamamoto H, Takeda E. Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men. Kidney Int. 2006 Dec; 70(12):2141-7. PMID: 17063170.
      Citations: 100     Fields:    Translation:Humans
    39. Sato T, Yamamoto H, Sawada N, Nashiki K, Tsuji M, Muto K, Kume H, Sasaki H, Arai H, Nikawa T, Taketani Y, Takeda E. Restraint stress alters the duodenal expression of genes important for lipid metabolism in rat. Toxicology. 2006 Oct 29; 227(3):248-61. PMID: 16962226.
      Citations: 5     Fields:    Translation:AnimalsCells
    40. Sato T, Yamamoto H, Sawada N, Nashiki K, Tsuji M, Nikawa T, Arai H, Morita K, Taketani Y, Takeda E. Immobilization decreases duodenal calcium absorption through a 1,25-dihydroxyvitamin D-dependent pathway. J Bone Miner Metab. 2006; 24(4):291-9. PMID: 16816923.
      Citations: 7     Fields:    Translation:HumansAnimals
    41. Takeda E, Sato T, Taketani Y. Division of Cardiovascular Disease. Nutrigenomics. 2006; 3(60):270-275.
    42. Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, Morita K, Miyamoto K, Pike JW, Kato S, Takeda E. Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene. Biochim Biophys Acta. 2005 Dec 30; 1732(1-3):43-52. PMID: 16380173.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    43. Nashiki K, Taketani Y, Shuto E, Tanaka R, Tanimura A, Sawada N, Sato T, Takei Y, Arai H, Yamamoto H, Harada N, Takeda E. Evaluation of anti-stress nutrients in the endothelial cells with fluorescence indicator. J Med Invest. 2005 Nov; 52 Suppl:295-6. PMID: 16366519.
      Citations:    Fields:    Translation:AnimalsCells
    44. Takeda E, Yamamoto H, Nashiki K, Sato T, Arai H, Taketani Y. Inorganic phosphate homeostasis and the role of dietary phosphorus. J Cell Mol Med. 2004 Apr-Jun; 8(2):191-200. PMID: 15256067.
      Citations: 38     Fields:    Translation:HumansAnimals
    45. Takeda E, Taketani Y, Sawada N, Sato T, Yamamoto H. The regulation and function of phosphate in the human body. Biofactors. 2004; 21(1-4):345-55. PMID: 15630224.
      Citations: 32     Fields:    Translation:HumansCells
    46. Yamamoto H, Sato T, Sawada N, Takeda E. [The optimum amount of vitamin D for osteoporosis: in case of activated vitamin D treatment]. Clin Calcium. 2004 Jan; 14(1):56-9. PMID: 15576955.
      Citations:    Fields:    Translation:Humans
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