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Leonard Barasa PhD

TitleInstructor
InstitutionUMass Chan Medical School
DepartmentBiochemistry and Molecular Biotechnology
AddressUMass Chan Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone508-856-8314
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology


    Collapse Biography 
    Collapse education and training
    Egerton University, Egerton, , KenyaBEDSciences
    University of Nairobi, Nairobi, , KenyaMSChemistry
    St. John¿s University, Queens, NY, United StatesPHDPharmaceutical Sciences

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Elfawal MA, Goetz E, Kim Y, Chen P, Savinov SN, Barasa L, Thompson PR, Aroian RV. High-Throughput Screening of More Than 30,000 Compounds for Anthelmintics against Gastrointestinal Nematode Parasites. ACS Infect Dis. 2025 Jan 10; 11(1):104-120. PMID: 39653369.
      Citations:    
    2. Elfawal MA, Goetz E, Kim YM, Chen P, Savinov SN, Barasa L, Thompson PR, Aroian RV. High-throughput screening of more than 30,000 compounds for anthelmintics against gastrointestinal nematode parasites. bioRxiv. 2024 Oct 31. PMID: 39554023.
      Citations:    
    3. Dong T, Barasa L, Yu X, Ouyang W, Shao L, Quan C, Wang SH, Zhang J, Salmon M, Tsung A, Alam HB, Ma J, Thompson PR, Li Y. AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment-Efficacy and Mechanism. Int J Biol Sci. 2024; 20(13):5043-5055. PMID: 39430255.
      Citations:    
    4. Karadkhelkar NM, Gupta P, Barasa L, Chilamakuri R, Hlordzi CK, Acharekar N, Agarwal S, Chen ZS, Yoganathan S. Chemical Derivatization Leads to the Discovery Of Novel Analogs of Azotochelin, a Natural Siderophore, as Promising Anticancer Agents. ChemMedChem. 2024 Jul 02; 19(13):e202300715. PMID: 38598189.
      Citations:    
    5. Pasquero S, Gugliesi F, Biolatti M, Dell'Oste V, Albano C, Bajetto G, Griffante G, Trifir? L, Brugo B, Raviola S, Lacarbonara D, Yang Q, Sudeshna S, Barasa L, Haniff H, Thompson PR, Landolfo S, De Andrea M. Citrullination profile analysis reveals peptidylarginine deaminase 3 as an HSV-1 target to dampen the activity of candidate antiviral restriction factors. PLoS Pathog. 2023 Dec; 19(12):e1011849. PMID: 38055760.
      Citations:    Fields:    Translation:HumansCells
    6. Geary B, Sun B, Tilvawala RR, Barasa L, Tsoyi K, Rosas IO, Thompson PR, Ho IC. Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA. Front Immunol. 2023; 14:1290585. PMID: 38094295.
      Citations:    Fields:    Translation:HumansAnimals
    7. Najafi S, Barasa L, Frianela JMJ, Alkhamisy JH, Yoganathan S, Perron JC. Novel Indolyl-Benzimidazole Compounds Promote in vitro Wound Healing and Osteogenic Differentiation of Pluripotent Cells. Front Biosci (Landmark Ed). 2023 10 27; 28(10):268. PMID: 37919087.
      Citations:    
    8. Barasa L, Thompson PR. Protein citrullination: inhibition, identification and insertion. Philos Trans R Soc Lond B Biol Sci. 2023 11 20; 378(1890):20220240. PMID: 37778377.
      Citations: 1     Fields:    Translation:HumansCells
    9. Barasa L, Chaudhuri S, Zhou JY, Jiang Z, Choudhary S, Green RM, Wiggin E, Cameron M, Humphries F, Fitzgerald KA, Thompson PR. Development of LB244, an Irreversible STING Antagonist. J Am Chem Soc. 2023 09 20; 145(37):20273-20288. PMID: 37695732.
      Citations:    Fields:    Translation:Humans
    10. Humphries F, Shmuel-Galia L, Jiang Z, Zhou JY, Barasa L, Mondal S, Wilson R, Sultana N, Shaffer SA, Ng SL, Pesiridis GS, Thompson PR, Fitzgerald KA. Targeting STING oligomerization with small-molecule inhibitors. Proc Natl Acad Sci U S A. 2023 08 15; 120(33):e2305420120. PMID: 37549268.
      Citations: 1     Fields:    Translation:AnimalsCells
    11. Icso JD, Barasa L, Thompson PR. SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism. Biochemistry. 2023 07 04; 62(13):2065-2078. PMID: 37307562.
      Citations:    Fields:    Translation:AnimalsCells
    12. Najafi S, Barasa L, Huang SY, Yoganathan S, Perron JC. Discovery of a novel class of benzimidazoles as highly effective agonists of bone morphogenetic protein (BMP) receptor signaling. Sci Rep. 2022 07 15; 12(1):12146. PMID: 35840622.
      Citations:    
    13. Barasa L, Vemana HP, Surubhotla N, Ha SS, Kong J, Yong A, Croft JL, Dukhande VV, Yoganathan S. Synthesis and Biological Evaluation of Structurally Diverse Benzimidazole Scaffolds as Potential Chemotherapeutic Agents. Anticancer Agents Med Chem. 2020; 20(3):301-314. PMID: 31746304.
      Citations:    
    14. Kulkarni NS, Parvathaneni V, Shukla SK, Barasa L, Perron JC, Yoganathan S, Muth A, Gupta V. Tyrosine kinase inhibitor conjugated quantum dots for non-small cell lung cancer (NSCLC) treatment. Eur J Pharm Sci. 2019 May 15; 133:145-159. PMID: 30946965.
      Citations:    
    15. Barasa L, Yoganathan S. An efficient one-pot conversion of carboxylic acids into benzimidazoles via an HBTU-promoted methodology. RSC Adv. 2018 Oct 15; 8(62):35824-35830. PMID: 35547918.
      Citations:    
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