Header Logo

Jessica Brooke Spinelli Phd

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentProgram in Molecular Medicine
AddressUMass Chan School of Medicine
373 Plantation Street
Worcester MA 01605
vCardDownload vCard
    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    Collapse Biography 
    Collapse education and training
    Hofstra University, Hempstead, NY, United StatesBSBiochemistry
    Harvard University, Cambridge, MA, United StatesPHDChemical Biology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Honeywell ME, Isidor MS, Harper NW, Fontana RE, Birdsall GA, Cruz-Gordillo P, Porto SA, Jerome M, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ. Functional genomic screens with death rate analyses reveal mechanisms of drug action. Nat Chem Biol. 2024 Mar 13. PMID: 38480981.
    2. Lee N, Park SJ, Lange M, Tseyang T, Doshi MB, Kim TY, Song Y, Kim DI, Greer PL, Olzmann JA, Spinelli JB, Kim D. Selenium reduction of ubiquinone via SQOR suppresses ferroptosis. Nat Metab. 2024 Feb; 6(2):343-358. PMID: 38351124.
    3. Santamans AM, Cicu?ndez B, Mora A, Villalba-Orero M, Rajlic S, Crespo M, Vo P, Jerome M, Mac?as ?, L?pez JA, Leiva M, Rocha SF, Le?n M, Rodr?guez E, Leiva L, Pintor Chocano A, Garc?a Lunar I, Garc?a-?lvarez A, Hernansanz-Agust?n P, Peinado VI, Barber? JA, Iba?ez B, V?zquez J, Spinelli JB, Daiber A, Oliver E, Sabio G. MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension. Sci Adv. 2024 Jan 19; 10(3):eadk6524. PMID: 38241373.
      Citations:    Fields:    Translation:HumansAnimals
    4. Doshi MB, Lee N, Tseyang T, Ponomarova O, Goel HL, Spears M, Li R, Zhu LJ, Ashwood C, Simin K, Jang C, Mercurio AM, Walhout AJM, Spinelli JB, Kim D. Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells. Nature. 2023 Nov; 623(7987):625-632. PMID: 37880368.
      Citations: 1     Fields:    Translation:HumansCells
    5. Park G, Haley JA, Le J, Jung SM, Fitzgibbons TP, Korobkina ED, Li H, Fluharty SM, Chen Q, Spinelli JB, Trivedi CM, Jang C, Guertin DA. Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis. Nat Metab. 2023 07; 5(7):1204-1220. PMID: 37337122.
      Citations: 5     Fields:    Translation:Animals
    6. Tseyang T, Valeros J, Vo P, Spinelli JB. Oxygen-Independent Assays to Measure Mitochondrial Function in Mammals. J Vis Exp. 2023 May 19; (195). PMID: 37318248.
      Citations:    Fields:    Translation:AnimalsCells
    7. Honeywell ME, Isidor MS, Harper NW, Fontana RE, Cruz-Gordillo P, Porto SA, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ. p53 controls choice between apoptotic and non-apoptotic death following DNA damage. bioRxiv. 2023 May 16. PMID: 36712034.
    8. Shinde AB, Nunn ER, Wilson GA, Chvasta MT, Pinette JA, Myers JW, Peck SH, Spinelli JB, Zaganjor E. Inhibition of nucleotide biosynthesis disrupts lipid accumulation and adipogenesis. J Biol Chem. 2023 05; 299(5):104635. PMID: 36963490.
      Citations:    Fields:    Translation:AnimalsCells
    9. Godbole AA, Gopalan S, Nguyen TK, Munden AL, Lui DS, Fanelli MJ, Vo P, Lewis CA, Spinelli JB, Fazzio TG, Walker AK. S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress. Elife. 2023 02 09; 12. PMID: 36756948.
      Citations: 1     Fields:    Translation:Animals
    10. Dall'Agnese A, Platt JM, Zheng MM, Friesen M, Dall'Agnese G, Blaise AM, Spinelli JB, Henninger JE, Tevonian EN, Hannett NM, Lazaris C, Drescher HK, Bartsch LM, Kilgore HR, Jaenisch R, Griffith LG, Cisse II, Jeppesen JF, Lee TI, Young RA. The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance. Nat Commun. 2022 12 06; 13(1):7522. PMID: 36473871.
      Citations: 11     Fields:    Translation:Humans
    11. Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, Zaganjor E, McBrayer SK, Sorger PK, Sharpe AH, Wucherpfennig KW, Santagata S, Agar NYR, Suv? ML, Haigis MC. Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function. Science. 2022 09 30; 377(6614):1519-1529. PMID: 36173860.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    12. Cangelosi AL, Puszynska AM, Roberts JM, Armani A, Nguyen TP, Spinelli JB, Kunchok T, Wang B, Chan SH, Lewis CA, Comb WC, Bell GW, Helman A, Sabatini DM. Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine. Science. 2022 07; 377(6601):47-56. PMID: 35771919.
      Citations: 9     Fields:    Translation:AnimalsCells
    13. Spinelli JB, Zaganjor E. Mitochondrial efficiency directs cell fate. Nat Cell Biol. 2022 02; 24(2):125-126. PMID: 35165414.
      Citations: 3     Fields:    Translation:Cells
    14. Spinelli JB, Rosen PC, Sprenger HG, Puszynska AM, Mann JL, Roessler JM, Cangelosi AL, Henne A, Condon KJ, Zhang T, Kunchok T, Lewis CA, Chandel NS, Sabatini DM. Fumarate is a terminal electron acceptor in the mammalian electron transport chain. Science. 2021 Dec 03; 374(6572):1227-1237. PMID: 34855504.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    15. van Gastel N, Spinelli JB, Haigis MC, Scadden DT. Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice. Bio Protoc. 2021 Oct 05; 11(19):e4171. PMID: 34722818.
    16. Zaganjor E, Yoon H, Spinelli JB, Nunn ER, Laurent G, Keskinidis P, Sivaloganathan S, Joshi S, Notarangelo G, Mulei S, Chvasta MT, Tucker SA, Kalafut K, van de Ven RAH, Clish CB, Haigis MC. SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis. Cell Rep. 2021 07 13; 36(2):109345. PMID: 34260923.
      Citations: 12     Fields:    Translation:AnimalsCells
    17. Condon KJ, Orozco JM, Adelmann CH, Spinelli JB, van der Helm PW, Roberts JM, Kunchok T, Sabatini DM. Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction. Proc Natl Acad Sci U S A. 2021 Jan 26; 118(4). PMID: 33483422.
      Citations: 44     Fields:    Translation:HumansCells
    18. van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, Haigis MC, Scadden DT. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metab. 2020 09 01; 32(3):391-403.e6. PMID: 32763164.
      Citations: 50     Fields:    Translation:Animals
    19. Yoon H, Spinelli JB, Zaganjor E, Wong SJ, German NJ, Randall EC, Dean A, Clermont A, Paulo JA, Garcia D, Li H, Rombold O, Agar NYR, Goodyear LJ, Shaw RJ, Gygi SP, Auwerx J, Haigis MC. PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle. Cell Metab. 2020 08 04; 32(2):215-228.e7. PMID: 32663458.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    20. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell. 2018 09 20; 175(1):101-116.e25. PMID: 30220459.
      Citations: 152     Fields:    Translation:HumansCells
    21. Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. 2018 08; 560(7716):102-106. PMID: 30022159.
      Citations: 214     Fields:    Translation:AnimalsCells
    22. Spinelli JB, Haigis MC. The multifaceted contributions of mitochondria to cellular metabolism. Nat Cell Biol. 2018 07; 20(7):745-754. PMID: 29950572.
      Citations: 492     Fields:    Translation:HumansAnimalsCells
    23. Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC. Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3. Cell Rep. 2018 02 20; 22(8):1945-1955. PMID: 29466723.
      Citations: 15     Fields:    Translation:AnimalsCells
    24. Spinelli JB, Yoon H, Ringel AE, Jeanfavre S, Clish CB, Haigis MC. Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass. Science. 2017 11 17; 358(6365):941-946. PMID: 29025995.
      Citations: 185     Fields:    Translation:HumansAnimalsCells
    25. Spinelli JB, Kelley LP, Haigis MC. An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues. Sci Rep. 2017 09 04; 7(1):10304. PMID: 28871132.
      Citations: 9     Fields:    Translation:HumansCells
    26. Zaganjor E, Spinelli JB, Haigis MC. Strength in numbers: Phosphofructokinase polymerization prevails in the liver. J Cell Biol. 2017 08 07; 216(8):2239-2241. PMID: 28716843.
      Citations: 2     Fields:    Translation:Cells
    27. Brown KK, Spinelli JB, Asara JM, Toker A. Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer. Cancer Discov. 2017 04; 7(4):391-399. PMID: 28255083.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    28. Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016 07 12; 24(1):104-17. PMID: 27411012.
      Citations: 175     Fields:    Translation:AnimalsCells
    Spinelli's Networks
    Click the
    buttons for more information and interactive visualizations!
    Concepts (167)
    Co-Authors (13)
    Similar People (60)
    Same Department Expand Description
    Physical Neighbors