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Paul Thompson to Humans

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This is a "connection" page, showing publications Paul Thompson has written about Humans.
Paul Thompson
Connection Strength
1.460
Humans
  1. Barasa L, Thompson PR. Protein citrullination: inhibition, identification and insertion. Philos Trans R Soc Lond B Biol Sci. 2023 11 20; 378(1890):20220240.
    View in: PubMed
    Score: 0.032
  2. Icso JD, Thompson PR. A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels. J Biol Chem. 2023 11; 299(11):105284.
    View in: PubMed
    Score: 0.032
  3. Barasa L, Chaudhuri S, Zhou JY, Jiang Z, Choudhary S, Green RM, Wiggin E, Cameron M, Humphries F, Fitzgerald KA, Thompson PR. Development of LB244, an Irreversible STING Antagonist. J Am Chem Soc. 2023 09 20; 145(37):20273-20288.
    View in: PubMed
    Score: 0.032
  4. Green RM, Thompson PR. Current insights into the role of citrullination in thrombosis. Curr Opin Chem Biol. 2023 08; 75:102313.
    View in: PubMed
    Score: 0.031
  5. Mondal S, Chen Y, Lockbaum GJ, Sen S, Chaudhuri S, Reyes AC, Lee JM, Kaur AN, Sultana N, Cameron MD, Shaffer SA, Schiffer CA, Fitzgerald KA, Thompson PR. Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2. J Am Chem Soc. 2022 11 23; 144(46):21035-21045.
    View in: PubMed
    Score: 0.030
  6. Sen S, Sultana N, Shaffer SA, Thompson PR. Proximity-Dependent Labeling of Cysteines. J Am Chem Soc. 2021 11 24; 143(46):19257-19261.
    View in: PubMed
    Score: 0.028
  7. Maurais AJ, Salinger AJ, Tobin M, Shaffer SA, Weerapana E, Thompson PR. A Streamlined Data Analysis Pipeline for the Identification of Sites of Citrullination. Biochemistry. 2021 09 28; 60(38):2902-2914.
    View in: PubMed
    Score: 0.028
  8. Mondal S, Thompson PR. Chemical biology of protein citrullination by the protein A arginine deiminases. Curr Opin Chem Biol. 2021 08; 63:19-27.
    View in: PubMed
    Score: 0.027
  9. Mondal S, Wang S, Zheng Y, Sen S, Chatterjee A, Thompson PR. Site-specific incorporation of citrulline into proteins in mammalian cells. Nat Commun. 2021 01 04; 12(1):45.
    View in: PubMed
    Score: 0.027
  10. Loring HS, Parelkar SS, Mondal S, Thompson PR. Identification of the first noncompetitive SARM1 inhibitors. Bioorg Med Chem. 2020 09 15; 28(18):115644.
    View in: PubMed
    Score: 0.026
  11. Loring HS, Icso JD, Nemmara VV, Thompson PR. Initial Kinetic Characterization of Sterile Alpha and Toll/Interleukin Receptor Motif-Containing Protein 1. Biochemistry. 2020 03 03; 59(8):933-942.
    View in: PubMed
    Score: 0.025
  12. Loring HS, Thompson PR. Emergence of SARM1 as a Potential Therapeutic Target for Wallerian-type Diseases. Cell Chem Biol. 2020 01 16; 27(1):1-13.
    View in: PubMed
    Score: 0.025
  13. Mondal S, Gong X, Zhang X, Salinger AJ, Zheng L, Sen S, Weerapana E, Zhang X, Thompson PR. Halogen Bonding Increases the Potency and Isozyme Selectivity of Protein Arginine Deiminase 1 Inhibitors. Angew Chem Int Ed Engl. 2019 09 02; 58(36):12476-12480.
    View in: PubMed
    Score: 0.024
  14. Zheng L, Nagar M, Maurais AJ, Slade DJ, Parelkar SS, Coonrod SA, Weerapana E, Thompson PR. Calcium Regulates the Nuclear Localization of Protein Arginine Deiminase 2. Biochemistry. 2019 07 09; 58(27):3042-3056.
    View in: PubMed
    Score: 0.024
  15. Sen S, Mondal S, Zheng L, Salinger AJ, Fast W, Weerapana E, Thompson PR. Development of a Suicide Inhibition-Based Protein Labeling Strategy for Nicotinamide N-Methyltransferase. ACS Chem Biol. 2019 04 19; 14(4):613-618.
    View in: PubMed
    Score: 0.024
  16. Mondal S, Thompson PR. Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination. Acc Chem Res. 2019 03 19; 52(3):818-832.
    View in: PubMed
    Score: 0.023
  17. Tilvawala R, Thompson PR. Peptidyl arginine deiminases: detection and functional analysis of protein citrullination. Curr Opin Struct Biol. 2019 12; 59:205-215.
    View in: PubMed
    Score: 0.023
  18. Nagar M, Tilvawala R, Thompson PR. Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination. Front Immunol. 2019; 10:244.
    View in: PubMed
    Score: 0.023
  19. Nemmara VV, Thompson PR. Development of Activity-Based Proteomic Probes for Protein Citrullination. Curr Top Microbiol Immunol. 2019; 420:233-251.
    View in: PubMed
    Score: 0.023
  20. Loring HS, Thompson PR. Kinetic Mechanism of Nicotinamide N-Methyltransferase. Biochemistry. 2018 09 25; 57(38):5524-5532.
    View in: PubMed
    Score: 0.023
  21. Nemmara VV, Tilvawala R, Salinger AJ, Miller L, Nguyen SH, Weerapana E, Thompson PR. Citrullination Inactivates Nicotinamide- N-methyltransferase. ACS Chem Biol. 2018 09 21; 13(9):2663-2672.
    View in: PubMed
    Score: 0.023
  22. Tilvawala R, Nguyen SH, Maurais AJ, Nemmara VV, Nagar M, Salinger AJ, Nagpal S, Weerapana E, Thompson PR. The Rheumatoid Arthritis-Associated Citrullinome. Cell Chem Biol. 2018 06 21; 25(6):691-704.e6.
    View in: PubMed
    Score: 0.022
  23. Mondal S, Parelkar SS, Nagar M, Thompson PR. Photochemical Control of Protein Arginine Deiminase (PAD) Activity. ACS Chem Biol. 2018 04 20; 13(4):1057-1065.
    View in: PubMed
    Score: 0.022
  24. Clancy KW, Russell AM, Subramanian V, Nguyen H, Qian Y, Campbell RM, Thompson PR. Citrullination/Methylation Crosstalk on Histone H3 Regulates ER-Target Gene Transcription. ACS Chem Biol. 2017 06 16; 12(6):1691-1702.
    View in: PubMed
    Score: 0.021
  25. Muth A, Subramanian V, Beaumont E, Nagar M, Kerry P, McEwan P, Srinath H, Clancy K, Parelkar S, Thompson PR. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 04 13; 60(7):3198-3211.
    View in: PubMed
    Score: 0.021
  26. Fuhrmann J, Thompson PR. Protein Arginine Methylation and Citrullination in Epigenetic Regulation. ACS Chem Biol. 2016 Mar 18; 11(3):654-68.
    View in: PubMed
    Score: 0.019
  27. Clancy KW, Weerapana E, Thompson PR. Detection and identification of protein citrullination in complex biological systems. Curr Opin Chem Biol. 2016 Feb; 30:1-6.
    View in: PubMed
    Score: 0.019
  28. Lewallen DM, Bicker KL, Subramanian V, Clancy KW, Slade DJ, Martell J, Dreyton CJ, Sokolove J, Weerapana E, Thompson PR. Chemical Proteomic Platform To Identify Citrullinated Proteins. ACS Chem Biol. 2015 Nov 20; 10(11):2520-8.
    View in: PubMed
    Score: 0.018
  29. Slade DJ, Fang P, Dreyton CJ, Zhang Y, Fuhrmann J, Rempel D, Bax BD, Coonrod SA, Lewis HD, Guo M, Gross ML, Thompson PR. Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design. ACS Chem Biol. 2015 Apr 17; 10(4):1043-53.
    View in: PubMed
    Score: 0.018
  30. Subramanian V, Knight JS, Parelkar S, Anguish L, Coonrod SA, Kaplan MJ, Thompson PR. Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors. J Med Chem. 2015 Feb 12; 58(3):1337-44.
    View in: PubMed
    Score: 0.018
  31. Wang M, Fuhrmann J, Thompson PR. Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion. Biochemistry. 2014 Dec 23; 53(50):7884-92.
    View in: PubMed
    Score: 0.017
  32. Dreyton CJ, Knuckley B, Jones JE, Lewallen DM, Thompson PR. Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism. Biochemistry. 2014 Jul 15; 53(27):4426-33.
    View in: PubMed
    Score: 0.017
  33. Slade DJ, Horibata S, Coonrod SA, Thompson PR. A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming. Bioessays. 2014 Aug; 36(8):736-40.
    View in: PubMed
    Score: 0.017
  34. Slade DJ, Subramanian V, Fuhrmann J, Thompson PR. Chemical and biological methods to detect post-translational modifications of arginine. Biopolymers. 2014 Feb; 101(2):133-43.
    View in: PubMed
    Score: 0.016
  35. Dreyton CJ, Anderson ED, Subramanian V, Boger DL, Thompson PR. Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15; 22(4):1362-9.
    View in: PubMed
    Score: 0.016
  36. Rust HL, Subramanian V, West GM, Young DD, Schultz PG, Thompson PR. Using unnatural amino acid mutagenesis to probe the regulation of PRMT1. ACS Chem Biol. 2014 Mar 21; 9(3):649-55.
    View in: PubMed
    Score: 0.016
  37. Lewallen DM, Sreelatha A, Dharmarajan V, Madoux F, Chase P, Griffin PR, Orth K, Hodder P, Thompson PR. Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation. ACS Chem Biol. 2014 Feb 21; 9(2):433-42.
    View in: PubMed
    Score: 0.016
  38. Bicker KL, Thompson PR. The protein arginine deiminases: Structure, function, inhibition, and disease. Biopolymers. 2013 Feb; 99(2):155-63.
    View in: PubMed
    Score: 0.015
  39. Lewallen DM, Steckler CJ, Knuckley B, Chalmers MJ, Thompson PR. Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates. Mol Biosyst. 2012 Jun; 8(6):1701-6.
    View in: PubMed
    Score: 0.014
  40. Obianyo O, Thompson PR. Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6). J Biol Chem. 2012 Feb 17; 287(8):6062-71.
    View in: PubMed
    Score: 0.014
  41. Jones JE, Slack JL, Fang P, Zhang X, Subramanian V, Causey CP, Coonrod SA, Guo M, Thompson PR. Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem Biol. 2012 Jan 20; 7(1):160-5.
    View in: PubMed
    Score: 0.014
  42. Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y, Hashimoto H, Sato M, Hofseth LJ, Thompson PR. The development of N-a-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-a-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. J Med Chem. 2011 Oct 13; 54(19):6919-35.
    View in: PubMed
    Score: 0.014
  43. Obianyo O, Causey CP, Jones JE, Thompson PR. Activity-based protein profiling of protein arginine methyltransferase 1. ACS Chem Biol. 2011 Oct 21; 6(10):1127-35.
    View in: PubMed
    Score: 0.014
  44. Rust HL, Thompson PR. Kinase consensus sequences: a breeding ground for crosstalk. ACS Chem Biol. 2011 Sep 16; 6(9):881-92.
    View in: PubMed
    Score: 0.014
  45. Slack JL, Jones LE, Bhatia MM, Thompson PR. Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity. Biochemistry. 2011 May 17; 50(19):3997-4010.
    View in: PubMed
    Score: 0.014
  46. Slack JL, Causey CP, Luo Y, Thompson PR. Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4. ACS Chem Biol. 2011 May 20; 6(5):466-76.
    View in: PubMed
    Score: 0.013
  47. Knuckley B, Jones JE, Bachovchin DA, Slack J, Causey CP, Brown SJ, Rosen H, Cravatt BF, Thompson PR. A fluopol-ABPP HTS assay to identify PAD inhibitors. Chem Commun (Camb). 2010 Oct 14; 46(38):7175-7.
    View in: PubMed
    Score: 0.013
  48. Slack JL, Causey CP, Thompson PR. Protein arginine deiminase 4: a target for an epigenetic cancer therapy. Cell Mol Life Sci. 2011 Feb; 68(4):709-20.
    View in: PubMed
    Score: 0.013
  49. Bicker KL, Obianyo O, Rust HL, Thompson PR. A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1. Mol Biosyst. 2011 Jan; 7(1):48-51.
    View in: PubMed
    Score: 0.013
  50. Knuckley B, Causey CP, Jones JE, Bhatia M, Dreyton CJ, Osborne TC, Takahara H, Thompson PR. Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3. Biochemistry. 2010 Jun 15; 49(23):4852-63.
    View in: PubMed
    Score: 0.013
  51. Obianyo O, Causey CP, Osborne TC, Jones JE, Lee YH, Stallcup MR, Thompson PR. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem. 2010 Jun 14; 11(9):1219-23.
    View in: PubMed
    Score: 0.013
  52. Knuckley B, Causey CP, Pellechia PJ, Cook PF, Thompson PR. Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation. Chembiochem. 2010 Jan 25; 11(2):161-5.
    View in: PubMed
    Score: 0.012
  53. Jones JE, Causey CP, Lovelace L, Knuckley B, Flick H, Lebioda L, Thompson PR. Characterization and inactivation of an agmatine deiminase from Helicobacter pylori. Bioorg Chem. 2010 Apr; 38(2):62-73.
    View in: PubMed
    Score: 0.012
  54. Jones JE, Causey CP, Knuckley B, Slack-Noyes JL, Thompson PR. Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential. Curr Opin Drug Discov Devel. 2009 Sep; 12(5):616-27.
    View in: PubMed
    Score: 0.012
  55. Obianyo O, Osborne TC, Thompson PR. Kinetic mechanism of protein arginine methyltransferase 1. Biochemistry. 2008 Sep 30; 47(39):10420-7.
    View in: PubMed
    Score: 0.011
  56. Osborne TC, Obianyo O, Zhang X, Cheng X, Thompson PR. Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis. Biochemistry. 2007 Nov 20; 46(46):13370-81.
    View in: PubMed
    Score: 0.011
  57. Knuckley B, Bhatia M, Thompson PR. Protein arginine deiminase 4: evidence for a reverse protonation mechanism. Biochemistry. 2007 Jun 05; 46(22):6578-87.
    View in: PubMed
    Score: 0.010
  58. Luo Y, Arita K, Bhatia M, Knuckley B, Lee YH, Stallcup MR, Sato M, Thompson PR. Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization. Biochemistry. 2006 Oct 03; 45(39):11727-36.
    View in: PubMed
    Score: 0.010
  59. Xue T, Liu X, Song C, Fei S, Gu J, Han Y, Xing J, Liu X, Liang F, Thompson PR, Zhang X. Citrullination of AKT2 Catalyzed by PAD1 Facilitates the Maintenance of Stemness Characteristics of Ovarian Cancer Stem-Like Cells in Ovarian Cancer. Adv Sci (Weinh). 2025 Oct; 12(39):e01014.
    View in: PubMed
    Score: 0.009
  60. Kearney PL, Bhatia M, Jones NG, Yuan L, Glascock MC, Catchings KL, Yamada M, Thompson PR. Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis. Biochemistry. 2005 Aug 09; 44(31):10570-82.
    View in: PubMed
    Score: 0.009
  61. Mishra N, Mohs M, Wittmann N, Gross S, Thompson PR, Bossaller L. PLC and PAD2 Regulate Extracellular Calcium-Triggered Release of Macrophage Extracellular DNA Traps. Eur J Immunol. 2025 Apr; 55(4):e202350942.
    View in: PubMed
    Score: 0.009
  62. Yu X, Song Y, Dong T, Ouyang W, Quan C, Shao L, Barasa L, Thompson PR, Zhang M, Ma J, Kurabayashi K, Li Y. Citrullination of NF-?B p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury. Adv Sci (Weinh). 2025 May; 12(18):e2413253.
    View in: PubMed
    Score: 0.009
  63. Elfawal MA, Goetz E, Kim Y, Chen P, Savinov SN, Barasa L, Thompson PR, Aroian RV. High-Throughput Screening of More Than 30,000 Compounds for Anthelmintics against Gastrointestinal Nematode Parasites. ACS Infect Dis. 2025 Jan 10; 11(1):104-120.
    View in: PubMed
    Score: 0.009
  64. Olea-Flores M, Sharma T, Verdejo-Torres O, DiBartolomeo I, Thompson PR, Padilla-Benavides T, Imbalzano AN. Muscle-specific pyruvate kinase isoforms, PKM1 and PKM2, regulate mammalian SWI/SNF proteins and histone 3 phosphorylation during myoblast differentiation. FASEB J. 2024 Jun 15; 38(11):e23702.
    View in: PubMed
    Score: 0.008
  65. Mishra AK, Ye T, Banday S, Thakare RP, Su CT, Pham NNH, Ali A, Kulshreshtha A, Chowdhury SR, Simone TM, Hu K, Zhu LJ, Eisenhaber B, Deibler SK, Simin K, Thompson PR, Kelliher MA, Eisenhaber F, Malonia SK, Green MR. Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer. Cell Rep. 2024 04 23; 43(4):114041.
    View in: PubMed
    Score: 0.008
  66. Yusuf IO, Parsi S, Ostrow LW, Brown RH, Thompson PR, Xu Z. PAD2 dysregulation and aberrant protein citrullination feature prominently in reactive astrogliosis and myelin protein aggregation in sporadic ALS. Neurobiol Dis. 2024 03; 192:106414.
    View in: PubMed
    Score: 0.008
  67. Pasquero S, Gugliesi F, Biolatti M, Dell'Oste V, Albano C, Bajetto G, Griffante G, Trifir? L, Brugo B, Raviola S, Lacarbonara D, Yang Q, Sudeshna S, Barasa L, Haniff H, Thompson PR, Landolfo S, De Andrea M. Citrullination profile analysis reveals peptidylarginine deaminase 3 as an HSV-1 target to dampen the activity of candidate antiviral restriction factors. PLoS Pathog. 2023 Dec; 19(12):e1011849.
    View in: PubMed
    Score: 0.008
  68. Geary B, Sun B, Tilvawala RR, Barasa L, Tsoyi K, Rosas IO, Thompson PR, Ho IC. Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA. Front Immunol. 2023; 14:1290585.
    View in: PubMed
    Score: 0.008
  69. Xue T, Fei S, Gu J, Li N, Zhang P, Liu X, Thompson PR, Zhang X. Inhibiting MEK1 R189 citrullination enhances the chemosensitivity of docetaxel to multiple tumour cells. Philos Trans R Soc Lond B Biol Sci. 2023 11 20; 378(1890):20220246.
    View in: PubMed
    Score: 0.008
  70. Yusuf IO, Qiao T, Parsi S, Tilvawala R, Thompson PR, Xu Z. Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models. Acta Neuropathol Commun. 2022 09 08; 10(1):135.
    View in: PubMed
    Score: 0.007
  71. Binder V, Chruscicka-Smaga B, Bergum B, Jaisson S, Gillery P, Sivertsen J, Hervig T, Kaminska M, Tilvawala R, Nemmara VV, Thompson PR, Potempa J, Marti HP, Mydel P. Carbamylation of Integrin aIIb?3: The Mechanistic Link to Platelet Dysfunction in ESKD. J Am Soc Nephrol. 2022 10; 33(10):1841-1856.
    View in: PubMed
    Score: 0.007
  72. Mart?n Monreal MT, Rebak AS, Massarenti L, Mondal S, ?enolt L, ?dum N, Nielsen ML, Thompson PR, Nielsen CH, Damgaard D. Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4. Front Immunol. 2021; 12:716250.
    View in: PubMed
    Score: 0.007
  73. Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T, Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR, Ho IC. PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis. Matrix Biol. 2021 08; 102:70-84.
    View in: PubMed
    Score: 0.007
  74. Griffante G, Gugliesi F, Pasquero S, Dell'Oste V, Biolatti M, Salinger AJ, Mondal S, Thompson PR, Weerapana E, Lebbink RJ, Soppe JA, Stamminger T, Girault V, Pichlmair A, Oroszl?n G, Coen DM, De Andrea M, Landolfo S. Human cytomegalovirus-induced host protein citrullination is crucial for viral replication. Nat Commun. 2021 06 23; 12(1):3910.
    View in: PubMed
    Score: 0.007
  75. Funabashi K, Sawata M, Nagai A, Akimoto M, Mashimo R, Takahara H, Kizawa K, Thompson PR, Ite K, Kitanishi K, Unno M. Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design. Arch Biochem Biophys. 2021 Sep 15; 708:108911.
    View in: PubMed
    Score: 0.007
  76. Tian Y, Qu S, Alam HB, Williams AM, Wu Z, Deng Q, Pan B, Zhou J, Liu B, Duan X, Ma J, Mondal S, Thompson PR, Stringer KA, Standiford TJ, Li Y. Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis. JCI Insight. 2020 10 15; 5(20).
    View in: PubMed
    Score: 0.007
  77. Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Succination inactivates gasdermin D and blocks pyroptosis. Science. 2020 09 25; 369(6511):1633-1637.
    View in: PubMed
    Score: 0.006
  78. Li G, Young CH, Snow B, Christensen AO, Demoruelle MK, Nemmara VV, Thompson PR, Rothfuss HM, Cherrington BD. Identification and Characterization of the Lactating Mouse Mammary Gland Citrullinome. Int J Mol Sci. 2020 Apr 10; 21(7).
    View in: PubMed
    Score: 0.006
  79. Uysal-Onganer P, MacLatchy A, Mahmoud R, Kraev I, Thompson PR, Inal JM, Lange S. Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines. Int J Mol Sci. 2020 Feb 22; 21(4).
    View in: PubMed
    Score: 0.006
  80. Sun B, Chang HH, Salinger A, Tomita B, Bawadekar M, Holmes CL, Shelef MA, Weerapana E, Thompson PR, Ho IC. Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination. JCI Insight. 2019 11 14; 4(22).
    View in: PubMed
    Score: 0.006
  81. Li F, Miao L, Xue T, Qin H, Mondal S, Thompson PR, Coonrod SA, Liu X, Zhang X. Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells. J Exp Clin Cancer Res. 2019 Oct 10; 38(1):414.
    View in: PubMed
    Score: 0.006
  82. Mishra N, Schwerdtner L, Sams K, Mondal S, Ahmad F, Schmidt RE, Coonrod SA, Thompson PR, Lerch MM, Bossaller L. Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1? Maturation and ASC Speck Formation in Macrophages. J Immunol. 2019 08 15; 203(4):795-800.
    View in: PubMed
    Score: 0.006
  83. Sorvillo N, Mizurini DM, Coxon C, Martinod K, Tilvawala R, Cherpokova D, Salinger AJ, Seward RJ, Staudinger C, Weerapana E, Shapiro NI, Costello CE, Thompson PR, Wagner DD. Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury. Circ Res. 2019 08 16; 125(5):507-519.
    View in: PubMed
    Score: 0.006
  84. Cau L, Takahara H, Thompson PR, Serre G, M?chin MC, Simon M. Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in?Reconstructed Human Epidermis. J Invest Dermatol. 2019 09; 139(9):1889-1897.e4.
    View in: PubMed
    Score: 0.006
  85. Liu Y, Lightfoot YL, Seto N, Carmona-Rivera C, Moore E, Goel R, O'Neil L, Mistry P, Hoffmann V, Mondal S, Premnath PN, Gribbons K, Dell'Orso S, Jiang K, Thompson PR, Sun HW, Coonrod SA, Kaplan MJ. Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus. JCI Insight. 2018 12 06; 3(23).
    View in: PubMed
    Score: 0.006
  86. DeVore SB, Young CH, Li G, Sundararajan A, Ramaraj T, Mudge J, Schilkey F, Muth A, Thompson PR, Cherrington BD. Histone Citrullination Represses MicroRNA Expression, Resulting in Increased Oncogene mRNAs in Somatolactotrope Cells. Mol Cell Biol. 2018 10 01; 38(19).
    View in: PubMed
    Score: 0.006
  87. Wong A, Bryzek D, Dobosz E, Scavenius C, Svoboda P, Rapala-Kozik M, Lesner A, Frydrych I, Enghild J, Mydel P, Pohl J, Thompson PR, Potempa J, Koziel J. A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA. J Immunol. 2018 04 01; 200(7):2327-2340.
    View in: PubMed
    Score: 0.005
  88. Qin H, Liu X, Li F, Miao L, Li T, Xu B, An X, Muth A, Thompson PR, Coonrod SA, Zhang X. PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling. Cancer Lett. 2017 11 28; 409:30-41.
    View in: PubMed
    Score: 0.005
  89. Kenny EF, Herzig A, Kr?ger R, Muth A, Mondal S, Thompson PR, Brinkmann V, Bernuth HV, Zychlinsky A. Diverse stimuli engage different neutrophil extracellular trap pathways. Elife. 2017 06 02; 6.
    View in: PubMed
    Score: 0.005
  90. Horibata S, Rogers KE, Sadegh D, Anguish LJ, McElwee JL, Shah P, Thompson PR, Coonrod SA. Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration. BMC Cancer. 2017 05 26; 17(1):378.
    View in: PubMed
    Score: 0.005
  91. Kosgodage US, Trindade RP, Thompson PR, Inal JM, Lange S. Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy. Int J Mol Sci. 2017 May 09; 18(5).
    View in: PubMed
    Score: 0.005
  92. Cau L, Pendaries V, Lhuillier E, Thompson PR, Serre G, Takahara H, M?chin MC, Simon M. Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown. J Dermatol Sci. 2017 May; 86(2):106-113.
    View in: PubMed
    Score: 0.005
  93. Zhang X, Liu X, Zhang M, Li T, Muth A, Thompson PR, Coonrod SA, Zhang X. Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development. Sci Rep. 2016 12 08; 6:38727.
    View in: PubMed
    Score: 0.005
  94. Chang HH, Liu GY, Dwivedi N, Sun B, Okamoto Y, Kinslow JD, Deane KD, Demoruelle MK, Norris JM, Thompson PR, Sparks JA, Rao DA, Karlson EW, Hung HC, Holers VM, Ho IC. A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22. JCI Insight. 2016 Oct 20; 1(17):e90045.
    View in: PubMed
    Score: 0.005
  95. Papadaki G, Kambas K, Choulaki C, Vlachou K, Drakos E, Bertsias G, Ritis K, Boumpas DT, Thompson PR, Verginis P, Sidiropoulos P. Neutrophil extracellular traps exacerbate Th1-mediated autoimmune responses in rheumatoid arthritis by promoting DC maturation. Eur J Immunol. 2016 11; 46(11):2542-2554.
    View in: PubMed
    Score: 0.005
  96. Bawadekar M, Gendron-Fitzpatrick A, Rebernick R, Shim D, Warner TF, Nicholas AP, Lundblad LK, Thompson PR, Shelef MA. Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation. Arthritis Res Ther. 2016 07 22; 18(1):173.
    View in: PubMed
    Score: 0.005
  97. Hosseinzadeh A, Thompson PR, Segal BH, Urban CF. Nicotine induces neutrophil extracellular traps. J Leukoc Biol. 2016 11; 100(5):1105-1112.
    View in: PubMed
    Score: 0.005
  98. Ghari F, Quirke AM, Munro S, Kawalkowska J, Picaud S, McGouran J, Subramanian V, Muth A, Williams R, Kessler B, Thompson PR, Fillipakopoulos P, Knapp S, Venables PJ, La Thangue NB. Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response. Sci Adv. 2016 Feb; 2(2):e1501257.
    View in: PubMed
    Score: 0.005
  99. Horibata S, Vo TV, Subramanian V, Thompson PR, Coonrod SA. Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells. J Vis Exp. 2015 May 20; (99):e52727.
    View in: PubMed
    Score: 0.005
  100. Witalison EE, Cui X, Hofseth AB, Subramanian V, Causey CP, Thompson PR, Hofseth LJ. Inhibiting protein arginine deiminases has antioxidant consequences. J Pharmacol Exp Ther. 2015 Apr; 353(1):64-70.
    View in: PubMed
    Score: 0.004
  101. Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, R?diger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, Wilson DM. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015 Mar; 11(3):189-91.
    View in: PubMed
    Score: 0.004
  102. Witalison EE, Thompson PR, Hofseth LJ. Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation. Curr Drug Targets. 2015; 16(7):700-10.
    View in: PubMed
    Score: 0.004
  103. Smith CK, Vivekanandan-Giri A, Tang C, Knight JS, Mathew A, Padilla RL, Gillespie BW, Carmona-Rivera C, Liu X, Subramanian V, Hasni S, Thompson PR, Heinecke JW, Saran R, Pennathur S, Kaplan MJ. Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus. Arthritis Rheumatol. 2014 Sep; 66(9):2532-2544.
    View in: PubMed
    Score: 0.004
  104. Dwivedi N, Neeli I, Schall N, Wan H, Desiderio DM, Csernok E, Thompson PR, Dali H, Briand JP, Muller S, Radic M. Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity. FASEB J. 2014 Jul; 28(7):2840-51.
    View in: PubMed
    Score: 0.004
  105. U KP, Subramanian V, Nicholas AP, Thompson PR, Ferretti P. Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway. Biochim Biophys Acta. 2014 Jun; 1843(6):1162-71.
    View in: PubMed
    Score: 0.004
  106. Dillon MB, Rust HL, Thompson PR, Mowen KA. Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity. J Biol Chem. 2013 Sep 27; 288(39):27872-80.
    View in: PubMed
    Score: 0.004
  107. Knight JS, Zhao W, Luo W, Subramanian V, O'Dell AA, Yalavarthi S, Hodgin JB, Eitzman DT, Thompson PR, Kaplan MJ. Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus. J Clin Invest. 2013 Jul; 123(7):2981-93.
    View in: PubMed
    Score: 0.004
  108. Foyn H, Jones JE, Lewallen D, Narawane R, Varhaug JE, Thompson PR, Arnesen T. Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors. ACS Chem Biol. 2013; 8(6):1121-7.
    View in: PubMed
    Score: 0.004
  109. Cui X, Witalison EE, Chumanevich AP, Chumanevich AA, Poudyal D, Subramanian V, Schetter AJ, Harris CC, Thompson PR, Hofseth LJ. The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest. PLoS One. 2013; 8(1):e53791.
    View in: PubMed
    Score: 0.004
  110. McElwee JL, Mohanan S, Griffith OL, Breuer HC, Anguish LJ, Cherrington BD, Palmer AM, Howe LR, Subramanian V, Causey CP, Thompson PR, Gray JW, Coonrod SA. Identification of PADI2 as a potential breast cancer biomarker and therapeutic target. BMC Cancer. 2012 Oct 30; 12:500.
    View in: PubMed
    Score: 0.004
  111. Zhang X, Bolt M, Guertin MJ, Chen W, Zhang S, Cherrington BD, Slade DJ, Dreyton CJ, Subramanian V, Bicker KL, Thompson PR, Mancini MA, Lis JT, Coonrod SA. Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor a target gene activation. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13331-6.
    View in: PubMed
    Score: 0.004
  112. Mohamed BM, Verma NK, Davies AM, McGowan A, Crosbie-Staunton K, Prina-Mello A, Kelleher D, Botting CH, Causey CP, Thompson PR, Pruijn GJ, Kisin ER, Tkach AV, Shvedova AA, Volkov Y. Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo. Nanomedicine (Lond). 2012 Aug; 7(8):1181-95.
    View in: PubMed
    Score: 0.004
  113. Evjenth RH, Brenner AK, Thompson PR, Arnesen T, Fr?ystein N?, Lillehaug JR. Human protein N-terminal acetyltransferase hNaa50p (hNAT5/hSAN) follows ordered sequential catalytic mechanism: combined kinetic and NMR study. J Biol Chem. 2012 Mar 23; 287(13):10081-10088.
    View in: PubMed
    Score: 0.004
  114. Zhang X, Gamble MJ, Stadler S, Cherrington BD, Causey CP, Thompson PR, Roberson MS, Kraus WL, Coonrod SA. Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells. PLoS Genet. 2011 Jun; 7(6):e1002112.
    View in: PubMed
    Score: 0.003
  115. Lange S, G?gel S, Leung KY, Vernay B, Nicholas AP, Causey CP, Thompson PR, Greene ND, Ferretti P. Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability. Dev Biol. 2011 Jul 15; 355(2):205-14.
    View in: PubMed
    Score: 0.003
  116. Chumanevich AA, Causey CP, Knuckley BA, Jones JE, Poudyal D, Chumanevich AP, Davis T, Matesic LE, Thompson PR, Hofseth LJ. Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor. Am J Physiol Gastrointest Liver Physiol. 2011 Jun; 300(6):G929-38.
    View in: PubMed
    Score: 0.003
  117. Li P, Yao H, Zhang Z, Li M, Luo Y, Thompson PR, Gilmour DS, Wang Y. Regulation of p53 target gene expression by peptidylarginine deiminase 4. Mol Cell Biol. 2008 Aug; 28(15):4745-58.
    View in: PubMed
    Score: 0.003
  118. Yao H, Li P, Venters BJ, Zheng S, Thompson PR, Pugh BF, Wang Y. Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis. J Biol Chem. 2008 Jul 18; 283(29):20060-8.
    View in: PubMed
    Score: 0.003
  119. Cebrat M, Kim CM, Thompson PR, Daugherty M, Cole PA. Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorg Med Chem. 2003 Jul 31; 11(15):3307-13.
    View in: PubMed
    Score: 0.002
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.