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Julia M Flynn PhD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentBiochemistry and Molecular Biotechnology
AddressUMass Chan Medical School
364 Plantation Street, LRB
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    Collapse Biography 
    Collapse education and training
    Brown University, Providence, RI, United StatesBSBiochemistry
    Massachusetts Institute of Technology, Cambridge, MA, United StatesPHDBiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Flynn JM, Joyce ME, Bolon DNA. Dominant negative mutations in yeast Hsp90 reveal triage decision mechanism targeting client proteins for degradation. bioRxiv. 2024 Apr 30. PMID: 38260708.
    2. Flynn JM, Zvornicanin SN, Tsepal T, Shaqra AM, Kurt Yilmaz N, Jia W, Moquin S, Dovala D, Schiffer CA, Bolon DNA. Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance. ACS Infect Dis. 2024 04 12; 10(4):1174-1184. PMID: 38472113.
    3. Flynn JM, Huang QYJ, Zvornicanin SN, Schneider-Nachum G, Shaqra AM, Yilmaz NK, Moquin SA, Dovala D, Schiffer CA, Bolon DNA. Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease. ACS Infect Dis. 2023 07 14; 9(7):1372-1386. PMID: 37390404.
      Citations: 1     Fields:    Translation:HumansCells
    4. Mathy CJP, Mishra P, Flynn JM, Perica T, Mavor D, Bolon DNA, Kortemme T. A complete allosteric map of a GTPase switch in its native cellular network. Cell Syst. 2023 03 15; 14(3):237-246.e7. PMID: 36801015.
      Citations: 5     Fields:    Translation:Cells
    5. Flynn JM, Samant N, Schneider-Nachum G, Barkan DT, Yilmaz NK, Schiffer CA, Moquin SA, Dovala D, Bolon DNA. Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms. Elife. 2022 06 20; 11. PMID: 35723575.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    6. Flynn JM, Rossouw A, Cote-Hammarlof P, Fragata I, Mavor D, Hollins C, Bank C, Bolon DN. Comprehensive fitness maps of Hsp90 show widespread environmental dependence. Elife. 2020 03 04; 9. PMID: 32129763.
      Citations: 26     Fields:    Translation:AnimalsCells
    7. Starr TN, Flynn JM, Mishra P, Bolon DNA, Thornton JW. Pervasive contingency and entrenchment in a billion years of Hsp90 evolution. Proc Natl Acad Sci U S A. 2018 04 24; 115(17):4453-4458. PMID: 29626131.
      Citations: 38     Fields:    Translation:AnimalsCells
    8. Canale AS, Cote-Hammarlof PA, Flynn JM, Bolon DN. Evolutionary mechanisms studied through protein fitness landscapes. Curr Opin Struct Biol. 2018 02; 48:141-148. PMID: 29351890.
      Citations: 18     Fields:    Translation:HumansCells
    9. Mishra P, Flynn JM, Starr TN, Bolon DNA. Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function. Cell Rep. 2016 Apr 19; 15(3):588-598. PMID: 27068472.
      Citations: 39     Fields:    Translation:AnimalsCells
    10. Flynn JM, Mishra P, Bolon DN. Mechanistic Asymmetry in Hsp90 Dimers. J Mol Biol. 2015 Sep 11; 427(18):2904-11. PMID: 25843003.
      Citations: 11     Fields:    Translation:HumansCells
    11. Sauer RT, Bolon DN, Burton BM, Burton RE, Flynn JM, Grant RA, Hersch GL, Joshi SA, Kenniston JA, Levchenko I, Neher SB, Oakes ES, Siddiqui SM, Wah DA, Baker TA. Sculpting the proteome with AAA(+) proteases and disassembly machines. Cell. 2004 Oct 01; 119(1):9-18. PMID: 15454077.
      Citations: 187     Fields:    Translation:HumansAnimalsCells
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