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Rachael Sirianni PhD, MS, MSE, BSE

TitleProfessor
InstitutionUMass Chan Medical School
DepartmentNeurological Surgery
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
Phone508-334-1000
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentNeurological Surgery

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMillennium MD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentNeuroscience

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science


    Collapse Biography 
    Collapse education and training
    Arizona State University, Tempe, AZ, United StatesBEBioengineering
    Yale University, New Haven, CT, United StatesMSBiomedical Engineering
    Yale University, New Haven, CT, United StatesPHDBiomedical Engineering

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhang W, Oh JH, Zhang W, Aldrich CC, Sirianni RW, Elmquist WF. Central nervous system distributional kinetics of selected histone deacetylase inhibitors. J Pharmacol Exp Ther. 2025 Jan; 392(1):100014. PMID: 39893010.
      Citations:    
    2. Zhang W, Oh JH, Zhang W, Aldrich CC, Sirianni RW, Elmquist WF. Central Nervous System Distributional Kinetics of Selected Histone Deacetylase Inhibitors. J Pharmacol Exp Ther. 2024 Apr 26. PMID: 38670802.
      Citations:    
    3. Zhang W, Oh JH, Zhang W, Aldrich CC, Sirianni RW, Elmquist WF. Pharmacokinetics of Panobinostat: Interspecies Difference in Metabolic Stability. J Pharmacol Exp Ther. 2024 Mar 15; 389(1):96-105. PMID: 38409112.
      Citations:    
    4. Simmons A, Mihalek O, Bimonte Nelson HA, Sirianni RW, Stabenfeldt SE. Acute brain injury and nanomedicine: sex as a biological variable. Front Biomater Sci. 2024; 3. PMID: 39450372.
      Citations:    
    5. Zhang W, Oh JH, Zhang W, Rathi S, Larson JD, Wechsler-Reya RJ, Sirianni RW, Elmquist WF. Central Nervous System Distribution of Panobinostat in Preclinical Models to Guide Dosing for Pediatric Brain Tumors. J Pharmacol Exp Ther. 2023 12; 387(3):315-327. PMID: 37827699.
      Citations:    Fields:    Translation:HumansAnimals
    6. Fowler MJ, Riley CO, Tomasson E, Mehta S, Grande-Allen J, Ballester L, Sandberg DI, Janssen CF, Sirianni RW. Engineering subarachnoid trabeculae with electrospun poly(caprolactone) (PCL) scaffolds to study leptomeningeal metastasis in medulloblastoma. Biomater Adv. 2023 Dec; 155:213646. PMID: 37918168.
      Citations:    Fields:    Translation:HumansAnimals
    7. Heffernan JM, McNamara JB, Vernon BL, Mehta S, Sirianni RW. PNJ scaffolds promote microenvironmental regulation of glioblastoma stem-like cell enrichment and radioresistance. Biomater Sci. 2022 Feb 01; 10(3):819-833. PMID: 34994746.
      Citations:    Fields:    Translation:HumansCells
    8. Bell LC, Fuentes AE, Healey DR, Chao R, Bakkar N, Sirianni RW, Medina DX, Bowser RP, Ladha SS, Semmineh NB, Stokes AM, Quarles CC. Longitudinal evaluation of myofiber microstructural changes in a preclinical ALS model using the transverse relaxivity at tracer equilibrium (TRATE): A preliminary study. Magn Reson Imaging. 2022 01; 85:217-221. PMID: 34715291.
      Citations:    Fields:    Translation:HumansAnimals
    9. Chaudhuri S, Fowler MJ, Baker C, Stopka SA, Regan MS, Sablatura L, Broughton CW, Knight BE, Stabenfeldt SE, Agar NYR, Sirianni RW. ?-Cyclodextrin-poly (?-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors. ACS Appl Mater Interfaces. 2021 May 12; 13(18):20960-20973. PMID: 33905245.
      Citations: 8     Fields:    Translation:Animals
    10. Prakapenka AV, Pe?a VL, Strouse I, Northup-Smith S, Schrier A, Ahmed K, Bimonte-Nelson HA, Sirianni RW. Intranasal 17?-Estradiol Modulates Spatial Learning and Memory in a Rat Model of Surgical Menopause. Pharmaceutics. 2020 Dec 17; 12(12). PMID: 33348722.
      Citations:    
    11. Prakapenka AV, Quihuis AM, Carson CG, Patel S, Bimonte-Nelson HA, Sirianni RW. Poly(lactic-co-glycolic Acid) Nanoparticle Encapsulated 17?-Estradiol Improves Spatial Memory and Increases Uterine Stimulation in Middle-Aged Ovariectomized Rats. Front Behav Neurosci. 2020; 14:597690. PMID: 33424559.
      Citations:    
    12. Sandberg DI, Kharas N, Yu B, Janssen CF, Trimble A, Ballester LY, Patel R, Mohammad AS, Elmquist WF, Sirianni RW. High-dose MTX110 (soluble panobinostat) safely administered into the fourth ventricle in a nonhuman primate model. J Neurosurg Pediatr. 2020 08 01; 26(2):127-135. PMID: 32357333.
      Citations: 6     Fields:    
    13. Medina DX, Chung EP, Teague CD, Bowser R, Sirianni RW. Intravenously Administered, Retinoid Activating Nanoparticles Increase Lifespan and Reduce Neurodegeneration in the SOD1G93A Mouse Model of ALS. Front Bioeng Biotechnol. 2020; 8:224. PMID: 32292776.
      Citations:    
    14. Fowler MJ, Cotter JD, Knight BE, Sevick-Muraca EM, Sandberg DI, Sirianni RW. Intrathecal drug delivery in the era of nanomedicine. Adv Drug Deliv Rev. 2020; 165-166:77-95. PMID: 32142739.
      Citations: 41     Fields:    Translation:HumansAnimals
    15. Chung EP, Cotter JD, Prakapenka AV, Cook RL, DiPerna DM, Sirianni RW. Targeting Small Molecule Delivery to the Brain and Spinal Cord via Intranasal Administration of Rabies Virus Glycoprotein (RVG29)-Modified PLGA Nanoparticles. Pharmaceutics. 2020 Jan 24; 12(2). PMID: 31991664.
      Citations:    
    16. Householder KT, Dharmaraj S, Sandberg DI, Wechsler-Reya RJ, Sirianni RW. Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice. Sci Rep. 2019 08 29; 9(1):12587. PMID: 31467368.
      Citations: 25     Fields:    Translation:Animals
    17. Sandberg DI, Yu B, Patel R, Hagan J, Miesner E, Sabin J, Smith S, Fletcher S, Shah MN, Sirianni RW, Taylor MD. Infusion of 5-Azacytidine (5-AZA) into the fourth ventricle or resection cavity in children with recurrent posterior Fossa Ependymoma: a pilot clinical trial. J Neurooncol. 2019 Jan; 141(2):449-457. PMID: 30460634.
      Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
    18. Householder KT, DiPerna DM, Chung EP, Luning AR, Nguyen DT, Stabenfeldt SE, Mehta S, Sirianni RW. pH driven precipitation of quisinostat onto PLA-PEG nanoparticles enables treatment of intracranial glioblastoma. Colloids Surf B Biointerfaces. 2018 Jun 01; 166:37-44. PMID: 29533842.
      Citations: 10     Fields:    Translation:HumansAnimals
    19. DiPerna DM, Prakapenka AV, Chung EP, Sirianni RW. Non-Enzymatic Tissue Homogenization for Biodistribution Analysis. Methods Mol Biol. 2018; 1831:191-199. PMID: 30051433.
      Citations: 1     Fields:    Translation:Animals
    20. Prakapenka AV, Hiroi R, Quihuis AM, Carson C, Patel S, Berns-Leone C, Fox C, Sirianni RW, Bimonte-Nelson HA. Contrasting effects of individual versus combined estrogen and progestogen regimens as working memory load increases in middle-aged ovariectomized rats: one plus one does not equal two. Neurobiol Aging. 2018 04; 64:1-14. PMID: 29316527.
      Citations: 20     Fields:    Translation:AnimalsCells
    21. Moutal A, Villa LS, Yeon SK, Householder KT, Park KD, Sirianni RW, Khanna R. CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation. Mol Neurobiol. 2018 May; 55(5):4403-4416. PMID: 28660485.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    22. Prakapenka AV, Bimonte-Nelson HA, Sirianni RW. Engineering poly(lactic-co-glycolic acid) (PLGA) micro- and nano-carriers for Controlled Delivery of 17?-Estradiol. Ann Biomed Eng. 2017 Jul; 45(7):1697-1709. PMID: 28634732.
      Citations: 7     Fields:    Translation:HumansAnimals
    23. Heffernan JM, McNamara JB, Borwege S, Vernon BL, Sanai N, Mehta S, Sirianni RW. PNIPAAm-co-Jeffamine? (PNJ) scaffolds as in?vitro models for niche enrichment of glioblastoma stem-like cells. Biomaterials. 2017 Oct; 143:149-158. PMID: 28802102.
      Citations: 8     Fields:    Translation:HumansCells
    24. Medina DX, Householder KT, Ceton R, Kovalik T, Heffernan JM, Shankar RV, Bowser RP, Wechsler-Reya RJ, Sirianni RW. Optical barcoding of PLGA for multispectral analysis of nanoparticle fate in vivo. J Control Release. 2017 05 10; 253:172-182. PMID: 28263836.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    25. Addington CP, Dharmawaj S, Heffernan JM, Sirianni RW, Stabenfeldt SE. Hyaluronic acid-laminin hydrogels increase neural stem cell transplant retention and migratory response to SDF-1a. Matrix Biol. 2017 07; 60-61:206-216. PMID: 27645115.
      Citations: 19     Fields:    Translation:AnimalsCells
    26. Kobes JE, Daryaei I, Howison CM, Bontrager JG, Sirianni RW, Meuillet EJ, Pagel MD. Improved Treatment of Pancreatic Cancer With Drug Delivery Nanoparticles Loaded With a Novel AKT/PDK1 Inhibitor. Pancreas. 2016 09; 45(8):1158-66. PMID: 26918875.
      Citations: 11     Fields:    Translation:AnimalsCells
    27. Navaei A, Truong D, Heffernan J, Cutts J, Brafman D, Sirianni RW, Vernon B, Nikkhah M. PNIPAAm-based biohybrid injectable hydrogel for cardiac tissue engineering. Acta Biomater. 2016 Mar 01; 32:10-23. PMID: 26689467.
      Citations: 28     Fields:    Translation:AnimalsCells
    28. Dutta D, Salifu M, Sirianni RW, Stabenfeldt SE. Tailoring sub-micron PLGA particle release profiles via centrifugal fractioning. J Biomed Mater Res A. 2016 03; 104(3):688-696. PMID: 26517011.
      Citations: 9     Fields:    Translation:Animals
    29. Cook RL, Householder KT, Chung EP, Prakapenka AV, DiPerna DM, Sirianni RW. A critical evaluation of drug delivery from ligand modified nanoparticles: Confounding small molecule distribution and efficacy in the central nervous system. J Control Release. 2015 Dec 28; 220(Pt A):89-97. PMID: 26471392.
      Citations: 28     Fields:    Translation:AnimalsCells
    30. Addington CP, Heffernan JM, Millar-Haskell CS, Tucker EW, Sirianni RW, Stabenfeldt SE. Enhancing neural stem cell response to SDF-1a gradients through hyaluronic acid-laminin hydrogels. Biomaterials. 2015 Dec; 72:11-9. PMID: 26340314.
      Citations: 21     Fields:    Translation:AnimalsCells
    31. Heffernan JM, Overstreet DJ, Srinivasan S, Le LD, Vernon BL, Sirianni RW. Temperature responsive hydrogels enable transient three-dimensional tumor cultures via rapid cell recovery. J Biomed Mater Res A. 2016 Jan; 104(1):17-25. PMID: 26123863.
      Citations: 6     Fields:    Translation:HumansCells
    32. Householder KT, DiPerna DM, Chung EP, Wohlleb GM, Dhruv HD, Berens ME, Sirianni RW. Intravenous delivery of camptothecin-loaded PLGA nanoparticles for the treatment of intracranial glioma. Int J Pharm. 2015 Feb 20; 479(2):374-80. PMID: 25562639.
      Citations: 31     Fields:    Translation:Animals
    33. Heffernan JM, Overstreet DJ, Le LD, Vernon BL, Sirianni RW. Bioengineered Scaffolds for 3D Analysis of Glioblastoma Proliferation and Invasion. Ann Biomed Eng. 2015 Aug; 43(8):1965-77. PMID: 25515315.
      Citations: 29     Fields:    Translation:HumansCells
    34. Sirianni RW, Zheng MQ, Patel TR, Shafbauer T, Zhou J, Saltzman WM, Carson RE, Huang Y. Radiolabeling of poly(lactic-co-glycolic acid) (PLGA) nanoparticles with biotinylated F-18 prosthetic groups and imaging of their delivery to the brain with positron emission tomography. Bioconjug Chem. 2014 Dec 17; 25(12):2157-65. PMID: 25322194.
      Citations: 17     Fields:    Translation:Animals
    35. McCall RL, Cacaccio J, Wrabel E, Schwartz ME, Coleman TP, Sirianni RW. Pathogen-inspired drug delivery to the central nervous system. Tissue Barriers. 2014; 2(4):e944449. PMID: 25610755.
      Citations: 11     Fields:    
    36. McCall RL, Sirianni RW. PLGA nanoparticles formed by single- or double-emulsion with vitamin E-TPGS. J Vis Exp. 2013 Dec 27; (82):51015. PMID: 24429733.
      Citations: 81     Fields:    
    37. Sirianni RW, Zheng MQ, Saltzman WM, Huang Y, Carson RE. Direct, quantitative, and noninvasive imaging of the transport of active agents through intact brain with positron emission tomography. Mol Imaging Biol. 2013 Oct; 15(5):596-605. PMID: 23624949.
      Citations: 4     Fields:    Translation:AnimalsCells
    38. Chimento A, Casaburi I, Bartucci M, Patrizii M, Dattilo R, Avena P, And? S, Pezzi V, Sirianni R. Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells. Cell Death Dis. 2013 Aug 01; 4:e747. PMID: 23907461.
      Citations: 17     Fields:    Translation:AnimalsCells
    39. Zhou J, Patel TR, Sirianni RW, Strohbehn G, Zheng MQ, Duong N, Schafbauer T, Huttner AJ, Huang Y, Carson RE, Zhang Y, Sullivan DJ, Piepmeier JM, Saltzman WM. Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):11751-6. PMID: 23818631.
      Citations: 111     Fields:    Translation:Animals
    40. Chimento A, Sirianni R, Zolea F, Bois C, Delalande C, And? S, Maggiolini M, Aquila S, Carreau S, Pezzi V. Gper and ESRs are expressed in rat round spermatids and mediate oestrogen-dependent rapid pathways modulating expression of cyclin B1 and Bax. Int J Androl. 2011 Oct; 34(5 Pt 1):420-9. PMID: 20969598.
      Citations: 23     Fields:    Translation:AnimalsCells
    41. Sirianni RW, Olausson P, Chiu AS, Taylor JR, Saltzman WM. The behavioral and biochemical effects of BDNF containing polymers implanted in the hippocampus of rats. Brain Res. 2010 Mar 19; 1321:40-50. PMID: 20096671.
      Citations: 18     Fields:    Translation:Animals
    42. Sirianni RW, Jang EH, Miller KM, Saltzman WM. Parameter estimation methodology in a model of hydrophobic drug release from a polymer coating. J Control Release. 2010 Mar 19; 142(3):474-82. PMID: 19958804.
      Citations: 4     Fields:    Translation:HumansCells
    43. Sirianni RW, Kremer J, Guler I, Chen YL, Keeley FW, Saltzman WM. Effect of extracellular matrix elements on the transport of paclitaxel through an arterial wall tissue mimic. Biomacromolecules. 2008 Oct; 9(10):2792-8. PMID: 18785771.
      Citations: 6     Fields:    Translation:HumansCells
    44. Sirianni R, Carr BR, And? S, Rainey WE. Inhibition of Src tyrosine kinase stimulates adrenal androgen production. J Mol Endocrinol. 2003 Jun; 30(3):287-99. PMID: 12790800.
      Citations: 10     Fields:    Translation:HumansCells
    45. Sirianni R, Sirianni R, Carr BR, Pezzi V, Rainey WE. A role for src tyrosine kinase in regulating adrenal aldosterone production. J Mol Endocrinol. 2001 Jun; 26(3):207-15. PMID: 11357057.
      Citations: 11     Fields:    Translation:AnimalsCells
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