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Craig Mello to Caenorhabditis elegans Proteins

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This is a "connection" page, showing publications Craig Mello has written about Caenorhabditis elegans Proteins.
Craig Mello
Connection Strength
10.288
Caenorhabditis elegans Proteins
  1. Ding YH, Ochoa HJ, Ishidate T, Shirayama M, Mello CC. The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing. Cell Rep. 2023 05 30; 42(5):112408.
    View in: PubMed
    Score: 0.578
  2. Dai S, Tang X, Li L, Ishidate T, Ozturk AR, Chen H, Dude AL, Yan YH, Dong MQ, Shen EZ, Mello CC. A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing. Cell Rep. 2022 09 06; 40(10):111265.
    View in: PubMed
    Score: 0.554
  3. Kim H, Ding YH, Lu S, Zuo MQ, Tan W, Conte D, Dong MQ, Mello CC. PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans. Elife. 2021 05 18; 10.
    View in: PubMed
    Score: 0.506
  4. Ishidate T, Ozturk AR, Durning DJ, Sharma R, Shen EZ, Chen H, Seth M, Shirayama M, Mello CC. ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals. Mol Cell. 2018 05 17; 70(4):639-649.e6.
    View in: PubMed
    Score: 0.411
  5. Shen EZ, Chen H, Ozturk AR, Tu S, Shirayama M, Tang W, Ding YH, Dai SY, Weng Z, Mello CC. Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C.?elegans Germline. Cell. 2018 02 22; 172(5):937-951.e18.
    View in: PubMed
    Score: 0.404
  6. Seth M, Shirayama M, Tang W, Shen EZ, Tu S, Lee HC, Weng Z, Mello CC. The Coding Regions of Germline mRNAs Confer Sensitivity to Argonaute Regulation in C.?elegans. Cell Rep. 2018 02 27; 22(9):2254-2264.
    View in: PubMed
    Score: 0.404
  7. Tang W, Seth M, Tu S, Shen EZ, Li Q, Shirayama M, Weng Z, Mello CC. A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C.?elegans. Dev Cell. 2018 03 26; 44(6):762-770.e3.
    View in: PubMed
    Score: 0.404
  8. Elewa A, Shirayama M, Kaymak E, Harrison PF, Powell DR, Du Z, Chute CD, Woolf H, Yi D, Ishidate T, Srinivasan J, Bao Z, Beilharz TH, Ryder SP, Mello CC. POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA. Dev Cell. 2015 Jul 06; 34(1):108-18.
    View in: PubMed
    Score: 0.336
  9. Tsai HY, Chen CC, Conte D, Moresco JJ, Chaves DA, Mitani S, Yates JR, Tsai MD, Mello CC. A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi. Cell. 2015 Jan 29; 160(3):407-19.
    View in: PubMed
    Score: 0.327
  10. Kim H, Ishidate T, Ghanta KS, Seth M, Conte D, Shirayama M, Mello CC. A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans. Genetics. 2014 Aug; 197(4):1069-80.
    View in: PubMed
    Score: 0.312
  11. Shirayama M, Stanney W, Gu W, Seth M, Mello CC. The Vasa Homolog RDE-12 engages target mRNA and multiple argonaute proteins to promote RNAi in C. elegans. Curr Biol. 2014 Apr 14; 24(8):845-51.
    View in: PubMed
    Score: 0.309
  12. Seth M, Shirayama M, Gu W, Ishidate T, Conte D, Mello CC. The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression. Dev Cell. 2013 Dec 23; 27(6):656-63.
    View in: PubMed
    Score: 0.303
  13. Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D, Yates JR, Mello CC. Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans. Cell. 2013 Dec 19; 155(7):1532-44.
    View in: PubMed
    Score: 0.303
  14. Conine CC, Batista PJ, Gu W, Claycomb JM, Chaves DA, Shirayama M, Mello CC. Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3588-93.
    View in: PubMed
    Score: 0.232
  15. Liu J, Maduzia LL, Shirayama M, Mello CC. NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division. Dev Biol. 2010 Mar 15; 339(2):366-73.
    View in: PubMed
    Score: 0.230
  16. Claycomb JM, Batista PJ, Pang KM, Gu W, Vasale JJ, van Wolfswinkel JC, Chaves DA, Shirayama M, Mitani S, Ketting RF, Conte D, Mello CC. The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell. 2009 Oct 02; 139(1):123-34.
    View in: PubMed
    Score: 0.226
  17. Gu W, Shirayama M, Conte D, Vasale J, Batista PJ, Claycomb JM, Moresco JJ, Youngman EM, Keys J, Stoltz MJ, Chen CC, Chaves DA, Duan S, Kasschau KD, Fahlgren N, Yates JR, Mitani S, Carrington JC, Mello CC. Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell. 2009 Oct 23; 36(2):231-44.
    View in: PubMed
    Score: 0.226
  18. Batista PJ, Ruby JG, Claycomb JM, Chiang R, Fahlgren N, Kasschau KD, Chaves DA, Gu W, Vasale JJ, Duan S, Conte D, Luo S, Schroth GP, Carrington JC, Bartel DP, Mello CC. PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. Mol Cell. 2008 Jul 11; 31(1):67-78.
    View in: PubMed
    Score: 0.207
  19. Yigit E, Batista PJ, Bei Y, Pang KM, Chen CC, Tolia NH, Joshua-Tor L, Mitani S, Simard MJ, Mello CC. Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Cell. 2006 Nov 17; 127(4):747-57.
    View in: PubMed
    Score: 0.185
  20. Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 2006 Jan 27; 124(2):343-54.
    View in: PubMed
    Score: 0.175
  21. Shirayama M, Soto MC, Ishidate T, Kim S, Nakamura K, Bei Y, van den Heuvel S, Mello CC. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Curr Biol. 2006 Jan 10; 16(1):47-55.
    View in: PubMed
    Score: 0.174
  22. Nakamura K, Kim S, Ishidate T, Bei Y, Pang K, Shirayama M, Trzepacz C, Brownell DR, Mello CC. Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos. Genes Dev. 2005 Aug 01; 19(15):1749-54.
    View in: PubMed
    Score: 0.169
  23. Chen CC, Simard MJ, Tabara H, Brownell DR, McCollough JA, Mello CC. A member of the polymerase beta nucleotidyltransferase superfamily is required for RNA interference in C. elegans. Curr Biol. 2005 Feb 22; 15(4):378-83.
    View in: PubMed
    Score: 0.164
  24. Kim Y, Nguyen TT, Durning DJ, Ishidate T, Aydemir O, Mello CC, Hu Y, Kahn TW, Aroian RV. Resistance to Cry14A family Bacillus thuringiensis crystal proteins in Caenornabditis elegans operates via the nhr-31 transcription factor and vacuolar-type ATPase pathway. PLoS Pathog. 2024 Oct; 20(10):e1012611.
    View in: PubMed
    Score: 0.160
  25. Pang KM, Ishidate T, Nakamura K, Shirayama M, Trzepacz C, Schubert CM, Priess JR, Mello CC. The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos. Dev Biol. 2004 Jan 01; 265(1):127-39.
    View in: PubMed
    Score: 0.152
  26. Unhavaithaya Y, Shin TH, Miliaras N, Lee J, Oyama T, Mello CC. MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans. Cell. 2002 Dec 27; 111(7):991-1002.
    View in: PubMed
    Score: 0.141
  27. Bei Y, Hogan J, Berkowitz LA, Soto M, Rocheleau CE, Pang KM, Collins J, Mello CC. SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos. Dev Cell. 2002 Jul; 3(1):113-25.
    View in: PubMed
    Score: 0.137
  28. Tabara H, Yigit E, Siomi H, Mello CC. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell. 2002 Jun 28; 109(7):861-71.
    View in: PubMed
    Score: 0.137
  29. Grishok A, Mello CC. RNAi (Nematodes: Caenorhabditis elegans). Adv Genet. 2002; 46:339-60.
    View in: PubMed
    Score: 0.132
  30. Makeyeva YV, Shirayama M, Mello CC. Cues from mRNA splicing prevent default Argonaute silencing in C.?elegans. Dev Cell. 2021 09 27; 56(18):2636-2648.e4.
    View in: PubMed
    Score: 0.130
  31. Ghanta KS, Ishidate T, Mello CC. Microinjection for precision genome editing in Caenorhabditis elegans. STAR Protoc. 2021 09 17; 2(3):100748.
    View in: PubMed
    Score: 0.129
  32. Spichal M, Heestand B, Billmyre KK, Frenk S, Mello CC, Ahmed S. Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility. Nat Commun. 2021 03 03; 12(1):1420.
    View in: PubMed
    Score: 0.125
  33. Chaves DA, Dai H, Li L, Moresco JJ, Oh ME, Conte D, Yates JR, Mello CC, Gu W. The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C.?elegans. Mol Cell. 2021 02 04; 81(3):546-557.e5.
    View in: PubMed
    Score: 0.123
  34. Grishok A, Tabara H, Mello CC. Genetic requirements for inheritance of RNAi in C. elegans. Science. 2000 Mar 31; 287(5462):2494-7.
    View in: PubMed
    Score: 0.117
  35. Tabara H, Sarkissian M, Kelly WG, Fleenor J, Grishok A, Timmons L, Fire A, Mello CC. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell. 1999 Oct 15; 99(2):123-32.
    View in: PubMed
    Score: 0.113
  36. Shin TH, Yasuda J, Rocheleau CE, Lin R, Soto M, Bei Y, Davis RJ, Mello CC. MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans. Mol Cell. 1999 Aug; 4(2):275-80.
    View in: PubMed
    Score: 0.112
  37. Rocheleau CE, Yasuda J, Shin TH, Lin R, Sawa H, Okano H, Priess JR, Davis RJ, Mello CC. WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans. Cell. 1999 Jun 11; 97(6):717-26.
    View in: PubMed
    Score: 0.111
  38. Shi Y, Mello C. A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans. Genes Dev. 1998 Apr 01; 12(7):943-55.
    View in: PubMed
    Score: 0.102
  39. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998 Feb 19; 391(6669):806-11.
    View in: PubMed
    Score: 0.101
  40. Rocheleau CE, Downs WD, Lin R, Wittmann C, Bei Y, Cha YH, Ali M, Priess JR, Mello CC. Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell. 1997 Aug 22; 90(4):707-16.
    View in: PubMed
    Score: 0.098
  41. Mello CC, Schubert C, Draper B, Zhang W, Lobel R, Priess JR. The PIE-1 protein and germline specification in C. elegans embryos. Nature. 1996 Aug 22; 382(6593):710-2.
    View in: PubMed
    Score: 0.091
  42. Tang W, Tu S, Lee HC, Weng Z, Mello CC. The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans. Cell. 2016 Feb 25; 164(5):974-84.
    View in: PubMed
    Score: 0.088
  43. Mello CC, Draper BW, Priess JR. The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo. Cell. 1994 Apr 08; 77(1):95-106.
    View in: PubMed
    Score: 0.077
  44. Kim S, Ishidate T, Sharma R, Soto MC, Conte D, Mello CC, Shirayama M. Wnt and CDK-1 regulate cortical release of WRM-1/?-catenin to control cell division orientation in early Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):E918-27.
    View in: PubMed
    Score: 0.071
  45. Shirayama M, Seth M, Lee HC, Gu W, Ishidate T, Conte D, Mello CC. piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline. Cell. 2012 Jul 06; 150(1):65-77.
    View in: PubMed
    Score: 0.068
  46. Thivierge C, Makil N, Flamand M, Vasale JJ, Mello CC, Wohlschlegel J, Conte D, Duchaine TF. Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. Nat Struct Mol Biol. 2011 Dec 18; 19(1):90-7.
    View in: PubMed
    Score: 0.066
  47. Vasale JJ, Gu W, Thivierge C, Batista PJ, Claycomb JM, Youngman EM, Duchaine TF, Mello CC, Conte D. Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3582-7.
    View in: PubMed
    Score: 0.058
  48. van Wolfswinkel JC, Claycomb JM, Batista PJ, Mello CC, Berezikov E, Ketting RF. CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs. Cell. 2009 Oct 02; 139(1):135-48.
    View in: PubMed
    Score: 0.057
  49. Tops BB, Tabara H, Sijen T, Simmer F, Mello CC, Plasterk RH, Ketting RF. RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans. Nucleic Acids Res. 2005; 33(1):347-55.
    View in: PubMed
    Score: 0.041
  50. Grigorenko AP, Moliaka YK, Soto MC, Mello CC, Rogaev EI. The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14955-60.
    View in: PubMed
    Score: 0.040
  51. Shin TH, Mello CC. Chromatin regulation during C. elegans germline development. Curr Opin Genet Dev. 2003 Oct; 13(5):455-62.
    View in: PubMed
    Score: 0.037
  52. Venkatesan K, McManus HR, Mello CC, Smith TF, Hansen U. Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead. Nucleic Acids Res. 2003 Aug 01; 31(15):4304-16.
    View in: PubMed
    Score: 0.037
  53. Conte D, Mello CC. RNA interference in Caenorhabditis elegans. Curr Protoc Mol Biol. 2003 May; Chapter 26:Unit 26.3.
    View in: PubMed
    Score: 0.036
  54. Soto MC, Qadota H, Kasuya K, Inoue M, Tsuboi D, Mello CC, Kaibuchi K. The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans. Genes Dev. 2002 Mar 01; 16(5):620-32.
    View in: PubMed
    Score: 0.033
  55. Victor M, Bei Y, Gay F, Calvo D, Mello C, Shi Y. HAT activity is essential for CBP-1-dependent transcription and differentiation in Caenorhabditis elegans. EMBO Rep. 2002 Jan; 3(1):50-5.
    View in: PubMed
    Score: 0.033
  56. Batchelder C, Dunn MA, Choy B, Suh Y, Cassie C, Shim EY, Shin TH, Mello C, Seydoux G, Blackwell TK. Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1. Genes Dev. 1999 Jan 15; 13(2):202-12.
    View in: PubMed
    Score: 0.027
  57. Tabara H, Hill RJ, Mello CC, Priess JR, Kohara Y. pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans. Development. 1999 Jan; 126(1):1-11.
    View in: PubMed
    Score: 0.027
  58. Draper BW, Mello CC, Bowerman B, Hardin J, Priess JR. MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos. Cell. 1996 Oct 18; 87(2):205-16.
    View in: PubMed
    Score: 0.023
  59. Watts JL, Etemad-Moghadam B, Guo S, Boyd L, Draper BW, Mello CC, Priess JR, Kemphues KJ. par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3. Development. 1996 Oct; 122(10):3133-40.
    View in: PubMed
    Score: 0.023
  60. Seydoux G, Mello CC, Pettitt J, Wood WB, Priess JR, Fire A. Repression of gene expression in the embryonic germ lineage of C. elegans. Nature. 1996 Aug 22; 382(6593):713-6.
    View in: PubMed
    Score: 0.023
  61. Mickey KM, Mello CC, Montgomery MK, Fire A, Priess JR. An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell. Development. 1996 Jun; 122(6):1791-8.
    View in: PubMed
    Score: 0.022
  62. Levitan DJ, Boyd L, Mello CC, Kemphues KJ, Stinchcomb DT. par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):6108-12.
    View in: PubMed
    Score: 0.020
  63. Bowerman B, Draper BW, Mello CC, Priess JR. The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos. Cell. 1993 Aug 13; 74(3):443-52.
    View in: PubMed
    Score: 0.018
  64. Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 2005 Jul 28; 436(7050):593-7.
    View in: PubMed
    Score: 0.011
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.