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John Pezzuto PhD, DSc

TitleAdjunct Professor
InstitutionUMass Chan – Baystate Regional Campus
DepartmentMedicine at UMass Chan - Baystate
AddressWestern New England University
1215 Wilbraham Road
Springfield MA 01119
Phone413-796-2323
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    Collapse Biography 
    Collapse education and training
    Rutgers University Camden, Camden, NJ, United StatesBAChemistry
    University of Medicine and Dentistry of New Jersey, Newark, NJ, United StatesPHD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Beyo?lu D, Park EJ, Quiñones-Lombraña A, Dave A, Parande F, Pezzuto JM, Idle JR. Addition of grapes to both a standard and a high-fat Western pattern diet modifies hepatic and urinary metabolite profiles in the mouse. Food Funct. 2022 Aug 15; 13(16):8489-8499. PMID: 35876245.
      Citations:    Fields:    
    2. Dave A, Park EJ, Kumar A, Parande F, Beyo?lu D, Idle JR, Pezzuto JM. Consumption of Grapes Modulates Gene Expression, Reduces Non-Alcoholic Fatty Liver Disease, and Extends Longevity in Female C57BL/6J Mice Provided with a High-Fat Western-Pattern Diet. Foods. 2022 Jul 05; 11(13). PMID: 35804799.
      Citations:    
    3. Parande F, Dave A, Park EJ, McAllister C, Pezzuto JM. Effect of Dietary Grapes on Female C57BL6/J Mice Consuming a High-Fat Diet: Behavioral and Genetic Changes. Antioxidants (Basel). 2022 Feb 18; 11(2). PMID: 35204296.
      Citations:    
    4. Ahmad B, Khan MR, Shah NA, Kondratyuk TP, Ahmed N, Pezzuto JM, Gul A, Khattak A. Investigation of Chemopreventive and Antiproliferative Potential of Dicliptera roxburghiana. Integr Cancer Ther. 2022 Jan-Dec; 21:15347354211069934. PMID: 34991410.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Molina J, Nikolic D, Jeevarathanam JR, Abzalimov R, Park EJ, Pedales R, Mojica EE, Tandang D, McLaughlin W, Wallick K, Adams J, Novy A, Pell SK, van Breemen RB, Pezzuto JM. Living with a giant, flowering parasite: metabolic differences between Tetrastigma loheri Gagnep. (Vitaceae) shoots uninfected and infected with Rafflesia (Rafflesiaceae) and potential applications for propagation. Planta. 2021 Nov 29; 255(1):4. PMID: 34841446.
      Citations:    Fields:    Translation:Animals
    6. Zaman KAU, Hu Z, Wu X, Hou S, Saito J, Kondratyuk TP, Pezzuto JM, Cao S. NF-?B Inhibitory and Antibacterial Helvolic and Fumagillin Derivatives from Aspergillus terreus. J Nat Prod. 2020 03 27; 83(3):730-737. PMID: 32163285.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    7. Heinrich M, Appendino G, Efferth T, Fürst R, Izzo AA, Kayser O, Pezzuto JM, Viljoen A. Best practice in research - Overcoming common challenges in phytopharmacological research. J Ethnopharmacol. 2020 Jan 10; 246:112230. PMID: 31526860.
      Citations: 99     Fields:    Translation:HumansAnimals
    8. Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM. Physalactone and 4?-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. J Nat Prod. 2019 03 22; 82(3):492-499. PMID: 30649869.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Pezzuto JM. Resveratrol: Twenty Years of Growth, Development and Controversy. Biomol Ther (Seoul). 2019 01 01; 27(1):1-14. PMID: 30332889.
      Citations:    
    10. Zhang M, Park EJ, Kondratyuk TP, Pezzuto JM, Sun D. Synthesis and Structure-Activity Relationships of Tetrahydro-?-carboline Derivatives as Anticancer and Cancer-chemopreventive Agents. Anticancer Res. 2018 Aug; 38(8):4425-4433. PMID: 30061206.
      Citations:    Fields:    Translation:AnimalsCells
    11. da Silva ES, Oliveira BG, Pereira ACH, Pimentel EF, Pezzuto JM, Lenz D, Kondratyuk TP, Andrade TU, Fronza M, Scherer R, Maia JF, Romão W, Alves FL, Ventura JA, Endringer DC. Induction of NAD (P)H: Quinone reductase 1 (QR1) and antioxidant activities in vitro of 'Toranja Burarama' (Citrus maxima [Burm.] Merr.). Phytother Res. 2018 Oct; 32(10):2059-2068. PMID: 29998488.
      Citations:    Fields:    Translation:AnimalsCells
    12. Prior AM, Yu X, Park EJ, Kondratyuk TP, Lin Y, Pezzuto JM, Sun D. Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1. Bioorg Med Chem Lett. 2017 12 15; 27(24):5393-5399. PMID: 29153737.
      Citations: 2     Fields:    Translation:HumansCells
    13. Cai YS, Sarotti AM, Gündisch D, Kondratyuk TP, Pezzuto JM, Turkson J, Cao S. Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities. Bioorg Med Chem Lett. 2017 10 15; 27(20):4630-4634. PMID: 28927792.
      Citations:    Fields:    Translation:HumansAnimalsCells
    14. Li CS, Sarotti AM, Huang P, Dang UT, Hurdle JG, Kondratyuk TP, Pezzuto JM, Turkson J, Cao S. NF-?B inhibitors, unique ?-pyranol-?-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462. Sci Rep. 2017 09 05; 7(1):10424. PMID: 28874704.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    15. Chang LC, Sang-Ngern M, Pezzuto JM, Ma C. The Daniel K. Inouye College of Pharmacy Scripts: Poha Berry (Physalis peruviana) with Potential Anti-inflammatory and Cancer Prevention Activities. Hawaii J Med Public Health. 2016 11; 75(11):353-359. PMID: 27920947.
      Citations: 4     Fields:    Translation:HumansAnimals
    16. Youn UJ, Park EJ, Kondratyuk TP, Sripisut T, Laphookhieo S, Pezzuto JM, Chang LC. Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis. Fitoterapia. 2016 Oct; 114:92-97. PMID: 27575322.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    17. Issa ME, Berndt S, Carpentier G, Pezzuto JM, Cuendet M. Bruceantin inhibits multiple myeloma cancer stem cell proliferation. Cancer Biol Ther. 2016 09; 17(9):966-75. PMID: 27434731.
      Citations: 10     Fields:    Translation:HumansCells
    18. Kondratyuk TP, Adrian JA, Wright B, Park EJ, van Breemen RB, Morris KR, Pezzuto JM. Evidence supporting the conceptual framework of cancer chemoprevention in canines. Sci Rep. 2016 05 24; 6:26500. PMID: 27216246.
      Citations: 1     Fields:    Translation:Animals
    19. Youn UJ, Park EJ, Kondratyuk TP, Sang-Ngern M, Wall MM, Wei Y, Pezzuto JM, Chang LC. Anti-inflammatory and Quinone Reductase Inducing Compounds from Fermented Noni (Morinda citrifolia) Juice Exudates. J Nat Prod. 2016 06 24; 79(6):1508-13. PMID: 27196335.
      Citations: 7     Fields:    Translation:AnimalsCells
    20. Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM. Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4?-hydroxywithanolide E isolated from Physalis peruviana. Mol Nutr Food Res. 2016 06; 60(6):1482-500. PMID: 27006100.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    21. Fatima N, Kondratyuk TP, Park EJ, Marler LE, Jadoon M, Qazi MA, Mehboob Mirza H, Khan I, Atiq N, Chang LC, Ahmed S, Pezzuto JM. Endophytic fungi associated with Taxus fuana (West Himalayan Yew) of Pakistan: potential bio-resources for cancer chemopreventive agents. Pharm Biol. 2016 Nov; 54(11):2547-2554. PMID: 27159021.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    22. Sang-Ngern M, Youn UJ, Park EJ, Kondratyuk TP, Simmons CJ, Wall MM, Ruf M, Lorch SE, Leong E, Pezzuto JM, Chang LC. Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity. Bioorg Med Chem Lett. 2016 Jun 15; 26(12):2755-2759. PMID: 27210437.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    23. Guan Y, Wang D, Tan GT, Van Hung N, Cuong NM, Pezzuto JM, Fong HH, Soejarto DD, Zhang H. Litsea Species as Potential Antiviral Plant Sources. Am J Chin Med. 2016; 44(2):275-90. PMID: 27080941.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    24. Jafri L, Saleem S, Kondrytuk TP, Haq IU, Ullah N, Pezzuto JM, Mirza B. Hedera nepalensis K. Koch: A Novel Source of Natural Cancer Chemopreventive and Anticancerous Compounds. Phytother Res. 2016 Mar; 30(3):447-53. PMID: 26692176.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    25. Cragg GM, Pezzuto JM. Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents. Med Princ Pract. 2016; 25 Suppl 2:41-59. PMID: 26679767.
      Citations: 123     Fields:    Translation:Humans
    26. Youn UJ, Sripisut T, Park EJ, Kondratyuk TP, Fatima N, Simmons CJ, Wall MM, Sun D, Pezzuto JM, Chang LC. Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4719-4723. PMID: 26343828.
      Citations: 6     Fields:    Translation:AnimalsCells
    27. Vang O, Pezzuto JM. Introduction to Resveratrol and Health: 3rd International Conference. Ann N Y Acad Sci. 2015 Aug; 1348(1):v-vi. PMID: 26315296.
      Citations: 2     Fields:    Translation:Humans
    28. Chelsky ZL, Yue P, Kondratyuk TP, Paladino D, Pezzuto JM, Cushman M, Turkson J. A Resveratrol Analogue Promotes ERKMAPK-Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells. Mol Pharmacol. 2015 Sep; 88(3):524-33. PMID: 26138072.
      Citations: 12     Fields:    Translation:HumansCells
    29. Jabeen F, Panda SS, Kondratyuk TP, Park EJ, Pezzuto JM, Hall CD, Katritzky AR. Synthesis, molecular docking and anticancer studies of peptides and iso-peptides. Bioorg Med Chem Lett. 2015 Aug 01; 25(15):2980-4. PMID: 26048799.
      Citations: 1     Fields:    Translation:HumansCells
    30. Hussain RA, Badshah A, Pezzuto JM, Ahmed N, Kondratyuk TP, Park EJ. Ferrocene incorporated selenoureas as anticancer agents. J Photochem Photobiol B. 2015 Jul; 148:197-208. PMID: 25966308.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    31. Pezzuto JM, Ma CS. Academic pharmacy strikes Hawai'i. Part 2. Hawaii J Med Public Health. 2015 Mar; 74(3):120-8. PMID: 25821655.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    32. Park EJ, Pezzuto JM. The pharmacology of resveratrol in animals and humans. Biochim Biophys Acta. 2015 Jun; 1852(6):1071-113. PMID: 25652123.
      Citations: 92     Fields:    Translation:HumansAnimals
    33. Pezzuto JM, Pezzuto MF. The Daniel K. Inouye College of Pharmacy scripts: Academic pharmacy strikes Hawai'i (part 1). Hawaii J Med Public Health. 2015 Jan; 74(1):33-6. PMID: 25628981.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    34. Parrish SM, Yoshida WY, Kondratyuk TP, Park EJ, Pezzuto JM, Kelly M, Williams PG. Spongiapyridine and related spongians isolated from an Indonesian Spongia sp. J Nat Prod. 2014 Jul 25; 77(7):1644-9. PMID: 24992702.
      Citations: 4     Fields:    Translation:AnimalsCells
    35. García ME, Nicotra VE, Oberti JC, Ríos-Luci C, León LG, Marler L, Li G, Pezzuto JM, van Breemen RB, Padrón JM, Hueso-Falcón I, Estévez-Braun A. Antiproliferative and quinone reductase-inducing activities of withanolides derivatives. Eur J Med Chem. 2014 Jul 23; 82:68-81. PMID: 24878636.
      Citations:    Fields:    Translation:HumansAnimalsCells
    36. Chai X, Youn UJ, Sun D, Dai J, Williams P, Kondratyuk TP, Borris RP, Davies J, Villanueva IG, Pezzuto JM, Chang LC. Herbicidin congeners, undecose nucleosides from an organic extract of Streptomyces sp. L-9-10. J Nat Prod. 2014 Feb 28; 77(2):227-33. PMID: 24533857.
      Citations: 4     Fields:    Translation:HumansCells
    37. Pan W, Liu K, Guan Y, Tan GT, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HH, Zhang H. Bioactive compounds from Vitex leptobotrys. J Nat Prod. 2014 Mar 28; 77(3):663-7. PMID: 24404757.
      Citations: 4     Fields:    Translation:AnimalsCells
    38. Park EJ, Shen L, Sun D, Pezzuto JM. Inhibitory effect of a callophycin A derivative on iNOS expression via inhibition of Akt in lipopolysaccharide-stimulated RAW 264.7 cells. J Nat Prod. 2014 Mar 28; 77(3):527-35. PMID: 24299616.
      Citations: 2     Fields:    Translation:AnimalsCells
    39. Pezzuto JM, Kondratyuk TP, Ogas T. Resveratrol derivatives: a patent review (2009 - 2012). Expert Opin Ther Pat. 2013 Dec; 23(12):1529-46. PMID: 24032623.
      Citations: 10     Fields:    Translation:HumansAnimals
    40. Pansanit A, Park EJ, Kondratyuk TP, Pezzuto JM, Lirdprapamongkol K, Kittakoop P. Vermelhotin, an anti-inflammatory agent, suppresses nitric oxide production in RAW 264.7 cells via p38 inhibition. J Nat Prod. 2013 Sep 27; 76(9):1824-7. PMID: 24016057.
      Citations: 6     Fields:    Translation:AnimalsCells
    41. Andreani A, Leoni A, Locatelli A, Morigi R, Rambaldi M, Cervellati R, Greco E, Kondratyuk TP, Park EJ, Huang K, van Breemen RB, Pezzuto JM. Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles. Eur J Med Chem. 2013 Oct; 68:412-21. PMID: 23994869.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    42. Ogas T, Kondratyuk TP, Pezzuto JM. Resveratrol analogs: promising chemopreventive agents. Ann N Y Acad Sci. 2013 Jul; 1290:21-9. PMID: 23855462.
      Citations: 15     Fields:    Translation:HumansAnimals
    43. Carlson S, Marler L, Nam SJ, Santarsiero BD, Pezzuto JM, Murphy BT. Potential chemopreventive activity of a new macrolide antibiotic from a marine-derived Micromonospora sp. Mar Drugs. 2013 Apr 03; 11(4):1152-61. PMID: 23552877.
      Citations: 7     Fields:    Translation:AnimalsCells
    44. Pezzuto JM, Patel P. Retraction of: Li CM, Jiang WL, Zhu HB, Hou J. Antifibrotic effects of protocatechuic aldehyde on experimental liver fibrosis. Pharm Biol. 2013 May; 51(5):675. PMID: 23510404.
      Citations:    Fields:    
    45. Park EJ, Pezzuto JM. Antioxidant marine products in cancer chemoprevention. Antioxid Redox Signal. 2013 Jul 10; 19(2):115-38. PMID: 23397932.
      Citations: 17     Fields:    Translation:HumansAnimals
    46. Conda-Sheridan M, Park EJ, Beck DE, Reddy PV, Nguyen TX, Hu B, Chen L, White JJ, van Breemen RB, Pezzuto JM, Cushman M. Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential. J Med Chem. 2013 Mar 28; 56(6):2581-605. PMID: 23472886.
      Citations: 6     Fields:    Translation:HumansCells
    47. Youn UJ, Chai X, Park EJ, Kondratyuk TP, Simmons CJ, Borris RP, Mirza B, Pezzuto JM, Chang LC. Biologically active withanolides from Withania coagulans. J Nat Prod. 2013 Jan 25; 76(1):22-8. PMID: 23316950.
      Citations: 9     Fields:    Translation:AnimalsCells
    48. Yu X, Park EJ, Kondratyuk TP, Pezzuto JM, Sun D. Synthesis of 2-arylindole derivatives and evaluation as nitric oxide synthase and NF?B inhibitors. Org Biomol Chem. 2012 Nov 28; 10(44):8835-47. PMID: 23044819.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    49. Mirza B, Kondratyuk TP, Park EJ, Burns BE, Marler LE, Pezzuto JM. Preliminary evaluation for cancer chemopreventive and cytotoxic potential of naturally growing ethnobotanically selected plants of Pakistan. Pharm Biol. 2013 Mar; 51(3):316-28. PMID: 23137214.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    50. Mayhoub AS, Marler L, Kondratyuk TP, Park EJ, Pezzuto JM, Cushman M. Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1). Bioorg Med Chem. 2012 Dec 15; 20(24):7030-9. PMID: 23142320.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    51. Park EJ, Pezzuto JM. Flavonoids in cancer prevention. Anticancer Agents Med Chem. 2012 Oct 01; 12(8):836-51. PMID: 22292763.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    52. Archer CR, Groll M, Stein ML, Schellenberg B, Clerc J, Kaiser M, Kondratyuk TP, Pezzuto JM, Dudler R, Bachmann AS. Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells. Biochemistry. 2012 Aug 28; 51(34):6880-8. PMID: 22870914.
      Citations: 9     Fields:    Translation:HumansCells
    53. Sun D, Hurdle JG, Lee R, Lee R, Cushman M, Pezzuto JM. Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead. ChemMedChem. 2012 Sep; 7(9):1541-5. PMID: 22847956.
      Citations: 13     Fields:    Translation:HumansCells
    54. Luqman S, Meena A, Singh P, Kondratyuk TP, Marler LE, Pezzuto JM, Negi AS. Neoflavonoids and tetrahydroquinolones as possible cancer chemopreventive agents. Chem Biol Drug Des. 2012 Oct; 80(4):616-24. PMID: 22726671.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    55. Youn UJ, Park EJ, Kondratyuk TP, Simmons CJ, Borris RP, Tanamatayarat P, Wongwiwatthananukit S, Toyama O, Songsak T, Pezzuto JM, Chang LC. Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea. Bioorg Med Chem Lett. 2012 Sep 01; 22(17):5559-62. PMID: 22850207.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    56. Chen L, Conda-Sheridan M, Reddy PV, Morrell A, Park EJ, Kondratyuk TP, Pezzuto JM, van Breemen RB, Cushman M. Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents. J Med Chem. 2012 Jun 28; 55(12):5965-81. PMID: 22712432.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    57. Park EJ, Pezzuto JM, Jang KH, Nam SJ, Bucarey SA, Fenical W. Suppression of nitric oxide synthase by thienodolin in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. Nat Prod Commun. 2012 Jun; 7(6):789-94. PMID: 22816309.
      Citations: 4     Fields:    Translation:AnimalsCells
    58. Kondratyuk TP, Park EJ, Yu R, Van Breemen RB, Asolkar RN, Murphy BT, Fenical W, Pezzuto JM. Novel marine phenazines as potential cancer chemopreventive and anti-inflammatory agents. Mar Drugs. 2012 Feb; 10(2):451-464. PMID: 22412812.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    59. Mayhoub AS, Marler L, Kondratyuk TP, Park EJ, Pezzuto JM, Cushman M. Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol. Bioorg Med Chem. 2012 Apr 01; 20(7):2427-34. PMID: 22386564.
      Citations: 8     Fields:    Translation:HumansCells
    60. Suh N, Pezzuto JM. Strawberry fields forever? Cancer Prev Res (Phila). 2012 Jan; 5(1):30-3. PMID: 22219164.
      Citations: 1     Fields:    Translation:HumansAnimals
    61. Park EJ, Kiselev E, Conda-Sheridan M, Cushman M, Pezzuto JM. Induction of apoptosis by 3-amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline via modulation of MAPKs (p38 and c-Jun N-terminal kinase) and c-Myc in HL-60 human leukemia cells. J Nat Prod. 2012 Mar 23; 75(3):378-84. PMID: 22148260.
      Citations: 6     Fields:    Translation:HumansCells
    62. Park EJ, Cheenpracha S, Chang LC, Pezzuto JM. Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by epimuqubilin A via IKK/I?B/NF-?B pathways in lipopolysaccharide-stimulated RAW 264.7 cells. Phytochem Lett. 2011 Dec 01; 4(4):426-431. PMID: 22180763.
      Citations:    
    63. Lewandowski C, Pezzuto JM. Pharmaceutical Biology: a retrospective. Pharm Biol. 2012 Jan; 50(1):1-5. PMID: 22014232.
      Citations:    Fields:    Translation:Humans
    64. Mayhoub AS, Marler L, Kondratyuk TP, Park EJ, Pezzuto JM, Cushman M. Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets. Bioorg Med Chem. 2012 Jan 01; 20(1):510-20. PMID: 22115839.
      Citations: 7     Fields:    Translation:HumansCells
    65. Shen L, Park EJ, Kondratyuk TP, Guendisch D, Marler L, Pezzuto JM, Wright AD, Sun D. Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents. Bioorg Med Chem. 2011 Nov 01; 19(21):6182-95. PMID: 21978950.
      Citations: 7     Fields:    Translation:HumansCells
    66. Park EJ, Cheenpracha S, Chang LC, Kondratyuk TP, Pezzuto JM. Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-?-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera. Nutr Cancer. 2011; 63(6):971-82. PMID: 21774591.
      Citations: 25     Fields:    Translation:AnimalsCells
    67. Kondratyuk TP, Park EJ, Marler LE, Ahn S, Yuan Y, Choi Y, Yu R, van Breemen RB, Sun B, Hoshino J, Cushman M, Jermihov KC, Mesecar AD, Grubbs CJ, Pezzuto JM. Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Mol Nutr Food Res. 2011 Aug; 55(8):1249-65. PMID: 21714126.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    68. Vang O, Ahmad N, Baile CA, Baur JA, Brown K, Csiszar A, Das DK, Delmas D, Gottfried C, Lin HY, Ma QY, Mukhopadhyay P, Nalini N, Pezzuto JM, Richard T, Shukla Y, Surh YJ, Szekeres T, Szkudelski T, Walle T, Wu JM. What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS One. 2011; 6(6):e19881. PMID: 21698226.
      Citations: 136     Fields:    Translation:Humans
    69. Luqman S, Meena A, Marler LE, Kondratyuk TP, Pezzuto JM. Suppression of tumor necrosis factor-?-induced nuclear factor ?B activation and aromatase activity by capsaicin and its analog capsazepine. J Med Food. 2011 Nov; 14(11):1344-51. PMID: 21663483.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    70. Park EJ, Kondratyuk TP, Morrell A, Kiselev E, Conda-Sheridan M, Cushman M, Ahn S, Choi Y, White JJ, van Breemen RB, Pezzuto JM. Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells. Cancer Prev Res (Phila). 2011 Apr; 4(4):592-607. PMID: 21464033.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    71. Zou J, Pan L, Li Q, Zhao J, Pu J, Yao P, Gong N, Lu Y, Kondratyuk TP, Pezzuto JM, Fong HH, Zhang H, Sun H. Rubesanolides A and B: diterpenoids from Isodon rubescens. Org Lett. 2011 Mar 18; 13(6):1406-9. PMID: 21332131.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    72. Yang JH, Kondratyuk TP, Jermihov KC, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Huang R, Liu Y, Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, Fong HH, Chen YG, Zhang HJ. Bioactive compounds from the fern Lepisorus contortus. J Nat Prod. 2011 Feb 25; 74(2):129-36. PMID: 21261296.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    73. Pezzuto JM. The phenomenon of resveratrol: redefining the virtues of promiscuity. Ann N Y Acad Sci. 2011 Jan; 1215:123-30. PMID: 21261650.
      Citations: 21     Fields:    Translation:HumansAnimals
    74. Choi Y, Jermihov K, Nam SJ, Sturdy M, Maloney K, Qiu X, Chadwick LR, Main M, Chen SN, Mesecar AD, Farnsworth NR, Pauli GF, Fenical W, Pezzuto JM, van Breemen RB, van Breemen RR. Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Anal Chem. 2011 Feb 01; 83(3):1048-52. PMID: 21192729.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    75. Marler L, Conda-Sheridan M, Cinelli MA, Morrell AE, Cushman M, Chen L, Huang K, Van Breemen R, Pezzuto JM. Cancer chemopreventive potential of aromathecins and phenazines, novel natural product derivatives. Anticancer Res. 2010 Dec; 30(12):4873-82. PMID: 21187465.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    76. Conda-Sheridan M, Marler L, Park EJ, Kondratyuk TP, Jermihov K, Mesecar AD, Pezzuto JM, Asolkar RN, Fenical W, Cushman M. Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284. J Med Chem. 2010 Dec 23; 53(24):8688-99. PMID: 21105712.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    77. Morais MC, Luqman S, Kondratyuk TP, Petronio MS, Regasini LO, Silva DH, Bolzani VS, Soares CP, Pezzuto JM. Suppression of TNF-? induced NF?B activity by gallic acid and its semi-synthetic esters: possible role in cancer chemoprevention. Nat Prod Res. 2010 Nov; 24(18):1758-65. PMID: 20408045.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    78. Calamini B, Ratia K, Malkowski MG, Cuendet M, Pezzuto JM, Santarsiero BD, Mesecar AD. Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem J. 2010 Jul 15; 429(2):273-82. PMID: 20450491.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    79. Hoshino J, Park EJ, Kondratyuk TP, Marler L, Pezzuto JM, van Breemen RB, Mo S, Li Y, Cushman M. Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem. 2010 Jul 08; 53(13):5033-43. PMID: 20527891.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    80. Luqman S, Pezzuto JM. NFkappaB: a promising target for natural products in cancer chemoprevention. Phytother Res. 2010 Jul; 24(7):949-63. PMID: 20577970.
      Citations: 59     Fields:    Translation:HumansCells
    81. Nam SJ, Gaudêncio SP, Kauffman CA, Jensen PR, Kondratyuk TP, Marler LE, Pezzuto JM, Fenical W. Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus Nocardiopsis. J Nat Prod. 2010 Jun 25; 73(6):1080-6. PMID: 20481500.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    82. Endringer DC, Valadares YM, Campana PR, Campos JJ, Guimarães KG, Pezzuto JM, Braga FC. Evaluation of Brazilian plants on cancer chemoprevention targets in vitro. Phytother Res. 2010 Jun; 24(6):928-33. PMID: 19957245.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    83. Gullett NP, Ruhul Amin AR, Bayraktar S, Pezzuto JM, Shin DM, Khuri FR, Aggarwal BB, Surh YJ, Kucuk O. Cancer prevention with natural compounds. Semin Oncol. 2010 Jun; 37(3):258-81. PMID: 20709209.
      Citations: 152     Fields:    Translation:HumansAnimals
    84. Sun B, Hoshino J, Jermihov K, Marler L, Pezzuto JM, Mesecar AD, Cushman M. Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15; 18(14):5352-66. PMID: 20558073.
      Citations: 14     Fields:    Translation:HumansAnimals
    85. Cheenpracha S, Park EJ, Yoshida WY, Barit C, Wall M, Pezzuto JM, Chang LC. Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits. Bioorg Med Chem. 2010 Sep 01; 18(17):6598-602. PMID: 20685125.
      Citations: 37     Fields:    Translation:Animals
    86. Cheenpracha S, Park EJ, Rostama B, Pezzuto JM, Chang LC. Inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells by the norsesterterpene peroxide, epimuqubilin A. Mar Drugs. 2010 Mar 01; 8(3):429-37. PMID: 20411107.
      Citations: 16     Fields:    Translation:AnimalsCells
    87. Yang JH, Kondratyuk TP, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Pegan S, Liu Y, Wang LQ, Mesecar AD, Van Breemen RB, Pezzuto JM, Fong HH, Chen YG, Zhang HJ. Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata. Phytochemistry. 2010 Apr; 71(5-6):641-7. PMID: 20100622.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    88. Cuendet M, Guo J, Luo Y, Chen S, Oteham CP, Moon RC, van Breemen RB, Marler LE, Pezzuto JM. Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice. Cancer Prev Res (Phila). 2010 Feb; 3(2):221-32. PMID: 20068129.
      Citations: 34     Fields:    Translation:HumansAnimals
    89. Schupp PJ, Kohlert-Schupp C, Whitefield S, Engemann A, Rohde S, Hemscheidt T, Pezzuto JM, Kondratyuk TP, Park EJ, Marler L, Rostama B, Wright AD. Cancer chemopreventive and anticancer evaluation of extracts and fractions from marine macro- and microorganisms collected from Twilight Zone waters around Guam. Nat Prod Commun. 2009 Dec; 4(12):1717-28. PMID: 20120114.
      Citations: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    90. Pezzuto JM, Venkatasubramanian V, Hamad M, Morris KR. Unraveling the relationship between grapes and health. J Nutr. 2009 Sep; 139(9):1783S-7S. PMID: 19625701.
      Citations: 11     Fields:    Translation:HumansAnimals
    91. Deng Y, Balunas MJ, Kim JA, Lantvit DD, Chin YW, Chai H, Sugiarso S, Kardono LB, Fong HH, Pezzuto JM, Swanson SM, de Blanco EJ, Kinghorn AD. Bioactive 5,6-dihydro-alpha-pyrone derivatives from Hyptis brevipes. J Nat Prod. 2009 Jun; 72(6):1165-9. PMID: 19422206.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    92. Endringer DC, Pezzuto JM, Braga FC. NF-kappaB inhibitory activity of cyclitols isolated from Hancornia speciosa. Phytomedicine. 2009 Nov; 16(11):1064-9. PMID: 19423310.
      Citations: 8     Fields:    Translation:Animals
    93. Maiti A, Reddy PV, Sturdy M, Marler L, Pegan SD, Mesecar AD, Pezzuto JM, Cushman M. Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 09; 52(7):1873-84. PMID: 19265439.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    94. Asolkar RN, Freel KC, Jensen PR, Fenical W, Kondratyuk TP, Park EJ, Pezzuto JM. Arenamides A-C, cytotoxic NFkappaB inhibitors from the marine actinomycete Salinispora arenicola. J Nat Prod. 2009 Mar 27; 72(3):396-402. PMID: 19117399.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    95. Mi Q, Pezzuto JM, Farnsworth NR, Wani MC, Kinghorn AD, Swanson SM. Use of the in vivo hollow fiber assay in natural products anticancer drug discovery. J Nat Prod. 2009 Mar 27; 72(3):573-80. PMID: 19161316.
      Citations: 26     Fields:    Translation:Cells
    96. Yao G, Kondratyuk TP, Tan GT, Pezzuto JM, Chang LC. Bioactive sulfated sesterterpene alkaloids and sesterterpene sulfates from the marine sponge Fasciospongia sp. J Nat Prod. 2009 Feb 27; 72(2):319-23. PMID: 19178162.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    97. Balunas MJ, Su B, Riswan S, Fong HH, Brueggemeier RW, Pezzuto JM, Kinghorn AD. Isolation and Characterization of Aromatase Inhibitors from Brassaiopsis glomerulata (Araliaceae). Phytochem Lett. 2009 Feb 19; 2(1):29-33. PMID: 20161072.
      Citations:    
    98. Cuendet M, Oteham CP, Maiti A, Craig BA, Cushman M, Moon RC, Pezzuto JM. Zapotin prevents mouse skin tumorigenesis during the stages of initiation and promotion. Anticancer Res. 2008 Nov-Dec; 28(6A):3705-9. PMID: 19189653.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    99. Guilford JM, Pezzuto JM. Natural products as inhibitors of carcinogenesis. Expert Opin Investig Drugs. 2008 Sep; 17(9):1341-52. PMID: 18694367.
      Citations: 16     Fields:    Translation:HumansAnimals
    100. Pezzuto JM. Grapes and human health: a perspective. J Agric Food Chem. 2008 Aug 27; 56(16):6777-84. PMID: 18662007.
      Citations: 36     Fields:    Translation:HumansAnimals
    101. Guo J, Liu A, Cao H, Luo Y, Pezzuto JM, van Breemen RB. Biotransformation of the chemopreventive agent 2',4',4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases. Drug Metab Dispos. 2008 Oct; 36(10):2104-12. PMID: 18653743.
      Citations: 13     Fields:    Translation:HumansCells
    102. Francy-Guilford J, Pezzuto JM. Mechanisms of cancer chemopreventive agents: a perspective. Planta Med. 2008 Oct; 74(13):1644-50. PMID: 18537076.
      Citations: 5     Fields:    Translation:Humans
    103. Kang SS, Cuendet M, Endringer DC, Croy VL, Pezzuto JM, Lipton MA. Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB. Bioorg Med Chem. 2009 Feb 01; 17(3):1044-54. PMID: 18487053.
      Citations: 18     Fields:    Translation:HumansCells
    104. Endringer DC, Guimarães KG, Kondratyuk TP, Pezzuto JM, Braga FC. Selective inhibition of aromatase by a dihydroisocoumarin from Xyris pterygoblephara. J Nat Prod. 2008 Jun; 71(6):1082-4. PMID: 18462007.
      Citations: 8     Fields:    Translation:HumansAnimals
    105. Guo J, Liu D, Nikolic D, Zhu D, Pezzuto JM, van Breemen RB. In vitro metabolism of isoliquiritigenin by human liver microsomes. Drug Metab Dispos. 2008 Feb; 36(2):461-8. PMID: 18006650.
      Citations: 16     Fields:    Translation:HumansCells
    106. Liu D, Guo J, Luo Y, Broderick DJ, Schimerlik MI, Pezzuto JM, van Breemen RB. Screening for ligands of human retinoid X receptor-alpha using ultrafiltration mass spectrometry. Anal Chem. 2007 Dec 15; 79(24):9398-402. PMID: 17997524.
      Citations: 11     Fields:    Translation:HumansCells
    107. Maiti A, Cuendet M, Croy VL, Endringer DC, Pezzuto JM, Cushman M. Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer. J Med Chem. 2007 Jun 14; 50(12):2799-806. PMID: 17511439.
      Citations: 30     Fields:    Translation:Humans
    108. Maiti A, Cuendet M, Kondratyuk T, Croy VL, Pezzuto JM, Cushman M. Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J Med Chem. 2007 Jan 25; 50(2):350-5. PMID: 17228877.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    109. Williams PG, Asolkar RN, Kondratyuk T, Pezzuto JM, Jensen PR, Fenical W. Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola. J Nat Prod. 2007 Jan; 70(1):83-8. PMID: 17253854.
      Citations: 29     Fields:    Translation:Cells
    110. Endringer DC, Pezzuto JM, Soares CM, Braga FC. L-(+)-Bornesitol. Acta Crystallogr Sect E Struct Rep Online. 2007; 63(2):o1067-o1068. PMID: 19011691.
      Citations:    
    111. Murillo G, Hirschelman WH, Ito A, Moriarty RM, Kinghorn AD, Pezzuto JM, Mehta RG. Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesis. Nutr Cancer. 2007; 57(1):28-37. PMID: 17516860.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    112. Choi JK, Murillo G, Su BN, Pezzuto JM, Kinghorn AD, Mehta RG. Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells. FEBS J. 2006 Dec; 273(24):5714-23. PMID: 17212786.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    113. Balunas MJ, Jones WP, Chin YW, Mi Q, Farnsworth NR, Soejarto DD, Cordell GA, Swanson SM, Pezzuto JM, Chai HB, Kinghorn AD. Relationships between inhibitory activity against a cancer cell line panel, profiles of plants collected, and compound classes isolated in an anticancer drug discovery project. Chem Biodivers. 2006 Aug; 3(8):897-915. PMID: 17193321.
      Citations: 11     Fields:    Translation:HumansCells
    114. Wright AD, de Nys R, Angerhofer CK, Pezzuto JM, Gurrath M. Biological activities and 3D QSAR studies of a series of Delisea pulchra (cf. fimbriata) derived natural products. J Nat Prod. 2006 Aug; 69(8):1180-7. PMID: 16933872.
      Citations: 5     Fields:    Translation:AnimalsCells
    115. He ZD, Ma CY, Tan GT, Sydara K, Tamez P, Southavong B, Bouamanivong S, Soejarto DD, Pezzuto JM, Fong HH, Zhang HJ. Rourinoside and rouremin, antimalarial constituents from Rourea minor. Phytochemistry. 2006 Jul; 67(13):1378-84. PMID: 16762381.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    116. Carcache-Blanco EJ, Cuendet M, Park EJ, Su BN, Rivero-Cruz JF, Farnsworth NR, Pezzuto JM, Douglas Kinghorn A. Potential cancer chemopreventive agents from Arbutus unedo. Nat Prod Res. 2006 Apr; 20(4):327-34. PMID: 16644527.
      Citations: 6     Fields:    Translation:AnimalsCells
    117. Homhual S, Bunyapraphatsara N, Kondratyuk T, Herunsalee A, Chaukul W, Pezzuto JM, Fong HH, Zhang HJ. Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza. J Nat Prod. 2006 Mar; 69(3):421-4. PMID: 16562850.
      Citations: 11     Fields:    Translation:AnimalsCells
    118. Cuendet M, Oteham CP, Moon RC, Pezzuto JM. Quinone reductase induction as a biomarker for cancer chemoprevention. J Nat Prod. 2006 Mar; 69(3):460-3. PMID: 16562858.
      Citations: 43     Fields:    Translation:AnimalsCells
    119. Soejarto DD, Zhang HJ, Fong HH, Tan GT, Ma CY, Gyllenhaal C, Riley MC, Kadushin MR, Franzblau SG, Bich TQ, Cuong NM, Hiep NT, Loc PK, Xuan le T, Hai NV, Hung NV, Chien NQ, Binh le T, Vu BM, Ly HM, Southavong B, Sydara K, Bouamanivong S, Pezzuto JM, Rose WC, Dietzman GR, Miller BE, Thuy TV. "Studies on biodiversity of Vietnam and Laos" 1998-2005: examining the impact. J Nat Prod. 2006 Mar; 69(3):473-81. PMID: 16562860.
      Citations: 10     Fields:    Translation:Animals
    120. Fang L, Ito A, Chai HB, Mi Q, Jones WP, Madulid DR, Oliveros MB, Gao Q, Orjala J, Farnsworth NR, Soejarto DD, Cordell GA, Swanson SM, Pezzuto JM, Kinghorn AD. Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines. J Nat Prod. 2006 Mar; 69(3):332-7. PMID: 16562829.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    121. Homhual S, Zhang HJ, Bunyapraphatsara N, Kondratyuk TP, Santarsiero BD, Mesecar AD, Herunsalee A, Chaukul W, Pezzuto JM, Fong HH. Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza. Planta Med. 2006 Feb; 72(3):255-60. PMID: 16534731.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    122. Zhang HJ, Ma C, Nguyen VH, Nguyen MC, Tan GT, Santarsiero BD, Mesecar AD, Soejarto DD, Pezzuto JM, Fong HH. Miliusanes, a class of cytotoxic agents from Miliusa sinensis. J Med Chem. 2006 Jan 26; 49(2):693-708. PMID: 16420055.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    123. Jang DS, Su BN, Pawlus AD, Kang YH, Kardono LB, Riswan S, Afriastini JJ, Fong HH, Pezzuto JM, Kinghorn AD. Beccaridiol, an unusual 28-nortriterpenoid from the leaves of Diplectria beccariana. Phytochemistry. 2006 Aug; 67(16):1832-7. PMID: 16426647.
      Citations: 1     Fields:    Translation:Animals
    124. Cuendet M, Mesecar AD, DeWitt DL, Pezzuto JM. An ELISA method to measure inhibition of the COX enzymes. Nat Protoc. 2006; 1(4):1915-21. PMID: 17487176.
      Citations: 12     Fields:    Translation:HumansAnimals
    125. Thole JM, Kraft TF, Sueiro LA, Kang YH, Gills JJ, Cuendet M, Pezzuto JM, Seigler DS, Lila MA. A comparative evaluation of the anticancer properties of European and American elderberry fruits. J Med Food. 2006; 9(4):498-504. PMID: 17201636.
      Citations: 12     Fields:    Translation:Animals
    126. Lee HY, Oh SH, Woo JK, Kim WY, Van Pelt CS, Price RE, Cody D, Tran H, Pezzuto JM, Moriarty RM, Hong WK. Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis. J Natl Cancer Inst. 2005 Nov 16; 97(22):1695-9. PMID: 16288123.
      Citations: 55     Fields:    Translation:AnimalsCellsPHPublic Health
    127. Liu G, Eggler AL, Dietz BM, Mesecar AD, Bolton JL, Pezzuto JM, van Breemen RB. Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. Anal Chem. 2005 Oct 01; 77(19):6407-14. PMID: 16194107.
      Citations: 18     Fields:    Translation:AnimalsCells
    128. He ZD, Ma CY, Zhang HJ, Tan GT, Tamez P, Sydara K, Bouamanivong S, Southavong B, Soejarto DD, Pezzuto JM, Fong HH. Antimalarial constituents from Nauclea orientalis (L.) L. Chem Biodivers. 2005 Oct; 2(10):1378-86. PMID: 17191939.
      Citations: 10     Fields:    Translation:AnimalsCells
    129. Jones WP, Lobo-Echeverri T, Mi Q, Chai H, Lee D, Soejarto DD, Cordell GA, Pezzuto JM, Swanson SM, Kinghorn AD. Antitumour activity of 3-chlorodeoxylapachol, a naphthoquinone from Avicennia germinans collected from an experimental plot in southern Florida. J Pharm Pharmacol. 2005 Sep; 57(9):1101-8. PMID: 16105231.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    130. Eggler AL, Liu G, Pezzuto JM, van Breemen RB, Mesecar AD. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10070-5. PMID: 16006525.
      Citations: 169     Fields:    Translation:HumansAnimalsCells
    131. Gills JJ, Jeffery EH, Matusheski NV, Moon RC, Lantvit DD, Pezzuto JM. Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion. Cancer Lett. 2006 May 08; 236(1):72-9. PMID: 15993536.
      Citations: 34     Fields:    Translation:Animals
    132. Jang DS, Su BN, Pawlus AD, Jones WP, Kleps RA, Bunyapraphatsara N, Fong HH, Pezzuto JM, Kinghorn AD. Limnophilaspiroketone, a highly oxygenated phenolic derivative from Limnophila geoffrayi. J Nat Prod. 2005 Jul; 68(7):1134-6. PMID: 16038568.
      Citations:    Fields:    Translation:AnimalsCells
    133. Zhang HJ, Nguyen VH, Nguyen MC, Soejarto DD, Pezzuto JM, Fong HH, Tan GT. Sesquiterpenes and butenolides, natural anti-HIV constituents from Litsea verticillata. Planta Med. 2005 May; 71(5):452-7. PMID: 15931585.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    134. Tamez PA, Lantvit D, Lim E, Pezzuto JM. Chemosensitizing action of cepharanthine against drug-resistant human malaria, Plasmodium falciparum. J Ethnopharmacol. 2005 Apr 08; 98(1-2):137-42. PMID: 15763374.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    135. Lobo-Echeverri T, Rivero-Cruz JF, Su BN, Chai HB, Cordell GA, Pezzuto JM, Swanson SM, Soejarto DD, Kinghorn AD. Constituents of the leaves and twigs of Calyptranthes pallens collected from an experimental plot in Southern Florida. J Nat Prod. 2005 Apr; 68(4):577-80. PMID: 15844953.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    136. Mi Q, Lantvit D, Reyes-Lim E, Chai H, Phifer SS, Wani MC, Wall ME, Tan GT, Cordell GA, Farnsworth NR, Kinghorn AD, Pezzuto JM. Apoptotic anticancer effect of alvaradoin E isolated from Alvaradoa haitiensis. Anticancer Res. 2005 Mar-Apr; 25(2A):779-87. PMID: 15868909.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    137. Rivero-Cruz JF, Lezutekong R, Lobo-Echeverri T, Ito A, Mi Q, Chai HB, Soejarto DD, Cordell GA, Pezzuto JM, Swanson SM, Morelli I, Kinghorn AD. Cytotoxic constituents of the twigs of Simarouba glauca collected from a plot in Southern Florida. Phytother Res. 2005 Feb; 19(2):136-40. PMID: 15852485.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    138. Gafner S, Lee SK, Cuendet M, Barthélémy S, Vergnes L, Labidalle S, Mehta RG, Boone CW, Pezzuto JM. Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems. Phytochemistry. 2004 Nov; 65(21):2849-59. PMID: 15501252.
      Citations: 20     Fields:    Translation:AnimalsCells
    139. Su BN, Jones WP, Cuendet M, Kardono LB, Ismail R, Riswan S, Fong HH, Farnsworth NR, Pezzuto JM, Kinghorn AD. Constituents of the stems of Macrococculus pomiferus and their inhibitory activities against cyclooxygenases-1 and -2. Phytochemistry. 2004 Nov; 65(21):2861-6. PMID: 15501253.
      Citations: 3     Fields:    Translation:Animals
    140. Jang DS, Cuendet M, Su BN, Totura S, Riswan S, Fong HH, Pezzuto JM, Kinghorn AD. Constituents of the seeds of Hernandia ovigera with inhibitory activity against cyclooxygenase-2. Planta Med. 2004 Oct; 70(10):893-6. PMID: 15490314.
      Citations:    Fields:    Translation:HumansAnimals
    141. Pezzuto JM. Resveratrol: a whiff that induces a biologically specific tsunami. Cancer Biol Ther. 2004 Sep; 3(9):889-90. PMID: 15467424.
      Citations: 2     Fields:    Translation:Humans
    142. Kinghorn AD, Su BN, Jang DS, Chang LC, Lee D, Gu JQ, Carcache-Blanco EJ, Pawlus AD, Lee SK, Park EJ, Cuendet M, Gills JJ, Bhat K, Park HS, Mata-Greenwood E, Song LL, Jang M, Pezzuto JM. Natural inhibitors of carcinogenesis. Planta Med. 2004 Aug; 70(8):691-705. PMID: 15326546.
      Citations: 30     Fields:    Translation:HumansAnimals
    143. Gu JQ, Graf TN, Lee D, Chai HB, Mi Q, Kardono LB, Setyowati FM, Ismail R, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kroll DJ, Falkinham JO, Wall ME, Wani MC, Kinghorn AD, Oberlies NH. Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia. J Nat Prod. 2004 Jul; 67(7):1156-61. PMID: 15270571.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    144. Nguyen QC, Nguyen VH, Santarsiero BD, Mesecar AD, Nguyen MC, Soejarto DD, Pezzuto JM, Fong HH, Tan GT. New 3-O-acyl betulinic acids from Strychnos vanprukii Craib. J Nat Prod. 2004 Jun; 67(6):994-8. PMID: 15217281.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    145. Hwang BY, Su BN, Chai H, Mi Q, Kardono LB, Afriastini JJ, Riswan S, Santarsiero BD, Mesecar AD, Wild R, Fairchild CR, Vite GD, Rose WC, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kinghorn AD. Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. J Org Chem. 2004 May 14; 69(10):3350-8. PMID: 15132542.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    146. Jang DS, Cuendet M, Fong HH, Pezzuto JM, Kinghorn AD. Constituents of Asparagus officinalis evaluated for inhibitory activity against cyclooxygenase-2. J Agric Food Chem. 2004 Apr 21; 52(8):2218-22. PMID: 15080623.
      Citations: 9     Fields:    Translation:AnimalsCells
    147. Cuendet M, Gills JJ, Pezzuto JM. Brusatol-induced HL-60 cell differentiation involves NF-kappaB activation. Cancer Lett. 2004 Mar 31; 206(1):43-50. PMID: 15019158.
      Citations: 14     Fields:    Translation:HumansCells
    148. Rivero-Cruz JF, Chai HB, Kardono LB, Setyowati FM, Afriatini JJ, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kinghorn AD. Cytotoxic constituents of the twigs and leaves of Aglaia rubiginosa. J Nat Prod. 2004 Mar; 67(3):343-7. PMID: 15043407.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    149. Diaz F, Chai HB, Mi Q, Su BN, Vigo JS, Graham JG, Cabieses F, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kinghorn AD. Anthrone and oxanthrone C-glycosides from Picramnia latifolia collected in Peru. J Nat Prod. 2004 Mar; 67(3):352-6. PMID: 15043409.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    150. Jang DS, Park EJ, Kang YH, Vigo JS, Graham JG, Cabieses F, Fong HH, Pezzuto JM, Kinghorn AD. Phenolic compounds obtained from stems of Couepia ulei with the potential to induce quinone reductase. Arch Pharm Res. 2004 Feb; 27(2):169-72. PMID: 15022717.
      Citations: 2     Fields:    Translation:Animals
    151. Cuendet M, Pezzuto JM. Antitumor activity of bruceantin: an old drug with new promise. J Nat Prod. 2004 Feb; 67(2):269-72. PMID: 14987068.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    152. Jang DS, Cuendet M, Pawlus AD, Kardono LB, Kawanishi K, Farnsworth NR, Fong HH, Pezzuto JM, Kinghorn AD. Potential cancer chemopreventive constituents of the leaves of Macaranga triloba. Phytochemistry. 2004 Feb; 65(3):345-50. PMID: 14751306.
      Citations: 5     Fields:    Translation:AnimalsCells
    153. Lee HY, Suh YA, Kosmeder JW, Pezzuto JM, Hong WK, Kurie JM. Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells. Clin Cancer Res. 2004 Feb 01; 10(3):1074-9. PMID: 14871987.
      Citations: 21     Fields:    Translation:HumansCells
    154. Cuendet M, Christov K, Lantvit DD, Deng Y, Hedayat S, Helson L, McChesney JD, Pezzuto JM. Multiple myeloma regression mediated by bruceantin. Clin Cancer Res. 2004 Feb 01; 10(3):1170-9. PMID: 14871997.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    155. Zhang HJ, Sydara K, Tan GT, Ma C, Southavong B, Soejarto DD, Pezzuto JM, Fong HH. Bioactive constituents from Asparagus cochinchinensis. J Nat Prod. 2004 Feb; 67(2):194-200. PMID: 14987058.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    156. Ito A, Chai HB, Kardono LB, Setowati FM, Afriastini JJ, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kinghorn AD. Saponins from the bark of Nephelium maingayi. J Nat Prod. 2004 Feb; 67(2):201-5. PMID: 14987059.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    157. Kang YH, Pezzuto JM. Induction of quinone reductase as a primary screen for natural product anticarcinogens. Methods Enzymol. 2004; 382:380-414. PMID: 15047113.
      Citations: 19     Fields:    Translation:Animals
    158. Li Y, Shin YG, Yu C, Kosmeder JW, Hirschelman WH, Pezzuto JM, van Breemen RB. Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: application to resveratrol absorption and metabolism. Comb Chem High Throughput Screen. 2003 Dec; 6(8):757-67. PMID: 14683481.
      Citations: 11     Fields:    Translation:HumansCells
    159. Topcu G, Aydogmus Z, Imre S, Gören AC, Pezzuto JM, Clement JA, Kingston DG. Brominated sesquiterpenes from the red alga Laurencia obtusa. J Nat Prod. 2003 Nov; 66(11):1505-8. PMID: 14640529.
      Citations: 9     Fields:    Translation:AnimalsCells
    160. Burdette JE, Liu J, Chen SN, Fabricant DS, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, Van Breemen RB, Farnsworth NR, Bolton JL. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J Agric Food Chem. 2003 Sep 10; 51(19):5661-70. PMID: 12952416.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    161. Mi Q, Cui B, Lantvit D, Reyes-Lim E, Chai H, Pezzuto JM, Kinghorn AD, Swanson SM. Pervilleine F, a new tropane alkaloid aromatic ester that reverses multidrug resistance. Anticancer Res. 2003 Sep-Oct; 23(5A):3607-15. PMID: 14666656.
      Citations: 4     Fields:    Translation:HumansCells
    162. Lee KH, Chai HB, Tamez PA, Pezzuto JM, Cordell GA, Win KK, Tin-Wa M. Biologically active alkylated coumarins from Kayea assamica. Phytochemistry. 2003 Sep; 64(2):535-41. PMID: 12943771.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    163. Su BN, Kang YH, Pinos RE, Santarsiero BD, Mesecar AD, Soejarto DD, Fong HH, Pezzuto JM, Kinghorn AD. Isolation and absolute stereochemistry of coussaric acid, a new bioactive triterpenoid from the stems of Coussarea brevicaulis. Phytochemistry. 2003 Sep; 64(1):293-302. PMID: 12946428.
      Citations: 4     Fields:    Translation:AnimalsCells
    164. Jang DS, Park EJ, Kang YH, Hawthorne ME, Vigo JS, Graham JG, Cabieses F, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria. J Nat Prod. 2003 Sep; 66(9):1166-70. PMID: 14510590.
      Citations: 10     Fields:    Translation:AnimalsCells
    165. Carcache-Blanco EJ, Kang YH, Park EJ, Su BN, Kardono LB, Riswan S, Fong HH, Pezzuto JM, Kinghorn AD. Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase. J Nat Prod. 2003 Sep; 66(9):1197-202. PMID: 14510596.
      Citations: 7     Fields:    Translation:AnimalsCells
    166. Jang DS, Park EJ, Kang YH, Su BN, Hawthorne ME, Vigo JS, Graham JG, Cabieses F, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Compounds obtained from sida acuta with the potential to induce quinone reductase and to inhibit 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions in a mouse mammary organ culture model. Arch Pharm Res. 2003 Aug; 26(8):585-90. PMID: 12967190.
      Citations: 7     Fields:    Translation:AnimalsCells
    167. Su BN, Park EJ, Nikolic D, Schunke Vigo J, Graham JG, Cabieses F, van Breemen RB, Fong HH, Farnsworth NR, Pezzuto JM, Kinghorn AD. Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora. J Nat Prod. 2003 Aug; 66(8):1089-93. PMID: 12932130.
      Citations: 3     Fields:    Translation:AnimalsCells
    168. Tan Y, Yu R, Pezzuto JM. Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation. Clin Cancer Res. 2003 Jul; 9(7):2866-75. PMID: 12855667.
      Citations: 47     Fields:    Translation:HumansCells
    169. Díaz F, Chávez D, Lee D, Mi Q, Chai HB, Tan GT, Kardono LB, Riswan S, Fairchild CR, Wild R, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD. Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. J Nat Prod. 2003 Jun; 66(6):865-7. PMID: 12828478.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    170. Su BN, Jung Park E, Vigo JS, Graham JG, Cabieses F, Fong HH, Pezzuto JM, Kinghorn AD. Activity-guided isolation of the chemical constituents of Muntingia calabura using a quinone reductase induction assay. Phytochemistry. 2003 Jun; 63(3):335-41. PMID: 12737982.
      Citations: 15     Fields:    Translation:AnimalsCells
    171. Zhang HJ, Tan GT, Santarsiero BD, Mesecar AD, Hung NV, Cuong NM, Doel Soejarto D, Pezzuto JM, Fong HH. New Sesquiterpenes from Litsea verticillata. J Nat Prod. 2003 May; 66(5):609-15. PMID: 12762792.
      Citations: 10     Fields:    Translation:AnimalsCells
    172. Gu JQ, Li W, Kang YH, Su BN, Fong HH, van Breemen RB, Pezzuto JM, Kinghorn AD. Minor withanolides from Physalis philadelphica: structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts. Chem Pharm Bull (Tokyo). 2003 May; 51(5):530-9. PMID: 12736452.
      Citations: 3     Fields:    Translation:AnimalsCells
    173. Fang L, Chai HB, Castillo JJ, Soejarto DD, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD. Cytotoxic constituents of Brachistus stramoniifolius. Phytother Res. 2003 May; 17(5):520-3. PMID: 12748990.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    174. Jang DS, Park EJ, Hawthorne ME, Vigo JS, Graham JG, Cabieses F, Santarsiero BD, Mesecar AD, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean). J Nat Prod. 2003 May; 66(5):583-7. PMID: 12762787.
      Citations: 12     Fields:    Translation:AnimalsCells
    175. Gafner S, Bergeron C, Batcha LL, Reich J, Arnason JT, Burdette JE, Pezzuto JM, Angerhofer CK. Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora. J Nat Prod. 2003 Apr; 66(4):535-7. PMID: 12713409.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    176. Su BN, Park EJ, Nikolic D, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses F, van Breemen RB, Fong HH, Farnsworth NR, Pezzuto JM, Kinghorn AD. Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity. J Org Chem. 2003 Mar 21; 68(6):2350-61. PMID: 12636402.
      Citations: 4     Fields:    Translation:AnimalsCells
    177. Murillo G, Kosmeder JW, Pezzuto JM, Mehta RG. Deguelin suppresses the formation of carcinogen-induced aberrant crypt foci in the colon of CF-1 mice. Int J Cancer. 2003 Mar 10; 104(1):7-11. PMID: 12532413.
      Citations: 17     Fields:    Translation:AnimalsCells
    178. Chun KH, Kosmeder JW, Sun S, Pezzuto JM, Lotan R, Hong WK, Lee HY. Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst. 2003 Feb 19; 95(4):291-302. PMID: 12591985.
      Citations: 74     Fields:    Translation:HumansCells
    179. Seo EK, Lee D, Shin YG, Chai HB, Navarro HA, Kardono LB, Rahman I, Cordell GA, Farnsworth NR, Pezzuto JM, Kinghorn AD, Wani MC, Wall ME. Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando. Arch Pharm Res. 2003 Feb; 26(2):124-7. PMID: 12643587.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    180. Zhang HJ, Tan GT, Hoang VD, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HH. Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. J Nat Prod. 2003 Feb; 66(2):263-8. PMID: 12608862.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    181. Duncan CJ, Cuendet M, Fronczek FR, Pezzuto JM, Mehta RG, Hamann MT, Ross SA. Chemical and biological investigation of the fungus Pulveroboletus ravenelii. J Nat Prod. 2003 Jan; 66(1):103-7. PMID: 12542354.
      Citations: 2     Fields:    Translation:AnimalsCells
    182. Hwang BY, Chai HB, Kardono LB, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD. Cytotoxic triterpenes from the twigs of Celtis philippinensis. Phytochemistry. 2003 Jan; 62(2):197-201. PMID: 12482456.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    183. Yu C, Shin YG, Kosmeder JW, Pezzuto JM, van Breemen RB. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun Mass Spectrom. 2003; 17(4):307-13. PMID: 12569440.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    184. Jang DS, Cuendet M, Hawthorne ME, Kardono LB, Kawanishi K, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Prenylated flavonoids of the leaves of Macaranga conifera with inhibitory activity against cyclooxygenase-2. Phytochemistry. 2002 Dec; 61(7):867-72. PMID: 12453581.
      Citations: 12     Fields:    Translation:AnimalsCells
    185. Zhang HJ, Tamez PA, Aydogmus Z, Tan GT, Saikawa Y, Hashimoto K, Nakata M, Hung NV, Xuan le T, Cuong NM, Soejarto DD, Pezzuto JM, Fong HH. Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva. Planta Med. 2002 Dec; 68(12):1088-91. PMID: 12494335.
      Citations: 13     Fields:    Translation:AnimalsCells
    186. Su BN, Cuendet M, Farnsworth NR, Fong HH, Pezzuto JM, Kinghorn AD. Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. Planta Med. 2002 Dec; 68(12):1125-8. PMID: 12494342.
      Citations: 6     Fields:    Translation:AnimalsCells
    187. Calderón AI, Terreaux C, Schenk K, Pattison P, Burdette JE, Pezzuto JM, Gupta MP, Hostettmann K. Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis. J Nat Prod. 2002 Dec; 65(12):1749-53. PMID: 12502307.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    188. Yu C, Shin YG, Chow A, Li Y, Kosmeder JW, Lee YS, Hirschelman WH, Pezzuto JM, Mehta RG, van Breemen RB. Human, rat, and mouse metabolism of resveratrol. Pharm Res. 2002 Dec; 19(12):1907-14. PMID: 12523673.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    189. Burdette JE, Chen SN, Lu ZZ, Xu H, White BE, Fabricant DS, Liu J, Fong HH, Farnsworth NR, Constantinou AI, Van Breemen RB, Pezzuto JM, Bolton JL. Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles. J Agric Food Chem. 2002 Nov 20; 50(24):7022-8. PMID: 12428954.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    190. Mehta RG, Pezzuto JM. Discovery of cancer preventive agents from natural products: from plants to prevention. Curr Oncol Rep. 2002 Nov; 4(6):478-86. PMID: 12354359.
      Citations: 14     Fields:    Translation:HumansAnimals
    191. Gu JQ, Park EJ, Vigo JS, Graham JG, Fong HH, Pezzuto JM, Kinghorn AD. Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase. J Nat Prod. 2002 Nov; 65(11):1616-20. PMID: 12444686.
      Citations: 3     Fields:    Translation:AnimalsCells
    192. Verotta L, Guerrini M, El-Sebakhy NA, Assad AM, Toaima SM, Radwan MM, Luo YD, Pezzuto JM. Cycloartane and oleanane saponins from egyptian astragalus spp. as modulators of lymphocyte proliferation. Planta Med. 2002 Nov; 68(11):986-94. PMID: 12451488.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    193. Jang DS, Park EJ, Hawthorne ME, Vigo JS, Graham JG, Cabieses F, Santarsiero BD, Mesecar AD, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase. J Agric Food Chem. 2002 Oct 23; 50(22):6330-4. PMID: 12381112.
      Citations: 2     Fields:    Translation:AnimalsCells
    194. Mi Q, Cui B, Silva GL, Lantvit D, Lim E, Chai H, Hollingshead MG, Mayo JG, Kinghorn AD, Pezzuto JM. Pervilleines B and C, new tropane alkaloid aromatic esters that reverse the multidrug-resistance in the hollow fiber assay. Cancer Lett. 2002 Oct 08; 184(1):13-20. PMID: 12104043.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    195. Christov KT, Moon RC, Lantvit DD, Boone CW, Steele VE, Lubet RA, Kelloff GJ, Pezzuto JM. 9-cis-retinoic acid but not 4-(hydroxyphenyl)retinamide inhibits prostate intraepithelial neoplasia in Noble rats. Cancer Res. 2002 Sep 15; 62(18):5178-82. PMID: 12234981.
      Citations: 10     Fields:    Translation:Animals
    196. Ito A, Chai HB, Lee D, Kardono LB, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD. Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii. Phytochemistry. 2002 Sep; 61(2):171-4. PMID: 12169311.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    197. Gören A, Topçu G, Bilsel G, Bilsel M, Aydo?mu? Z, Pezzuto JM. The chemical constituents and biological activity of essential oil of Lavandula stoechas ssp. stoechas. Z Naturforsch C J Biosci. 2002 Sep-Oct; 57(9-10):797-800. PMID: 12440714.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    198. Su BN, Park EJ, Mbwambo ZH, Santarsiero BD, Mesecar AD, Fong HH, Pezzuto JM, Kinghorn AD. New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes. J Nat Prod. 2002 Sep; 65(9):1278-82. PMID: 12350147.
      Citations: 34     Fields:    Translation:AnimalsCells
    199. Su BN, Chang LC, Park EJ, Cuendet M, Santarsiero BD, Mesecar AD, Mehta RG, Fong HH, Pezzuto JM, Kinghorn AD. Bioactive constituents of the seeds of Brucea javanica. Planta Med. 2002 Aug; 68(8):730-3. PMID: 12221597.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    200. Gu JQ, Park EJ, Totura S, Riswan S, Fong HH, Pezzuto JM, Kinghorn AD. Constituents of the twigs of Hernandia ovigera that inhibit the transformation of JB6 murine epidermal cells. J Nat Prod. 2002 Jul; 65(7):1065-8. PMID: 12141878.
      Citations: 5     Fields:    Translation:AnimalsCells
    201. Rimando AM, Cuendet M, Desmarchelier C, Mehta RG, Pezzuto JM, Duke SO. Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. J Agric Food Chem. 2002 Jun 05; 50(12):3453-7. PMID: 12033810.
      Citations: 62     Fields:    Translation:Animals
    202. Mi Q, Lantvit D, Reyes-Lim E, Chai H, Zhao W, Lee IS, Peraza-Sánchez S, Ngassapa O, Kardono LB, Riswan S, Hollingshead MG, Mayo JG, Farnsworth NR, Cordell GA, Kinghorn AD, Pezzuto JM. Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests. J Nat Prod. 2002 Jun; 65(6):842-50. PMID: 12088425.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    203. Blatt CT, Chávez D, Chai H, Graham JG, Cabieses F, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD. Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis. Phytother Res. 2002 Jun; 16(4):320-5. PMID: 12112286.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    204. Mi Q, Cui B, Chávez D, Chai H, Zhu H, Cordell GA, Hedayat S, Kinghorn AD, Pezzuto JM. Characterization of tropane alkaloid aromatic esters that reverse the multidrug-resistance phenotype. Anticancer Res. 2002 May-Jun; 22(3):1385-97. PMID: 12168815.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    205. Bhat KP, Pezzuto JM. Cancer chemopreventive activity of resveratrol. Ann N Y Acad Sci. 2002 May; 957:210-29. PMID: 12074974.
      Citations: 92     Fields:    Translation:HumansAnimals
    206. Misico RI, Song LL, Veleiro AS, Cirigliano AM, Tettamanzi MC, Burton G, Bonetto GM, Nicotra VE, Silva GL, Gil RR, Oberti JC, Kinghorn AD, Pezzuto JM. Induction of quinone reductase by withanolides. J Nat Prod. 2002 May; 65(5):677-80. PMID: 12027740.
      Citations: 6     Fields:    Translation:AnimalsCells
    207. Gu JQ, Gills JJ, Park EJ, Mata-Greenwood E, Hawthorne ME, Axelrod F, Chavez PI, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Sesquiterpenoids from Tithonia diversifolia with potential cancer chemopreventive activity. J Nat Prod. 2002 Apr; 65(4):532-6. PMID: 11975495.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    208. Chávez D, Cui B, Chai HB, García R, Mejía M, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD. Reversal of multidrug resistance by tropane alkaloids from the stems of Erythroxylum rotundifolium. J Nat Prod. 2002 Apr; 65(4):606-10. PMID: 11975514.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    209. Minguzzi S, Barata LE, Shin YG, Jonas PF, Chai HB, Park EJ, Pezzuto JM, Cordell GA. Cytotoxic withanolides from Acnistus arborescens. Phytochemistry. 2002 Mar; 59(6):635-41. PMID: 11867095.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    210. Kandil FE, Smith MA, Rogers RB, Pépin MF, Song LL, Pezzuto JM, Seigler DS. Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity. J Agric Food Chem. 2002 Feb 27; 50(5):1063-9. PMID: 11853481.
      Citations: 12     Fields:    Translation:AnimalsCells
    211. Hoang VD, Tan GT, Zhang HJ, Tamez PA, Hung NV, Cuong NM, Soejarto DD, Fong HH, Pezzuto JM. Natural anti-HIV agents-part I: (+)-demethoxyepiexcelsin and verticillatol from Litsea verticillata. Phytochemistry. 2002 Feb; 59(3):325-9. PMID: 11830141.
      Citations: 9     Fields:    Translation:AnimalsCells
    212. Su BN, Cuendet M, Hawthorne ME, Kardono LB, Riswan S, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD. Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity. J Nat Prod. 2002 Feb; 65(2):163-9. PMID: 11858749.
      Citations: 14     Fields:    Translation:AnimalsCells
    213. Zhang H, Fan Z, Tan GT, Chai HB, Pezzuto JM, Sun H, Fong HH. Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata. J Nat Prod. 2002 Feb; 65(2):215-7. PMID: 11858760.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    214. Peraza-Sánchez SR, Chai HB, Shin YG, Santisuk T, Reutrakul V, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD. Constituents of the leaves and twigs of Ficus hispida. Planta Med. 2002 Feb; 68(2):186-8. PMID: 11859479.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    215. Burdette JE, Liu J, Lantvit D, Lim E, Booth N, Bhat KP, Hedayat S, Van Breemen RB, Constantinou AI, Pezzuto JM, Farnsworth NR, Bolton JL. Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats. J Nutr. 2002 Jan; 132(1):27-30. PMID: 11773503.
      Citations: 20     Fields:    Translation:Animals
    216. Park EJ, Pezzuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev. 2002; 21(3-4):231-55. PMID: 12549763.
      Citations: 78     Fields:    Translation:HumansAnimals
    217. Lee SK, Heo YH, Steele VE, Pezzuto JM. Induction of apoptosis by 1,4-phenylenebis(methylene)selenocyanate in cultured human colon cancer cells. Anticancer Res. 2002 Jan-Feb; 22(1A):97-102. PMID: 12017340.
      Citations: 1     Fields:    Translation:HumansCells
    218. El Sayed KA, Hamann MT, Waddling CA, Jensen C, Lee SK, Dunstan CA, Pezzuto JM. Structurally Novel Bioconversion Products of the Marine Natural Product Sarcophine Effectively Inhibit JB6 Cell Transformation. J Org Chem. 1998 Oct 16; 63(21):7449-7455. PMID: 11672397.
      Citations: 15     Fields:    
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