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Stephen Bonasera MD, PhD

InstitutionUMass Chan – Baystate Regional Campus
DepartmentMedicine at UMass Chan - Baystate
AddressBaystate Medical Center
759 Chestnut Street
Springfield MA 01199
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    Collapse education and training
    Virginia Polytechnic Institute and State University, Blacksburg, VA, United StatesBS
    Georgia Institute of Technology, Atlanta, GA, United StatesMS
    Emory University, Atlanta, GA, United StatesMD
    Emory University, Atlanta, GA, United StatesPHD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Loss of epigenetic information as a cause of mammalian aging. Cell. 2024 Feb 29; 187(5):1312-1313. PMID: 38428398.
    2. Guterman EL, Kiekhofer RE, Wood AJ, Allen IE, Kahn JG, Dulaney S, Merrilees JJ, Lee K, Chiong W, Bonasera SJ, Braley TL, Hunt LJ, Harrison KL, Miller BL, Possin KL. Care Ecosystem Collaborative Model and Health Care Costs in Medicare Beneficiaries With Dementia: A Secondary Analysis of a Randomized Clinical Trial. JAMA Intern Med. 2023 11 01; 183(11):1222-1228. PMID: 37721734.
      Citations:    Fields:    Translation:Humans
    3. Chaudoin TR, Bonasera SJ, Dunaevsky A, Padmashri R. Exploring behavioral phenotypes in a mouse model of fetal alcohol spectrum disorders. Dev Neurobiol. 2023 Jul-Sep; 83(5-6):184-204. PMID: 37433012.
      Citations:    Fields:    Translation:HumansAnimals
    4. Sideman AB, Merrilees J, Dulaney S, Kiekhofer R, Braley T, Lee K, Chiong W, Miller B, Bonasera SJ, Possin KL. "Out of the clear blue sky she tells me she loves me": Connection experiences between caregivers and people with dementia. J Am Geriatr Soc. 2023 07; 71(7):2172-2183. PMID: 36917135.
      Citations:    Fields:    Translation:Humans
    5. Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Loss of epigenetic information as a cause of mammalian aging. Cell. 2023 01 19; 186(2):305-326.e27. PMID: 36638792.
      Citations: 96     Fields:    Translation:AnimalsCells
    6. Liu AK, Possin KL, Cook KM, Lynch S, Dulaney S, Merrilees JJ, Braley T, Kiekhofer RE, Bonasera SJ, Allen IE, Chiong W, Clark AM, Feuer J, Ewalt J, Guterman EL, Gearhart R, Miller BL, Lee KP. Effect of collaborative dementia care on potentially inappropriate medication use: Outcomes from the Care Ecosystem randomized clinical trial. Alzheimers Dement. 2023 05; 19(5):1865-1875. PMID: 36331050.
      Citations: 2     Fields:    Translation:Humans
    7. DeKorver NW, Chaudoin TR, Zhao G, Wang D, Arikkath J, Bonasera SJ. Complement Component C3 Loss leads to Locomotor Deficits and Altered Cerebellar Internal Granule Cell In Vitro Synaptic Protein Expression in C57BL/6 Mice. Mol Neurobiol. 2021 Nov; 58(11):5857-5875. PMID: 34415487.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Ligon C, Seong E, Schroeder EJ, DeKorver NW, Yuan L, Chaudoin TR, Cai Y, Buch S, Bonasera SJ, Arikkath J. d-Catenin engages the autophagy pathway to sculpt the developing dendritic arbor. J Biol Chem. 2020 08 07; 295(32):10988-11001. PMID: 32554807.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Manley NA, Bayen E, Braley TL, Merrilees J, Clark AM, Zylstra B, Schaffer M, Bayen AM, Possin KL, Miller BL, Schenk AK, Bonasera SJ. Long-term digital device-enabled monitoring of functional status: Implications for management of persons with Alzheimer's disease. Alzheimers Dement (N Y). 2020; 6(1):e12017. PMID: 32548234.
    10. Bernstein A, Merrilees J, Dulaney S, Harrison KL, Chiong W, Ong P, Heunis J, Choi J, Walker R, Feuer JE, Lee K, Dohan D, Bonasera SJ, Miller BL, Possin KL. Using care navigation to address caregiver burden in dementia: A qualitative case study analysis. Alzheimers Dement (N Y). 2020; 6(1):e12010. PMID: 32377557.
    11. Possin KL, Merrilees JJ, Dulaney S, Bonasera SJ, Chiong W, Lee K, Hooper SM, Allen IE, Braley T, Bernstein A, Rosa TD, Harrison K, Begert-Hellings H, Kornak J, Kahn JG, Naasan G, Lanata S, Clark AM, Chodos A, Gearhart R, Ritchie C, Miller BL. Effect of Collaborative Dementia Care via Telephone and Internet on Quality of Life, Caregiver Well-being, and Health Care Use: The Care Ecosystem Randomized Clinical Trial. JAMA Intern Med. 2019 12 01; 179(12):1658-1667. PMID: 31566651.
      Citations: 71     Fields:    Translation:Humans
    12. Guterman EL, Allen IE, Josephson SA, Merrilees JJ, Dulaney S, Chiong W, Lee K, Bonasera SJ, Miller BL, Possin KL. Association Between Caregiver Depression and Emergency Department Use Among Patients With Dementia. JAMA Neurol. 2019 Oct 01; 76(10):1166-1173. PMID: 31282955.
      Citations: 16     Fields:    
    13. Rosa TD, Possin KL, Bernstein A, Merrilees J, Dulaney S, Matuoka J, Lee KP, Chiong W, Bonasera SJ, Harrison KL, Kahn JG. Variations in Costs of a Collaborative Care Model for Dementia. J Am Geriatr Soc. 2019 12; 67(12):2628-2633. PMID: 31317539.
      Citations: 11     Fields:    Translation:Humans
    14. Chen Y, Wilson L, Kornak J, Dudley RA, Merrilees J, Bonasera SJ, Byrne CM, Lee K, Chiong W, Miller BL, Possin KL. The costs of dementia subtypes to California Medicare fee-for-service, 2015. Alzheimers Dement. 2019 07; 15(7):899-906. PMID: 31175026.
      Citations: 17     Fields:    Translation:Humans
    15. Bernstein A, Harrison KL, Dulaney S, Merrilees J, Bowhay A, Heunis J, Choi J, Feuer JE, Clark AM, Chiong W, Lee K, Braley TL, Bonasera SJ, Ritchie CS, Dohan D, Miller BL, Possin KL. The Role of Care Navigators Working with People with Dementia and Their Caregivers. J Alzheimers Dis. 2019; 71(1):45-55. PMID: 31322558.
      Citations: 17     Fields:    Translation:Humans
    16. Merrilees JJ, Bernstein A, Dulaney S, Heunis J, Walker R, Rah E, Choi J, Gawlas K, Carroll S, Ong P, Feuer J, Braley T, Clark AM, Lee K, Chiong W, Bonasera SJ, Miller BL, Possin KL. The Care Ecosystem: Promoting self-efficacy among dementia family caregivers. Dementia (London). 2020 Aug; 19(6):1955-1973. PMID: 30497302.
      Citations: 15     Fields:    Translation:Humans
    17. Chaudoin TR, Bonasera SJ. Mice lacking galectin-3 (Lgals3) function have decreased home cage movement. BMC Neurosci. 2018 05 02; 19(1):27. PMID: 29716523.
      Citations: 3     Fields:    Translation:Animals
    18. Rye Hanton C, Kwon YJ, Aung T, Whittington J, High RR, Goulding EH, Schenk AK, Bonasera SJ. Mobile Phone-Based Measures of Activity, Step Count, and Gait Speed: Results From a Study of Older Ambulatory Adults in a Naturalistic Setting. JMIR Mhealth Uhealth. 2017 Oct 03; 5(10):e104. PMID: 28974482.
      Citations: 5     Fields:    
    19. Zylstra B, Netscher G, Jacquemot J, Schaffer M, Shen G, Bowhay AD, Braley TL, Possin KL, Miller BL, Bayen AM, Bonasera SJ, Schenk AK. Extended, continuous measures of functional status in community dwelling persons with Alzheimer's and related dementia: Infrastructure, performance, tradeoffs, preliminary data, and promise. J Neurosci Methods. 2018 04 15; 300:59-67. PMID: 28865985.
      Citations: 13     Fields:    Translation:Humans
    20. DeKorver NW, Chaudoin TR, Bonasera SJ. Toll-Like Receptor 2 Is a Regulator of Circadian Active and Inactive State Consolidation in C57BL/6 Mice. Front Aging Neurosci. 2017; 9:219. PMID: 28769782.
    21. Bonasera SJ, Chaudoin TR, Goulding EH, Mittek M, Dunaevsky A. Decreased home cage movement and oromotor impairments in adult Fmr1-KO mice. Genes Brain Behav. 2017 06; 16(5):564-573. PMID: 28218824.
      Citations: 10     Fields:    Translation:Animals
    22. Possin KL, Merrilees J, Bonasera SJ, Bernstein A, Chiong W, Lee K, Wilson L, Hooper SM, Dulaney S, Braley T, Laohavanich S, Feuer JE, Clark AM, Schaffer MW, Schenk AK, Heunis J, Ong P, Cook KM, Bowhay AD, Gearhart R, Chodos A, Naasan G, Bindman AB, Dohan D, Ritchie C, Miller BL. Development of an adaptive, personalized, and scalable dementia care program: Early findings from the Care Ecosystem. PLoS Med. 2017 03; 14(3):e1002260. PMID: 28323819.
      Citations: 21     Fields:    Translation:Humans
    23. DeKorver NW, Lichty D, van der Hart M, Rassoulpour A, Bonasera SJ. Increased whole cerebellar serotonin in aged C57BL/6 mice. Matters (Zur). 2017; 2017. PMID: 28894740.
    24. Bonasera SJ, Arikkath J, Boska MD, Chaudoin TR, DeKorver NW, Goulding EH, Hoke TA, Mojtahedzedah V, Reyelts CD, Sajja B, Schenk AK, Tecott LH, Volden TA. Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits. Aging (Albany NY). 2016 09 20; 8(9):2153-2181. PMID: 27689748.
      Citations: 5     Fields:    Translation:AnimalsCells
    25. Bonasera SJ, Schenk AK, Luxenberg EJ, Wang X, Basbaum A, Tecott LH. Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli. PLoS One. 2015; 10(12):e0142906. PMID: 26630489.
      Citations: 4     Fields:    Translation:Animals
    26. Knibbe-Hollinger JS, Fields NR, Chaudoin TR, Epstein AA, Makarov E, Akhter SP, Gorantla S, Bonasera SJ, Gendelman HE, Poluektova LY. Influence of age, irradiation and humanization on NSG mouse phenotypes. Biol Open. 2015 Sep 09; 4(10):1243-52. PMID: 26353862.
      Citations: 17     Fields:    
    27. Volden TA, Reyelts CD, Hoke TA, Arikkath J, Bonasera SJ. Validation of Flow Cytometry and Magnetic Bead-Based Methods to Enrich CNS Single Cell Suspensions for Quiescent Microglia. J Neuroimmune Pharmacol. 2015 Dec; 10(4):655-65. PMID: 26260923.
      Citations: 2     Fields:    Translation:AnimalsCells
    28. Boska MD, Dash PK, Knibbe J, Epstein AA, Akhter SP, Fields N, High R, Makarov E, Bonasera S, Gelbard HA, Poluektova LY, Gendelman HE, Gorantla S. Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice. Mol Neurodegener. 2014 Dec 18; 9:58. PMID: 25523827.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    29. Bailey KL, Bonasera SJ, Wilderdyke M, Hanisch BW, Pavlik JA, DeVasure J, Robinson JE, Sisson JH, Wyatt TA. Aging causes a slowing in ciliary beat frequency, mediated by PKCe. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15; 306(6):L584-9. PMID: 24487393.
      Citations: 21     Fields:    Translation:AnimalsCells
    30. Carlson JD, Mittek M, Parkison SA, Sathler P, Bayne D, Psota ET, Perez LC, Bonasera SJ. Smart watch RSSI localization and refinement for behavioral classification using laser-SLAM for mapping and fingerprinting. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:2173-6. PMID: 25570416.
      Citations: 2     Fields:    Translation:Humans
    31. Sandkovsky U, Robertson KR, Meza JL, High RR, Bonasera SJ, Fisher CM, Marsh AJ, Sheehy MK, Fox HS, Swindells S. Pilot study of younger and older HIV-infected adults using traditional and novel functional assessments. HIV Clin Trials. 2013 Jul-Aug; 14(4):165-74. PMID: 23924589.
      Citations: 9     Fields:    Translation:Humans
    32. Balas MC, Bonasera SJ, Cohen MZ, Hertzog M, Sisson JH, Potter JF, Fitch A, Burke WJ. Measuring functional recovery in older patients discharged from intensive care units: is advanced technology an option? J Appl Gerontol. 2015 Apr; 34(3):NP22-40. PMID: 24652873.
      Citations:    Fields:    Translation:Humans
    33. Wan N, Qu W, Whittington J, Witbrodt BC, Henderson MP, Goulding EH, Schenk AK, Bonasera SJ, Lin G. Assessing Smart Phones for Generating Life-space Indicators. Environ Plann B Plann Des. 2013 Apr; 40(2):350-361. PMID: 28819332.
    34. Gennatas ED, Cholfin JA, Zhou J, Crawford RK, Sasaki DA, Karydas A, Boxer AL, Bonasera SJ, Rankin KP, Gorno-Tempini ML, Rosen HJ, Kramer JH, Weiner M, Miller BL, Seeley WW. COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structures. Neurology. 2012 May 22; 78(21):1663-9. PMID: 22573634.
      Citations: 15     Fields:    Translation:Humans
    35. Carlson RH, Huebner DR, Hoarty CA, Whittington J, Haynatzki G, Balas MC, Schenk AK, Goulding EH, Potter JF, Bonasera SJ. Treadmill gait speeds correlate with physical activity counts measured by cell phone accelerometers. Gait Posture. 2012 Jun; 36(2):241-8. PMID: 22475727.
      Citations: 10     Fields:    Translation:Humans
    36. Parkison SA, Carlson JD, Chaudoin TR, Hoke TA, Schenk AK, Goulding EH, P?rez LC, Bonasera SJ. A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:2392-5. PMID: 23366406.
      Citations: 7     Fields:    Translation:Animals
    37. Schenk AK, Witbrodt BC, Hoarty CA, Carlson RH, Goulding EH, Potter JF, Bonasera SJ. Cellular telephones measure activity and lifespace in community-dwelling adults: proof of principle. J Am Geriatr Soc. 2011 Feb; 59(2):345-52. PMID: 21288235.
      Citations: 23     Fields:    Translation:Humans
    38. Rabinovici GD, Furst AJ, Alkalay A, Racine CA, O'Neil JP, Janabi M, Baker SL, Agarwal N, Bonasera SJ, Mormino EC, Weiner MW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ. Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden. Brain. 2010 Feb; 133(Pt 2):512-28. PMID: 20080878.
      Citations: 138     Fields:    Translation:Humans
    39. Migliaccio R, Agosta F, Rascovsky K, Karydas A, Bonasera S, Rabinovici GD, Miller BL, Gorno-Tempini ML. Clinical syndromes associated with posterior atrophy: early age at onset AD spectrum. Neurology. 2009 Nov 10; 73(19):1571-8. PMID: 19901249.
      Citations: 107     Fields:    Translation:Humans
    40. Abdallah L, Bonasera SJ, Hopf FW, O'Dell L, Giorgetti M, Jongsma M, Carra S, Pierucci M, Di Giovanni G, Esposito E, Parsons LH, Bonci A, Tecott LH. Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. J Neurosci. 2009 Jun 24; 29(25):8156-65. PMID: 19553455.
      Citations: 35     Fields:    Translation:AnimalsCells
    41. Agosta F, Vossel KA, Miller BL, Migliaccio R, Bonasera SJ, Filippi M, Boxer AL, Karydas A, Possin KL, Gorno-Tempini ML. Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):2018-22. PMID: 19164761.
      Citations: 88     Fields:    Translation:Humans
    42. Webb A, Miller B, Bonasera S, Boxer A, Karydas A, Wilhelmsen KC. Role of the tau gene region chromosome inversion in progressive supranuclear palsy, corticobasal degeneration, and related disorders. Arch Neurol. 2008 Nov; 65(11):1473-8. PMID: 19001166.
      Citations: 18     Fields:    Translation:HumansCells
    43. Huang MC, Liao JJ, Bonasera S, Longo DL, Goetzl EJ. Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. FASEB J. 2008 Jul; 22(7):2142-50. PMID: 18267981.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    44. Bonasera SJ, Schenk AK, Luxenberg EJ, Tecott LH. A novel method for automatic quantification of psychostimulant-evoked route-tracing stereotypy: application to Mus musculus. Psychopharmacology (Berl). 2008 Mar; 196(4):591-602. PMID: 18097652.
      Citations: 12     Fields:    Translation:Animals
    45. Zhang J, Pho V, Bonasera SJ, Holtzman J, Tang AT, Hellmuth J, Tang S, Janak PH, Tecott LH, Huang EJ. Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat Neurosci. 2007 Jan; 10(1):77-86. PMID: 17159989.
      Citations: 67     Fields:    Translation:AnimalsCells
    46. Bonasera SJ, Chu HM, Brennan TJ, Tecott LH. A null mutation of the serotonin 6 receptor alters acute responses to ethanol. Neuropsychopharmacology. 2006 Aug; 31(8):1801-13. PMID: 16452990.
      Citations: 15     Fields:    Translation:Animals
    47. Nonogaki K, Abdallah L, Goulding EH, Bonasera SJ, Tecott LH. Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice. Diabetes. 2003 Feb; 52(2):315-20. PMID: 12540602.
      Citations: 40     Fields:    Translation:AnimalsCells
    48. Bonasera SJ, Tecott LH. Mouse models of serotonin receptor function: toward a genetic dissection of serotonin systems. Pharmacol Ther. 2000 Nov; 88(2):133-42. PMID: 11150593.
      Citations: 14     Fields:    Translation:HumansAnimals
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