The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes.
Bakshi R, Zaidi SK, Pande S, Hassan MQ, Young DW, Montecino M, Lian JB, van Wijnen AJ, Stein JL, Stein GS. The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes. J Cell Sci. 2008 Dec 01; 121(Pt 23):3981-90.
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Cell Line, Tumor
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Cell Nucleolus
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Chromosomes, Human, Pair 21
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Chromosomes, Human, Pair 8
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Core Binding Factor Alpha 2 Subunit
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Fluorescent Antibody Technique
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Genes, rRNA
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Humans
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Leukemia, Myeloid, Acute
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Mitosis
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Nucleolus Organizer Region
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Oncogene Proteins, Fusion
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RUNX1 Translocation Partner 1 Protein
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Translocation, Genetic