Substrate docking to ?-secretase allows access of ?-secretase modulators to an allosteric site.
Uemura K, Farner KC, Hashimoto T, Nasser-Ghodsi N, Wolfe MS, Koo EH, Hyman BT, Berezovska O. Substrate docking to ?-secretase allows access of ?-secretase modulators to an allosteric site. Nat Commun. 2010 Nov 30; 1:130.