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Christian Frese MD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentMedicine
AddressMilford Regional Medical Center
14 Prospect Street
Milford MA 01757
Phone508-473-1190
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMedicine
    DivisionHospital Medicine


    Collapse Biography 
    Collapse education and training
    University of California, Los Angeles, Los Angeles, CA, United StatesBSPsychobiology
    Boston University School of Medicine, Boston, MA, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mu?oz-Gutierrez V, Cornejo FA, Schmidt K, Frese CK, Halte M, Erhardt M, Elsholz AKW, Turgay K, Charpentier E. Bacillus subtilis remains translationally active after CRISPRi-mediated replication initiation arrest. mSystems. 2024 Apr 16; 9(4):e0022124. PMID: 38546227.
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    2. Birk MS, Charpentier E, Frese CK. Automated Phosphopeptide Enrichment for Gram-Positive Bacteria. J Proteome Res. 2021 Oct 01; 20(10):4886-4892. PMID: 34473931.
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    3. Birk MS, Ahmed-Begrich R, Tran S, Elsholz AKW, Frese CK, Charpentier E. Time-Resolved Proteome Analysis of Listeria monocytogenes during Infection Reveals the Role of the AAA+ Chaperone ClpC for Host Cell Adaptation. mSystems. 2021 Aug 31; 6(4):e0021521. PMID: 34342529.
      Citations:    
    4. Krishnamoorthy G, Kaiser P, Constant P, Abu Abed U, Schmid M, Frese CK, Brinkmann V, Daff? M, Kaufmann SHE. Role of Premycofactocin Synthase in Growth, Microaerophilic Adaptation, and Metabolism of Mycobacterium tuberculosis. mBio. 2021 08 31; 12(4):e0166521. PMID: 34311585.
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    5. Apel F, Andreeva L, Knackstedt LS, Streeck R, Frese CK, Goosmann C, Hopfner KP, Zychlinsky A. The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps. Sci Signal. 2021 03 09; 14(673). PMID: 33688080.
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    6. Bae-Gartz I, Kasper P, Gro?mann N, Breuer S, Janoschek R, Kretschmer T, Appel S, Schmitz L, Vohlen C, Quaas A, Schweiger MR, Grimm C, Fischer A, Ferrari N, Graf C, Frese CK, Lang S, Demir M, Schramm C, Fink G, Goeser T, D?tsch J, Hucklenbruch-Rother E. Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming. Sci Rep. 2020 09 22; 10(1):15424. PMID: 32963289.
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    7. Gerbracht JV, Boehm V, Britto-Borges T, Kallabis S, Wiederstein JL, Ciriello S, Aschemeier DU, Kr?ger M, Frese CK, Altm?ller J, Dieterich C, Gehring NH. CASC3 promotes transcriptome-wide activation of nonsense-mediated decay by the exon junction complex. Nucleic Acids Res. 2020 09 04; 48(15):8626-8644. PMID: 32621609.
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    8. Schnirch L, Nadler-Holly M, Siao SW, Frese CK, Viner R, Liu F. Expanding the Depth and Sensitivity of Cross-Link Identification by Differential Ion Mobility Using High-Field Asymmetric Waveform Ion Mobility Spectrometry. Anal Chem. 2020 08 04; 92(15):10495-10503. PMID: 32643919.
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    9. Szczepanowska K, Senft K, Heidler J, Herholz M, Kukat A, H?hne MN, Hofsetz E, Becker C, Kaspar S, Giese H, Zwicker K, Guerrero-Castillo S, Baumann L, Kauppila J, Rumyantseva A, M?ller S, Frese CK, Brandt U, Riemer J, Wittig I, Trifunovic A. A salvage pathway maintains highly functional respiratory complex I. Nat Commun. 2020 04 02; 11(1):1643. PMID: 32242014.
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    10. G?bel J, Engelhardt E, Pelzer P, Sakthivelu V, Jahn HM, Jevtic M, Folz-Donahue K, Kukat C, Schauss A, Frese CK, Giavalisco P, Ghanem A, Conzelmann KK, Motori E, Bergami M. Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling. Cell Metab. 2020 04 07; 31(4):791-808.e8. PMID: 32220306.
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    11. Sch?fer H, Beckert B, Frese CK, Steinchen W, Nuss AM, Beckstette M, Hantke I, Driller K, Sudzinov? P, Kr?sn? L, Kaever V, Dersch P, Bange G, Wilson DN, Turgay K. The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis. PLoS Genet. 2020 03; 16(3):e1008275. PMID: 32176689.
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    12. Shytaj IL, Lucic B, Forcato M, Penzo C, Billingsley J, Laketa V, Bosinger S, Stanic M, Gregoretti F, Antonelli L, Oliva G, Frese CK, Trifunovic A, Galy B, Eibl C, Silvestri G, Bicciato S, Savarino A, Lusic M. Alterations of redox and iron metabolism accompany the development of HIV latency. EMBO J. 2020 05 04; 39(9):e102209. PMID: 32157726.
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    13. Kaiser RWJ, Ignarski M, Van Nostrand EL, Frese CK, Jain M, Cukoski S, Heinen H, Schaechter M, Seufert L, Bunte K, Frommolt P, Keller P, Helm M, Bohl K, H?hne M, Schermer B, Benzing T, H?pker K, Dieterich C, Yeo GW, M?ller RU, Fabretti F. A protein-RNA interaction atlas of the ribosome biogenesis factor AATF. Sci Rep. 2019 07 30; 9(1):11071. PMID: 31363146.
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    14. Ignarski M, Rill C, Kaiser RWJ, Kaldirim M, Neuhaus R, Esmaillie R, Li X, Klein C, Bohl K, Petersen M, Frese CK, H?hne M, Atanassov I, Rinschen MM, H?pker K, Schermer B, Benzing T, Dieterich C, Fabretti F, M?ller RU. The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells. J Am Soc Nephrol. 2019 04; 30(4):564-576. PMID: 30867249.
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    15. Cagnetta R, Wong HH, Frese CK, Mallucci GR, Krijgsveld J, Holt CE. Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring. Mol Cell. 2019 02 07; 73(3):474-489.e5. PMID: 30595434.
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    16. Irmak D, Fatima A, Guti?rrez-Garcia R, Rinschen MM, Wagle P, Altm?ller J, Arrigoni L, Hummel B, Klein C, Frese CK, Sawarkar R, Rada-Iglesias A, Vilchez D. Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations. Hum Mol Genet. 2018 12 01; 27(23):4117-4134. PMID: 30452683.
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    17. Cagnetta R, Frese CK, Shigeoka T, Krijgsveld J, Holt CE. Rapid Cue-Specific Remodeling of the Nascent Axonal Proteome. Neuron. 2018 07 11; 99(1):29-46.e4. PMID: 30008298.
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    18. H?hne M, Frese CK, Grahammer F, Dafinger C, Ciarimboli G, Butt L, Binz J, Hackl MJ, Rahmatollahi M, Kann M, Schneider S, Altintas MM, Schermer B, Reinheckel T, G?bel H, Reiser J, Huber TB, Kramann R, Seeger-Nukpezah T, Liebau MC, Beck BB, Benzing T, Beyer A, Rinschen MM. Single-nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney Int. 2018 06; 93(6):1308-1319. PMID: 29530281.
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    19. Castello A, Frese CK, Fischer B, J?rvelin AI, Horos R, Alleaume AM, Foehr S, Curk T, Krijgsveld J, Hentze MW. Identification of RNA-binding domains of RNA-binding proteins in cultured cells on a system-wide scale with RBDmap. Nat Protoc. 2017 Dec; 12(12):2447-2464. PMID: 29095441.
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    20. Frese CK, Mikhaylova M, Stucchi R, Gautier V, Liu Q, Mohammed S, Heck AJR, Altelaar AFM, Hoogenraad CC. Quantitative Map of Proteome Dynamics during Neuronal Differentiation. Cell Rep. 2017 02 07; 18(6):1527-1542. PMID: 28178528.
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    21. Liao Y, Castello A, Fischer B, Leicht S, F?ehr S, Frese CK, Ragan C, Kurscheid S, Pagler E, Yang H, Krijgsveld J, Hentze MW, Preiss T. The Cardiomyocyte RNA-Binding Proteome: Links to Intermediary Metabolism and Heart Disease. Cell Rep. 2016 08 02; 16(5):1456-1469. PMID: 27452465.
      Citations:    
    22. Castello A, Fischer B, Frese CK, Horos R, Alleaume AM, Foehr S, Curk T, Krijgsveld J, Hentze MW. Comprehensive Identification of RNA-Binding Domains in Human Cells. Mol Cell. 2016 08 18; 63(4):696-710. PMID: 27453046.
      Citations:    
    23. Sysoev VO, Fischer B, Frese CK, Gupta I, Krijgsveld J, Hentze MW, Castello A, Ephrussi A. Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila. Nat Commun. 2016 07 05; 7:12128. PMID: 27378189.
      Citations:    
    24. Schmidlin T, Boender AJ, Frese CK, Heck AJ, Adan RA, Altelaar AF. Diet-induced neuropeptide expression: feasibility of quantifying extended and highly charged endogenous peptide sequences by selected reaction monitoring. Anal Chem. 2015 Oct 06; 87(19):9966-73. PMID: 26376940.
      Citations:    
    25. Balluff B, Frese CK, Maier SK, Sch?ne C, Kuster B, Schmitt M, Aubele M, H?fler H, Deelder AM, Heck A, Hogendoorn PC, Morreau J, Maarten Altelaar AF, Walch A, McDonnell LA. De novo discovery of phenotypic intratumour heterogeneity using imaging mass spectrometry. J Pathol. 2015 Jan; 235(1):3-13. PMID: 25201776.
      Citations:    
    26. Kelstrup CD, Frese C, Heck AJ, Olsen JV, Nielsen ML. Analytical utility of mass spectral binning in proteomic experiments by SPectral Immonium Ion Detection (SPIID). Mol Cell Proteomics. 2014 Aug; 13(8):1914-24. PMID: 24895383.
      Citations:    
    27. Mommen GP, Frese CK, Meiring HD, van Gaans-van den Brink J, de Jong AP, van Els CA, Heck AJ. Expanding the detectable HLA peptide repertoire using electron-transfer/higher-energy collision dissociation (EThcD). Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):4507-12. PMID: 24616531.
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    28. Frese CK, Boender AJ, Mohammed S, Heck AJ, Adan RA, Altelaar AF. Profiling of diet-induced neuropeptide changes in rat brain by quantitative mass spectrometry. Anal Chem. 2013 May 07; 85(9):4594-604. PMID: 23581470.
      Citations:    
    29. Frese CK, Nolting D, Altelaar AF, Griep-Raming J, Mohammed S, Heck AJ. Characterization of electron transfer dissociation in the Orbitrap Velos HCD cell. J Am Soc Mass Spectrom. 2013 Nov; 24(11):1663-70. PMID: 23605687.
      Citations:    
    30. Jones EA, Schmitz N, Waaijer CJ, Frese CK, van Remoortere A, van Zeijl RJ, Heck AJ, Hogendoorn PC, Deelder AM, Altelaar AF, Bov?e JV, McDonnell LA. Imaging mass spectrometry-based molecular histology differentiates microscopically identical and heterogeneous tumors. J Proteome Res. 2013 Apr 05; 12(4):1847-55. PMID: 23480610.
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    31. Frese CK, Zhou H, Taus T, Altelaar AF, Mechtler K, Heck AJ, Mohammed S. Unambiguous phosphosite localization using electron-transfer/higher-energy collision dissociation (EThcD). J Proteome Res. 2013 Mar 01; 12(3):1520-5. PMID: 23347405.
      Citations:    
    32. Frese CK, Altelaar AF, van den Toorn H, Nolting D, Griep-Raming J, Heck AJ, Mohammed S. Toward full peptide sequence coverage by dual fragmentation combining electron-transfer and higher-energy collision dissociation tandem mass spectrometry. Anal Chem. 2012 Nov 20; 84(22):9668-73. PMID: 23106539.
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    33. Altelaar AF, Frese CK, Preisinger C, Hennrich ML, Schram AW, Timmers HT, Heck AJ, Mohammed S. Benchmarking stable isotope labeling based quantitative proteomics. J Proteomics. 2013 Aug 02; 88:14-26. PMID: 23085607.
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    34. Fr?nzel B, Penkova M, Frese C, Metzler-Nolte N, Andreas Wolters D. Escherichia coli exhibits a membrane-related response to a small arginine- and tryptophan-rich antimicrobial peptide. Proteomics. 2012 Aug; 12(14):2319-30. PMID: 22685012.
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    35. Munoz J, Low TY, Kok YJ, Chin A, Frese CK, Ding V, Choo A, Heck AJ. The quantitative proteomes of human-induced pluripotent stem cells and embryonic stem cells. Mol Syst Biol. 2011 Nov 22; 7:550. PMID: 22108792.
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    36. Frese CK, Altelaar AF, Hennrich ML, Nolting D, Zeller M, Griep-Raming J, Heck AJ, Mohammed S. Improved peptide identification by targeted fragmentation using CID, HCD and ETD on an LTQ-Orbitrap Velos. J Proteome Res. 2011 May 06; 10(5):2377-88. PMID: 21413819.
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    37. Fr?nzel B, Frese C, Penkova M, Metzler-Nolte N, Bandow JE, Wolters DA. Corynebacterium glutamicum exhibits a membrane-related response to a small ferrocene-conjugated antimicrobial peptide. J Biol Inorg Chem. 2010 Nov; 15(8):1293-303. PMID: 20658302.
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